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( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.
정호성,김상은,이준형,박철완,이 근 大韓應急醫學會 1996 대한응급의학회지 Vol.7 No.1
Mortality after cervical spine injury(CSI) is reported as high as 10∼30%, and it is intimately related to the initial management and cardiopulmonary function. We analyzed the cause of death for 29 patients who expired at Chung Ang Gil Hospital after CSI between 1990 and 1994. Of 198 patients with CSI, 43 patients(21m7%) died. Except 14 cases with concomitant fatal head injury and/or multiple systemic injuries, the mortality rate of CSI was 14.6%. Male to female ratio was over 6:1. Fourth to sixth decades constituted 69.0%. Common causes of CSI were traffic accidents(58.6%) and fall/slip(34.5%). The level of CSI was above C5(upper cervical group: UCG) in 65.5%, and below C4(lower cervical group: LCG) in 34.5%. Most of them(86.2%) died within four weeks after CSI. Early death(within 7 days) was more common in the UCG(57.9%) than the LCG(20.0%). Associated injuries were found in 72.4%, and the head injury was the most common one. The higher the Injury Severity Score(ISS), the earlier the patients expired(Fisher`s test, P<0.05). On arrival, hypotension(systolic blood pressure below 90mmHg), bradycardia(less than 60/min), and respiratory arrest was found in 31.0%, 34.5% and 17.2%, respectively. The episode of bradycardia was found in 58.6%. It was more common in cases of early death(69.2%) than those of the late death(50.0%). Hypoxia, hypercarbia, and acidosis was observed in 20.7%, 17.2%, and 51.7%, respectively. Respiratory failure was responsible for the majority(89.7%) of death. In UCG and the cases of the early death, primary respiratory dysfunction was the main cause of death, while in LCG and the cases of the late death, pulmonary complication was the major reason(Fisher`s test P<0.01, P<0.01, respectively).
崔山鎬,梁永晟,金圭石,金錫中,金弼中 江原大學校 産業技術硏究所 1991 産業技術硏究 Vol.11 No.-
A model for the strenghth of composite beams with reinfforced web openings is presented. All of theh models are based on the static theorem of ultimated strength of reinforced rectangular perforated composite beam and is compared to the test.
Catenary 곡면을 갖는 막구조물의 치환기법에 관한 연구
임채욱,송평훈,김승덕,송호산 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)
Membrane structure systems and cable net structure systems are attracting people's attention as they are used in many buildings because of their light materials and airy appearances. If a membrane structure system or a cable net structure system does not have sufficiently high initial stiffness, it may be in unstable state. But if the initial stiffness is secured, the system will be in stable state. In this study the nonlinear finite element formulae for membrane and cable members considering geometric nonlinearity is derived, and then a catenary's membrane structure, and a tension membrane structure by Nass(Nonlinear Analysis for Spatial Structures) program is analyzed. The suitable scheme, which membrane structure are assigned by cable elements for overcoming the unfitted shape problem, is shown that the section of cable is assigned by element's area.
