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LOCAL ANOMALIES AROUND THE THIRD PEAK IN THE CMB ANGULAR POWER SPECTRUM OF WMAP 7-YEAR DATA
Ko, Kyeong Yeon,Park, Chan-Gyung,Hwang, Jai-Chan The Korean Astronomical Society 2013 Journal of The Korean Astronomical Society Vol.46 No.2
We estimate the power spectra of the cosmic microwave background radiation (CMB) temperature anisotropy in localized regions of the sky using the Wilkinson Microwave Anisotropy Probe (WMAP) 7-year data. We find that the north and south hat regions at high Galactic latitude ($|b|{\geq}30^{\circ}C$) show an anomaly in the power spectrum amplitude around the third peak, which is statistically significant up to 3. We try to explain the cause of the observed anomaly by analyzing the low Galactic latitude ($|b|$ < $30^{\circ}C$) regions where the galaxy contamination is expected to be stronger, and the regions weakly or strongly dominated byWMAP instrument noise. We also consider the possible effect of unresolved radio point sources. We find another but less statistically significant anomaly in the low Galactic latitude north and south regions whose behavior is opposite to the one at high latitude. Our analysis shows that the observed north-south anomaly at high latitude becomes weaker on regions with high number of observations (weak instrument noise), suggesting that the anomaly is significant at sky regions that are dominated by the WMAP instrument noise. We have checked that the observed north-south anomaly has weak dependences on the bin-width used in the power spectrum estimation, and on the Galactic latitude cut. We also discuss the possibility that the detected anomaly may hinge on the particular choice of the multipole bin around the third peak. We anticipate that the issue of whether or not the anomaly is intrinsic one or due to WMAP instrument noise will be resolved by the forthcoming Planck data.
건강보험청구자료를 이용한 HER2 양성 전이성 유방암 환자의 조기 사망에 따른 간접적 질병 부담 분석
고화연(Hwa Yeon Ko),최아형(Ahhyung Choi),홍빈(Bin Hong),배지환(Ji-Hwan Bae),오인선(In-Sun Oh),박선경(Sun-Kyeong Park),박연희(Yeon Hee Park),신주영(Ju-Young Shin) 대한약학회 2023 약학회지 Vol.67 No.3
The premature deaths caused by human epidermal growth factor receptor-2 protein (HER2) positive metastatic breast cancer (MBC) among working age groups result in significant socioeconomic losses. This study aims to quantify the socioeconomic burden of disease in female patients and provide evidence that can inform healthcare policy decisions. We identified deaths from HER2-positive MBC over the period from 2007 to 2021, using nationwide claims data of South Korea. Then, we estimated years of potential life lost (YPLL), years of potential productivity lost (YPPLL), and cost of productivity loss (CPL) to quantify socioeconomic burden of the disease. During the period from 2011 to 2020, a total of 3,576 patients died from HER2-positive MBC. The total YPLL over the period of 10 years from 2011 to 2020 was 128,605 years, corresponding to an average of approximately 36.0 years per deceased patient. The total YPPLL during the same period was 55,608 years, corresponding to an average of approximately 15.6 years per deceased patient. Additionally, total CPL of approximately 310 million won per deceased patient was incurred. All three disease burden indicators were highest among the age group of 40 to 54 years, which are individuals in their most productive time of life.
Ko, Aram,Han, Su Yeon,Choi, Chel Hun,Cho, Hanbyoul,Lee, Min-Sik,Kim, Soo-Youl,Song, Joon Seon,Hong, Kyeong-Man,Lee, Han-Woong,Hewitt, Stephen M.,Chung, Joon-Yong,Song, Jaewhan Nature Publishing Group UK 2018 Cell death and differentiation Vol.25 No.6
<P>Oncogene-induced senescence (OIS) is a critical tumor-suppressor mechanism, which prevents hyper-proliferation and transformation of cells. c-Myc promotes OIS through the transcriptional activation of p14ARF followed by p53 activation. Although the oncogene-mediated transcriptional regulation of p14ARF has been well addressed, the post-translational modification of p14ARF regulated by oncogenic stress has yet to be investigated. Here, we found that c-Myc increased p14ARF protein stability by inducing the transcription of ubiquitin-specific protease 10 (USP10). USP10, in turn, mediated the deubiquitination of p14ARF, preventing its proteasome-dependent degradation. USP10-null mouse embryonic fibroblasts and human primary cells depleted of USP10 bypassed c-Myc-induced senescence via the destabilization of p14ARF, and these cells displayed accelerated hyper-proliferation and transformation. Clinically the c-Myc-USP10-p14ARF axis was disrupted in non-small cell lung cancer patients, resulting in significantly worse overall survival. Our studies indicate that USP10 induced by c-Myc has a crucial role in OIS by maintaining the stability of key tumor suppressor p14ARF.</P>
