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Induced Pluripotent Stem Cells as a Novel Tool in Psychiatric Research
Sewoong Kim,MinKyoung Kim,Daeyoung Oh,SangHyuk Lee,Borah Kim 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.1
Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) provides a valuable opportunity to study neurodevelopmental and neurodegenerative psychiatric diseases by offering an unlimited source for patient-specific neuronal and glial cells. The present review focuses on the recent advancements in modeling psychiatric disorders such as Phelan-McDermid syndrome, Timothy syndrome, Rett syndrome, schizophrenia, bipolar disorder, and dementia. The treatment effects identified in studies on iPSCs using known therapeutic compounds are also summarized in this review. Here we discuss validation of cellular models and explore iPSCs as a novel drug screening tool. Although there are several limitations associated with the current methods used to study mental disorders, using iPSCs as a model system provides the advantage of rewinding and reviewing the development and degeneration of human neural cells.
Min Kuk Kim,이강수,Borah Kim,Tai Kiu Choi,이상혁 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.2
ObjectiveaaIntolerance of uncertainty (IU) is a transdiagnostic construct in various anxiety and depressive disorders. However, the relationship between IU and panic symptom severity is not yet fully understood. We examined the relationship between IU, panic, and depressive symptoms during mindfulness-based cognitive therapy (MBCT) in patients with panic disorder. MethodsaaWe screened 83 patients with panic disorder and subsequently enrolled 69 of them in the present study. Patients participating in MBCT for panic disorder were evaluated at baseline and at 8 weeks using the Intolerance of Uncertainty Scale (IUS), Panic Disorder Severity Scale-Self Report (PDSS-SR), and Beck Depression Inventory (BDI). ResultsaaThere was a significant decrease in scores on the IUS (p<0.001), PDSS (p<0.001), and BDI (p<0.001) following MBCT for panic disorder. Pre-treatment IUS scores significantly correlated with pre-treatment PDSS (p=0.003) and BDI (p=0.003) scores. We also found a significant association between the reduction in IU and PDSS after controlling for the reduction in the BDI score (p<0.001). ConclusionaaIU may play a critical role in the diagnosis and treatment of panic disorder. MBCT is effective in lowering IU in patients with panic disorder.
A Case of Linear Milia en Plaque on the Central Face
( Jung Wook Kim ),( Sang Hyun Kim ),( Doo Jin Oh ),( De Borah Lee ),( Seon Wook Hwang ),( Sung Wook Park ) 대한피부과학회 2007 Annals of Dermatology Vol.19 No.2
Milia en plaque (MEP) is a rarely-described benign, cutaneous dermatosis, characterized by numerous tiny milia within an erythematous base which usually occurs around the ears. We report a case of a well-defined, linear MEP arising from the right side of the forehead to the nasal bridge. This case is of particular interest as the site of occurrence is uncommon and the shape of lesion is atypical. (Ann Dermatol (Seoul) 19(2) 81~83, 2007)
UNBOXING THE BLACK BOX OF GOVERNANCE STRUCTURE IN CROSS-SECTOR PATNERSHIP
Jihye Kim,Jiwon Song,Dhruba, Borah 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07
In this conceptual paper, we use the multiple agency theory to explain the governance issues in cross-sector partnerships. In doing so, we identify five typologies of cross-sector partnerships, each distinct from one another in terms of the governance structure. We also discuss three problems that occur in these relationships, mainly differences in institutional logic, temporal differences, and free-riding and opportunistic behavior, as well as how these problems affect each type of cross-sector partnership. These findings make several significant contributions to the literature and theories. First, this is one of the few studies to use agency theory to examine the governance structures and problems in cross-sector partnerships. Second, our study further contributes to solidifying our understanding of the agency problems arising in cross-sector collaborations. Lastly, our study confirms their presence in other types of cross-sector partnerships as well and we maintain that these problems do not affect each type of cross-sector partnership in the same way, leading us to offer more nuanced implications for researchers and practitioners.
Recent development in thermoplastic/wood composites and nanocomposites: A review
Dae Su Kim,Jyoti Sankar Borah 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.11
Thermoplastic composites filled with wood-base fillers have gained increasing attention, because compared to virgin polymers they have many advantages of light weight, high strength and stiffness, low cost, biodegradability and renewability. These advantages let them find a large dispersal in many areas of technical applications. However, poor interfacial interaction between hydrophilic wood-base fillers and hydrophobic polymer matrices should be improved to get reasonable physical properties for their wide applications. The interfacial interaction could be improved by addition of coupling agents and chemical modifications of wood-base fillers. To improve physical properties of the thermoplastic/wood composites, further nanofillers can be incorporated. This review summarizes recent developments in thermoplastic/wood composites and deals with wood-base fillers for thermoplastics, various interface modification methods and various thermoplastic/wood composites as well as nanocomposites. This review can provide reasonable future perspectives in this research area and stimulate development of new innovative thermoplastic/ wood composites as well as nanocomposites.
