http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Kim, H. G.,Gater, D. L.,Kim, Y. C. Springer Science + Business Media 2018 Drug delivery and translational research Vol.8 No.1
<P>Although vitamin D3 (VD3), which is the main form of vitamin D, can be produced in human skin under the sunlight, vitamin D deficiency emerged as a major public health problem worldwide. Mainly, oral supplements or vitamin D-fortified foods are distributed to help supplementation of vitamin D. However, those oral methods are limitedly supplied in the Middle East countries, and oral absorption has low efficiency due to many barriers and various changes of conditions along the route. Then, it is recommended to take them every day in order to maintain the adequate serum level of vitamin D. Alternatively, transdermal delivery system could provide a convenient way to get sustained supplement of vitamin D by its advantages like avoiding first-pass effect of the liver and providing release for long periods of time. In this study, we introduced transdermal delivery system for sustained vitamin D release using coating microneedles that easily pierce the skin layer with enough mechanical strength and allow the localization of drugs within the dermal region. According to the experimental results, poly (lactic-co-glycolic acid) (PLGA) successfully encapsulated VD3 as a nanoparticle form with appropriate properties for transdermal delivery such as size distribution, skin compatibility, and effective release of encapsulated compound. Finally, PVD3 layers coated on solid microneedles were completely dissolved into intradermal region in porcine skin model and revealed better performance for VD3 release into plasma compared to ointment base transdermal method.</P>
Liu, Tie,Kim, Kee-Tae,Yoo, Hyunju,Liu, Sheng-yuan,Tatematsu, Ken’ichi,Qin, Sheng-Li,Zhang, Qizhou,Wu, Yuefang,Wang, Ke,Goldsmith, Paul F.,Juvela, Mika,Lee, Jeong-Eun,Tó,th, L. Viktor,Mardones, D American Astronomical Society 2016 The Astrophysical journal Vol.829 No.2
<P>We observed 146 Galactic clumps in HCN (4-3) and CS (7-6) with the Atacama Submillimeter Telescope Experiment 10 m telescope. A tight linear relationship between star formation rate and gas mass traced by dust continuum emission was found for both Galactic clumps and the high redshift (z > 1) star forming galaxies (SFGs), indicating a constant gas depletion time of similar to 100 Myr for molecular gas in both Galactic clumps and high z SFGs. However, low z galaxies do not follow this relation and seem to have a longer global gas depletion time. The correlations between total infrared luminosities (L-TIR) and molecular line luminosities (L-mol') of HCN (4-3) and CS (7-6) are tight and sublinear extending down to clumps with L-TIR similar to 10(3) L-circle dot. These correlations become linear when extended to external galaxies. A bimodal behavior in the L-TIR-L-mol' correlations was found for clumps with different dust temperature, luminosity-to-mass ratio, and sigma(line)/sigma(vir). Such bimodal behavior may be due to evolutionary effects. The slopes of L-TIR-L-mol' correlations become more shallow as clumps evolve. We compared our results with lower J transition lines in Wu et al. (2010). The correlations between clump masses and line luminosities are close to linear for low effective excitation density tracers but become sublinear for high effective excitation density tracers for clumps with L-TIR larger than L-TIR similar to 10(4.5) L-circle dot. High effective excitation density tracers cannot linearly trace the total clump masses, leading to a sublinear correlations for both M-clump-L-mol' and L-TIR-L-mol' relations.</P>
Sen, Sinol,Ingale, S.L.,Kim, J.S.,Kim, K.H.,Kim, Y.W.,Khong, Chou,Lohakare, J.D.,Kim, E.K.,Kim, H.S.,Kwon, I.K.,Chae, B.J. Asian Australasian Association of Animal Productio 2011 Animal Bioscience Vol.24 No.8
