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배추의 형질전환용 선발항생제로서 Paromomycin의 이용
조미애,민성란,고석민,유장렬,이준행,최필선,Cho, Mi-Ae,Min, Sung-Ran,Ko, Suck-Min,Liu, Jang-Ryol,Lee, Jun-Haeng,Choi, Pil-Son 한국식물생명공학회 2006 식물생명공학회지 Vol.33 No.4
정상' 배추와 '서울' 배추의 배축절편을 선발마커로서 hygromycin 저항성유전자를 갖고 있는 pCAMBIA1301와 paromomycin저항성유전자를 갖고 있는 pPTN290으로 각각 형질 전환된 LBA4404 또는 EHA101균주와 공동배양한 후 선발배지에서 배양하면서 형질전환체를 선발하였다. 형질전환빈도는 사용된 항생제와 품종에 따라서 현저하게 차이가 있었으며, 특히 paromomycin은 hygromycin보다 효과적이었고 정상 배추는 서울배추보다 양호하였다. 가장 높은 형질전환빈도는 (0.70%) 100mg/L paromomycin이 첨가된 선발배지에서 정상배추의배축을 배양할 경우 얻어졌다. GUS양성반응으로 확인 한 결과 정상배추에서 9개체와 서울배추에서 3개체를 각각 얻었으며, 온실에서 생장한 후 $T_1$종자를 수확하였다. $T_1$ 종자를 다시 발아시켜 유식물체를 얻은 후 GUS양성반응을 확인함으로서 외래유전자가 안정적으로 발현하고 있음을 확인하였다. Hypocotyl explants of Chinese cabbage (us. 'Jeong Sang' and 'Seoul') produced adventitious shoots on Murashige and Skoog (MS) basal medium supplemented with 4mg/L $AgNO_3$, 5 mg/L acetosyringone, 4 mg/L 6-benzyladenine and 3mg/L alpha-naphthaleneacetic acid (SI) after cocoultivation with strains of Agrobacterium tumefaciens (LBA4404) harboring the pCAMBIA1301 and the $_PPTN290$ containing hygromycin-resistance gene and paromomycin-resistance gene as a selectable marker genes, respectively. There was a significant difference in the frequency of transgenic plants depending on antibiotics and cultivars used. Paromomycin was better than hygromycin, and cultivar 'Jeong-sang' was higher than 'c.v. Seoul' in the frequency of transgenic plants. In particular, the highest frequency (0.70%) of transgenic plants was obtained from selection medium (SI) containing 100mg/L paromomycin in c.v., 'Jeong-sang' GUS positive response were obtained 9 plants and 3 plants from the cultivars, 'Jeong-sang' and 'Seoul', respectively. They were grown to maturity in a greenhouse and normally produced $T_1$ seeds. GUS histochemical assay for progeny $(T_1)$ revealed that the transgenes were expressed in the plant genome.
( Sung Jun Ko ),( Kui Hyun Yoon ),( Sang Hee Lee ) 영남대학교 의과대학 2024 Yeungnam University Journal of Medicine Vol.41 No.2
Background: Missing isoniazid (INH) resistance during tuberculosis (TB) diagnosis can worsen the outcomes of INH-resistant TB. The BD MAX MDR-TB assay (BD MAX) facilitates the rapid detection of TB and INH and rifampin (RIF) resistance; however, data related to its performance in clinical setting remain limited. Moreover, its effect on treatment outcomes has not yet been studied. Methods: We compared the performance of BD MAX for the detection of INH/RIF resistances to that of the line probe assay (LPA) in patients with pulmonary TB (PTB), using the results of a phenotypic drug sensitivity test as a reference standard. The treatment outcomes of patients who used BD MAX were compared with those of patients who did not. Results: Of the 83 patients included in the study, the BD MAX was used for an initial PTB diagnosis in 39 patients. The sensitivity of BD MAX for detecting PTB was 79.5%. The sensitivity and specificity of BD MAX for INH resistance were both 100%, whereas these were 50.0% and 95.8%, respectively, for RIF resistance. The sensitivity and specificity of BD MAX were comparable to those of LPA. The BD MAX group had a shorter time interval from specimen request to the initiation of anti-TB drugs (2.0 days vs. 5.5 days, p=0.001). Conclusion: BD MAX showed comparable performance to conventional tests for detecting PTB and INH/RIF resistances. The implementation of BD MAX as a diagnostic tool for PTB resulted in a shorter turnaround time for the initiation of PTB treatment.
The effectiveness of outpatient pulmonary rehabilitation for chronic lung diseases
( Jun Tak Choi ),( Myoung-hwan Ko ),( Sung-hee Park ),( Jeong-hwan Seo ),( Yu Hui Won ),( Yong Chul Lee ) 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-
Objective: To determine whether functional ability of patients with chronic lung diseases could be improved after pulmonaryrehabilitation (PR). Methods: Patients in Regional Respiratory Center were allocated to an eight-week PR program. The PR program consisted of aerobic training, resistance training, upper extremity mobilization and respiratory muscle training. Maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP), peak cough flow (PCF) for pulmonary function, six minute walk test for physical activity, Modified medical research council (MMRC) dyspnea scale, and COPD assessment test (CAT) were tested and followed after the PR program. Results: Sixteen of fifty-three patients actively completed PR programs and pre- and post-evaluations without follow up loss. Among these 16 patients, eight patients attended the hospital based PR, four attended the home based PR, and the others attended the hospital & home based PR. All of these patients improved in MIP by 7.25 cm H2O, MEP by 9.5 cm H2O, PCF by 23.18 L/min, six minute walking distance by 30.21 m without statistical significance. Conclusion: The results showed that the compliance of out-patient PR programs was approximately 30.3%. Although there was no statistical significance in the pre-post evaluations, the out-patient PR program could produce positive response in chronic lung diseases. Therefore, this study supports the necessity of the active pulmonary rehabilitation for the improvement of physical function and pulmonary function of various chronic lung diseases in Korea.
