2D 및 3D 디지털 이미지 분석과 함께 Moire Tophography 분석을 이용한 화장품의 가슴 탄력개선 효과 평가

서영경 ( Young Kyoung Seo ),유미애 ( Mi Ae Yoo ),류자현 ( Ja Hyun Ryu ),김소정 ( So Jeong Kim ),조성아 ( Seong A Cho ),남개원 ( Gae Won Nam ),조준철 ( Jun-cheol Cho ),부용출 ( Yong Chool Boo ),고재숙 ( Jae-sook Koh ) 대한화장품학회 2012 대한화장품학회지 Vol.38 No.4

외과적으로 가슴의 볼륨 측정은 석고법, 가슴 X선 사진을 이용한 가슴의 볼륨을 산출하는 방법과 MRI, 3차원 측정 시스템 등을 이용한 측정 방법들이 주로 이용되었다. 그러나 최근 화장품 영역에서 가슴 볼륨 증가 및 탄력개선 제품의 증가로 효능평가가 필요하나 외과적 방법들의 적용은 어려운 실정이다. 그리하여 본 연구는 화장품 영역에서 최초로 등고선 사진을 이용하여 가슴 탄력개선을 평가하였다. 또한 가슴둘레 측정, 디지털 이미지 분석, 3차원 가슴이미지 분석 값과의 상관성을 비교하였고 등고선 사진평가를 가슴의 탄력을 평가하는 새로운 방법으로 제안하고자 하였다. 본 연구는 병력조사 및 피부 상태 진단을 통해 건강한 여성 피험자 30명이 시험에 참여하였다. 피험자로 하여금 제품사용전과 2주, 4주, 8주 후 시점에서 가슴둘레 측정, 유두점의 각도와 거리 분석, Moire’s Topography를 이용한 scoring, 3D가슴측정을 실시하여 가슴확대 및 탄력개선 정도를 평가하였다. 평가 결과 디지털 이미지를 분석결과 유두점의 각도(Angle)는 시점별로 증가하는 경향을 보였으나 유의성은 없었다. 유두점으로부터 밑가슴까지의 길이(Length)는 시점별로 유의하게 증가하였다(p < 0.05). 또한, 유두점으로부터 밑가슴까지의 높이는 4주 후, 8주 후 시점에서 통계적으로 유의하게 증가하였다(p < 0.05). Moire’s Topography Score 평가 결과 각 시점별로 유의하게 개선하였다(p < 0.05). 3차원 가슴 부피 분석 값은 각 시점별로 증가하는 경향을 보였으나 통계적 유의성은 없었다. 상관성 분석결과 Moire tophography score는 디지털 이미지 분석 값 중 길이, 높이와 유의한 상관성이 있었고 3차원 부피 분석 값과 유의한 상관성이 관찰되었다. 따라서 Moire’s Topography Score 평가는 이미지 분석과 3차원 부피분석 평가법과 더불어 화장품에 의한 탄력 및 처짐 개선을 평가하는 데 중요한 평가방법으로 사용될 것으로 사료된다. Cosmetic products which might augment the breast have attracted an attention and objective methods for the evaluation of such products are in high demand. This study was conducted to establish a method for assessing the breast-firmming effects of cosmetics. This study included a total of 30 healthy Korean females aged 20-50 years. A cosmetic product was applied by massaging it onto the breast twice a day for 8 weeks. Measurement of breast girth with a tape ruler, 2D and 3D digital image analyses, and Moire topographic analysis were performed before and following the treatment. The application of a cosmetic onto the breast significantly increased breast girth at 2, 4 and 8 weeks without a significant change in underbreast girth, implicating the breast might be augmented. The 2D image analysis indicated that the arc length of the breast which represents the surface distance from the nipple to the periphery of the under-breast was significantly increased at 2, 4 and 8 weeks. The height of the breast which represents the perpendicular distance from the nipple to the periphery of the under-breast was also increased significantly at 4 and 8 weeks. The 3D image analysis of body surface also demonstrated a significant increase of breast volume at 2, 4 and 8 weeks. Moire topographic analysis indicated that breast sagging was significantly reduced at 2, 4 and 8 weeks. The results of this study suggest that Moire topography in combination with 2D and 3D digital image analyses may be useful for evaluating the breast-augmenting effects of cosmetics.