A feeding trial was conducted to investigate the effect of dietary supplementation of Bacillus subtilis LS 1-2 grown on citrus-juice waste and corn-soybean substrate on growth performance, nutrient retention, caecal microbial population and intestinal morphology in broilers. Three hundred twenty d-old Ross chicks were randomly allotted to 4 treatments on the basis of BW in a randomized complete block design. Each treatment had 4 replicates of 20 chicks in each. Experimental diets were fed in 2 phases, starter (d 0 to 21) and finisher (d 21 to 35). Dietary treatments were; negative control (NC: basal diet without any antimicrobial), positive control (PC: basal diet added with 20 mg/kg Avilamycin), basal diet added with 0.30% Bacillus subtilis LS 1-2 grown on corn-soybean substrate (P1), and basal diet added with 0.30% Bacillus subtilis LS 1-2 grown on citrus-juice waste substrate (P2). Overall BW gain, feed intake and FCR were better (p<0.05) in PC, P1 and P2 treatments as compared to NC. Moreover, overall BW gain and FCR in PC and P2 treatments were greater than P1. Retention of CP, GE (d 21, d 35) and DM (d 35) were increased (p<0.05) in treatments PC, P1 and P2 compared with NC. At d 35, caecal Clostridium and Coliform counts were lower (p<0.05) in treatments PC, P1 and P2 than NC. Moreover, Clostridium and Coliform counts in treatment PC was lower (p<0.05) than P1. Villus height and villus height to crypt depth ratio in both duodenum and ileum were increased (p<0.05) in treatments PC, P1, P2 as compared to NC. However, retention of nutrients, caecal microbial population and intestinal morphology remained comparable among treatments P1 and P2. It is concluded that Bacillus subtilis LS 1-2 inclusion at 0.30% level had beneficial effects on broilers' growth performance, nutrient retention, caecal microflora and intestinal morphology. Additionally, citrus-juice waste can be used as substrate for growth of probiotic Bacillus subtilis LS 1-2.
OGLE-2015-BLG-1482L: The First Isolated Low-mass Microlens in the Galactic Bulge
Chung, S.-J.,Zhu, W.,Udalski, A.,Lee, C.-U.,Ryu, Y.-H.,Jung, Y. K.,Shin, I.-G.,Yee, J. C.,Hwang, K.-H.,Gould, A.,Albrow, M.,Cha, S.-M.,Han, C.,Kim, D.-J.,Kim, H.-W.,Kim, S.-L.,Kim, Y.-H.,Lee, Y.,Park, American Astronomical Society 2017 The Astrophysical Journal Vol.838 No.2
<P>We analyze the single microlensing event OGLE-2015-BLG-1482 simultaneously observed from two ground-based surveys and from Spitzer. The Spitzer data exhibit finite-source effects that are. due to the passage of the lens close to or directly over. the surface of the source star as seen from Spitzer. Such finite-source effects generally yield measurements of the angular Einstein radius, which when combined with the microlens parallax derived from a comparison between the ground-based and the Spitzer light curves. yields the lens mass and lens-source relative parallax. From this analysis, we find that the lens of OGLE-2015-BLG-1482 is a very low-mass star with a. mass 0.10 +/- 0.02 M-circle dot or a brown dwarf with a. mass 55 +/- 9MJ, which are. located at D-LS = 0.80 +/- 0.19 kpc and D-LS = 0.54 +/- 0.08 kpc, respectively,. where DLS is the distance between the lens and the source, and thus it is the first isolated low-mass microlens that has been decisively located in the Galactic bulge. The degeneracy between the two solutions is severe ( Delta chi(2) = 0.3). The fundamental reason for the degeneracy is that the finite-source effect is seen only in a single data point from Spitzer, and this single data point gives rise to two solutions for rho, the angular size of the source in units of the angular Einstein ring radius. Because the rho degeneracy can be resolved only by relatively high-cadence observations around the peak, while the Spitzer cadence is typically similar to 1 day(-1), we expect that events for which the finite-source effect is seen only in the Spitzer data may frequently exhibit this rho degeneracy. For OGLE-2015-BLG-1482, the relative proper motion of the lens and source for the low-mass star is mu(rel) = 9.0 +/- 1.9 mas yr(-1), while for the brown dwarf it is 5.5 +/- 0.5 mas yr(-1). Hence, the degeneracy can be resolved within similar to 10 years from direct-lens imaging by using next-generation instruments with high spatial resolution.</P>
