스쿠버다이빙을 통한 스포츠관광 활성화 연구

조동진,이강욱,박현서,박상규 朝鮮大學校 스포츠科學硏究所 2006 스포츠科學硏究 Vol.17 No.-

본 연구는 스쿠버관광의 현황을 파악하고 현안과제 및 개선방안을 통한 스포츠관광 활성화에 목적을 두고자 한다. 이를 위해 문헌조사와 포커스그룹인터뷰를 통해 전문가적인 방안을 제시하였다. 인터뷰 대상은 전국에서 활동중인 스쿠버강사를 대상으로 지역적 안배를 고려하였고 평균 나이41세, 강사경력 11년의 활동경력을 가진 전문가들이였으며 제주도에서 인터뷰가 실시되었다. 본 연구의 결과, 첫째, 관련업계 종사자들이 현안 문제를 해결하기 위해서는 적극적인 노력이 요구되며 둘째, 다양한 교육과 이벤트를 통한 수익창출과 장비 국산화를 통한 저가의 장비개발이 필요하며 셋째, 투자를 통한 시설의 확충으로 편리성을 제공하여야 하며 다양한 홍보를 통해 스쿠버의 안전성과 교육적 효과에 대해 대중에게 알려야 하는 것으로 분석되었다. The purpose of this study is to understand the situation of scuba tourism and revitalize sports tourism by examining pending tasks and methods for revitalization. In order to achieve this, literature review and focus group interview were used to present professional methods. An interview was conducted with practicing scuba instructors nationwide in Jeju-do in consideration of local arrangement. Subjects' mean age was 41, and mean career was 11 years. The following results were obtained. First, related-industry practitioners should make active efforts to solve pending problems. Second, it is needed to create profit through various education and events, and develop inexpensive equipment through the localization of equipment. Finally, it is needed to provide convenience with the expansion and improvement of facilities through investment, and introduce the safety and educational effect of scuba to the public using a variety of PR activity.

간암과 간세포이형성 부위의 철침착 저항성에 대한 조직학적 연구

조욱행,강대영 충남대학교 의과대학 지역사회의학연구소 1993 충남의대잡지 Vol.20 No.1

Liver cell dysplasia(LCD) is commonly associated with some liver diseases such as liver cirrhosis or hepatocellular carcinoma and has been regarded as a premaligant condition. In order to clarify the question of whether or not LCD is a premalignant liver lesion, iron special staining, Prussian blue, was done. The specimens were collected at the department of pathology, Chungnam National University College of Medicine from January 1983 to September 1992. The results were as follows: 1. Of observed 48 cases, 34 were hepatocellular carcinoma(70.8%), 11 were metastatic carcinoma(22.9%), and 3 were hepatoblastoma(6.3%). 2. LCD was present in 26 of 34 cases(76.5%) of hepatocellular carcinoma, 5 of 11 cases(45.5%) of metastatic carcinoma, and 1 of 3 case(33.3%) of hepatoblastoma. 3. The carcinoma cells were free of iron deposition(iron excluding foci) in contrast to the neighboring dysplastic or nonneoplastic normal hepatocytes. 4. The presence of iron deposition in LCD cases was similar to or more severe than that of normal hepatocytes. In summary, the results obtained from the present study indicate that LCD reflects neither a regenerating condition nor a premalignant lesion but suggests a reactive change or accompaning lession.

全南住民에 있어서 惡性腫瘍의 統計的 觀察 (第2報)