Combining Protein-Shelled Platinum Nanoparticles with Graphene to Build a Bionanohybrid Capacitor
San, Boi Hoa,Kim, Jang Ah,Kulkarni, Atul,Moh, Sang Hyun,Dugasani, Sreekantha Reddy,Subramani, Vinod Kumar,Thorat, Nanasaheb D.,Lee, Hyun Ho,Park, Sung Ha,Kim, Taesung,Kim, Kyeong Kyu American Chemical Society 2014 ACS NANO Vol.8 No.12
<P>The electronic properties of biomolecules and their hybrids with inorganic materials can be utilized for the fabrication of nanoelectronic devices. Here, we report the charge transport behavior of protein-shelled inorganic nanoparticles combined with graphene and demonstrate their possible application as a bionanohybrid capacitor. The conductivity of PepA, a bacterial aminopeptidase used as a protein shell (PS), and the platinum nanoparticles (PtNPs) encapsulated by PepA was measured using a field effect transistor (FET) and a graphene-based FET (GFET). Furthermore, we confirmed that the electronic properties of PepA-PtNPs were controlled by varying the size of the PtNPs. The use of two poly(methyl methacrylate) (PMMA)-coated graphene layers separated by PepA-PtNPs enabled us to build a bionanohybrid capacitor with tunable properties. The combination of bioinorganic nanohybrids with graphene is regarded as the cornerstone for developing flexible and biocompatible bionanoelectronic devices that can be integrated into bioelectric circuits for biomedical purposes.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2014/ancac3.2014.8.issue-12/nn503178t/production/images/medium/nn-2014-03178t_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn503178t'>ACS Electronic Supporting Info</A></P>
The Effects of Music during Balance Training for Six Weeks on Elderly Persons' Balancing Ability
Kim, Nyeon Jun,Choi, Jung Hyun,An, Ho Jung,Kim, Ji Sung,Choi, Yoo Rim,Wang, Jung San,Lee, Sang Bin,Yoo, Kyung Tae,Hwang, Hyun Sook,Kim, Soon Hee International Academy of Physical Therapy Research 2015 Journal of International Academy of Physical Ther Vol.6 No.1
The purpose of the present study is to provide exercises, together with music, that are helpful for elderly people's balancing ability, and to determine their effects in order to provide data for the promotion of elderly persons' health. Thirty elderly persons were randomly assigned to a balance training group(BTG) of 15 subjects, or a music and balance training group (music therapy + balance training [MTBTG]) of 15 subjects; intervention was implemented three times per week for six weeks. To measure the changes in their balancing ability before and after the experiment, the limit of stability, the "Timed Up and Go"(TUG) test, and the Berg Balance Scale (BBS) were measured. Changes in the limit of stability before and after the experiment were shown to be significant in both the BTG and the MTBTG. Changes in the limit of stability of the right side before and after the experiment showed statistically significant differences between the BTG and the MTBTG. Changes in the TUG test and the BBS before and after the experiment were shown to be statistically significant in both the BTG and the MTBTG. The application of music during balance training thus is considered to have a positive effect on elderly persons' balancing ability.
Polymeric nanoparticles for protein kinase activity
Kim, Jong-Ho,Lee, Seulki,Kim, Kwangmeyung,Jeon, Hyesung,Park, Rang-Woon,Kim, In-San,Choi, Kuiwon,Kwon, Ick Chan Royal Society of Chemistry 2007 Chemical communications Vol.2007 No.13
<P>Nanoparticles were prepared from poly-ion complexes, possessing both PEI–FITC–(PKA-specific substrate) (kemptide) and PAA–TRITC, which produce intermolecular FRET; the nanoparticles were dissociated by phosphorylation, presented a strong FITC intensity and can be applied to high-throughput screening for large chemical libraries, for drug discovery of kinase inhibitors.</P> <P>Graphic Abstract</P><P>Nanoparticles were prepared from poly-ion complexes. The nanoparticles were dissociated by phosphorylation, presented a strong FITC intensity and can be applied to high-throughput screening for large chemical libraries, for drug discovery of kinase inhibitors. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b612773h'> </P>
The Effect of Group Exercise Program on Cognitive Function of Elderly people
Kim, Nyeon Jun,Kim, Moo Ki,Moon, Ok Kon,An, Ho Jung,Shin, Hee Joon,Choi, Yoo Rim,Wang, Jung San,Lee, Joon Hee,Park, Joo Hyun,Kim, Soon Hee International Academy of Physical Therapy Research 2014 Journal of International Academy of Physical Ther Vol.5 No.2
The goal of this study was to assess the effect of a group exercise program on cognitive function of elderly people. Subjects were chosen to be elders with dementia having minor to moderate degrees of cognitive function. Study was started out by randomly dividing the 16 subjects into two groups, each with 8 people; the group exercise group and the control group. The group exercise group performed 8 weeks of group exercise program and general physiotherapy while the control group only performed general physiotherapy. Cognitive function was measured by Korean version mini-mental state examination. The study group's attention and calculation statistically significantly improved but the control group saw no statistically significant change. The group exercise program affected improvement in cognitive function of elderly people with dementia and in particular, was effective for enhancing their attention and calculation.