갱년기 여성에서 호르몬 대체요법시 Vitamin D₃추가투여가 골밀도에 미치는 영향

유순원(Sun Won Yoo),조현희(Hyun Hee Jo),여경아(Kyeong A Yeo),유영옥(Young Ok Lew),권동진(Dong Jin Kwon),정기욱(Gi Wook Chung),김장흡(Jang Heub Kim),김진홍(Jin Hong Kim) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.6

연구목적 : 갱년기 여성에서 호르몬 대체요법 실시시 Vit. D3의 추가 투여가 골밀도에 미치는 영향을 알아보고자 하였다. 연구 대상 : 1992년부터 1998년 사이에 갱년기 클리닉을 방문한 388명을 대상으로 하여 투여 방법에 따라 5군으로 나누었다. A 군 : 에스트로젠 단독요법군 (n=148), B 군 : 에스트로젠-프로제스테론 병합요법군 (n=103), C군 : 에스트로젠 + Vit. D3 투여군 (n=36), D 군 : 에스트로젠, 프로제스테론 + Vit.D3 투여군, E 군 : 비 투여군 (n=60). 연구 방법 : 호르몬 대체 요법 시작 전과 시작 후 2년 간격으로 이중에너지 방사선 흡수 계측법(DEXA, Hologic)을 사용하여 요추의 골밀도와 대퇴골 경부의 골밀도를 측정하였다. 통계 : 연구 대상군들의 골밀도 변화 비교는 paired t-test, one way ANOVA test와 student's t-test를 실시하였다. 결과 : 각 치료군간의 환자특성 및 기저 골밀도 치에 따른 환자특성은 차이가 없었으며, 프로제스테론 병합투여 여부는 골밀도에 의의있는 영향을 끼치지 않았다. Vit.D3 추가 투여시 기저 골밀도가 정상인 군은 대퇴 골두와 요추에서 단독 호르몬 치료군에 비해 모두 의의 있는 증가소견을 보이지 않았으나 기저 골밀도가 골결핍을 보인 군은 에스트로젠과 Vit.D3 투여군의 경우 요추에서 6.1±3.6% (p > 0.05), 대퇴 골두에서 8.5±3.1%(p < 0.05), 프로제스테론 병합요법과 Vit.D3 투여군의 경우 요추에서 5.9±4.1% (p > 0.05), 대퇴골두에서 6.7±4.1%(p < 0.05), 골다공증을 보인 군은 위순서대로 각각 6.7±3.4% (p > 0.05), 11.0±2.1%(p < 0.05), 6.1±1.1% (p > 0.05), 9.1±0.8%(p < 0.05)을 보였다. 결론 : 갱년기 호르몬 치료시 Vit.D3 추가투여는 기저 골밀도가 정상인 군에서는 골밀도 증가에 의의가 없으며, 골결핍증과 골다공증이 있는 여성은 Vit.D3 추가 병합투여가 골밀도 증가 도움을 준다고 할 수 있지만 요추보다는 대퇴골두 골밀도 증가에 더욱 효과가 있다고 할수 있다. Objective : To determine the effect of the addition of Vit. D3 (1,25-Dihydroxychole calciferol D3) to the conventional postmenopausal hormone replacement therapy on bone mineral density(BMD) Design : A 2-year retrospective , randomized study Setting : Department of Obstetrics and Gynecology of Catholic university hospital Patients : 388 postmenopausal women were recruited and divided into 5 groups according to treatment regimen; A: conjugated estrogens only treated group(n=146), B : conjugated estrogens and progesterone treated group(n=103), C : conjugated estrogens and Vit.D3 treated group (n=36), D : conjugated estrogens, progesterone and Vit.D3 treated group (n=41), E : control group (n=60). Methods : The bone mineral density of the lumbar spines and femoral neck were determined by dual-energy X-ray absorptiometry(DEXA) every 2 years.Statistics : The difference between before and after treatment was determined by paired t-test. The comparison among the groups were determined by one way ANOVA test and student's t-test Results : The addition of progesterone to estrogen showed insignificant increase in the lumbar and femoral neck BMD. The addition of Vit. D3 compared with conventional hormone replacement therapy insignificantly influened bone density in women with initially normal BMD, but definitely increase in women with initially osteopenic and osteoporotic BMD of femoral neck rather than lumar spine(p<0.05). Conclusion : The use of Vit. D3 combined with postmenopausal estrogen replacement effects the increase of BMD in low bone density than normal bone density, especially femoral neck.

p-Anisaldehyde가 조골세포 분화에 미치는 영향

김경민 ․ 이도원 ․ 김현준 ․ 김아랑 ․ 장원구 대구대학교 산업기술연구소 2018 産業技術硏究 Vol.29 No.2

p-Anisaldehyde is a natural fragrance extracted from Pimpinella anisum L., and used as a preservative. This study examined the effect of p-anisaldehyde on osteoblast differentiation. First, cytotoxicity tests were carried out after examining the concentrations that did not show toxicity to the cells. The expression of osteoblast differentiation marker gene was confirmed by RT-PCR and was not effective in the treatment with p-anisaldehyde alone. However, p-anisaldehyde decreased the expression levels of inhibitor of differentiation-1 (Id1), distalless related homeobox (Dlx5), and runt-related transcription factor 2 (Runx2), which are osteogenic differentiation marker genes, which are increased in osteogenic condition. alkaline phosphatase (ALP) activity was also confirmed by ALP staining that p-anisaldehyde reduced ALP activity. These results show that p-anisaldehyde is effective in reducing osteoblast differentiation.

