문학,문화 : 디지털 시대 도시의 생태학적 전망

이경래 ( Kyung Lae Lee ),박규현 ( Kyou Hyun Park ),조연정 ( Yeon Jung Cho ) 경희대학교 비교문화연구소 2012 비교문화연구 Vol.26 No.-

City`s Ecological Landscape in the Digital Age Lee Kyung-Lae, Park Kyou-Hyun, Cho Yeon-Jung We all know how beautiful our wild and it`s importance to our living planet Earth. But did you realise the speed at which man himself is damaging it`s unique natural habitat. We are well on our way to destroy our forests, plants, wetlands. We are polluting our oceans and seas. This way, we`re driving numerous animal species, plant species and many others into extinction. Everyone should be aware of the importance of our natural environment. We live in the period of echocide. Why we need nature to survive and how we can deal with the environmental problems we face. This paper has the purpose to reform city`s environment. Because, Metropolis and megalopolis are the principal cause of environmental disruption. To reform the city is needed to consider digital technology in our age. In the face of economic and cultural globalization, many have argued that we live an increasingly placeless world. However, as a growing number of cities participate and compete in key marketplaces of advanced capitalism, the spectacle of the city is more than ever a significant medium of communication in its own right. In doing so, this work is focused specifically on the dimension of city`s media environment. To that end, the paper examined U-City and U-Eco city. In this study, we will introduce the study on model of U-Eco City as one way for the eco-freindly future city.

디아릴설포닐이미다졸론의 결정구조상의 분자간 인력구조- C-H가 관여된 수소결합

박경래,장석영 충남대학교 약학대학 의약품개발연구소 2002 藥學論文集 Vol.17 No.-

In the search for a water soluble form of the potential anticancer agent, (S)-(+)-4-Phenyl-1-[1-(4-aminobenzoyl)indoline-5-sulfonyl]-4,5-dihydro-2-imidazolone (I), a series of salt forms were investigated using x-ray single crystal crystallography. The stoichiometrically correct form was found as a 2:1 HCl salt and this HCl salt of the title compound (I) crystallises in space group C2 as [C_24H_22N_4O_4S][C_24H_23N_4O_4S]^+CL^- from a methanol/methylenechloride solution. In this unusual crystal, there are two conformers, which show different structural characteristics. The terminal amine is clearly protonated in the one form with NH_3-Cl distance of 3.110Å, whereas the amine group in the other form is expected to be unprotonated with NH_2-Cl distance of 3.502Å. The role of imidazolone NH group in salt formation is also very peculiar. The imidazolone NH of the two conformers have almost the same distance (3.106Å and 3.103Å) to Cl ion in the crystal packing. In the crystal structure, there are eight distinct hydrogen bonds comprising four N-H…Cl, three N-H…O and one N-H…N, one of which builds bifurcated hydrogen bond with two acceptors sharing one H atom. There exist also one carbonyl oxygen atom accepting two hydrogen atoms. Furthermore, C-H…O contacts assist in the overall hydrogen bonding process.

Backpropagation 학습알고리즘을 이용한 형상검출

박경우,조정래,이기준 광주보건대학 1997 論文集 Vol.22 No.-

The Backpropagation learning method is composed of input layer, Middle layer, and Output layer as a Hierarchical Network. Because we can settle Weight of Middle layer using difference which is output value of Output layer and Error value, in proportion to the times of learning, we can obtain a good quality of output layer.

분자모델링에 의한 시메티딘, 파모티딘, 라니티딘 유도체 등의 H_2-길항제의 수용액상의 형태에 관한 연구

박경래,문병기 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-

The solution structure of cimetidine, famotidine and ranitidine was investigated using molecular dynamics simulation on the basis of MM^+ Force Field. The solution environment was mimicked only implicity by the use of constant dielectric constant. To search a most stable conformation starting from the crystal structure the geometry optimization was not the proper method. The dynamics simulation time necessary to sample the reasonable global potential energy minima was 1ns to 4ns even with these small organic molecules. After the sufficient time of free dynamics the molecules could set to most stable conformations which are quite different from that in X-ray structures.

라세미 혼합물 이산화티에핀의 결정구조

박경래,장석영 충남대학교 약학대학 의약품개발연구소 2000 藥學論文集 Vol.16 No.-

The solid structure of 2,7-Dihydro-3,4,5,6-dibenzothiepin-1-dioxide(I) was determined by x-ray diffraction method and it crystallized in P2(1)/C space group from saturated ethanol solution. Due to the axis of chirality in bridged biphenyl group compound I can exist in either Ra or Sa form and the conformational flexibility of 7-membered thiepin ring allows that each enantiomer interconverts to the other form at temperature above 80℃ in solution. In the crystal structure, there are two enantiomers in exact stoichiometry of 1:1 and the sulfonyl groups of Ra and Sa forms are facing to each other. Two types of hydrogen bond involving C-H group are responsible for crystalline cohesion.

