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The Improvement of Learning and Memory Ability of Normal Persons by BF-7
Lee, Sang-Hyung,Kim, Yong-Sik,Kang, Yong-Koo,Kwon, Oh-Sang,Shin, Yong-Kyoo,Song, Jln-Ho,Lee, Moo-Yeol,Lee, Kwang-Gill,Yeo, Joo-Hong,Lee, Won-Bok,Lee, Tae-Jin,Kim, Sung-Su The Korean Society of Pharmacology 2004 The Korean Journal of Physiology & Pharmacology Vol.8 No.6
To investigate whether BF-7, extracted from Bombyx mori, improved learning and memory of ordinary people, Rey-Kim Memory Test was performed with placebo group (32 persons), 200 mg BF-7 treated group (33 persons) and 400 mg BF-7 treated group (34 persons). BF-7 enhanced significantly learning and memory function in a dose-dependent manner. To know how BF-T plays such a positive role, we measured the concentration of acetylcholine in the brain from memory impairment animal model. Treatment of BF-7 significantly increased the concentration of acetylcholine. So, it is supposed that the protection of cholinergic neuron and/or keeping proper concentration of acetylcholine might be one of the mechanisms by which BF-7 improve brain function. So, our results suggest that the BF-7 is effective material for improving learning and memory ability.
Lee, Eui-Yeol,Shin, Yong-Kyoo,Lee, Chung-Soo 중앙대학교 의과대학 의과학연구소 1991 中央醫大誌 Vol.16 No.3
Flavonoid는 항산화 능력과 금속이온에 대한 킬레이트 능력을 포함한 다양한 생물학적 효과를 갖고 있는 것으로 보고하고 있다. Cu^++와 H_2O_2 또는 xanthine과 xanthine oxidase에 의한 collagen 변성에 미치는 rutin과 quercetin의 효과를 관찰하였다. Rutin과 quercetin이 hydroxyl 라디칼과 singlet oxygen의 형성에 나타내는 효과를 조사하였다. 산소 라디칼 제거물인 SOD, catalase, DMSO와 DABCO는 Cu^++와 H_2O_2에 의한 collagen 변성을 억제하였다. Xanthine과 xanthine oxidase에 의한 collagen 변성은 SOD, catalase와 DABCO에 의하여 억제되었으나 DMSO에 의하여 억제되지 않았다. Rutin은 또한 xanthine과 xanthine oxidase에 의한 collagen 변성을 저해하였으나 quercetin은 영향을 나타내지 않았다. Cu^++와 H_2O_2 또는 xanthine과 xanthine oxidase의 상호작용에 의한 소듐 salicylate의 hydroxylation은 rutin, quercetin과 DMSO에 의하여 억제되었다. 자외선 조사에 의한 DPBF의 산화는 rutin과 ^1O_2 제거 물질인 DABA에 의하여 억제되었으며 quercetin에 의해서 약간 억제되었다. 이상의 결과로부터 Cu^++와 H_2O_2 또는 xanthine과 xanthine oxidase에 의한 collagen 변성에 대한 rutin과 quercetin의 보호작용은 산소 라디칼 특히 ^1O_2의 제거 작용과 Cu^++에 대한 효과적인 킬레이트 작용에 의할 것으로 추정된다.
실물크기 모형실을 이용한 벽 일체형 집광장치의 자연채광성능 평가
이호열(Lee Ho-Yeol),이주윤(Lee Ju-Yoon),송규동(Song Kyoo-Dong) 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2
Recently, various daylighting systems have been developed and applied to buildings. However, existing daylighting systems are of no practical use due to a high initial cost and difficulties in maintenance. In addition, there is a main problem of securing sufficient additional space for collecting daylight and to be available in the overcast sky. Wall-type daylight system, which is the subject of this study and doesn't need additional space for collecting daylight, is a very useful day lighting system, because it can substitute for a vertical wall of a building. The purpose of this study is to evaluate the day lighting performance of Wall-type Daylight Collecting system using two mock-up models. The performance of the general windows were compared with that of Wall-type Daylight Collecting systems placed on the windows in terms of illuminance distribution on the work plane at the height of 75cm and luminance distribution on the south wall.
