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대한간학회지 제8차 춘계학술대회 초록집 : 구연 ; 만성 B형 간염환자에서 라미부딘 치료 중 HBeAg소실 후 재발에 관련된 인자
최창원 ( Choe Chang Won ),김경오 ( Kim Gyeong O ),권오상 ( Kwon O Sang ),송석호 ( Song Seog Ho ),주기탁 ( Ju Gi Tag ),김선숙 ( Kim Seon Sug ),최덕주 ( Choe Deog Ju ),김주현 ( Kim Ju Hyeon ),연종은 ( Yeon Jong Eun ),변관수 ( Byeon 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
대한간학회지 제8차 춘계학술대회 초록집 : 구연 ; HBsAg(+) 비대상성 간경변에서 HBV DNA양성 여부에 따른 환자의 생존율
권오상 ( Kwon O Sang ),조남영 ( Jo Nam Yeong ),최창원 ( Choe Chang Won ),안수현 ( An Su Hyeon ),백수정 ( Baeg Su Jeong ),정혁상 ( Jeong Hyeog Sang ),김선숙 ( Kim Seon Sug ),최덕주 ( Choe Deog Ju ),김주현 ( Kim Ju Hyeon ),연종은 ( 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
위아전절제술 후 잔위의 헬리코박터 파이로리 양성률에 영향을 미치는 인자
김은수 ( Kim Eun Su ),박동균 ( Park Dong Gyun ),홍순홍 ( Hong Sun Hong ),정문기 ( Jeong Mun Gi ),권오상 ( Kwon O Sang ),김선숙 ( Kim Seon Sug ),구양서 ( Gu Yang Seo ),김유경 ( Kim Yu Gyeong ),강동훈 ( Kang Dong Hun ),최덕주 ( Choe 대한소화기학회 2003 대한소화기학회지 Vol.42 No.2
Background/Aims: It was reported that the prevalence of Helicobacter pylori (H. pylori) infection decreased after gastrectomy, but persistent H. pylori infection may cause residual gastritis or stump cancer. We studied the prevalence of H. pylori infection in patients who had undergone subtotal gastrectomy for the treatment of gastric cancer and the factors that influence H. pylori positivity in the remnant stomach. Methods: Ninety-eight patients who had undergone radical subtotal gastrectomy (RSG group) for the treatment of gastric cancer and eighty-four patients diagnosed as having gastric cancer (GC group) were enrolled. H. pylori status was diagnosed by rapid urease test, histological examination, and 13C-urea breath test. We evaluated whether there were differences in various clinical characteristics according to the H. pylori status in the remnant stomach. Results: The prevalences of H. pylori infection in RSG group and GC group were 55% and 69%, respectively. In RSG group, the prevalence of H. pylori was 76.9% in patients aged 49 or less, and it decreased with age. The prevalence of H. pylori within 3 years of gastrectomy was 59.5% and it decreased to 28.6% after 3 years of gastrectomy. Conclusions: The positive rate of H. pylori in RSG group is lower than that in GC group and decreases with age and time interval after operation. (Korean J Gastroenterol 2003;42:108-114)
한국인에서 Transforming Growth Factor-beta1 유전자의 Codon 10/25에서의 다형성과 간경변, 간세포암과의 관계
권오상 ( Kwon O Sang ),송석호 ( Song Seog Ho ),주기탁 ( Ju Gi Tag ),정문기 ( Jeong Mun Gi ),박동균 ( Park Dong Gyun ),김선숙 ( Kim Seon Sug ),김연석 ( Kim Yeon Seog ),구양서 ( Gu Yang Seo ),김유경 ( Kim Yu Gyeong ),최덕주 ( Choe D 대한소화기학회 2003 대한소화기학회지 Vol.42 No.3
Background/Aims: The genetic polymorphism of transforming growth factor-beta1 (TGF-β1) at codons 10 and 25 which influences the production of TGF-β1 is related to fibrogenesis in the lung and liver. We evaluated the genetic polymorphism at codons 10 and 25 in controls and in patients with liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Methods: Blood samples were collected from controls (n=35), patients with LC (n=64), and HCC (n=49). Genomic DNA was isolated and polymerase chain reaction (PCR) was done for a segment including codons 10 and 25. The results of direct sequencing for PCR products were compared between the controls and the patients. Results: There was no genetic polymorphism at codon 25 and three types of genetic polymorphism at codon 10. The leucine homozygous genotype (CTG/CTG) at codon 10 was more common in patients with LC than the controls (p=0.01) and especially in patients with LC caused by HBV (p=0.004). The polymorphism at codons 10 in patients with HCC was similar to the controls. However, leucine homozygous genotype was more common in patients with HCC of uninodular morphology than those of massive morphology (p=0.007). Conclusions: The genetic polymorphism of TGF-β1 at codon 10 might be associated with LC and morphology of HCC. The potential usefulness of TGF-β1 genotyping needs further studies in large scale. (Korean J Gastroenterol 2003;42:212-219)