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Yoo, Kwai Han,Lee, Hyewon,Suh, Cheolwon Elsevier Science Publishers 2018 INTERNATIONAL JOURNAL OF HEMATOLOGY Vol.107 No.4
<P>Lymphomas are a heterogeneous group of disease entities with well-defined clinical, morphological, immunophenotypic, and cytogenetic characteristics. Moreover, regional and racial differences have been reported in their incidence and subtype compositions. Here, we reviewed the epidemiology of lymphomas and summarized the recent achievements in specific subtypes prevalent in Korean population, focusing on clinical studies conducted by the Consortium for Improving Survival of Lymphoma (CISL) of the Korean Society of Hematology Lymphoma Working Party (KSH-LWP).</P>
Genomic Alterations in Biliary Tract Cancer Using Targeted Sequencing <sup>1</sup>
Yoo, Kwai Han,Kim, Nayoung K.D.,Kwon, Woo Il,Lee, Chung,Kim, Sun Young,Jang, Jiryeon,Ahn, Jungmi,Kang, Mihyun,Jang, Hyojin,Kim, Seung Tae,Ahn, Soomin,Jang, Kee-Taek,Park, Young Suk,Park, Woong-Yang,Le Neoplasia Press 2016 Translational oncology Vol.9 No.3
<P><I>Background:</I> Biliary tract cancers (BTCs) are rare and heterogeneous group of tumors classified anatomically into intrahepatic and extrahepatic bile ducts and gallbladder adenocarcinomas. Patient-derived tumor cell (PDC) models with genome analysis can be a valuable platform to develop a method to overcome the clinical barrier on BTCs. <I>Material and Methods:</I> Between January 2012 and June 2015, 40 BTC patients’ samples were collected. PDCs were isolated and cultured from surgical specimens, biopsy tissues, or malignant effusions including ascites and pleural fluid. Genome analysis using targeted panel sequencing as well as digital multiplexed gene analysis was applied to PDCs as well as primary tumors. <I>Results:</I> Extrahepatic cholangiocarcinoma (<I>N</I> = 15, 37.5%), intrahepatic cholangiocarcinoma (<I>N</I> = 10, 25.0%), gallbladder cancer (<I>N</I> = 14, 35.0%), and ampulla of Vater cancer (<I>N</I> = 1, 2.5%) were included. We identified 15 mutations with diverse genetic alterations in 19 cases of BTC from primary tumor specimens. The most common molecular alterations were in TP53 (8/19, 42.1%), including missense mutations such as C242Y, E285K, G112S, P19T, R148T, R248Q, and R273L. We also detected two NRAS mutations (G12C and Q61L), two KRAS mutations (G12A and G12S), two ERBB2 mutations (V777L and pM774delinsMA) and amplification, and three PIK3CA mutations (N345K, E545K, and E521K). PDC models were successfully established in 27 of 40 samples (67.5%), including 22/24 from body fluids (91.7%) and 5/16 from tissue specimens (31.3%). <I>Conclusions:</I> PDC models are promising tools for uncovering driver mutations and identifying rational therapeutic strategies in BTC. Application of this model is expected to inform clinical trials of drugs for molecular-based targeted therapy.</P>
Kwai Han Yoo 대한혈액학회 2022 Blood Research Vol.57 No.-
The accurate assessment of initial disease status and therapeutic responses is critical to the optimal management of patients with lymphoma. Currently, staging and treatment response evaluation for lymphoma has been standardized into the Lugano classification. Lugano classification incorporates positron emission tomography (PET) into the existing response criteria, and response assessment using FDG-PET/CT has been proven to predict the prognosis in various lymphoma subtypes effectively. We will briefly review the current staging and response evaluation system and explore the role of functional imaging in the field of lymphoma.
