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권오기,심재설,이홍식 중앙대학교 건설환경연구소 2001 環境科學硏究 Vol.12 No.1
The numerical model is presented for the prediction of wave fields in a harbor with partially reflecting boundaries. The water depth is assumed to be constant, and the solution was obtained by the boundary element approach. The present numerical study is based on the linear diffraction theory with regular waves. The results of the present model have been compared with the results of previous physical modeling. Good agreement was obtained in all cases. Based on these comparisons, the present numerical model is and accurate and efficient tool to predict the wave fields in a harbor with partially reflection boundaries in constant water depth.
옥재욱 ( Og Jae Ug ),최기현 ( Choe Gi Hyeon ),오재인 ( O Jae In ),권건호 ( Kwon Geon Ho ),양동호 ( Yang Dong Ho ),김경수 ( Kim Gyeong Su ),이용희 ( Lee Yong Hui ) 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.6
Fabry disease, angiokeratoma corporis diffusum, is a rare X-linked inborn error of glycosphingolipid metabolism due to the lack of the lysosomal enzyme, α-galactosidase A, resulting in a progressive deposition of specific neutral glycosphingolipids within the lysosomes of endothelial and smooth muscle cells of the cardiovascular and renal systems predominantly. We reported a case of Fabry disease, following renal biopsy for the investigation of proteinuria(Creatinine clearance 87.28 mL/min/1.73, serum creatinine 1.1 mg/dL, 24-hour urine protein 1,125 mg, 24-hour urine creatinine 1,382 mg). The patient was 46 year old male. He had experienced anterior chest pain regarded as angina pectoris for a few years. A 12- lead electrocardiogram was abnormal(T-wave inversion in II, III, AVF, and V3-V6), but echocardiography and coronary angiography revealed no abnormal. Kidney biopsy findings showed lamella inclusion bodies on electron microscopy, which are typical finding of Fabry disease. The patient is followed at O.P.D without any significant complaints for 18 months after diagnosis of Fabry disease.
신 청소율 검사(Renal Clearance Study)를 이용하여 진단한 Gitelman씨 증후군 2예
기주영 ( Gi Ju Yeong ),김혜영 ( Kim Hye Yeong ),임정묵 ( Im Jeong Mug ),오광식 ( O Gwang Sig ),박영선 ( Park Yeong Seon ),권순길 ( Kwon Sun Gil ),신종성 ( Sin Jong Seong ),김미성 ( Kim Mi Seong ),지정훈 ( Ji Jeong Hun ),엄재호 ( E 대한신장학회 2001 Kidney Research and Clinical Practice Vol.20 No.6
We have experienced two patients who had hypokalemic metabolic alkalosis as well as hypomagnesemia and hypocalciuria with elevated plasma renin activity. We have performed renal clearance study after water loading, administration of furosemide and thiazide in two patients and two normal controls. Maximal free water clearance per 100 mL glomerular filtration rate(C_(H2O) ) and distal fractional chloride reabsorption[ C_(H2O) /(C_(H2O) +C_(Cl))] in our patients were reduced than the controls. Chloride clearance(C_(Cl)) was increased after furosemide administration but not after thiazide administration. Distal fractional chloride reabsorption[C_(H2O) /(C_(H2O) +C_(Cl))] was dramatically decreased by furosemide administration in our patients, whereas thiazide had little effect on it. Fractional excretion of sodium, chloride, magnesium, calcium was increased by furosemide administration, whereas thiazide administration had little effect on this parameters. These findings suggested the presence of a defect in the distal convoluted tubule rather than in the thick ascending loop of Henle. Herein, we report two cases of Gitelman`s syndrome diagnosed by renal clearace study after water loading, administration of furosemide and thiazide.
포스터 전시 : 간 ; 고주파 열치료 후 간세포암의 예후에 영향을 미치는 인자
권기태 ( Kwon Gi Tae ),이동석 ( Lee Dong Seog ),박수영 ( Park Su Yeong ),김은수 ( Kim Eun Su ),박창근 ( Park Chang Geun ),조창민 ( Jo Chang Min ),탁원영 ( Tag Won Yeong ),권영오 ( Kwon Yeong O ),김성국 ( Kim Seong Gug ),최용환 ( C 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> 간세포암 환자에서 고주파 열치료 후 국소 재발에 영향을 미치는 인자로 종괴의 크기, 위치 등이 의미가 있다고 알려져 있다. 저자들은 위 두 인자를 포함한 여러 임상적 요소들이 고주파 열치료를 시행한 환자의 예후에 영향을 미치는지 여부를 알아보고자 하였다. <대상 및 방법> 1999년 10월부터 2002년 12월까지 본원에서 간세포암으로 진단되어 고주파 열치료를 시행 받은 환자 중 단일 결절의 환자 107명을 대상으로 하였다. 역동성 복부 전산화
한국인에서 Transforming Growth Factor-beta1 유전자의 Codon 10/25에서의 다형성과 간경변, 간세포암과의 관계
권오상 ( Kwon O Sang ),송석호 ( Song Seog Ho ),주기탁 ( Ju Gi Tag ),정문기 ( Jeong Mun Gi ),박동균 ( Park Dong Gyun ),김선숙 ( Kim Seon Sug ),김연석 ( Kim Yeon Seog ),구양서 ( Gu Yang Seo ),김유경 ( Kim Yu Gyeong ),최덕주 ( Choe D 대한소화기학회 2003 대한소화기학회지 Vol.42 No.3
Background/Aims: The genetic polymorphism of transforming growth factor-beta1 (TGF-β1) at codons 10 and 25 which influences the production of TGF-β1 is related to fibrogenesis in the lung and liver. We evaluated the genetic polymorphism at codons 10 and 25 in controls and in patients with liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Methods: Blood samples were collected from controls (n=35), patients with LC (n=64), and HCC (n=49). Genomic DNA was isolated and polymerase chain reaction (PCR) was done for a segment including codons 10 and 25. The results of direct sequencing for PCR products were compared between the controls and the patients. Results: There was no genetic polymorphism at codon 25 and three types of genetic polymorphism at codon 10. The leucine homozygous genotype (CTG/CTG) at codon 10 was more common in patients with LC than the controls (p=0.01) and especially in patients with LC caused by HBV (p=0.004). The polymorphism at codons 10 in patients with HCC was similar to the controls. However, leucine homozygous genotype was more common in patients with HCC of uninodular morphology than those of massive morphology (p=0.007). Conclusions: The genetic polymorphism of TGF-β1 at codon 10 might be associated with LC and morphology of HCC. The potential usefulness of TGF-β1 genotyping needs further studies in large scale. (Korean J Gastroenterol 2003;42:212-219)