2축 솔라셀 센서모듈을 이용한 태양광 추적시스템의 설계 · 제작
전우열(U-Yeol Jeon),강민정(Min-Jung Gang),이승환(Seung-Hwan Lee),김힘찬(Him-Chan Kim),문동윤(Dong-Youn Moon),김희수(Hee-Su Kim),손민정(Min-Jung Son),이지은(Ji-Eun Lee),이주현(Ju-Hyun Lee),우혁재(Hyeok-Jae Woo),신규재(Kyoo-Jae Shin) 대한전자공학회 2015 대한전자공학회 학술대회 Vol.2015 No.6
Solar tracking system has the asembly of remote servo control and remote monitoring. It is composed of solar illumination of the solar azimuth one solar cell sensor device for detecting a value and integrated control device including the integrated control panel for remote transmission by the wireless communication by the servo control and solar module assembly to follow the sun azimuth in response to the control signal. The proposed algorithm is verified through experimental results.
The Improvement of Learning and Memory Ability of Normal Persons by BF-7
Sang Hyung Lee,Yong Sik Kim,Yong Koo Kang,Oh Sang Kwon,Yong Kyoo Shin,Jin Ho Song,Moo Yeol Lee,Kwang-Gill Lee,Joo-Hong Yeo,Won Bok Lee,Tae Jin Lee,Sung Su Kim 대한생리학회-대한약리학회 2004 The Korean Journal of Physiology & Pharmacology Vol.8 No.6
To investigate whether BF-7, extracted from Bombyx mori, improved learning and memory of ordinary people, Rey-Kim Memory Test was performed with placebo group (32 persons), 200 mg BF-7 treated group (33 persons) and 400 mg BF-7 treated group (34 persons). BF-7 enhanced significantly learning and memory function in a dose-dependent manner. To know how BF-7 plays such a positive role, we measured the concentration of acetylcholine in the brain from memory impairment animal model. Treatment of BF-7 significantly increased the concentration of acetylcholine. So, it is supposed that the protection of cholinergic neuron and/or keeping proper concentration of acetylcholine might be one of the mechanisms by which BF-7 improve brain function. So, our results suggest that the BF-7 is effective material for improving learning and memory ability.
Lee Seung-Won,Hong Seong-Eui,Lee Kyoo-Yeol,Choi Do-Il,Chung Hae-Young,Hur Cheol-Goo Korea Genome Organization 2006 Genomics & informatics Vol.4 No.2
With the rapid development of MS technologiesy, the demands for a more sophisticated MS interpretation algorithm haves grown as well. We have developed a new protein fingerprinting method using a binomial distribution, (fBIND). With the fBIND, we improved the performance accuracy of protein fingerprinting up to the maximum 49% (more than MOWSE) and 2% than(at a previous binomial distribution approach studied by of Wool et al.) as compared to the established algorithms. Moreover, we also suggest a the statistical approach to define the significance of transcription factors and motifs in the identified proteins based on the Gene Ontology (GO). Abbreviations: fBIND, fingerprinting using binomial distribution; GO, Gene Ontology; MS, Mass Spectrometry; PMF, peptide mass fingerprinting; nr, nonredundant; SGD, Saccharomyces Genome Database
이종현,신장규,이상룡,천희곤,조찬섭,심준환,류인식,박석홍,허정준,박기열 경북대학교 센서기술연구소 1994 연차보고서 Vol.1994 No.-
자동차의 air-bag 장치에 실용될 수 있는 압저항형 단결정 실리콘 가속도센서 칩을 개발하기 위하여 결정 실리콘 미세구조의 제조방법을 확립하고, 단위공정의 검증을 통하여 일괄공정에 의한 PROTO-TYPE 칩을 만드는 기술을 연구하였다. 단결정 실리콘 미세구조는 선택확산법을 이용하여 정확히 선택된 영역에만 air-gap을 형성하여 미세구조의 측면식각을 방지하는 선택확산법에 의한 실리콘 마이크로머시닝 기술로 제조하였다. 일괄공정을 위한 단위공정확립을 위하여 PROTY-TYPE 8빔 브릿지형 가속도 센서를 제조하였다. 제조된 칩의 가속도에 따른 출력전압은 선형성을 나타내고 있으며, 감도는 약 50 ㎶/V·g로 나타났다. 이 감도는 50G용 가속도센서의 사양을 만족하지 못했다. 이는 공정에 의한 문제라기 보다는 가속도센서의 시뮬레이션에 의해 설계한 구조가 이미 원하는 감도에 못 미친다는 것으로 생각된다. 따라서 2차 공정으로 제조될 가속도센서의 파라미터를 SuperSAP 유한요소 패키지를 이용하여 실리콘 미세구조부의 파라미터에 따른 특성을 시뮬레이션하였다. 설계된 50G용 가속도센서의 mass Pad의 반경 및 빔 길이, 빔 폭, 빔 두께, 그리고 mass의 각 파라미터 값은 700 ㎛, 120 ㎛, 5 ㎛, 1.0 ㎎ 이었다. 