이슬기 ( Seulkee Lee ),유쾌한 ( Kwai Han Yoo ),이걸 ( Keol Lee ),김인영 ( In Young Kim ),권희진 ( Hee Jin Kwon ),정혜민 ( Hyemin Jeong ),고은미 ( Eun Mi Koh ) 대한내과학회 2015 대한내과학회지 Vol.88 No.3
Overlap syndrome is defined as a disease entity that fulfills the classification criteria of at least two different rheumatologic diseases simultaneously. Overlap of systemic sclerosis (SSc) and rheumatoid arthritis (RA) is less common than the overlap of polymyositis with SSc or systemic lupus erythematosus. Distinguishing RA from SSc can be difficult because arthralgia is a frequent symptom of both. We observed three cases of RA and SSc overlap. In each case, RA occurred in sequence with SSc, with a period of 4-15 years between the onset of each disease. In one case, the patient had diffuse SSc, which is rare among overlap syndrome patients. Previously, only one case of overlap syndrome involving SSc and RA has been reported in Korea; herein, we report our cases with a review of the literature. (Korean J Med 2015;88:350-355)
Multicenter retrospective analysis of patients with chronic lymphocytic leukemia in Korea
Jun Ho Yi,이경원,이지현,Kwai Han Yoo,Chul Won Jung,Dae Sik Kim,Jeong-Ok Lee,Hyeon Seok Eom,Ja Min Byun,Youngil Koh,Sung Soo Yoon,Jin Seok Kim,Jee Hyun Kong,Ho-Young Yhim,Deok Hwan Yang,Dok Hyun Yoon,Do Hyou 대한혈액학회 2021 Blood Research Vol.56 No.4
Background Chronic lymphocytic leukemia (CLL) is the most common type of adult leukemia in Western countries but is rare in the East Asian countries. Due to its rarity and the lack of feasible novel agents and laboratory prognostic tools, there are limited data on the clinical outcomes of this disease in Asia. To clarify the current treatment status, we performed a multicenter retrospective analysis of patients with CLL in Korea. Methods The medical records of 192 eligible patients between 2008 and 2019 were reviewed for clinical characteristics, treatment courses, and outcomes. The first-line treatment regimens of the patients included in this analysis were as follows: fludarabine/cyclophosphamide/ rituximab (FCR) (N=117, 52.7%), obinutuzumab plus chlorambucil (GC) (N=30, 13.5%), and chlorambucil monotherapy (N=24, 10.8%). Results The median progression-free survival (PFS) was 55.6 months, and the average 2-year PFS rate was 80.3%. PFS was not significantly different between the patients receiving FCR and those receiving GC; however, chlorambucil treatment was associated with significantly inferior PFS (P <0.001). The median overall survival was 136.3 months, and the average 5- and 10-year OS rates were 82.0% and 57.4%, respectively. Conclusion This is one of the largest studies involving Korean patients with CLL. Although the patients had been treated with less favored treatment regimens, the outcomes were not different from those reported in Western studies.
감염 : 반복하여 재발한 류마티스 결절증(nodulosis) 1예
이슬기 ( Seul Kee Lee ),유쾌한 ( Kwai Han Yoo ),이걸 ( Keol Lee ),김인영 ( In Young Kim ),권희진 ( Hee Jin Kwon ),차훈석 ( Hoon Suk Cha ),황지원 ( Ji Won Hwang ) 대한내과학회 2015 대한내과학회지 Vol.88 No.2
Rheumatoid nodulosis, a benign variant of rheumatoid arthritis (RA), is a rare condition characterized by multiple subcutaneous nodules and positive rheumatoid factor in the absence of systemic manifestations or joint disease. Asymptomatic nodules rarely require treatment, and are unlikely to recur after excision, except in cases in which RA develops. Here, we describe an unusual case of recurrent rheumatoid nodulosis in a 42-year-old female presenting with recurrent subcutaneous nodules on the plantar side of her left foot, which caused pain when walking. Nodules were initially excised to control symptoms; however, since the excision, the nodules have recurred twice in the absence of other RA symptoms. (Korean J Med 2015;88:241-245)
Case Reports : Pituitary Granulomatosis with Polyangiitis Presenting with Central Diabetes Insipidus
( In Young Kim ),( Seulkee Lee ),( Hee Jin Kwon ),( Keol Lee ),( Kwai Han Yoo ),( Hoon Suk Cha ),( Eun Mi Koh ),( Jaejoon Lee ) 대한류마티스학회 2015 대한류마티스학회지 Vol.22 No.3
We report on a case of limited form of granulomatosis with polyangiitis (GPA) with pituitary involvement which presented with central diabetes insipidus. This rare form of GPA has not been reported in Korea. The patient presented with fever, headache, productive cough, nasal symptoms, and polyuria. Laboratory data and imaging studies demonstrated inflammatory lesions in nasal sinus and lungs. Pituitary stalk thickening and enhancement were observed on brain magnetic resonance imaging. The histopathology of the lung lesions showed chronic active granulomatous inflammation. Polyuria, hyperosmolar hypernatremia, and decreased urine osmolality which responded to synthetic vasopressin analog were consistent with central diabetes insipidus. Based on the clinical findings and histopathological results, a diagnosis of GPA with pituitary involvement was established. Treatment with desmopressin as well as concurrent glucocorticoids and immunosuppressant resulted in clinical improvement.
( Keol Lee ),( Hee Jin Kwon ),( In Young Kim ),( Kwai Han Yoo ),( Seulkee Lee ),( Yang Won Min ),( Poong Lyul Rhee ) 대한간학회 2016 Gut and Liver Vol.10 No.1
Noncardiac chest pain (NCCP) is one of the most common esophageal symptoms and lacks a clearly defined mechanism. The most common cause of NCCP is gastroesophageal reflux disease (GERD). One of the accepted mechanisms of NCCP in a patient without GERD has been altered visceral sensitivity. Mast cells may play a role in visceral hypersensitivity in irritable bowel syndrome. In this case, a patient with NCCP and dysphagia who was unresponsive to proton pump inhibitor treatment had an increased esophageal mast cell infiltration and responded to 14 days of antihistamine and antileukotriene treatment. We suggest that there may be a relationship between esophageal symptoms such as NCCP and esophageal mast cell infiltration. (Gut Liver 2016;10:152-155)