Piceatannol Inhibits Inflammatory Response in Macrophage Co-Cultured with Adipocytes

Kyeong A Jang,Mi-Kyoung Seo,Su-Koung Lee,Yu-Jin Hwang 한국식품영양과학회 2020 한국식품영양과학회 학술대회발표집 Vol.2020 No.10

First record of a marine microalgal species, Jaagichlorella roystonensis (Trebouxiophyceae) isolated from Jungmun Saekdal Beach, Jeju Island, Korea

Jo, Seung-Woo,Kang, Nam Seon,Lee, Jung A,Kim, Kyeong Mi,Jang, Hyeong Seok,Yoon, Moongeun,Hong, Ji Won,Yoon, Ho-Sung Korean Society of Environmental Biology 2020 환경생물 : 환경생물학회지 Vol.38 No.2

A eukaryotic marine microalga was isolated from Jungmun Saekdal Beach, Jeju Island, Korea and an integrated approach, including molecular phylogeny and morphology, was used to determine its taxonomical status. Molecular phylogenetic evidence inferred from the small subunit (SSU) 18S rRNA sequence and internal transcribed spacer (ITS) secondary structure analysis clearly showed that the isolate belonged to the recently described species, Jaagichlorella roystonensis. Distinctive morphological keys of the species were also observed by light microscopy and scanning/transmission electron microscopy(S/TEM). In this study, a Korean marine J. roystonensis species was described for the first time and was subsequently added to the national culture collections in Korea.

The Antioxidant Activity of Aster glehni by Extraction Methods

Kyeong-A Jang,Su-Koung Lee,Da-Bin Lee,Han-Na Chu,Eun-Suk Jung,Min-Sook Kang,Haeng-Ran Kim 한국식품영양과학회 2022 한국식품영양과학회 학술대회발표집 Vol.2022 No.10

Dysfunction of Endothelial Progenitor Cells under Diabetic Conditions and its Underlying Mechanisms

Kyeong-A Kim,배옥남,Young-Jun Shin,Jeong-Hyeon Kim,Hanna Lee,Sun-Young Noh,Seung-Hoon Jang 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.2

Cardiovascular complications have been major concerns in the treatment of diabetes, and up to 80% of all deaths in diabetic patients are linked to cardiovascular problems. Impaired angiogenesis is one of the most serious symptoms associated with diabetes, resulting in delayed wound healing and lower limb amputation. Endothelial progenitor cells (EPCs), a subpopulation of adult stem cells, are recruited from bone marrow to the injured vessel to promote endothelial regeneration and neovascularization, playing an important role in angiogenesis. Interestingly, several clinical studies have showed that the number of recruited EPCs is reduced and their function is decreased under diabetic conditions, implying that diabetic EPC dysfunction may contribute to defective angiogenesis and resultant cardiovascular complications in diabetes. To recover the functional abilities of diabetic EPCs and to address possible application of EPC cell therapy to diabetic patients, some studies provided explanations for diabetic EPC dysfunction including increased oxidative stress, involvement of the inflammatory response, alteration in the nitric oxide pathway and reduced signals for EPC recruitment. This review discusses clinical evidence of impairment of EPC functions under diabetic conditions and the suggested mechanisms for diabetic EPC dysfunction.

A physiologically-based pharmacokinetic model adequately predicted the human pharmacokinetic profiles of YH4808, a novel K⁺-competitive acid blocker

Lee, Hyun A.,Lee, Kyeong-Ryoon,Jang, Seong Bok,Chung, Soo Yong,Yu, Kyung-Sang,Lee, Howard Elsevier 2019 European journal of pharmaceutical sciences Vol.130 No.-

<P><B>Abstract</B></P> <P>A physiologically-based pharmacokinetic (PBPK) model was developed for YH4808, a novel potassium-competitive acid blocker, using the SimCYP® Simulator based on the physicochemical, in vitro preclinical and clinical data of YH4808. The PBPK model was optimized using YH4808 concentrations obtained from the single-dose phase I clinical trial. Overall, the PBPK model adequately predicted the observed pharmacokinetic profiles of YH4808 in humans. The pharmacokinetic profiles of YH4808 after multiple oral administrations were predicted using a refined PBPK model. The ratios of model-predicted to observed C<SUB>max</SUB>, AUC<SUB>inf</SUB> and AUC<SUB>τ</SUB> values on Day 1 and Day 7 at 100 mg were 0.7–1.0. However, the model failed to predict a decreased exposure after multiple oral administration particularly at higher doses of 200 and 400 mg. The reduced solubility of YH4808 at higher pH was hypothesized as the main cause of the reduction in exposure such that absorption was decreased as pH was increased. This hypothesis was confirmed by PBPK modeling and simulation, where intragastric pH was increased by YH4808.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