반도체 공정기술, 관성질량 제조법 및 선택확산을 이용한 마이크로머시닝을 사용하여 일괄공정으로 8빔 브린지형 가속도센서를 제조하였다. We researched the establishment of the silicon microstructure fabrication technique to develop a piezoresistive type silicon acceleration sensor chip and the technique to make a proto-type chip by the verification of the unit-process. Silicon microstructure is fabricated silicon micro-machining by selective diffusion method. This method prevent a side-etching of microstructure because selective diffused region is only formed an air-gap. We fabricated a proto-type 8-beam bridge-type acceleration sensor to establish the unit-process for the batch-process. The output voltage of the chip represented linearity with acceleration, and the sensitivity was about 50 ㎶/V·g. But this sensitivity dosen't satisfy the requirements of a practical acceleration sensor. The cause of this result is assumed not process problem, but the structure designed by simulation isn't suitable already. Threfore, the characteristics of parameters of the acceleration sensor that will be fabricated by 2nd-process is simulated by SuperSAP finite-element package. The determined parameter values of beam length, beam width, beam thickness, mass, and mass radius are 120 ㎛, 5 ㎛, 1.0 ㎎, and 700 ㎛, respectively. We fabricated 8-beam bridge-type acceleration sensor by batch-process using a semiconductor process technique, proof-mass fabrication method, and micromachinig using selective diffusion.
Jong Kyoo Park,Jae Yeol Lee,Lawrence T. Drzal,Donghwan Cho 한국탄소학회 2016 Carbon Letters Vol.17 No.-
In the present study, exfoliated graphite nanoplatelets (xGnP) with different particle sizes were coated onto polyacrylonitrile-based carbon fibers by a direct coating method. The flexural properties, interlaminar shear strength, and the morphology of the xGnP-coated carbon fiber/phenolic matrix composites were investigated in terms of their longitudinal flexural strength and modulus, interlaminar shear strength, and by optical and scanning electron microscopic observations. The results were compared with a phenolic matrix composite counterpart prepared without xGnP. The flexural properties and interlaminar shear strength of the xGnP-coated carbon fiber/phenolic matrix composites were found to be higher than those of the uncoated composite. The flexural and interlaminar shear strengths were affected by the particle size of the xGnP, while the particle size had no significant effect on the flexural modulus. It seems that the interfacial contacts between the xGnP-coated carbon fibers and the phenolic matrix play a role in enhancing the flexural strength as well as the interlaminar shear strength of the composites.
( Tae Kyoo Lim ),( Byug Chul Yu ),( Dae Sung Ma ),( Gil Jae Lee ),( Min A Lee ),( Sung Yeol Hyun ),( Yang Bin Jeon ),( Kang Kook Choi ) 대한외상학회 2017 大韓外傷學會誌 Vol.30 No.4
Purpose: The optic nerve sheath diameter (ONSD) measured by ultrasonography is among the indicators of intracranial pressure (ICP) elevation. However, whether ONSD measurement is useful for initial treatment remains controversial. Thus, this study aimed to investigate the relationship between ONSD measured by computed tomography (CT) and ICP in patients with traumatic brain injury (TBI). Methods: A total of 246 patients with severe trauma from January 1, 2015 until December 31, 2015 were included in the study. A total of 179 patients with brain damage with potential for ICP elevation were included in the TBI group. The remaining 67 patients comprised the non-TBI group. A comparison was made between the two groups. Receiver operating characteristic (ROC) curve analysis was performed to determine the accuracy of ONSD when used as a screening test for the TBI group including those with TBI with midline shift (with elevated ICP). Results: The mean injury severity score (ISS) and glasgow coma scale (GCS) of all patients were 24.2±6.1 and 5.4±0.8, respectively. The mean ONSD of the TBI group (5.5±1.0 mm) was higher than that of the non-TBI group (4.7±0.6 mm). Some significant differences in age (55.3±18.1 vs. 49.0±14.8, p<0.001), GCS (11.7±4.1 versus 13.3±3.0, p<0.001), and ONSD (5.5±1.0 vs. 4.7±0.6, p< 0.001) were observed between the TBI and the non-TBI group. An ROC analysis was used to assess the correlation between TBI and ONSD. Results showed an area under the ROC curve (AUC) value of 0.752. The same analysis was used in the TBI with midline shift group, which showed an AUC of 0.912. Conclusions: An ONSD of >5.5 mm, measured on CT, is a good indicator of ICP elevation. However, since an ONSD is not sensitive enough to detect an increased ICP, it should only be used as one of the parameters in detecting ICP along with other screening tests.