Prostaglandin A₂-induced Apoptosis is Not Inhibited by Heme Oygenase-1 in U2OS Cells

Kyoung-Won Ko(고경원),Sun-Young Lee(이선영),Ji-Hyun Ahn(안지현),Jaetaek Kim(김재택),In-Kyung Kim(김인경),Ho-Shik Kim(김호식) 한국생명과학회 2008 생명과학회지 Vol.18 No.11

Prostaglandin A₂ (PGA₂)는 사람 골육종 세포인 U2OS 세포주에서 apoptosis와 heme oxygenase (HO)-1의 발현을 함께 유도하였다. PGA₂에 의한 apoptosis는 HO-1의 과도한 발현이나 HO-1에 대한 small interfering RNA에 의한 발현저하에 의하여 변동되지 않았으나 H₂O₂에 의한 세포사망은 HO-1의 발현 수준에 반비례하여 변동되었다. 또한 thiol antioxidant인 N-acetyl-L-cysteine (NAC)은 PGA₂에 의한 세포사망과 HO-1의 발현 증가를 모두 차단하였지만, non-thiol antioxidant인 butylated hydroxyanisole (BHA)과 ascorbic acid는 세포사망과 HO-1의 발현 유도를 차단하지 않았다. 이와 같은 결과들은 PGA₂는 산화성 손상에 의해서가 아니라 PGA₂의 thiol-reactivity에 의하여 apoptosis와 HO-1의 발현을 유도하며, HO-1의 발현은 PGA₂에 의한 apoptosis와는 독립적인 현상이거나 기능적으로 apoptosis 유도의 하부에 위치하고 apoptosis의 진행에는 기여하지 않을 것이라는 것을 시사해 준다. Prostaglandin A₂ (PGA₂), one of cyclopentenone PGs, induced both apoptosis and heme oxygenase (HO)-1 expression in U2OS cells. PGA₂-induced apoptosis was not perturbed by either over-expression or knock-down of HO-1, whereas H₂O₂-induced cell death was inversely modulated by the expression level of HO-1. In addition, N-acetyl-L-cysteine (NAC), a thiol antioxidant, blocked both apoptosis and HO-1 expression induced by PGA₂. But, non-thiol antioxidants like butylated hydorxyanisole (BHA) and ascorbic acid did not block either apoptosis or HO-1-induction. Taken together, these results suggest that PGA₂ induces both apoptosis and HO-1 expression, which are critically related to the thiol-reactivity of PGA₂, but not oxidative stress, and HO-1 expression may be independent or functionally located downstream of apoptosis by PGA₂ without contribution to apoptosis progression.

허준의 「 동의보감 」 연구

김호 ( Ho Kim ) 한국과학사학회 1994 한국과학사학회지 Vol.16 No.1

한국산 거미의 종 목록(2015년도 개정)

김주필(Joo Pil Kim),예성훈(Seong Hun Ye),이준기(Jun Gi Lee),이준호(Jun Ho Lee) 한국거미연구소 2015 한국거미 Vol.31 No.1

