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한국인 다낭성 난포증후군 환자에서 5,10-Methylenetetrahydrofolate Reductase의 677번 유전자 다형성에 관한 연구
이교원,정유미,이숙환,윤태기,곽인평,윤선웅,최중섭,김계현,한종설,김성도,김남근,차광렬,백광현,이수만,Lee, Kyo-Won,Jeong, Yu-Mi,Lee, Sook-Hwan,Yoon, Tae-Ki,Kwak, In-Pyung,Yoon, Seon-Woong,Choi, Joong-Sub,Kim, Kye-Hyun,Han, Jong-Sul,Kim, Sung-Do,K 대한생식의학회 2003 Clinical and Experimental Reproductive Medicine Vol.30 No.3
Objective: To investigate the association of genetic background between MTHFR C677T genotype and infertile females with polycystic ovarian syndrome. Materials and Methods: We compared 86 infertile females with polycystic ovarian syndrome (PCOS) with 100 healthy fertile females with one or more offspring. Pyrosequencing analysis for MTHFR C677T variation was performed on polymerase chain reaction (PCR) product of study group. To validate pyrosequencing data of C677T variation for randomly selected 50 samples, we compared the pyrosequencing result with the PCR-RFLP (Restriction Fragment Length Polymorphism) result of MTHFR C677T genotype. Results: The prevalence of the C677T mutant homozygous (TT) was significantly lower (p=0.0085) in females with PCOS (8.14%) than in fertile females (21.00%). MTHFR 677 TT genotype had a decreased risk (3.7-fold) of PCOS compared with wild type (MTHFR 677 CC). Conclusion: Our data support a role for MTHFR mutant homozygous (677 TT) genotype in reducing risk in Korean infertile females with Polycystic ovarian syndrome.
미배양 양수세포에서 다중중합효소 연쇄반응을 이용한 Duchenne 형 근이영양증 ( DMD ) 의 신속한 진단
이교원(Kyo Won Lee),이숙환(Sook Hwan Lee) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.10
Objective : To evaluate the efficacy of prenatal multiplex PCR with uncultured amniocytes, in the case of family history of DMD due to exon deletion. Methods : After amniocentesis, fetal sex was confirmed using fluorescence in situ hybridization (FISH) with interphase cells' of amniocyte. Then amniocytes were lysed and multiplex PCR test was performed.Result : PCR was done for 17 exons devided into 4 groups. Seventeen exons were all amplified with their right size.Conclusions : This method is DNA analysis for rapid prenatal diagnosis of DMD with uncultured amniocytes in the family of DMD. This is useful when preimplantation genetic diagnosis or chorionic villi sampling are not available.
융모막 세포에서 다중중합효소 연쇄반응을 이용한 Duchenne형 근이영양증의 산전 진단
이교원(Kyo Won Lee),윤선웅(Seon Woong Yoon),장우섭(Woo Sup Chang),김진영(Jin Yeong Kim),이숙환(Sook Hwan Lee),이상준(Sang Joon Lee),김성도(Sung Do Kim),한종설(Jong Sul Han) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.9
Objective: To evaluate the efficacy of prenatal multiplex PCR with chorionic villi, in the case of family history of DMD due to exon deletion. Methods: DNA was extracted when cells' size are 1x 106 on T- flask surface area reach to 25 cm2 after 2 weeks from sex confirmation. Average DNA concentration was 50-100 ng and multiplex PCR test was performed from DNA extraction. Result: PCR was done for 17 exons devided into 4 groups. Seventeen exons were all amplified with their right size. Conclusions: This method is DNA analysis for prenatal diagnosis of DMD with chorionic villi in the family of DMD. This is useful when preimplantation genetic diagnosis is not available.
전자궁적출술 후 발생한 자궁부속기 병변의 복강경 수술에 관한 임상적 고찰
이정훈 ( Jung Hun Lee ),이효원 ( Hyo Won Lee ),경민선 ( Min Sun Kyung ),정언석 ( Un Suk Jung ),이교원 ( Kyo Won Lee ),한종설 ( Jong Sul Han ),최중섭 ( Joong Sub Choi ) 대한산부인과학회 2007 Obstetrics & Gynecology Science Vol.50 No.5
Objective: To evaluate the feasibility and effectiveness of laparoscopic adnexal surgery in posthysterectomy patients and review clinical characteristics including comparison of the adhesion score of left with that of right adnexal mass. Methods: From February 2004 to January 2007, we reviewed the medical records of 23 post-hysterectomy patients who received laparoscopic adnexal surgery including age, parity, type of hysterectomy, operative indications, histopathological diagnosis, operating time, size of the adnexal mass, adhesion score, change in the hemoglobin level, hospital stay, and any complications. Results: The median age of patients was 48 years (range 35-69 years), and median parity was 2 (0-3). The median operating time was 100 minutes (range 35-180 minutes), and the median size of the adnexal mass was 7.1 cm (range 4-12 cm). The median change in hemoglobin level was 1.8 g/dL (range 0.6-4.1 g/dL). The median hospital stay was 4 days (range 3-19 days). The adhesion score was significantly higher in the left adnexal mass than in the right adnexal mass. Histopathological diagnosis included 6 cases of mucinous cystadenoma, 6 cases of functional cyst, 4 cases of hydrosalpinx, 3 cases of serous cystadenoma, 1 case of fibrothecoma, 1 case of mucinous adenofibroma, 1 case of endometrioma, and 1 case of tubo-ovarian abscess. There were no intraoperative complications or conversion to laparotomy. One case of postoperative ileus was noted. Conclusion: The skilled laparoscopic surgeon is capable of achieving successful result by performing laparoscopic surgery primarily to patients with adnexal mass for posthysterectomy patients who are expected to suffer severe adhesion. In posthysterectomy patients, left adnexal mass has more extensive adhesion than right adnexal mass, and these finding was represented as a high adhesion score of left adnexal mass.
