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        • KCI등재

          운동강도의 차이가 고령 골감소증 여성의 골대사지표 및 RANKL/RANK/OPG 시스템 사이토카인에 미치는 영향

          김창선 ( Chang-sun Kim ),효진 ( Hyo-jin Kim ),지연 ( Ji-yeon Kim ),지원 ( Ji-won Kim ),박동호 ( Dong-ho Park ),임승택 ( Seung-taek Lim ),민석기 ( Seok-ki Min ) 한국운동생리학회(구 한국운동과학회) 2017 운동과학 Vol.26 No.1

          PURPOSE: Regular exercise augments the bone mineral density in postmenopausal elderly women. However, its acute effects by different intensities on bone metabolic markers and cytokines of the RANKL/RANK/OPG system have not been determined. Our aim was to investigate the effects exercise intensity difference on these markers and RANKL/RANK/OPG system in Korean osteopenia elderly women. METHODS: Twelve osteopenia elderly women (T-score -2.46±0.48; aged 68.17±3.04 years) examined these markers and RANKL/RANK/OPG system responses to acute high (80% VO<sub>2</sub>max ; HIGH group), low (40% VO<sub>2</sub>max; LOW group) intensity with a cycle ergometer, and sedentary rest (CON group) in a randomized, cross-over repeated measures design. The concentrations of bone metabolic markers and cytokines measured before, immediately after and then recovery 60 minutes after exercise. mRNA expressions of RANKL & OPG from PBMC were also measured at same times. RESULTS: There were no significant changes in the serum CTx and RANKL, and mRNA expression of RNAKL, indicating bone resorption (NS). On the other hand, although the serum OPG showed significant change in high intensity (p=.027; group×time), the serum OC showed significant change in low intensity (p=.044; group×time), indicating bone formation, respectively. CONCLUSIONS: These results suggest that a single bout exercise might effect on bone formation alone with OPG responds to high intensity, OC responds to low intensity. Additional studies are needed on the difference in change between OC and OPG due to exercise intensity.

        • KCI등재

          일회성 운동이 골감소증 고령여성의 골대사성 사이토카인 생성에 미치는 영향

          김창선 ( Chang-sun Kim ),효진 ( Hyo-jin Kim ),지연 ( Ji-yeon Kim ),지원 ( Ji-won Kim ),임순길 ( Soon-gill Lim ),박동호 ( Dong-ho Park ) 한국운동생리학회(구 한국운동과학회) 2016 운동과학 Vol.25 No.4

          PURPOSE: Although overproduction of cytokines from peripheral blood mononuclear cell (PBMC) was associated with the reduction of bone mass, bone metabolic cytokines production according to exercise is still not clear. We aimed to test whether changes in production of bone metabolic cytokines after a bout exercise in osteopenia elderly women. METHOD: Nine osteopenia elderly women (T-score -2.61±0.46; aged 67.67±3.24 years) underwent a bout exercise of 60 %VO<sub>2</sub>max (EX group) with a cycle ergometer. To clarify the changes during exercise, we designed repeated measure ANOVA as the sedentary control (CON group) to perform blood sampling without exercise. The concentrations and the mRNA expressions of cytokines were measured before, immediately after and then recovery 60 minutes after exercise. Serum Ca, Pi, Mg, and ALP were also measured at same times. RESULTS: There were no significant changes in the concentrations of serum TNF-alpha, IL-6, IL-1beta, and INF-gamma (NS). Although the mRNA expression of most cytokines also show no significant changes (NS), only TNF-alpha mRNA expression showed significant difference between groups (p=.008). On the other hand, serum Ca showed significant difference between times (p=.002), that of EX group was significantly increased at immediately after exercise compared to baseline (p<.05), and it was decreased at recovery period (p<.01). CONCLUSIONS: These results suggest that a bout exercise of moderate intensity might not be effect on production of bone metabolic cytokines both level of serum and mRNA from PBMC, and induced temporal hypercalcemia.