한국산 거미 목록을 최근 분류체계와 새롭게 추가된 분류군을 총망라하여 재정리하였다. 그 결과, 한국산 거미류의 수는 총 48과 281속 795종으로 조사되었으며, 이전 김과 김(2010)의 발표보다 2과 16속 69종이 많았다. 이전의 김과 김(2010)의 목록에서 이용된 분류체계와 비교해 크게 변동된 사항으로는 기존의 코리나거미과(Family Corinnidae)에 속하는 3개 속(Genus Cetonana 괴물거미속(개칭), Genus Paratrachelas 어리괭이거미속, Genus Trachelas 괭이거미속)과 2개 속(Genus Orthobula 십자삼지거미속, Genus Phrurolithus 도사거미속)이 각각 괭이거미과(Family Trachelidae)(신칭)와 도사거미과 (Family Phrurolithidae)(신칭)로 분리, 신설되었으며(Ramírez, 2014), 밭고랑거미과(Family Liocranidae)의 족제비거미속(Genus Itatsina)이 미투기거미과(Family Miturgidae)의 1속(Genus Prochora)에 하위 동종이명(synonymy)으로 편입됨(Bosselaers & Jocqué, 2013)에 따라 Prochora 속의 국명이 족제비거미속으로 개칭되었다. 또한 오소리거미과(Family Zoridae)가 미투기거미과(Family Miturgidae)에 하위 동종이명으로 편입되었으며(Ramírez, 2014), 기존에 미투기거미과에 속해 있던 1속(Genus Cheiracanthium 어리염낭거미속)이 미투기거미과로부터 분리, 신설된 장다리염낭거미과(Family Eutichuridae)(신칭)로 분류되었다(Ramírez, 2014). 그 밖에 속, 종의 단위에서 분류군 신설, 동종이명, 오동정 등의 분류 체계 변동 사항이 있었으며, 이를 본 목록에서 확인할 수 있다. 더불어 근래에 추가된 2종의 무자격명(Nomen nudum) 처리된 종과, 국립공원 생물종 목록집(2012)에 기재되었으나 논문으로 정식 발표되지 않은 미기록종 22종을 별도로 기술하였다. 한국산 거미류는 접시거미과(101종), 꼬마거미과(84종), 왕거미과(79종), 깡충거미과(73종), 그리고 늑대거미과(57종) 이하 순으로 종수가 많았으며, 위의 5과가 전체 종수의 약 50%(394종)을 차지하였다. 전체 795종 중 한국산 고유종은 173종(21.8%)이었고, 일본산 거미류와 512종(64.4%), 중국산과 497종(62.5%), 러시아산과 360종(45.3%), 대만산과 103종(13.1%) 동일종이었다. 또한, 구북구산(Palearctic region)이 80종(10%), 전북구산(Holarctic region)이 37종(4.7%), 그리고 세계공통종(Cosmopolitan species)이 13종(1.6%)으로 분석되었다. A revised new-version of the check list of Korean spiders, including recent systematic systems and new taxa, is presented in this paper. According to additional references in the last 5 years, a total of 795 species of 281 genera belonging to 48 families were checked in Korean spider fauna, and there are 69 species of 16 genera belonging to 2 families more than the previous check list(Kim & Kim, 2010). Typical examples of some changes in systematic systems of Korean spiders compared with the previous check list(Kim & Kim, 2010) are as follows : Two families, the family Trachelidae and the family Phrurolithidae, previously in the family Corinnidae are raised to family status(by Ramírez, 2014). In Korea, the family Trachelidae includes 3 genera(Gen. Cetonana, Gen. Paratrachelas, Gen. Trachelas) and the family Phrurolithidae includes 2 genera(Gen. Orthobula, Gen. Phrurolithus); The family Eutichuridae is raised to family status, which was previously in the family Miturgidae(by Ramírez, 2014). There is one genus(Gen. Cheiracanthium) in the family Eutichuridae in Korea; The family Zoridae is included as a junior synonym of the family Miturgidae(by Ramírez, 2014); The genus Itatsina is included as a junior synonym of the genus Prochora in the family Miturgidae(Bosselaers & Jocqué, 2013). One Pisaurid species(Dolomedes jirisanensis) and a Sparassid genus(Gen. Joopilia, Joopilia joopilis) are nomina nuda. Additionally, There are 22 unrecorded species, which was found by Korean National Park Research Institute(2012) but was not described as papers, check list of them is presented separately from the check list of Korean spiders in this paper. Linyphiidae(101 sp.), Theridiidae(84 sp.), Araneidae(79 sp.), Salticidae(73 sp.), and Lycosidae(57 sp.) spiders are the most in the Korean spider fauna, and species in that 5 families formed about 50%(394 sp.) of the whole Korean spiders. In zoogeographical distribution, Korean spider fauna was found containing 80 Pa, 37 Holarctic, 13 Co, and 173 Korean endemic species. And comparison with faunas of neighboring countries, 512 species of Korean spiders also live in Japan(64.4%), 497 species live in C(62.5%), 360 species live in Russia(45.3%) and 103 species live in Taiwan(13.1%).

