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Clinical outcomes in patients treated with radiotherapy after surgery for cervical cancer
Yang, Kyungmi,Park, Won,Huh, Seung Jae,Bae, Duk-Soo,Kim, Byoung-Gie,Lee, Jeong-Won The Korean Society for Radiation Oncology 2017 Radiation Oncology Journal Vol.35 No.1
Purpose: The purpose of this study was to analyze clinical outcomes from cervical cancer and stratify patients into risk groups for prognostic factors for early-stage disease. Materials and Methods: We retrospectively reviewed patients with stage IB or IIA cervical cancer treated with adjuvant radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) following primary surgery at Samsung Medical Center from 2001 to 2011. Adjuvant RT was added for patients with intermediate-risk factors, and adjuvant CCRT was performed on high-risk patients after surgery. Results: We reviewed 247 patients-149 in the high-risk group and 98 in intermediate-risk group. The median follow-up was 62 months. Loco-regional failure (LRF) alone occurred in 7 patients (2.8%), distant metastasis alone in 37 patients (15.0%) and LRF with DM in 4 patients (1.6%). The 5-year disease-free survival (DFS) and overall survival (OS) rates for both groups were 79.7% and 87.6%, respectively. In the high-risk group, the 5-year DFS and OS probabilities were 72.5% and 81.9%, respectively. Histologic type, pathologic tumor size, and the number of pelvic lymph node (PLN) metastasis were significant prognostic factors for DFS and OS. We suggest a scoring system (0-3) using these prognostic factors to predict poor prognosis in high-risk patients. Using this system, patients with higher scores have higher recurrence and lower survival rates. Conclusion: In the high-risk cervical-cancer group who received primary surgery and adjuvant CCRT, non-squamous type, large tumor size and the number of PLN metastasis were significant prognostic factors, and the number of these factors was associated with survival rates.
Hyunseok Lee(Hyunseok Lee),Dongryul Oh(Dongryul Oh),Yong Chan Ahn(Yong Chan Ahn),Hongryull Pyo(Hongryull Pyo),Kyungmi Yang(Kyungmi Yang),Jae Myoung Noh(Jae Myoung Noh) 대한방사선종양학회 2024 Radiation Oncology Journal Vol.42 No.1
Purpose: This retrospective study aimed to compare clinical outcomes and dosimetric parameters between radiation therapy (RT) techniques in patients with thymic epithelial tumor (TET). Materials and Methods: From January 2016 to December 2020, 101 patients with TET received adjuvant RT (median, 52.8 Gy; range, 48.4 to 66.0). Three different RT techniques were compared: three-dimensional conformal RT (3D-CRT; n = 59, 58.4%), intensity-modulated RT (IMRT; n = 23, 22.8%), and proton beam therapy (PBT; n = 19, 18.8%). Results: The median age of the patients and the follow-up period were 55 years (range, 28 to 79) and 43.4 months (range, 7.7 to 77.2). Patients in the PBT group were of the youngest age (mean age, 45.4 years), while those in IMRT group had the largest clinical target volume (mean volume, 149.6 mL). Patients in the PBT group had a lower mean lung dose (4.4 Gy vs. 7.6 Gy vs. 10.9 Gy, respectively; p < 0.001), lower mean heart dose (5.4 Gy vs. 10.0 Gy vs. 13.1 Gy, respectively; p = 0.003), and lower mean esophageal dose than patients in the 3D-CRT and IMRT groups (6.3 Gy vs. 9.8 Gy vs. 13.5 Gy, respectively; p = 0.011). Twenty patients (19.8%) showed disease recurrence, and seven patients (6.9%) died. The differences in the survival rates between RT groups were not statistically significant. Conclusion: In patients with TET who underwent adjuvant RT, PBT resulted in a lower dose of exposure to adjacent organs at risk. Survival outcomes for patients in PBT group were not significantly different from those in other groups.