曺圭赫,柳柱容,尹康爀,鄭相愚,梁東旭,李珉撤,崔燦 全南大醫大 1983 전남의대학술지 Vol.20 No.4

유로 변경식 고도하수처리 공정의 최적 제어 알고리즘에 관한 연구

조욱상,강성욱,허형우 한국공업화학회 2004 응용화학 Vol.8 No.2

Alcaligenes latus의 배양방법에 따른 생분해성 플라스틱의 생산특성

박성연,조강현,최희식,류희욱,조경숙 이화여자대학교 환경문제연구소 1998 이화환경연구 Vol.2 No.-

생장과 동시에 poly(3-hydroxybutyrate, PHB) 를 체내에 축적하고, 값싼 당류인 sucrose를 이용할 수 있는 Alcaligenes latus의 생장과 PHB 생산을 최적화 할 수 있는 배양 조건에 대하여 연구하였다. 균주 생장과 PHB 생산성에 미치는 sucrose의 초기농도의 영향을 5L 발효조를 이용하여 회분식 배양 방법에 의해 조사하였다. PHB생산성은 sucrose농도가 10g/L에서 30g/L로 증가함에 따라 0.11에서 0.36g-PHB/L·h까지 증가하였고, 그 이상의 농도에서는 큰 변화없이 0.36∼0.39g-PHB/L·h에서 일정하게 유지되었다. 균주의 비증식속도는 sucrose 농도 증가함에 따라 증가하여 30g/L에서 최대값 0.44h()을 보였으며, sucrose의 농도가 30g/L을 초과하면 균주의 생장은 기질에 의해 저해 받았다. A. latus를 이용하여 대량으로 PHB를 생산하기 위해 유가식 배양과 반연속 유가식 배양을 수행하였다. 인산염 제한하에서 유가식 배양에 의해 얻은 PHB 생산성은 1.14g-PHB/L·h로, 인산염 제한없는 조건에서 얻은 PHB생산성(2.10g-PHB/L·h)에 비해서 훨씬 작았다. PHB함량은 영양소 제한에 관계없이 55∼60%이었다. 영양소 제한 없이 반연속 유가식 배양법에 의해 PHB생산성을 4.5∼4.8g-PHB/L·h까지 향상시킬 수 있었다. 평균 PHB 함량, 소비된 sucrose당 건조 균체중량 수율 및 PHB 생산 수율은 각각 60%, 0.48 및 0.32이었다. 그러므로, 생장과 동시에 PHB를 축적할 수 있는 A. latus를 이용하여 PHB를 생산할 경우, 반연속 유가식 배양법은 높은 PHB생산성을 얻을 수 있는 유망한 배양법임을 알 수 있다. Optimum conditions for cell growth and poly(3-hydroxybutyrate, PHB) biosynthesis of Alcaligenes latus, which can accumulate PHB simultaneously in associated with cell growth and grows well on a cheap carbon source such as sucrose, were investigated. The effect of initial sucrose concentration, ranged from 10 to 50g/L, on the cell growth and PHB accumulation were studied by a batch culture in a 5L fermentor. PHB productivity was increased from 0.11 to 0.36g-PHB/L·h with increasing sucrose concentration up to 30g/L, and it was fairly constant between concentrations of 30g/L and 50g/L. The maximum specific growth rate, 0.44h(), was obtained at 30g-sucrose/L, and the growth was inhibited at concentrations of sucrose over 30g/L. A. latus was also cultivated to attain high PHB productivity by fed-batch or semicontinuous fed-batch culture techniques. PHB productivity by a fed-batch culture under phosphate limitation(1.14g-PHB/L·h) were smaller than that without nutrient limitation(2.10g-PHB/L·h). but there is no significant difference of PHB content(55∼60%) obtained in both culture. By a semicontinuous fed-batch culture without nutrient limitation, high PHB productivity could be obtained as 4.5∼4.8g-PHB/L·h. The average PHB content, the yield of dry cell weight, and the yield of per consumed sucrose were 60%, 0.48, and 0.32, respectively. These results suggest that the semicontinuous fed-batch culture technique is one of promising methods to achieve high PHB productivity by A. latus.

식도를 포함한 전위장관을 침범한 전이성 악성 흑색종 1예

최정영,김준기,신성하,고영춘,조상욱,서강석,강명원,임연근,여향순,김경수 全南大醫大 2001 전남의대학술지 Vol.37 No.1

소아에서 간질발작의 임상양상과 뇌파검사의 관계

이승현(Seung Hyeon Lee),손동우(Dong Woo Son),은병욱(Byung Wook Eun),심소연(So Yeon Sim),최덕영(Deok Young Choi),선용한(Yong Han Sun),조강호(Kang Ho Cho0, 류 일(Eell Ryoo),전인상(In Sang Jeon0, 차 한(Hann Tchah) 대한소아신경학회 2009 대한소아신경학회지 Vol.17 No.2