서부 경남지역 토마토 농장에서 분리된 Staphylococcus aureus의 내독소 유전자의 특성과 항생제 감수성

김진수(Jin-Soo Kim),이진하(Jin-Ha Lee),김지훈(Ji-Hun Kim),최주미(Ju-Mi Choi),김세리(Se-Ri Kim),하상도(Sang-Do Ha),김근성(Keun-Sung Kim),이규호(Kyu-Ho Lee),김민곤(Min-Gon Kim),김광엽(Kwang-Yup Kim),김철호(Cheol-Ho Kim),정덕화(Duck-Hwa Ch 한국식품과학회 2006 한국식품과학회지 Vol.38 No.2

코르크를 활용한 실내공기질 개선용 흡착 경화체의 특성

김연호 ( Kim Yeon-ho ),이상수 ( Lee Sang-soo ) 한국건축시공학회 2019 한국건축시공학회 학술발표대회 논문집 Vol.19 No.2

Recently, the risk of fine dust is emerging in Korea. According to the OECD report, the incidence of hospitalization and mortality from lung disease is increased, and the incidence of lung cancer and mortality from ischemic heart disease with prolonged exposure are increased. In addition, indoor air quality has become an important factor affecting the human body as indoor life has increased due to the Industrial Revolution. Air pollutants that cause indoor air deterioration typically include particulate dusts as described above, formaldehyde and VOCs released in gaseous form from adhesive wood products used in building materials and furniture. May cause breathing problems. In this study, we analyzed the properties of adsorption matrix for improving indoor air quality using cork.

안구상골종

김홍복(Hong Bok Kim),유호민(Ho Min Yoo),이성철(Sung Chul Lee),김윤원(Yoon Won Kim) 대한안과학회 1981 대한안과학회지 Vol.22 No.4

주행차량의 공기역학적 주행안전성 평가를 위한 알고리즘 개발연구

김창선(Chang-Sun Kim),이승현(Seung-Hyun Lee),김철호(Chul-Ho Kim) 한국자동차공학회 2014 한국자동차공학회 부문종합 학술대회 Vol.2014 No.5

The objectives of vehicle aerodynamic design is on the fuel economy, reduction of the harmful emissions and minimizing vibration and noise and the driving stability of the vehicle. Especially in case of a sedan, aerodynamic driving stability of a vehicle is the main focus, and for this, the proper evaluation of aerodynamic driving stability of a vehicle is required. In this study, we yield the size of moving moment on the body of the vehicle generated by side wind when sedan type vehicle drives on the road and complete a numerical algorithm to evaluate aerodynamic driving stability of a vehicle judging whether such moving moment has a serious impact on vehicle driving stability. The model vehicle for the study is sedan type vehicle shape recommended by SAE. In the study, we yield the pressure drag and the position of C.P. on the body of the vehicle generated when the vehicle drives with side wind using CFD technique. Based on this, we also calculated pitching, rolling and yawing moment of the body of the vehicle generated on the center of gravity, and the result from comparing turning moment values and the size of rotational resistance moment of the body of the vehicle can be used as the basis to judge driving stability such as off-course and rollover of the vehicle. After driving stability of a vehicle when the vehicle drives 100km/h with 15m/s side wind is evaluated using the numerical algorithm drawn from the study, the value of yawing moment is 606N.m, rolling moment -773N.m and pitching moment 84N.m. These values are smaller than each value of rotational resistance moment the model vehicle has, and therefore, the model vehicle’s driving stability is guaranteed when driving 100km/h with 15m/s side wind.