Kim, Kyungmi,Kwon, Hyeok-Chan,Ma, Sunihl,Lee, Eunsong,Yun, Seong-Cheol,Jang, Gyumin,Yang, Hyunha,Moon, Jooho American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.36
<P>Organic-inorganic hybrid perovskite solar cells (PSCs) have recently attracted tremendous attention because of their excellent efficiency and the advantage of a low-cost fabrication process. As a transparent electrode for PSCs, the application of copper nanowire (CuNW)-network was limited because of its thermal/chemical instability, despite its advantages in terms of high optical/electrical properties and low-cost production. Here, the copper-nickel core-shell nanowire (Cu@Ni NW)-based composite electrode is proposed as a bottom window electrode for PSCs, without the involvement of a high-cost precious metal and vacuum process. The dense and uniform Ni protective shell for CuNWs is attainable by simple electroless plating, and the resulting Cu@Ni NWs exhibit outstanding chemical stability as well as thermal stability compared with bare CuNWs. When the Ni layer with the optimal thickness is introduced, the Cu@Ni NW electrode shows a high transmittance of 80.5% AVT at 400-800 nm, and a sheet resistance of 49.3 ± 5 Ω sq<SUP>-1</SUP>. Using the highly stable Cu@Ni NWs, the composite electrode structure is fabricated with sol-gel-derived Al-doped zinc oxide (AZO) over-layer for better charge collection and additional protection against iodine ions from the perovskite. The PSCs fabricated with AZO/Cu@Ni NW-based composite electrode demonstrate a power conversion efficiency (PCE) of 12.2% and excellent long-term stability maintaining 91% of initial PCE after being stored for 500 h at room temperature. Experimental results demonstrate the potential of highly stable Cu@Ni NW-based electrodes as the cost-effective alternative transparent electrode, which can facilitate the commercialization of PSCs.</P> [FIG OMISSION]</BR>
The senior anesthesiologists and their medical profession in Korea: based on a survey
Kim Kyungmi,Baek Sungwoon,Choi In-Cheol,Yang Hong Seuk 대한마취통증의학회 2021 Anesthesia and pain medicine Vol.16 No.2
Background: The number of aging physicians is increasing as the global population ages. With aging, anesthesiologists would be expected to experience changes in their professional position. Therefore, we aimed to investigate the current professional status of Korean anesthesiologists aged over 60 years. Methods: Registered anesthesiologists aged over 60 years in Korea were invited for a survey. The questionnaire addressed 10 subjects with 40 questions that focused on demographics, practical activities, work conditions, difficulties experienced due to physical changes caused by aging, and economic status. Results: In total, 122 anesthesiologists responded to the survey (response rate: 15.7%). Of them, 30.3% were working in honorary and advisory positions at tertiary hospitals, while 19.7% were working as pain physicians. Majority of the respondents were working for 5 days a week (41.8%) and 6–8 hours/day (48.4%). Majority of them (79.5%) were generally satisfied with their present life. Conclusions: Majority of the senior anesthesiologists were working at general hospitals and they reported being “satisfied” with the current status of their life. However, the clinical practice and retirement strategies of senior anesthesiologists need to be evaluated systematically to prepare for the continuing gradual increase in the number of senior anesthesiologists.
Kwon, Hyeok-Chan,Yang, Wooseok,Lee, Daehee,Ahn, Jihoon,Lee, Eunsong,Ma, Sunihl,Kim, Kyungmi,Yun, Seong-Cheol,Moon, Jooho American Chemical Society 2018 ACS NANO Vol.12 No.5
<P>Organometal halide perovskite materials have become an exciting research topic as manifested by intense development of thin film solar cells. Although high-performance solar-cell-based planar and mesoscopic configurations have been reported, one-dimensional (1-D) nanostructured perovskite solar cells are rarely investigated despite their expected promising optoelectrical properties, such as enhanced charge transport/extraction. Herein, we have analyzed the 1-D nanostructure effects of organometal halide perovskite (CH<SUB>3</SUB>NH<SUB>3</SUB>PbI<SUB>3-<I>x</I></SUB>Cl<SUB><I>x</I></SUB>) on recombination and charge carrier dynamics by utilizing a nanoporous anodized alumina oxide scaffold to fabricate a vertically aligned 1-D nanopillared array with controllable diameters. It was observed that the 1-D perovskite exhibits faster charge transport/extraction characteristics, lower defect density, and lower bulk resistance than the planar counterpart. As the aspect ratio increases in the 1-D structures, in addition, the charge transport/extraction rate is enhanced and the resistance further decreases. However, when the aspect ratio reaches 6.67 (diameter ∼30 nm), the recombination rate is aggravated due to high interface-to-volume ratio-induced defect generation. To obtain the full benefits of 1-D perovskite nanostructuring, our study provides a design rule to choose the appropriate aspect ratio of 1-D perovskite structures for improved photovoltaic and other optoelectrical applications.</P> [FIG OMISSION]</BR>
Transformation of charge polarity at HfO2/GaN interfaces through post-deposition annealing
Han Yoolim,Go Ju Mi,Yang Kyungmi,Kim Minsu,Kim Kwangeun 한국물리학회 2024 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.84 No.5
The transformation of charge polarity at HfO2/GaN interfaces was investigated through the post-deposition annealing (PDA) at 500 °C, 700 °C and 900 °C for 3 min. The change in surface property of atomic-layer deposition HfO2/GaN with the PDA conditions was estimated by a contact angle measurement. The PDA improved surface adhesion and thus decreased the contact angle of HfO2, which was shown with the PDA up to 700 °C. The increased contact angle with the PDA at 900 °C was presumably due to the transformation of crystallinity of HfO2 flm from amorphous to polycrystalline. The charge polarity at the HfO2/GaN interfaces was changed from negative to positive with the elevated PDA temperature. The energy band bending at the HfO2/GaN interfaces was described based on the elemental binding energy obtained by X-ray photoelectron spectroscopy. The charge polarity at the HfO2/GaN interface was converted at the 700 °C PDA with increased net charge density. The PDA afected the interface property of HfO2/GaN and determined the interface polarity and charge density.