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한국인에서 Transforming Growth Factor-beta1 유전자의 Codon 10/25에서의 다형성과 간경변, 간세포암과의 관계
권오상 ( Kwon O Sang ),송석호 ( Song Seog Ho ),주기탁 ( Ju Gi Tag ),정문기 ( Jeong Mun Gi ),박동균 ( Park Dong Gyun ),김선숙 ( Kim Seon Sug ),김연석 ( Kim Yeon Seog ),구양서 ( Gu Yang Seo ),김유경 ( Kim Yu Gyeong ),최덕주 ( Choe D 대한소화기학회 2003 대한소화기학회지 Vol.42 No.3
Background/Aims: The genetic polymorphism of transforming growth factor-beta1 (TGF-β1) at codons 10 and 25 which influences the production of TGF-β1 is related to fibrogenesis in the lung and liver. We evaluated the genetic polymorphism at codons 10 and 25 in controls and in patients with liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Methods: Blood samples were collected from controls (n=35), patients with LC (n=64), and HCC (n=49). Genomic DNA was isolated and polymerase chain reaction (PCR) was done for a segment including codons 10 and 25. The results of direct sequencing for PCR products were compared between the controls and the patients. Results: There was no genetic polymorphism at codon 25 and three types of genetic polymorphism at codon 10. The leucine homozygous genotype (CTG/CTG) at codon 10 was more common in patients with LC than the controls (p=0.01) and especially in patients with LC caused by HBV (p=0.004). The polymorphism at codons 10 in patients with HCC was similar to the controls. However, leucine homozygous genotype was more common in patients with HCC of uninodular morphology than those of massive morphology (p=0.007). Conclusions: The genetic polymorphism of TGF-β1 at codon 10 might be associated with LC and morphology of HCC. The potential usefulness of TGF-β1 genotyping needs further studies in large scale. (Korean J Gastroenterol 2003;42:212-219)
대한간학회지 제8차 춘계학술대회 초록집 : 구연 ; 만성 B형 간염환자에서 라미부딘 치료 중 HBeAg소실 후 재발에 관련된 인자
최창원 ( Choe Chang Won ),김경오 ( Kim Gyeong O ),권오상 ( Kwon O Sang ),송석호 ( Song Seog Ho ),주기탁 ( Ju Gi Tag ),김선숙 ( Kim Seon Sug ),최덕주 ( Choe Deog Ju ),김주현 ( Kim Ju Hyeon ),연종은 ( Yeon Jong Eun ),변관수 ( Byeon 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)