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( Hyung Oh Kim ),( Chun Gyoo Ihm ),( Tae Won Lee ),( Kyung Hwan Jeong ),( Seul Ki Kim ),( Ji Yun Park ),( Jin Sug Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: We report a rare case of CAPD peritonitis caused by Ochrobacterium anthropi. Introductions: Among the continuous ambulatory peritoneal dialysis(CAPD) patients, peritonitis is one of the most commonly taken complications, and also the general cause of dialytic modality exchange to hemodialysis. Usual pathogens of CAPD peritonitis may be bacteria, fungi, mycobacteria. Coagulase negative staphylococci, S. aureus, campylobacter, pseudomonas are common reported pathogens among the bacteria, of CAPD peritonitis cases, meanwhile candida is among fungi. Ochrobacterium anthropi is one species of Brucellaceae, which is rare pathogen of human disease. Case (Methods and results): 73 years old female, who was on CAPD due to diabetic end stage renal disease visited Kyung-Hee University hospital with intermittent abdominal pain. Body fi uid analysis showed increased white blood cell(WBC) count of 26,750/mm3 with her peritoneal fi uid. Culture study with peritoneal fi uid suggested O. anthropi, and DNA sequencing with PCR was consistent with O. anthropi. Intraperitoneal ceftazidime and cefazolin were administrated as empirical antibiotics. Ceftazidime resistance was noted with the result of antibiotics sensitivity test at 7th day of hospitalization, and antibiotics were changed into intraperitoneal gentamicin, which showed sensitivity to the pathogen. CAPD catheter removal and antibiotics re-exchange into imipenem and cefazolin, which were other sensitive antibiotics by the sensitivity test, were done since clinical manifestation and peritoneal fi uid WBC count was repeatedly improved and aggravated. The patient discharged with improved lab test results and resolving clinical symptoms afterward. Conclusions: We presentators report rare case of CAPD peritonitis with pathogen of O. anthropi. The pathogen of the case confi rmed by classical microbiologic, and molecular biologic Methods: The patient was unable to treat only with antibiotics, thus CAPD catheter, which might be act as colonizing source, was removed, and the disease resolved.
S-470 Relationships between blood pressure and clinico-pathological findings in IgA nephropathy
( Hyung-seok Ihm ),( Da-rae Kim ),( Jin-sug Kim ),( Kyung-hwan Jeoung ),( Tae-won Lee ),( Chun-gyoo Ihm ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Objective: Several factors contribute to the development of hypertension in patients with IgA nephropathy (IgAN). This study was conducted to find the relationships between baseline blood pressure (BP) and clinico-pathological findings in patients with IgAN and normal renal function. Design and Method: Clinico-pathological findings were analyzed in a total of 163 patients with IgAN and serum creatinine £ 1.1 mg/dL from The Kyung-Hee Cohort of Glomerulonephritis. The glomerular surface area (GSA) was determined using imaging analysis software. The serum and urine angiotensinogen (AGT) concentrations were measured using human ELISA kits.?Results: Mean serum creatinine concentration was 0.86 (0.5~1.1) mg/dL. Systolic BP was ≥ 130 mmHg in 72 patients (44%) and ≥ 140 mmHg in 42 (26%). Patients with systolic BP ≥ 130 mmHg as compared with those <130 mmHg had higher GSA and tubulointerstitial fibrosis and showed worse follow-up clinical findings: higher concentrations of serum creatinine, larger amount of proteinuria and lower levels of GFR. Systolic BP was positively correlated with age, baseline and follow-up proteinuria, serum uric acid concentrations and IgM deposit and negatively with follow-up GFR and the slope of change in 1/serum creatinine for 2 years, while it has no significant relationships with serum and urine AGT and 24 hour urinary sodium excretion. Conclusions: This study showed that systolic BP was associated with renal progression and pathological findings, glomerulomegaly and tubulointerstitial fibrosis, in patients with IgAN.
김재필(Jae Phil Kim),조대옥(Dae Ok Cho),고경식(Kyung Sik Ko),안재형(Jai Hyung Ahn),이태원(Tae Won Lee),임천규(Chun Gyoo Ihm),김명재(Myung Jae Kim) 대한내과학회 1995 대한내과학회지 Vol.49 No.1
N/A Objectives: Renal transplantation is a major therapeutic advance for patients with chronic renal failure. But recipients of renal transplantation are prone to infection with both common and unusual organisms. And infectious diseases remain a major cause of morbidity and mortality in renal transplant recipients. This study was to analyze the infections in renal transplant recipients; its occurrence according to sites and organisms; comparison among immunosuppressive agents; prognostic differences of urinary tract infections(UTI) between those developed during 1 month after transplantation and those not developed; graft outcome; and patients mortality. Mothods: 181 renal transplant recipients were examined. They received renal transplantion between january 1979 and December 1992 at the Kyung-Hee University Hospital. 158 of them received transplantation from living-related donors, 22 from living-unrelated donors, and 1 from cadaver donor. Their age at the time of transplantation ranged from 14 to 66 years(mean 35.6 years), and the male to female ratio was 2.3: 1. The observation period ranged from 1 to 144 months(41.26±31.71, mean±S. D.). Results: 1) 110 recipients(60.7% of total) had 232 episodes of infectious complications whereas 71(39.3% of total) had no infectious episodes. About half of infectious episodes(128 episodes, 55.2% ) occurred during 1 month after transplantation. 2) The most common site of infection was urinary tract(138 episodes, 59.2%) whth the next sites coming in this order, bacteremia(32 episodes, 13.8%), pulmonary(21 episodes, 9.1%), and skin(21 episodes, 9.1%). 3) The causative organisms of UTI ranked in this order E. coli 21.7%, staphylococcus spp 14.5%, and pseudomonas spp 13.0%. 4) The causative organisms of bacteremia ranked in this order E. coli 34.4% salmonella spp 18.8%, pseudomonas spp 12.5 %, and staphylococcus spp 12.5%. 5) There was no significant differences of infectious episodes among immunosuppressive regimens. 6) Early UTI group(UTI occurred during 1 month after transplantation) recorded significantly higher incidence of urinary tract infections after 1 month that followed than non-UTI group. But there was no differences between two groups on graft and patients outcome. 7) The major cause of death was life-threatening infections(63.2 %). Conclusion: Most infections due to various organisms may occur during 1 month after transplantation. And still they constitute a major cause of death in renal transplant recipients.