Kim, Kyeong Han,Jang, Soobin,Lee, Ju Ah,Go, Ho-Yeon,Jung, Jeeyoun,Park, Sunju,Lee, Myeong Soo,Ko, Seong-Gyu Mary Ann Liebert 2018 The journal of alternative and complementary medic Vol.24 No.6
<P>Introduction: Infertility has long been recognized as a treatable disease, and complementary and alternative medicine treatments, such as acupuncture and moxibustion, have been used in Korea and China. This study describes female infertility treatment programs that used traditional Korean medicine (TKM) and were conducted by local governments in Korea and evaluates its effectiveness and safety. Methods: The authors officially requested related information from the report of the infertility treatment programs and related sources from 2006 to 2016 from the Health & Welfare Ministry of Korea and the Association of Korean Medicine (AKOM). Additional information was obtained from six Korean databases. Data including basic information about the programs, participant information, interventions, and outcomes were abstracted. Results: A total of 9 reports, including multiple years of data from 6 programs (total 13 programs), were identified. In these 13 programs, a total of 1023 female subjects participated, and 205 of the 887 subjects who completed the program reported a successful pregnancy, indicating a 23.1% pregnancy rate. The programs lasted 3-9 months, and interventional elements, such as herbal medicine, acupuncture, fumigation, and massage, were identified. Significant adverse effects were not reported. Conclusions: This study suggests that infertility treatment programs with TKM interventions exhibited a positive effect on pregnancy in females with infertility. Thus, the infertility treatment programs with TKM interventions are expected to be useful and might serve as the primary treatment before assisted reproduction techniques.</P>
Necrophagous insect fauna on carcasses relative to the decomposition stages in Daejeon area
Bo-Yeon Choi,Seol-Hui Ko,So-Yeon Lim,Young-Gwang Song,Kyeong-Won Lee,Bong-Kyu Byun 한국응용곤충학회 2023 한국응용곤충학회 학술대회논문집 Vol.2023 No.10
닭 사체를 이용하여 장소, 기온, 습도별 시식성 곤충상을 파악하기 위해 대전광역시 전민동 일대의 3개의 장소 를 선택하여 닭 사체별로 유인되는 곤충의 종류와 군집 상의 차이와 출현양상을 조사하였다. 이를 위해, 닭 사체에 유인되는 곤충을 주기적으로 채집하고 해당 일자의 온도와 습도를 조사하여 기록했으며, 채집한 곤충들은 외부 형태적 특징으로 분류하고 개체수를 확인했다. 조사결과, 딱정벌레목과 파리목의 개체가 가장 많았고, 그 외에 바퀴목, 벌목, 노린재목 분류군에 속하는 다양한 곤충들이 유인된 것을 확인할 수 있었다. 본 연구 결과는 법곤충 시식성 곤충을 연구하는데 중요한 기초자료로 활용될 수 있도록 결과를 종합정리하였다.
JEONG, YEON WOO,LEE, GEUN-SHIK,KIM, JOUNG JOO,PARK, SUN WOO,KO, KYEONG HEE,KANG, MINA,KIM, YU KYUNG,JUNG, EUI-MAN,HYUN, SANG HWAN,SHIN, TAEYOUNG,JEUNG, EUI-BAE,HWANG, WOO SUK Spandidos Publications 2012 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.30 No.2
<P>Dogs are useful models for studying human metabolic diseases such as type 2 diabetes mellitus due to similarities in physiology, anatomy and life styles with humans. Somatic cell nuclear transfer (SCNT) facilitates the production of transgenic dogs. In this study, we generated transgenic dogs expressing the phosphoenolpyruvate carboxykinase (PEPCK) gene, which is closely involved in the pathogenesis of type 2 diabetes mellitus. In addition, we assessed the cloning efficiency associated with adult or fetal (cloned or natural mating) fibroblasts as a nuclear source. Cloning efficiency was determined by the fusion, pregnancy and cloning rates. The fusion rates were significantly high for fibroblasts from cloned fetuses, but the pregnancy and cloning rates were relatively high for cells from normal fetuses. Based on these data, fetal fibroblasts were selected as the nuclear donor for SCNT and genetically engineered to overexpress the PEPCK gene and dual selection marker genes controlled by the PEPCK promoter. The transgenic cells were introduced into oocytes and transferred into five recipient dogs, resulting in two pregnancies. Finally, three puppies were born and confirmed by microsatellite analysis to be genetically identical to the donor. One puppy successfully overexpressed PEPCK mRNA and protein in the liver. This canine disease model may be useful for studying the pathogenesis and/or therapeutic targets of type 2 diabetes mellitus.</P>