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Chang Dae Kum,Mi Jin Lee,Moon Sung Park,Young Bae Sohn,O Kyu Noh,Jang Hoon Lee 대한신생아학회 2019 Neonatal medicine Vol.26 No.1
Purpose: 17-Hydroxyprogesterone (17-OHP) screening results are difficult to interpret owing to the many influencing factors, and confirming the test results takes time. In this study, we examined the factors that affected the 17-OHP level in premature infants. We also evaluated the correlation between 17-OHP level and the clinical parameters related to adrenal cortical function. Methods: From January 2012 to April 2017, 358 very-low-birth-weight infants (VLBWI) born with birth weights of <1,500 g were included in the study. Their 17-OHP levels were measured in the neonatal screening test after birth and analyzed by considering various factors that may have influenced the values. Results: The 17-OHP levels negatively correlated with gestational age and birth weight. The values of the parameters that affected the 17-OHP levels were significantly higher in the infants with respiratory distress syndrome (RDS). In relation to the clinical parameters, blood pressure measured within 24 hours, 72 hours, and 1 week after birth negatively correlated with the 17-OHP level. Serum sodium and 17-OHP levels 24 hours after birth were found to be positively correlated. Urine outputs in 1 and 3 days after birth showed significant positive correlations with the 17-OHP level. Conclusion: The 17-OHP levels of the VLBWIs were higher when gestational age and birth weight were lower, and were influenced by RDS in the VLBWI. In addition, hypotension and urine output values may be useful in the neonatal intensive care unit as a predictor of early adrenal insufficiency.
Kum, Chang Dae,Lee, Mi Jin,Park, Jun Eun Yeungnam University College of Medicine 2019 Yeungnam University Journal of Medicine Vol.36 No.2
The dose of CD34+ cells is known to influence the outcome of allogeneic peripheral blood stem cell (PBSC) and/or T-cell-depleted transplantation. A previous study proposed that $2{\times}10^6\;CD34+\;cells/kg$ is the ideal minimum dose for allogeneic transplantation, although lower doses did not preclude successful therapy. In the case we present here, CD34+ cells were collected from a matched sibling donor on the day of allogeneic hematopoietic stem cell transplantation; however, the number of cells was not sufficient for transplantation. Consequently, PBSCs were collected three additional times and were infused along with cord blood cells from the donor that were cryopreserved at birth. The cumulative dose of total nuclear cells and CD34+ cells was $15.9{\times}10^8\;cells/kg$ and $0.95{\times}10^6\;cells/kg$, respectively. White blood cells from this patient were engrafted on day 12. In summary, we report successful engraftment after infusion of multiple low doses of CD34+ cells in a patient with severe aplastic anemia.
Chang Dae Kum,Mi Jin Lee,Jun Eun Park 영남대학교 의과대학 2019 Yeungnam University Journal of Medicine Vol.36 No.2
The dose of CD34+ cells is known to influence the outcome of allogeneic peripheral blood stem cell (PBSC) and/or T-cell-depleted transplantation. A previous study proposed that 2×106 CD34+ cells/kg is the ideal minimum dose for allogeneic transplantation, although lower doses did not preclude successful therapy. In the case we present here, CD34+ cells were collected from a matched sibling donor on the day of allogeneic hematopoietic stem cell transplantation; however, the number of cells was not sufficient for transplantation. Consequently, PBSCs were collected three additional times and were infused along with cord blood cells from the donor that were cryopreserved at birth. The cumulative dose of total nuclear cells and CD34+ cells was 15.9×108 cells/kg and 0.95×106 cells/kg, respectively. White blood cells from this patient were engrafted on day 12. In summary, we report successful engraftment after infusion of multiple low doses of CD34+ cells in a patient with severe aplastic anemia.
Kum Chang Dae,Rho Jung Gi,Park Hong Kyu,Lee Hae Sang,Hwang Jin Soon 대한소아내분비학회 2021 Annals of Pediatirc Endocrinology & Metabolism Vol.26 No.1
Purpose: Because small for gestational age (SGA) children who fail to experience catch-up growth have an increased risk of short stature in adulthood, growth hormone (GH) treatment is recommended for effective growth. In this study, we evaluated the effect of GH treatment during the prepubertal period and analyzed for correlation between GH treatment response and clinical factors in SGA children. Methods: A retrospective, single-center study was conducted from 2014 to 2020. A total of 34 prepubertal children of short stature up to 4 years of age and born as SGA were enrolled. We recorded clinical data including birth data, age, weight, height, bone age (BA), and insulin-like growth factor 1 (IGF-1) levels. Results: The mean gestational age and birth weight were 37.50±2.51 weeks and 2,200.00±546.79 g. At the start of GH treatment, the mean chronological age and BA were 5.54±1.73 years and 4.52±1.85 years, respectively. The height standard deviation score (SDS) (-2.47±0.45) and IGF-1 SDS (0.16±1.57) were calculated. Height velocity was 9.43±1.40 cm during the first GH treatment year and 7.63±1.16 cm during the second year (P<0.05). The treatment growth response was positively correlated with young age (P=0.047) and lower BA (P=0.049) at the start of treatment. In multiple regression analysis, IGF-1 SDS change had a significantly positive association with GH treatment response (P=0.045). Conclusion: GH treatment is effective for short stature SGA children who do not experience catch-up growth. Early initiation of GH treatment improved growth outcomes. As IGF-1 SDS is positively correlated with height SDS, IGF-1 monitoring is important during GH treatment of SGA prepubertal children.