이상혁,김보라,김찬형 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.1
Depression is heterogeneous in terms of its clinical aspect, diagnosis, cause, neurobiology, drug response and course. Because of the heterogeneity of major depressive disorder (MDD), DSM-IV classified MDD into various subtypes, such as melancholic, atypical, severe with psychotic feature, severe without psychotic feature, with postpartum onset, with catatonic feature, early-onset, late-onset, chronic, single or recurrent. In spite of the efforts of many clinicians trying to classify and explain the nature of MDD, depression is still qualified as a syndrome rather than a disease. When we see patients with MDD in clinical setting, we still use several subtypes of classical classification in order to comprehend the patient better. Psychiatrist should treat the patients with MDD according to their specific features and integrate the various information from them. For these reasons, depression is regarded as a complicated disease to identify and treat. Therefore, mental health professionals, especially psychiatrists should bu trained on these diverse characteristics of MDD and it is rccommended that the treatment of depression should be referred to a psychiatrist.
Kang, Eun-Ho,Kim, Borah,Choe, Ah Young,Lee, Jun-Yeob,Choi, Tai Kiu,Lee, Sang-Hyuk Elsevier 2015 Psychiatry Research Vol.225 No.1
<P><B>Abstract</B></P> <P>Panic disorder (PD) is a very common anxiety disorder and is often a chronic disabling condition. However, little is known about the factors that predict health-related quality of life (HRQOL) other than sociodemographic factors and illness-related symptomatology that explain HRQOL in only small to modest degrees. This study explored whether anxiety-related individual traits including anxiety sensitivity and trait anxiety can predict independently HRQOL in panic patients. Patients with panic disorder with or without agoraphobia (<I>N</I>=230) who met the diagnostic criteria in the Structured Clinical Interview for DSM-IV were recruited. Stepwise regression analysis was performed to determine the factors that predict HRQOL in panic disorder. HRQOL was assessed by the 36-item Short-Form Health Survey (SF-36). Anxiety sensitivity was an independent predictor of bodily pain and social functioning whereas trait anxiety independently predicted all of the eight domains of the SF-36. Our data suggests that the assessment of symptomatology as well as individual anxiety-related trait should be included in the evaluation of HRQOL in panic patients.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Panic disorder is a common anxiety disorder associated with low health-related quality of life (HRQOL). </LI> <LI> Little is known about the factors that predict HRQOL in panic patients. </LI> <LI> Anxiety sensitivity and trait anxiety were independent predictors of HRQOL. </LI> <LI> Our data suggests that the assessment of symptomatology as well as individual anxiety-related trait should be included in the evaluation of HRQOL in panic patients. </LI> </UL> </P>
Yoon, Seong H.,Gupta, Kailash C.,Borah, Jyoti S.,Park, Soo-Young,Kim, Young-Kyoo,Lee, Joon-Hyung,Kang, Inn-Kyu American Chemical Society 2014 Langmuir Vol.30 No.35
<P>A KB cancer cell-selective, liquid crystal microdroplets emulsion is prepared using folic acid-conjugated block copolymers (PS-<I>b</I>-PAA-FA) and sodium dodecyl sulfate (SDS) as a mediator to induce configurational transitions in 4-cyano-4′-pentylbiphenyl (5CB) liquid crystal microdroplets emulsion. The prepared liquid crystal microdroplets emulsion has shown a configurational transition from radial to bipolar on interacting with KB cancer cells, but no transition from radial to bipolar configuration is observed when liquid crystal microdroplets emulsion was allowed to interact with other normal cells such as fibroblast and osteoblast. The KB cancer cell selectivity of liquid crystal microdroplets emulsion has been considered due to the presence of KB cancer cell folate receptor-specific ligand (FA) at the surface of liquid crystal microdroplets, which allowed liquid crystal microdroplets to interact specifically with KB cancer cells. The ligand–receptor interactions have been considered responsible for triggering the configurational transitions from radial to bipolar in liquid crystal microdroplets emulsion. Thus, folate ligand anchored liquid crystal microdroplets emulsion has shown a potential to be used for <I>in vitro</I> detection of KB cancer cells in the early stage of tumor development.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2014/langd5.2014.30.issue-35/la502032k/production/images/medium/la-2014-02032k_0010.gif'></P>