Red meat consumption is associated with an increased overall cancer risk: a prospective cohort study in Korea

Wie, Gyung-Ah,Cho, Yeong-Ah,Kang, Hyun-hee,Ryu, Kyoung-A,Yoo, Min-Kyoung,Kim, Young-A,Jung, Kyu-Won,Kim, Jeongseon,Lee, Joo-Hyuk,Joung, Hyojee Cambridge University Press 2014 The British journal of nutrition Vol.112 No.2

<P>Cancer is a leading cause of death, and the dietary pattern in Korea is changing rapidly from a traditional Korean diet to a Westernised diet. In the present study, we investigated the effects of dietary factors on cancer risk with a prospective cohort study. Among 26 815 individuals who participated in cancer screening examinations from September 2004 to December 2008, 8024 subjects who completed a self-administered questionnaire concerning demographic and lifestyle factors, and a 3 d food record were selected. As of September 2013, 387 cancer cases were identified from the National Cancer Registry System, and the remaining individuals were included in the control group. The hazard ratio (HR) of cancer for the subjects older than or equal to 50 years of age was higher (HR 1·80, 95 % CI 1·41, 2·31; <I>P</I>< 0·0001) than that for the other subjects. Red meat consumption, Na intake and obesity (BMI ≥ 25 kg/m<SUP>2</SUP>) were positively associated with overall cancer incidence in men (HR 1·41, 95 % CI 1·02, 1·94; <I>P</I>= 0·0382), gastric cancer (HR 2·34, 95 % CI 1·06, 5·19; <I>P</I>= 0·0365) and thyroid cancer (HR 1·56, 95 % CI 1·05, 2·31; <I>P</I>= 0·0270), respectively. Participants who had at least three dietary risk factors among the high intakes of red meat and Na, low intakes of vegetables and fruits, and obesity suggested by the World Cancer Research Fund/American Institute for Cancer Research at baseline tended to have a higher risk of cancer than the others (HR 1·26, 95 % CI 0·99, 1·60; <I>P</I>= 0·0653). In summary, high intakes of red meat and Na were significant risk factors of cancer among Koreans.</P>

Hexane Soluble Fraction of Chungpesagan-tang Exhibits Protective Effect against Hypoxia/Reoxygenation-Induced N2a Cell Damage

( Kyoung A Kim ),( Hwa Jung Choi ),( Bang Geul Kim ),( Young Ran Park ),( Ji Sun Kim ),( Jae Ha Ryu ),( Yun Jo Soh ) 한국응용약물학회 2008 Biomolecules & Therapeutics(구 응용약물학회지) Vol.16 No.4

녹차, 백차, 황차, 우롱차 및 홍차의 추출조건에 따른 이화학적 성분 조성 변화 연구

이영상,정슬아,김정환,조경숙,신을기,이희영,류혜경,안현주,정원일,홍성학,Lee, Young-Sang,Jung, Seul-A,Kim, Jung-Hwan,Cho, Kyoung-Sook,Shin, Eul-Ki,Lee, Hee-Young,Ryu, Hye-Kyung,Ahn, Hyun-Ju,Jung, Won-Il,Hong, Sung-Hak 한국식품영양학회 2015 韓國食品營養學會誌 Vol.28 No.5