한국 대학의 취업지원역량 평가지표 개발에 관한 연구

김호원(Kim, Ho-Won),이종구(Lee, Jong-Gu),이재춘(Lee, Jae-Choon) 대한경영학회 2011 大韓經營學會誌 Vol.24 No.1

수자궁질증의 산전 태아 초음파 소견 1 예

김사진(Sa Jin Kim),김수평(Soo Pyung Kim),김민정(Min Joung Kim),이상호(Sang Ho Lee),이희중(Hee Joong Lee),문희봉(Hee Bong Moon),이지현(Jee Hyun Lee),박철훈(Chul Hun Park),이귀세라(Gui Se Ra Lee),신종철(Joung Chul Shin) 대한산부인과학회 2002 Obstetrics & Gynecology Science Vol.45 No.3

Cloacal anomalies are very rare congenital malformations with the incidence of 1/50,000-250,000 births. Hydrocolpos involves the dilatation of the vagina due to obstruction of the genital tract, leading to accumulation of secretions. Because of wide spectrum of abnormal anatomy involving urogenital and gastrointestinal systems, prenatal diagnosis is difficult. As ultrasound becomes more and more reliable, prenatal diagnosis is possible as early as in the second trimester. The presence of prenatally detected hydro (metro) colpos warrants a systematic evaluation of fetal and neonatal anatomy to rule out a large variety of possibly associated malformations or syndromes. We present a case of urogenital sinus maldevelopment which was initially presented as a fetal ascites.

디자인의 전유 행위에 대한 고찰

김양호(Kim yang-ho) 한국콘텐츠학회 2009 한국콘텐츠학회 종합학술대회 논문집 Vol.7 No.1

모더니즘 시대의 디자인은 효율성과 기능성을 중심으로 사물과 기기의 표준화를 목표로 제작되었으며 생산보다 소비가 많았던 산업 시대에서 디자인 수용자의 의지는 소비의 대상으로서의 역할에 한정되어졌다. 그러나 포스트모더니즘 시대 이후 디지털 환경에서 디자인 수용자는 단지 주어진 것만을 수동적으로 수용하지 않고 적극적인 개입을 하고 능동적인 관리를 할 수 있도록 변화됨으로 디자인 수용과정에 우상화, 관여, 조율, 조작, 흉내 등의 전유행위를 수반하게 된다. 앞으로의 디자인은 전문가들만이 생성하고 관리하는 체계에서 벗어나 수용자들과 함께 협업하는 상황으로 변화되고, 수용자의 다양한 전유 형태는 디자인 생산물을 둘러싼 제작 방법, 배포 행위 등의 디자인 제반 환경을 변동시킬 것이다. 이에 디자인 수용자들의 전유 행위를 통일화, 해체화, 재의미화 등으로 구분하여 고찰함으로써 제작자와 수용자간의 원활한 인식을 통해 획일화, 구조화에 저항하는 수용자들의 문화 환경 변화를 읽어 효과적인 디자인 제작 행위를 유도하고자 한다. Designs in the modernism era were produced for the purpose of standardization of items and devices centered on efficiency and functions, and the will of design consumers in the industrial era, when consumption exceeded production, was limited to the objects of consumption. But, after the post-modernism era, design consumers have started to entail acts of exclusive possession such as participation in the design idolization, partipation, tuning, control and parody as design consumers in the digital environment do not passively accept what is given to them anymore, and aggressively intervene in the process of design production and management. It is expected that designs will change from the system in which only professionals can produce and manage its production to that of cooperating with consumers to produce designs, and various forms of consumers' exclusive possession will change all sort of design environments including production methods surrounding design products and distribution. Therefore, this study seeks to induce efficient design production by understanding changes of consumers' cultural environment resisting standardization and structuralization with smoothy perception between producers and consumers through classification of consumers' appropriation into de-construction, re-signification and self-Identification.