A Novel MPPT Control of photovoltaic system using FLC algorithm
Sung-Jun Kang,Jae-Sub Ko,Jung-Sik Choi,Mi-Geum Jang,Ju-Hui Mun,Jin-Gook Lee,Dong-Hwa Chung 제어로봇시스템학회 2011 제어로봇시스템학회 국제학술대회 논문집 Vol.2011 No.10
This paper proposes a novel maximum power point tracking (MPPT) using a fuzzy logic control (FLC) algorithm for robust in environment changing. The power available at the output of photovoltaic (PV) cell keeps changing with radiation and temperature because solar cell exhibits a nonlinear current-voltage characteristic. So its maximum power point (MPP) of PV cells varies with radiation and temperature. MPPT methods are used in PV systems to make full utilization of PV array output power which depends on radiation and temperature. Conventional MPPT controller such as constant voltage (CV), perturbation and observation (PO) and incremental conductance (IC) are researched. But these controllers have the problem that is failure to MPP with environment changing. The proposed FLC controller is based the fuzzy control algorithm and able to robust control with environment changing. Also the PV systems applied FLC controller is modeled by PSIM and the response characteristics of FLC method according to the environment variation is analyzed through comparison with performance of conventional methods. The validity of this controller is proved through response results.
Ko, Jun Kyeung,Cha, Seung Heon,Lee, Tae Hong,Choi, Chang Hwa,Lee, Sang Weon,Lee, Jae Il The Korean Neurosurgical Society 2013 Journal of Korean neurosurgical society Vol.54 No.2
Objective : Aneurysms arising from the proximal segment of the anterior cerebral artery (A1) are rare and challenging to treat. The aim of this study was to report our experience with endovascular treatment of A1 Aneurysms. Methods : From August 2007 through May 2012, eleven A1 aneurysms in eleven patients were treated endovascularly. Six aneurysms were unruptured and 5 were ruptured. One patient with an unruptured A1 aneurysm presented with subarachnoid hemorrhage due to rupture of an anterior communicating artery aneurysm. Procedural data, clinical and angiographic results were reviewed retrospectively. Results : All of the aneurysms were successfully treated with coil embolization. Six were treated with a simple technique while the remaining 5 required adjunctive technique : double catheters (n=2), balloon-assisted (n=2), and stent-assisted (n=1). The immediate angiographic control showed a complete occlusion in all cases. Procedure-related complication occurred in only one patient : parent artery occlusion, which was not clinically significant. All patients had excellent clinical outcomes but one patient was discharged with a slight disability. No neurologic deterioration or bleeding was seen during the follow-up period in this cohort of patients. Follow-up angiography (mean, 20 months) was available in ten patients and revealed stable occlusion in all cases. Conclusion : Endovascular treatment is a feasible and effective therapeutic modality for A1 aneurysms. Tailored microcatheter shaping and/or adjunctive techniques are necessary for successful aneurysm embolization because of the projection and location of A1 aneurysms.
The Korea Cohort Consortium: The Future of Pooling Cohort Studies
Sang-Jun Lee,Kwang-Pil Ko,Jung Eun Lee,Inah Kim,Sun Ha Jee,Aesun Shin,Sun-Seog Kweon,Min-Ho Shin,Sangmin Park,Seungho Ryu,Sun Young Yang,Seung Ho Choi,Jeongseon Kim,Sang-Wook Yi,Daehee Kang,Keun-Young 대한예방의학회 2022 예방의학회지 Vol.55 No.5
Objectives: We introduced the cohort studies included in the Korean Cohort Consortium (KCC), focusing on large-scale cohort studies established in Korea with a prolonged follow-up period. Moreover, we also provided projections of the follow-up and estimates of the sample size that would be necessary for big-data analyses based on pooling established cohort studies, including population-based genomic studies. Methods: We mainly focused on the characteristics of individual cohort studies from the KCC. We developed “PROFAN”, a Shiny application for projecting the follow-up period to achieve a certain number of cases when pooling established cohort studies. As examples, we projected the follow-up periods for 5000 cases of gastric cancer, 2500 cases of prostate and breast cancer, and 500 cases of non-Hodgkin lymphoma. The sample sizes for sequencing-based analyses based on a 1:1 case-control study were also calculated. Results: The KCC consisted of 8 individual cohort studies, of which 3 were community-based and 5 were health screening-based cohorts. The population-based cohort studies were mainly organized by Korean government agencies and research institutes. The projected follow-up period was at least 10 years to achieve 5000 cases based on a cohort of 0.5 million participants. The mean of the minimum to maximum sample sizes for performing sequencing analyses was 5917-72 102. Conclusions: We propose an approach to establish a large-scale consortium based on the standardization and harmonization of existing cohort studies to obtain adequate statistical power with a sufficient sample size to analyze high-risk groups or rare cancer subtypes.