韓仁圭,李奉德,金春洙,Campbell, L.D. 서울대학교 1974 서울대학교 論文集 Vol.24 No.-
A series of experiment was conducted to study effects of the partial substitution of Canadian barley (0, 10, 20, 30, 40%) for corn in the rations of growing chicks. The growth rate, feed intake, feed efficiency, mortality, nutrients utilizability and economic return among 5 treatments were compared with 500 birds of growing chicks of laying Shaver strain(Starcross) for a period of 21 weeks. The results obtained are summarized as follows: 1. Although the protein content of Canadian barley (12%) was higher than that of local barley, the amino acids composition of Canadian barley was similar to that of local barley. Throughout the total experimental period the growth rate was not affected by the level of barley used in the starter, grower and pullet developer diets. 2. It was found that there was no statistical difference in feed intake, feed efficiency and mortality among 5 treatments. 3. Present data revealed that the feed cost required per kilogram of body weight gain was not affected by the level of barley incorporated into the diets of growing chicks. 4. Metabolizability of dry matter, protein, fiber and nitrogen free extract was not affected by the level of barley, although the fat utilizability was significantly (p<0.01) improved as the level of barley was increased. It is concluded that the partial substitution of barley for corn up to 40% level would have no adverse effects on the growing performance of the chicks.
Flavobacterium panacis sp. nov., isolated from rhizosphere of Panax ginseng
Kim, D. H.,Singh, P.,Farh, M. E.,Kim, Y. J.,Nguyen, N. L.,Lee, H. A.,Yang, D. C. Springer Science + Business Media 2016 Antonie van Leeuwenhoek Vol.109 No.9
<P>A novel bacterial strain, designated DCY106(T), was isolated from soil collected from the rhizosphere of ginseng (Panax ginseng), in Gochang, Republic of Korea. Strain DCY106(T) is Gram-negative, yellow-pigmented, non-flagellate, motile, non-spore-forming, rod-shaped, and strictly aerobic. The strain grows optimally at 25-30 degrees C and pH 6.5-7.5. Phylogenetically, strain DCY106(T) is closely related to Flavobacterium arsenitoxidans KCTC 22507(T) (98.41 %), followed by Flavobacterium cutihirudini LMG 26922(T) (97.67 %), Flavobacterium nitrogenifigens LMG 28694(T) (97.59 %), Flexibacter auranticus LMG 3987(T) (97.38 %), Flavobacterium defluvi KCTC 12612(T) (97.21 %) and Flavobacterium chilense LMG 26360(T) (97.05 %). The 16S rRNA gene sequence similarities to all other Flavobacterium species were below97 %. The DNAG+C content of strain DCY106(T) is 34.2 mol% and the DNA-DNA relatedness between strain DCY106(T) and F. cutihirudini LMG 26922(T), F. auranticus LMG 3987(T), F. defluvi KCTC 12612(T) and F. chilense LMG 26360(T) were below 40.0 %. The menaquinone of the type MK-6 was found to be the predominant respiratory quinone. The major polar lipids were identified as phosphatidylethanolamine, phosphatidylserine, two unidentified aminolipids (APL1, APL6) and one unidentified lipid L2.C-15:0, iso-C-15:0 and summed feature 3 (iso-C-15:0 2OH/C-16:1 omega 7c) were identified as the major fatty acids present in DCY106(T). The results of physiological and biochemical tests allowed strain DCY106(T) to be differentiated phenotypically from other recognized species belonging to the genus Flavobacterium. Therefore, it is suggested that the newly isolated organism represents a novel species, for which the name Flavobacterium panacis sp. nov. is proposed with the type strain designated as DCY106(T) (= JCM 31468(T) = KCTC 42747(T)).</P>