조리방법에 따른 가지(Solanum melongena L.)의 항염증 활성 평가

장경아 ( Kyeong A Jang ),박연희 ( Yeon Hee Park ),황유진 ( Yu Jin Hwang ),김행란 ( Haeng Ran Kim ) 한국식품조리과학회 2021 한국식품조리과학회지 Vol.37 No.6

Purpose: This study was conducted to investigate the anti-inflammatory effects of Solanum melongena L. (SM) using 3 kinds of cooking methods. Methods: To estimate the anti-inflammatory effect of SM, the production of nitric oxide (NO) and prostaglandin E₂ (PGE₂), gene expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and cytokines, and nuclear factor kappa B (NF-κ B) protein were measured. Results: Compared to raw SM, there was a decrease in the production of NO and pro-inflammatory cytokine mRNA in the cooked SM. All samples (10, 20, 50 μg/mL) dose-dependently decreased the production of NO and PGE2. Roasted SM (RSM) and steamed SM (SSM) treatment down-regulated iNOS, COX-2 and cytokines mRNA expression, and p50 and IκBα phosphorylation compared to the vehicle. Specifically, SSM showed the greatest anti-inflammatory effect. Conclusion: Thus, the cooking method may have a bearing on the anti-inflammatory effect of SM. This is presumed to be due to the change in the functional components during heating. However, further studies to identify the active compounds are required.

자활사업 참여자의 자활의지 예측요인 및 경로

장창수(Jang, Chang-Soo),윤경아(Yoon, Kyeong-A),배지연(Bae, Ji-Yeon) 한국지역사회학회 2015 지역사회연구 Vol.23 No.4

This study examined whether self-sufficiency participants’ job characteristics and self-esteem were associated with male and female participants’ willingness for self-sufficiency directly and indirectly through professional support. Hypotheses were tested using multivariate regression and Baron and Kenny’s(1986) steps for mediation with a sample of 307 self-sufficiency program participants in Daejeon area. The result demonstrates that task significance, autonomy, and self-esteem directly increase willingness for self-sufficiency. Associations between participants’ task significance and self-esteem were partially mediated through professional support. Task significance was statistically significant only for female participants and self-esteem was statistically significant for male and female participants. Associations between participants’ autonomy was fully mediated through professional support and statistically significant only for female participants. Implications for improving self-sufficiency program participants’ willingness for self-sufficiency are discussed as a function of self-sufficiency program participants’s job characteristics, self-esteem, and professional support.

Site-specific cancer risk in patients with type 2 diabetes: a nationwide population-based cohort study in Korea

Suk Kyeong Kim,Ju-Young Jang,Dong-Lim Kim,Young A Rhyu,Suh Eun Lee,Seung-Hyun Ko,Kyungdo Han,Kee-Ho Song,Korean Diabetes Association 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.3

Background/Aims: We aimed to evaluate site-specific cancer risk in diabetic patients and to investigate causal and temporal relationships by analyzing organ- specific cancer risk according to the duration of diabetes. Methods: Using a database provided by the Korean National Health Insurance Service, we conducted a retrospective, population-based cohort study of adults aged ≥ 30 years from January 2005 to December 2013. To verify the possibility of detection bias or reverse causation, we compared hazard ratios (HRs) for each cancer according to the following duration of diabetes: less than 6 months, 6 months to 3 years, and more than 3 years. Results: The incidence of overall cancer per 1,000 person-years was higher in patients with diabetes than in those without diabetes (20.36 vs. 10.83). The overall cancer risk according to the duration of diabetes was the highest within the first 6 months after diagnosis (HR, 2.03; 95% confidence interval [CI], 1.99 to 2.07), and the HR decreased with the duration of diabetes, ranging from 1.19 (95% CI, 1.18 to 1.21) between 6 months and 3 years to 1.12 (95% CI, 1.11 to 1.13) after 3 years. Both overall cancer risk and HR remained significantly higher in patients with diabetes than in those without diabetes. The risk for prostate cancer was higher in men with diabetes than in those without diabetes (HR, 1.12; 95% CI, 1.10 to 1.14). In women, the risk for endometrial cancer was significantly higher in patients with diabetes than in those without diabetes throughout the duration of diabetes. Conclusions: The risk for stomach, colorectum, liver, pancreas, and kidney cancer appeared to be higher in patients with diabetes than in those without diabetes regardless of the sex or duration of diabetes.