Association of colorectal adenoma with components of metabolic syndrome.
Kim, Byung Chang,Shin, Aesun,Hong, Chang Won,Sohn, Dae Kyung,Han, Kyung Su,Ryu, Kum Hei,Park, Bum Joon,Nam, Ji Hyung,Park, Ji Won,Chang, Hee Jin,Choi, Hyo Seong,Kim, Jeongseon,Oh, Jae Hwan Rapid Communications of Oxford Ltd ; Kluwer Academ 2012 Cancer causes & control Vol.23 No.5
<P>Recently, some studies have shown that diabetes mellitus and metabolic syndrome increase the risk of colorectal neoplasms. Although the mechanism is not known, those have been proposed to contribute to this phenomenon, including insulin resistance, oxidative stress, and adipokine production. The objective of this study was to assess the association between metabolic risk factors and colorectal neoplasm.</P>
고전압 응용을 위한 4H-SiC Schottky Barrier Diode의 제작 및 특성
금병훈,강수창,박종대,신무환 명지대학교 대학원 1998 대학원논문집 Vol.2 No.-
This paper discusses about the processing and characterization of the high breakdown voltage 4H-SiC Schottky Barrier Diode. Two types of the devices were fabricated one was fabricated using the passivation layer and the other was fabricated without the passivation. In case of the device with passivation layer, breakdown voltages were in the range 120 V to 300 V, which is quite higher compare to the devices fabaricated from Si or GaAs. However, this value is lower than the theoretically predicted value. The reverse leakage current of the devices was quite low which is less than 10^7 Amp at the reverse bias voltage of 220 V.
질량분석법을 이용한 알칼리토중금속 검출시 용매 분자의 방해작용과 검출한계
성대동,강상수,정진희,성낙창,최금찬 동아대학교 환경문제연구소 2003 硏究報告 Vol.25 No.2
At the detection of heavy alkaline-earth metal in the solution using mass spectrometer, the identification of exact molecular ion is difficult due to be surrounded with solvent molecules around the metal ion and to make the solvated cluster. An exact identification method is developed using the method in compensation for the number of solvation on the mass spectrum when the heavy alkaline-earth metal analyze. The cluster surrounded with solvent molecules is interpreted as solvation number and the solvation number could be applied to the determination of exact molecular ions to be drawn out an exact quantitative molecular mass ion on the mass spectrometry.
서영준,Kum Chang Dae,Rho Jung Gi,Shim Young Suk,Lee Hae Sang,Hwang Jin Soon 대한소아내분비학회 2022 Annals of Pediatirc Endocrinology & Metabolism Vol.27 No.2
Purpose: We investigated the possible effects of diabetic ketoacidosis (DKA) at the initial diagnosis of type 1 diabetes mellitus (T1DM) on the clinical outcomes of pediatric patients. Methods: Medical records of children and adolescents with newly diagnosed T1DM seen in the Ajou University Hospital from January 2008 to August 2020 were reviewed and analyzed. Results: Among 129 diagnosed T1DM patients, 40.3% presented with DKA. Although demographic and basic characteristics did not differ between DKA and non-DKA patients, DKA patients needed a significantly higher insulin dosage than non-DKA patients for 2 years after diagnosis. However, control of glycated hemoglobin was not different between the DKA and non-DKA groups during the observation period. In the biochemical analysis, C-peptide, insulin-like growth factor-1, and insulin-like growth factor binding protein 3, high-density lipoprotein cholesterol, free T4, and T3 values were lower, but thyroid-stimulating hormone, initial serum glucose, uric acid, total cholesterol, triglyceride, and low-density lipoprotein cholesterol values were higher in DKA patients than non-DKA patients at the diagnosis of T1DM; however, these differences were temporarily present and disappeared with insulin treatment. Other clinical outcomes, such as height, thyroid function, and urine microalbumin level, did not vary significantly between the DKA and non-DKA groups during 5 years of follow-up. Conclusion: DKA at initial presentation reflects the severity of disease progression, and the deleterious effects of DKA seem to impact insulin secretion. Although no difference in long-term prognosis was found, early detection of T1DM should help to reduce DKA-related islet damage and the socioeconomic burden of T1DM.
Selective Solvation for a Specific Interaction between Alkali Metal Halides and Protic Solvents
Sung, Dae-Dong,Lee, Yong-Hee,Jeong, Jin-Hee,Sung, Nak-Chang,Choi, Kum-Chan 東亞大學校附設基礎科學硏究所 2002 基礎科學硏究論文集 Vol.19 No.1
Interference and detection limit upon solvent molecules while the heavy alkalimetal analysis have been studied using mass spectrometer. The observed mass spectra for positively charged clusters for rubidium salts of chloride and iodide are interpreted to be interfered by solvent molecules. The solvation numbers show the range of n=1∼n=6 around the metal ion. Therefore it is needed a correction while the heavy alkali metal detection is proceeded using mass spectrometer carefully.