DIG System을 이용한 후레자일 X 증후군 ( Fragile X Syndrome ) 과 근이영양증 ( DMD ) 의 진단
이숙환(Sook Hwan Lee),조성원(Sung Won Cho),한정희(Jung Hee Han),이교원(Kyo Won Lee),한종설,차광은(Kwang Eun Cha),한세열(Se Yul Han),계정웅(Chung Woong Kay),조세현(Se Hyun Cho),엄기붕(Ki Boong Oum),곽인평(In Pyung Kwak) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.11
The aim of this study was to develop a rapid and safe non-radioactive DIG DNA labeling and detection for Southern blot analysis for fragile X syndrome and Duchenne muscular dystrophy (DMD). Southern blot analysis is accurate test showing expression of the (CGG)n repeat and abnormal methylation pattern of CpG island in hagile X syndrome, and good confirmative secondary test in case of deletion in DMD. But in terms of test rapidity, these conventional radioactive Southern analysis may not be feasible for rapid screening of prenatal samples and at-risk populations to determine their status and to provide genetic counseling to their families. As an alternative radioactive Southern blotting, DIG DNA labeling and detection system does not require handling of radioactive material nor require learning any new technology. The complete procedure of labeling the DNA and hybridization to detection of the first visible signal can be compbsbed witbin 7 days. In addition, hybridization solutions containing labeled DNA can be reused several times after renewed denaturation.
난관임신에서 융모성 성선자극호르몬과 영양배엽세포의 나팔관벽 침투에 관한 연구
이다연 ( Da Youn Lee ),윤효진 ( Hyo Jin Yoon ),김계현 ( Kye Hyun Kim ),김형문 ( Hyoung Moon Kim ),최중섭 ( Joong Sub Choi ),이교원 ( Kyo Won Lee ),한종설 ( Jong Sul Han ),손진희 ( Jin Hee Shon ),채승완 ( Seoung Wan Chae ),김수희 ( 대한산부인과학회 2005 Obstetrics & Gynecology Science Vol.48 No.9
다낭성 난소증후군을 가진 여성에서 비정상적인 당내성을 일으키는 예측인자
고아라 ( A Ra Koh ),이세진 ( Se Jin Lee ),박수연 ( Sue Yeon Park ),김민경 ( Min Kyung Kim ),김지예 ( Ji Ye Kim ),이교원 ( Kyo Won Lee ),김계현 ( Kye Hyun Kim ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.7
Objective: To determine the parameters associated with the risk for abnormal glucose tolerance (AGT) among women with polycystic ovary syndrome (PCOS) and to assess the optimal screening tests to predict AGT within this population. Methods: We evaluated 85 women with PCOS and 53 control women. All participants had an oral glucose tolerance test (OGTT) and hormonal blood profiles, including the measurement of follicle stimulating hormone, leutinizing hormone, estradiol testosterone, and serum lipid profiles. Results: Among the women with PCOS, those with AGT had significantly higher homeostasis model assessment of insulin resistance (P<0.001) values than those with normal glucose tolerance. The prevalence of impaired glucose tolerance (IGT) and/or impaired fasting glucose was 48.2% (41/85) in women with PCOS; 16 of 41 subjects with AGT were IGT. Six of 16 subjects (37.5%) with IGT had normal fasting plasma glucose (FPG<100mg/dL). Thus, the FPG failed to detect 37.5% of women with PCOS who were found to have AGT with the OGTT. Multivariate logistic regression analysis revealed that insulin, body mass index (BMI), age, and triglyceride (TG) were significant risk factors for abnormal glucose metabolism. Conclusion: Insulin, BMI, age, and TG predicted abnormal glucose metabolism in women with PCOS. The OGTT was a more reliable predictor of AGT than fasting plasma glucose. We recommend that women with PCOS undergo periodic screening for AGT using the OGTT, particularly if they have any of the above risk factors.