This study analyzes the chemical composition of green tea, white tea, yellow tea, oolong tea and black tea with respect to extraction temperature and time. The optimum extraction conditions for these teas were determined by assessing the chemical composition of tea brewed at different temperature (50, 60, 70, $80^{\circ}C$) and extraction times (1, 3, 5, 10 minute). Catechins contents were the largest at 5 minutes and generally declined by 10 minutes. Green tea catechins contents were highest when brewed at $70^{\circ}C$ and besides other teas a change of the trend variation at 70 and $80^{\circ}C$. These temperatures did not extract theaflavins in green tea. Extract temperature and time did not significantly affect theaflavins content of white tea, yellow tea, and oolong tea. Black tea, however, was noticeably dependent on extract conditions, which were most effective at $70^{\circ}C$, brewed for 5 minutes. Caffeine content of green tea, yellow tea, and oolong tea was highest at 5 minutes, but temperature did not appear to affect the content. White tea and black tea caffeine content was highest when brewed at $70^{\circ}C$ for 5 minutes. Theobromine content of green tea, yellow tea, oolong tea, and black tea did not show major differences between the study times or temperature, though the content in white tea increased with higher temperatures when brewed for 5 minutes. The extraction of phenolic compounds increased until 5 minutes, and showed not further increase at 10 minutes. Antioxidant capacity of green tea, white tea, and yellow tea were maximized at $70^{\circ}C$ for 5 minutes or $80^{\circ}C$ for 3 minutes, while oolong and black tea were reached maximum antioxidants at $70^{\circ}C$ for 5 minutes. In general, to optimize the beneficial chemical content of brewed tea, a water temperature of $70^{\circ}C$ for 5 minutes is recommended.

A Study on the Measurement of Male Korean Hand -Focusing on Glove Size-

( Kyoung Ok Ryu ),( Mi A Suh ) 복식문화학회 2003 Fashion, industry and education Vol.6 No.2

Comparison of Nutrient Intake and Diet Quality Between Hyperuricemia Subjects and Controls in Korea

( Kyoung A Ryu ),( Hyun Hee Kang ),( So Young Kim ),( Min Kyong Yoo ),( Jeong Seon Kim ),( Chan Haw Lee ),( Gyung Ah Wie ) 한국임상영양학회 2014 Clinical Nutrition Research Vol.3 No.1

Hyperuricemia is associated with metabolic syndrome as well as gout, and the prevalence of hyperuricemia is increasing in Korea. This study aimed to compare the nutrient intake and diet quality between hyperuricemia subjects and controls. Of the 28,589 people who participated in a health examination between 2008 and 2011, 9,010 subjects were selected whose 3-day food records were available. Clinical and laboratory data were collected from electronic medical records. Diet quality was evaluated using the food habit score (FHS), nutrient adequacy ratio (NAR), and mean adequacy ratio (MAR). The prevalence of hyperuricemia was 13.8% (27.1%, men; 5.2%, women). Body mass index, waist circumference, triglycerides, total cholesterol, and lowdensity lipoprotein cholesterol were significantly higher (p < 0.0001), while high-density cholesterol (p < 0.001) was significantly lower in the hyperuricemia subjects than in the controls. The hyperuricemia subjects had a lower intake of vitamin A (p < 0.004), vitamin C, folate, fiber, and calcium than the controls (p < 0.0001). Intake of vegetables and dairy products was significantly lower, whereas alcohol intake was significantly higher in the hyperuricemia subjects than in the controls ( p < 0.0001). The FHS (p < 0.0001), MAR (p < 0.0001), and NARs for vitamin A (p = 0.01), vitamin B2, vitamin C, folate, and calcium (p < 0.0001) were significantly lower in the hyperuricemia subjects than in the controls. In conclusion, the hyperuricemia subjects reported poorer diet quality than the controls, including higher alcohol intake and lower vegetable and dairy product intake.

A Study on the Measurement of Male Korean Hand : Focusing on Glove Size

Ryu, Kyoung-ok,Suh, Mi-a The Costume Culture Association 2003 Fashion, industry and education Vol.6 No.2

The purpose of this study was to develop the sizing system for men's glove. The combination of anthropometric and engineering aspects of glove pattern-making is difficult problem in engineering clothing. And the traditional measurements is not enough for glove. Therefore, to develop the hand measurement method and dimension for glove, a comprehensive list of candidate measurements was reviewed and the manufacturers (Their career was over the 15years) were interviewed on the method glove pattern-making. This study was conducted traditional and creative 88 two-dimensional anthropometric measurements and 4 photometric measurements for glove pattern-making. In addition, 16 creative measurements were instrumented using a special hand measuring board for measuring of landmark locations on the hand. The subjects were 260 men's right hand in the age group of 18 to 35 years old in korea.