        • KCI등재

          고령 여성의 근육량과 골밀도, 기초체력과의 관련성

          김창선(Chang-Sun Kim) 한국생활환경학회 2015 한국생활환경학회지 Vol.22 No.1

          Several studies have shown that decreased muscle weight is a risk factor of elderly disease. The aim of the present study is to evaluate the relation between muscle weight and bone mineral density and physical fitness in elderly women. Seventy three elderly women(aged 67.5 ± 3.6 yrs) were evaluated and divided according to their muscle weight level in quartiles. Subjects were divided as follows: Quartile 1 (Q1; <32.9 kg; n=18), Quartile 2 (Q2; ≥33.0 and <35.6 kg; n=18), Quartile 3 (Q3; ≥35.7 and <37.0 kg; n=18), Quartile 4 (Q4; ≥37.2 kg; n=19). Body composition, bone mineral density(BMD) and basal physical fitness were compared between four groups according to muscle weight levels. Body muscle weight was measured by using body composition analyzer(Inbody720, Biospace, Korea) and BMD of the total body was also measured by using dual energy X-ray absorptiometry(DEXA). Pearson"s correlation coefficient and level of significance were used to evaluate the correlations between measurements. There were significant differences for height and weight according to quartiles of muscle weight level, respectively(p<.001), and BMI and %BF also significantly increased in the order of Q1, Q2, Q3, and Q4 group(p<.001). BMD of Q2, Q3, and Q4 group were significantly higher than that of Q1 group(p<.001), BMC of Q3, and Q4 group were significantly higher than that of Q2 group(p<.001) and that of Q2 group were also higher than that of Q1 group(p<.001), Most of basal physical fitness showed no significant differences among quartiles of muscle weight level(NS). Age was negatively correlated with total BMD, T??score and total BMC, respectively(p<.05), and height, weight, BMI and muscle weight showed a positive correlations with most of BMD and BMC, respectively(p<.05, p<.01). A negative correlation was found between weight and 2min walking and chair sit & reach, respectively(p<.05), and BMI showed negative correlations with back scratch and one leg stand, respectively(p<.05). %BF was negatively correlated with chair sit & reach and one leg stand, respectively(p<.05, p<.01). These results suggest that decrease of muscle weight result in reducing of BMD, and osteoporosis is occur by this reducing of BMD in elderly women. Moreover, the keep of muscle weight through the maintain body composition such as weight and BMI is beneficial to maintain BMD of elderly women.

        • KCI등재

          흰쥐의 후지체공에 따른 앞다리와 뒷다리의 골밀도 차이

          김창선(Chang-sun Kim) 한국생활환경학회 2011 한국생활환경학회지 Vol.18 No.3

          Mechanical forces play a pivotal role in maintaining bone mass. Tail-suspension has long been employed to induce a pattern of osteopenia in rats and it has been used as a ground-based model for the spaceflight. This study was designed to clarify the change of BMD between the fore- and hind-limb induced by non-weight-bearing, eighteen 7-week-o1d female spraque-dawley rats completed tail-suspension for 2-week. After a week of stabilization, rats were randomly divided into three groups: before tail-suspension group (n=6, before), non-suspension control group (n=6, Con) and tail-suspension group (n=6, Sus). The rats were fed standard lab chow (CRF-l, Charles River, Japan) and water ad libitum while Con group were pair fed with the appropriate suspension rats for control of caloric intake. At before and after 2-week suspension, rats were sacrificed and femur and humerus were removed for analysis of bone mineral density (BMD) by dual energy X-ray absorptionmetry (DEXA, Lunar DPXL, DSA). Serum and twenty four hours urinary calcium (Ca) and phosphate (P) were determined by biochemical markers of bone metabolism. BMD of femur in the Con group were increased in approximately 16.5% as compared with that of the before group (p<.001), but that of the Sus group did not increased, and showed approximately 11.2% lower than that of the Con group(p<.01). However, BMD of humerus in the both group showed no difference between the Con and the Sus group(NS). Similarly, BMC of femur in the Con group were increased in approximately 45.5% as compared with that of the before group (p<.001), but that of the Sus group was small, and showed approximately 14.5% lower than that of the Con group (p<.01). However, BMC of humerus in the both group showed no difference between the Con and the Sus group (NS). The femur weight of the Sus group was decreased approximately in 8% as compared to the Con group (p<.05), but the humerus weight showed no difference between the Con and the Sus group. On the other hand, the serum Ca concentration and twenty four hours urinary Ca excretion between the Con and the Sus group showed similar levels. Twenty four hours urinary P excretion of the Sus group, however, dynamically decreased approximately 50% lower than that of the Con group (P<.05) while serum P concentration was increased (p<.001). These results suggest that the bone loss was occurred mainly a part of non-weight bearing, and that disturbed P homeostasis in this process.