Won Gi Kim,Seul Ah Lee,Sung Min Moon,Jin-Soo Kim,Su-Gwan Kim,Yong Kook Shin,Do Kyung Kim,Chun Sung Kim 대한구강생물학회 2016 International Journal of Oral Biology Vol.41 No.4
Anthricin (Deoxypodophyllotoxin), a naturally occurring flavolignan, has well known anti-cancer properties in several cancer cells, such as prostate cancer, cervical carcinoma and pancreatic cancer. However, the effects of Anthricin are currently unknown in oral cancer. We examined the anticancer effect and mechanism of action of Anthricin in human FaDu hypopharyngeal squamous carcinoma cells. Our data showed that Anthricin inhibits cell viability in a dose- and time-dependent manner (IC50 50 nM) in the MTT assay and Live & Dead assay. In addition, Anthricin treated FaDu cells showed marked apoptosis by DAPI stain and FACS. Furthermore, Anthricin activates anti-apoptotic factors such as caspase-3, -9 and poly (ADP-ribose) polymerase (PARP), suggesting that caspase-mediated pathways are involved in Anthricin- induced apoptosis. Anthricin treatment also leads to accumulation of the pro-apoptotic factor Bax, followed by inhibition of cell growth. Taken together, these results indicate that Anthricn-induced cell death of human FaDu hypopharyngeal squamous carcinoma cells is mediated by mitochondrial-dependent apoptotic pathway. In summary, our findings provide a framework for further exploration on Anthricin as a novel chemotherapeutic drug for human oral cancer.
Management Strategies of Livestock Wastε Minimization and Resource Conservation
Kyung-S∞k Kim,Hyo-Joung Won,Jae-Chun Chung,Deuk-soo Choi 유기성자원학회 2000 유기물자원화 Vol.8 No.1
There is no simple method to solve livestock waste problems satisfactorily. For a successful solution, various methods should be well organized orderly depending upon 띠e situation. Even in the livestock waste management, integrated waste management principle should be applied. Minirnization of livestock wastε gεneration is the fìrst priority. lt is also important to distribute fairly livestock farms througholit the nation.Efficient management of permit system is equally important. Perrnit should be given only when the 상rmer have enough grass-land 0 11 which the farmer can apply more than twO thirds of livestock waste generared or when the farm have an anaerobic digestor in which store livestock waste generared for ar leasr 3 months. 1n principle, livestock wasre should be rreared in the farm and it is dεsirable to operare composting faciliri않 in the farm sire too.
Kyung-Hwan Jeong,Tae-Won Lee,Chun-Gyoo Ihm,Sang-Ho Lee,Ju-Young Moon 생화학분자생물학회 2008 Experimental and molecular medicine Vol.40 No.2
Genetic polymorphisms may be linked to inter-in-dividual diferences in erythropoietin (EPO) resist-the IL-1B gene and the I/D polymorphism of the ACE gene for any association with EPO resistance index (ERI) in maintenance hemodialysis patients (n =167). Because EPO responsiveness is multi-factorial, we al-so included other possible influences (age, sex, time on dialysis, ACE inhibitor or angiotensin receptor blocker use, ferritin, transferrin saturation, intact PTH, high sensitivity C-reactive protein, albumin, Kt/V, and Multiple regression analysis showed significant asso-ciation of the IL-1B-511CC and ACE DD polymor-phisms with ERI (P= 0.038 and P= 0.004 in the re-cessive model, respectively). The combination (C) of alleles of two loci showed that C1 (I-T) was significantly asociated with ERI in the co-dominant and recesive models (P= 0.005 and P= 0.0001, respectively). Sub-jects who did not carry C1 showed significantly de-creased ERI (10.10± 5.15 IU/kg weight/g hemoglobin) compared to other study subjects (C1/C1 and C1/-; 12.97± 4.90 and 15.12± 7.43 IU/kg weight/g hemo-globin, respectively). Our study indicates that the IL-1B-51C/T and ACE I/D polymorphisms may be use-ful genetic markers of EPO requirement in hemodial-ysis patients. These findings might also provide a new perspective on therapeutic approaches to the treat-