난소 종양에서 Mullerian Inhibiting Substance와 그 수용체의 발현

서경아 ( Kyoung A Seo ),류기성 ( Ki Sung Ryu ),이정원 ( Chung Won Lee ),최미나 ( Mi Na Choi ),차정호 ( Jung Ho Cha ),김장흡 ( Jang Heub Kim ),한구택 ( Ku Taek Han ) 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.2

Mullerian inhibiting substance (MIS) is a glycoprotein hormone produced by fetal Sertoli cells that causes regression of the Mullerian ducts in males during sexual differentiation. Cell lines derived from human ovarian epithelium and rodent Leydig cell tu

Full-mouth rehabilitation in a Stevens-Johnson syndrome patient with severely worn dentition and abnormal root development

( Yeon-hee Park ),( Ri Ryu ),( Seung-geun Ahn ),( Kyoung-a Kim ),( Jae-min Seo ) 조선대학교 치의학연구원(구 조선대학교 구강생물학연구소) 2020 Oral Biology Research (Oral Biol Res) Vol.44 No.3

Stevens-Johnson syndrome (SJS) is a cytotoxic immune disorder that causes serious damage to the skin and mucous membranes. SJS is a rare disorder that is triggered by particular medications or infections. De Man (1979), for the first time, described an abnormal root development due to SJS. While systemic complications were frequently reported, the abnormal root development in SJS has been rarely reported as an oral and maxillofacial complication of SJS. In this case report, a 26-year-old woman who had experienced SJS at the age of 9 year exhibited excessive tooth wear on whole dentition. While multiple teeth with incomplete root development showed slightly increased mobility, these teeth were not pathological and were erupted up to their normal functional position. Therefore, full-mouth rehabilitation procedures were completed to protect the worn dentition and improve the masticatory function and anterior esthetics.

Crystal Structures of the LsrR Proteins Complexed with Phospho-AI-2 and Two Signal-Interrupting Analogues Reveal Distinct Mechanisms for Ligand Recognition

Ha, Jung-Hye,Eo, Yumi,Grishaev, Alexander,Guo, Min,Smith, Jacqueline A. I.,Sintim, Herman O.,Kim, Eun-Hee,Cheong, Hae-Kap,Bentley, William E.,Ryu, Kyoung-Seok American Chemical Society 2013 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.135 No.41

<P>Quorum sensing (QS) is a cell-to-cell communication system responsible for a variety of bacterial phenotypes including virulence and biofilm formation. QS is mediated by small molecules, autoinducers (AIs), including AI-2 that is secreted by both Gram-positive and -negative microbes. LsrR is a key transcriptional regulator that governs the varied downstream processes by perceiving AI-2 signal, but its activation via autoinducer-binding remains poorly understood. Here, we provide detailed regulatory mechanism of LsrR from the crystal structures in complexes with the native signal (phospho-AI-2, D5P) and two quorum quenching antagonists (ribose-5-phosphate, R5P; phospho-isobutyl-AI-2, D8P). Interestingly, the bound D5P and D8P molecules are not the diketone forms but rather hydrated, and the hydrated moiety forms important H-bonds with the carboxylate of D243. The D5P-binding flipped out F124 of the binding pocket, and resulted in the disruption of the dimeric interface-1 by unfolding the α7 segment. However, the same movement of F124 by the D8P′-binding did not cause the unfolding of the α7 segment. Although the LsrR-binding affinity of R5P (<I>K</I><SUB>d</SUB>, ∼1 mM) is much lower than that of D5P and D8P (∼2.0 and ∼0.5 μM), the α-anomeric R5P molecule fits into the binding pocket without any structural perturbation, and thus stabilizes the LsrR tetramer. The binding of D5P, not D8P and R5P, disrupted the tetrameric structure and thus is able to activate LsrR. The detailed structural and mechanistic insights from this study could be useful for facilitating design of new antivirulence and antibiofilm agents based on LsrR.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2013/jacsat.2013.135.issue-41/ja407068v/production/images/medium/ja-2013-07068v_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja407068v'>ACS Electronic Supporting Info</A></P>