        • SCOPUSKCI등재
        • KCI등재

          12주간 타워클라이밍 운동이 흰쥐의 상하지 골밀도에 미치는 영향

          김창선(Chang-Sun Kim),윤진환(Jin-Hwan Yoon) 한국생활환경학회 2012 한국생활환경학회지 Vol.19 No.2

          In general it is thought that mechanical loading through exercise increases and maintains bone mass. However, site differences in change of bone mineral density (BMD) by resistance exercise are unclear. The aim of this study was to evaluate the changes of BMD between the upper and lower limb induced by tower climbing exercise. This study was investigated effects of 12 weeks resistance exercise by tower climbing an incline on the change of upper and lower limb BMD in growing rats. Twelve male Fisher 344(F344) rats (aged 8 weeks) were divided into two group: control rats (CON, n=6) and tower climbing exercise rats (EXE, n=6). EXE group performed training that climbed the ladder at 8 times a day, 5day a week for 12 weeks. After experimental period, rats were sacrificed and femur and humerus were removed, and bone mineral density (BMD) and content (BMC) were measured by dual energy X-ray absorptionmetry (DEXA, Lunar DPXL, USA). Serum calcium (Ca), phosphate (P) and osteocalcin (OC) were determined by biochemical markers of bone metabolism. The statistical difference on the results was analyzed by independent t-test, As the results, although humerus, upper limb, BMD and BMC of EXE group showed no significant difference, femoral, lower limb, BMC (p<.05) and BMD (p<.001) of EXE group were significantly increased comparing CON group, respectively. The serum Ca, P and OC showed no significantly difference among groups. On the other hand, although femur BMD showed a significant positive correlation with OC (p<.05), there were not relationship between femur and humerus BMD (NS). These data suggested that increase of BMD by resistance exercise with climbing the ladder was appeared in only weight-bearing lower limb, namely this change of BMD might occur by site-specific.

        • SCOPUSKCI등재
        • SCOPUSKCI등재
        • SCOPUSKCI등재
        • KCI등재

          인체 감지 제어 기능을 갖는 UV LED Bar의 최적 설계

          김창선(Chang Sun Kim,)이재학(Jae Hak Lee,)고영진(Young Jin Goh) 한국전자통신학회 2017 한국전자통신학회 논문지 Vol.12 No.6

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          본 논문에서는 다용도로 사용 가능한 UV LED 바의 최적설계를 하였다. UV LED는 자외선을 방출하기 때문에 사용목적상 일정하게 자외선을 방출하는 것이 중요하다. 일정한 자외선이 방출되기 위해서는 동작 가능 입력 전압 범위 내에서 정전류원으로 구동되어야 하고 자외선 활용 특성 상 자외선 방출 유지 시간이 길기 때문에 방열이 특히 중요하다. 따라서 소비전력이 최소화 되도록 설계해야 한다. 또한 인체 보호가 필수적이기 때문에 거리 감지 센서와 블루투스를 이용해 인체 감지 여부에 따라 동작할 수 있게 알고리즘을 구성하였다. 자외선 UVA를 방출하기 위해 365nm UV LED 3개가 직렬로 사용되었으며 입력 전압 12V와 정전류 500mA에서 동작하며 효율은 87.5%, 소비전력은 6.006W이다. 그리고 자외선 조사량은 루트론 계측기로 측정하였을 경우 10cm 거리에서 5.35mW/cm2으로 측정 되었다. In this paper, it is performed the optimal design of the UV LED bar which can be used variously. The UV LED Bar emits ultraviolet rays, so it is important to emit ultraviolet rays constantly for the purpose of use. In order to emit a certain amount of ultraviolet rays as ever, the ultraviolet ray emission should be driven by a constant current source within the operable input voltage range. And also the heat dissipation is particularly important because of the long ultraviolet emission retention time due to the UV utilization characteristics. In addition, since human body protection is essential, the algorithm is configured to operate according to human body detection using distance sensor and Bluetooth. Three 365nm UV LEDs were used in series to emit ultraviolet UVA, operating at the constant current of 500mA with an efficiency of 87.5% and a power consumption of 6.006W. The ultraviolet radiation dose was measured at 5.35 mW / cm2 at the distance of 10 cm when measured by the Lutron ultraviolet measuring instruments.

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