베타차단제와 베타-사이클로덱스트린 복합체 내에서의 광학선택성에 대한 분자역학적 연구

장석영,박경래 충남대학교 약학대학 의약품개발연구소 2003 藥學論文集 Vol.18 No.-

Beta-blockers have been used in the treatment of hypertension, angina and cardiovascular disorder Their pharmacodynamic and pharmacokinetic characteristics between (R) and (S) enantiomers are different. We selected β-cyclodextrin (BCD) as a chiral selector and metoprolol (MT) and propranolol (PNP) as quest molecules to investigate mechanism for separation. The binding interactions and energetics in inclusion complex of (S)- and (R)-enatniomer in BCD were investigated by molecular dynamics (MD) simulation method. In the inclusion complex the guest molecules restrains the host molecule to a smaller range of atomic fluctuation due to the electrostatic interactions between polar groups of guest and BCD Free energy calculation for the transition of (S)- to (R)-form was performed using slow-growth method. The improper dihedral angle around the chiral center of (S)-form was perturbed to (R) form The thermodynamic integration gave a free energy change from (S)-MT-BCD to (R)-MT-BCD of 0.98 kJ/mol, which predicts the bigger stability of (R)-MT-BCD complex than that of (S)-isomer. In the case of PNP-BCD complex, a free energy change of 0.95 kJ/mol indicates that (S)-form complex was more stable than (R)-form complex.

COX-2 억제제의 결합구조와 활성 값의 예측

김혜정,박경래 충남대학교 약학대학 의약품개발연구소 2004 藥學論文集 Vol.19 No.-

The flexible docking studies for 88 selective COX-2 (cyclooxygenase-2) inhibitors belonging to three chemical classes (1.2-diary1 heterocycles, 1,3-diaryl cycloalkanopyrazoles, and diphenyl hydrazides) were conductedusing molecular dynamics. The binding energies calculated from docking were correlated with inhibitory activities by the least-squares fit method. The three chemical classes of inhibitors showed reasonable internal predictability (r2= 0 51, 0.49, and 0.54), but the sulfonyl-containing inhibitors demonstrated distinctively low binding energy compared to the others. The electrostatic interaction energy between the Arg513 of the COX-2 active site and sulfonyl group of the 1,2-diaryl heterocycles seemed to have the responsibility for difference in binding energy.

Silaethene CL₂Si=CHCH₂?Bu의 엔반응 : Unsaturated Compounds of 14Group Elements(Ⅸ)

김정균,박은미,구미영,박경래,손병영 東亞大學校 大學院 1992 大學院論文集 Vol.17 No.-

Silaethene Cl₂Si=CHCH₂?Bu 1, generated as a reaction intermediate by the thermal elimination of LiX from Cl₃SiCHLiCH₂?Bu 2, combines with ene-component containing compounds(propene, 2-methylpropene, DMB) to give 40∼90% yield ene-products. They can be isolated and spectroscopic identified.

온산만의 퇴적물과 총알고둥(Littorina brevicula)내 중금속 분포

이인숙,박경숙,최병래,송미연 이화여자대학교 환경문제연구소 1997 이화환경연구 Vol.1 No.-

To investigate the distribution of heavy metal concentrations in Onsan bay, concentrations of cadmium, copper, zinc and lead in surface sediments and the periwinkles (Littorina brevicula) were determined in February and July, 1996. The ranges of cadmium, copper, zinc, and lead concentrations in the surface sediments were 0.08∼3.72, 3∼307, 49∼1273 and 15∼399㎍/g dry weight, respectively. The decrease of concentration in heavy metals with distance from Daejeong stream indicated that this stream is the pollutant source of heavy metals in Onsan Bay. The concentrations of cadmium, copper, zinc and lead in L. brevicula were 0.11∼11.81, 21∼212, 30∼96 and 0.26∼4.12㎍/g dry weight in February and 1.01∼24.9, 66∼325.4, 54∼225 and 0.68∼8.41㎍/g dry weight in July, respectively. These concentrations in L. brevicula were the significantly different(p<0.001) with the season of sampling. However, overall distribution of concentrations of heavy metals in L. brevicula had very similar tendency that concentrations of heavy metal decreased with the distance from the pollutant source irrespective of the two seasons. Therefore, L.brevicula is considered as a useful indicator for heavy metals pollution. According to analysis of the organs, tissues such as the digestive gland, gill and viceral mussel accumulate high concentrations of heavy metals.

ABR 트래픽에 대한 피드백제어 모델

김희수,박경우,조정래,오창윤 광주보건대학 2000 論文集 Vol.25 No.-

The Asynchornous transfer mode (ATM) can be efficiently used to transport apcket data services. The switching system will support voice and packet data service simultaneously from end to end applications. To guarantee the quality of service (QoS) of the offered services, a source rate to send packet data is needed to control the network overload condition. Most existing control algorithms are shown to provide the threshold-based feedback control technique. However, real-time voice calls can be dynamically connected and released during data services in the network. If the feedback control information delays, a quality of the serviced voice can be degraded due to a time delay between the source and the destination in the high speed link. An adaptive algorithm based on the optimal least mean square error technique is presented for the predictive feedback control techinique. This algorithm is used to attempt predicting a future buffer size from weight(slope) adaptation of unknown functions, which are used for feedback control. In this paper, we have presented simulation results, which are related to the effective use of the algorithm.