목적:발작의 분류는 발작의 원인, 예후를 추정하거나 항경련제를 선택하는 데 있어 매우 중요하며 뇌파검사는 발작의 종류를 구분하고 적절한 치료를 하기 위해 시행하는 중요한 검사이다. 저자들은 소아에서 임상적 발작이 확실한 경우 간질발작의 임상양상과 뇌파검사 간의 일치 정도를 알아보고자 한다. 방법:2000년 1월 1일부터 2008년 9월 30일까지 1회 이상의 간질발작을 주소로 가천의대 길병원 소아청소년과에 방문한 환자 중 본원에서 처음으로 뇌파검사를 시행한 환자를 대상으로 하였다. 발작의 임상양상은 목격자와 본인의 설명을 기록한 의무기록지를 기준으로 하여 부분발작과 전신발작으로 분류하였고 뇌파검사는 발작간간질양방전을 기준으로 정상과 비정상으로 분류하였으며 각성과 수면상태 모두에서 시행하였다. 결과:총 461명의 환자의 뇌파검사 시의 평균 연령은 6.7세였고 남자는 247명, 여자는 214명이었다. 전체 환자에서 발작의 임상양상은 부분발작이 310명, 전신발작이 187명이었다. 각성뇌파검사에서 비정상은 158명으로 부분발작파가 118명, 전신발작파가 59명, 두 가지 발작파가 한 환자에서 나온 경우가 19명이었고, 수면뇌파검사에서는 비정상이 239명으로 부분발작파가 196명, 전신발작파가 77명, 두 가지 발작파가 한 환자에서 나온 경우가 34명이었으며 전체 환자에서는 비정상이 273명으로 부분발작파가 216명, 전신발작파가 97명, 두 가지 발작파가 한 환자에서 나온 경우가 40명이었다. 간질증후군은 전체 환자 중 90명에서 관찰되었다. 146명(41.5%)의 부분발작과 44명(23.4%)의 전신발작 및 79명(87.8 %)의 간질증후군이 뇌파소견과 일치하였다. 결론:영유아 및 소아에 있어 발작을 진단할 때에는 발작양상 분 아니라 정확한 뇌파소견을 세심하게 고려하여야 한다. Purpose:Electroencephalography(EEG) is an essential method carried out for classifying seizures and taking appropriate treatment. The aim of this study is to investigate the concordance between clinical findings of epileptic seizures and EEG in children. Methods:We enrolled 461 patients from those who visited Gil hospital from January 1, 2000 to September 30, 2008 with the chief complaint of epileptic seizure more than once and checked their first EEG at the same hospital. The clinical findings of seizure were based on the charts and interictal waking and sleep EEGs were done. Results:The mean age of the patients was 6.7 years old. 497 epileptic seizures occurred and its clinical finding included 310 of partial seizures and 187 of generalized seizures. In 315 waking EEG 158 were abnormal including 118 of partial seizures, 59 of generalized seizures and 19 of both seizures, in 431 sleep EEG 239 were abnormal including 196 of partial seizures, 77 of generalized seizures and 34 of both seizures, and in waking and/or sleep EEG 273 were abnormal including 216 of partial seizures, 97 of generalized seizures and 40 of both seizures. Epileptic syndromes were observed in 90 patients. 146(41.5%) of partial seizures, 44(23.4%) of generalized seizures, and 79(87.8%) of epileptic syndromes accorded with EEG. Conclusion:When diagnosing seizures in children, we must consider not only clinical findings but also accurate EEG findings.

A Study on the Revitalization Pattern of Industry in Decline: Focusing on Korean Shoe Industry

Kang-Sun LEE(Kang-Sun LEE),Kyu-Jin CHOI(Kyu-Jin CHOI),Sung-Wook KANG(Sung-Wook KANG),Dae-Myeong CHO(Dae-Myeong CHO) 동아시아경상학회 2022 The East Asian Journal of Business Economics Vol.10 No.4

Purpose - This study aims to study the activation pattern of declining industries by applying the Gompertz growth model using available resources based on the theory of industrial life cycle, classifying declining industries among Korean manufacturing industries, and identifying resource input characteristics. Research design and methodology - This study was conducted by combining the Gompertz growth model that predicts the limit of output based on available resources under the industrial life cycle theory. Using Gompertz model, this study analyzed the life cycle of 39 Korean manufacturing industries from the perspective of domestic production, number of employees, and fixed assets Results - According to a life cycle analysis of 39 manufacturing industries in Korea, the computer, textile, and shoe industries were classified as declining industries. Among them, research on resource input characteristics on the shoe industry showed that domestic production and the number of employees decreased, while the proportion of domestic R&D personnel and the number of research departments gradually increased. Conclusion - Among the declining industries in Korea, the shoe industry is considered to revitalize the industry, that is, to extend the life of the declining industry by offshoring its production site and improving constitution with a “R&D center for global” support.

Strategies for developing Alzheimer’s disease treatments: application of population pharmacokinetic and pharmacodynamic models

Kang Dong Wook,Cho Seok-jin,Choi Go-Wun,Cho Hea-Young 한국약제학회 2022 Journal of Pharmaceutical Investigation Vol.52 No.5

Background As the number of Alzheimer's disease (AD) patients steadily increases, many pharmaceutical industries and researchers are making efforts and investments in developing AD treatments. However, numerous AD new drug candidates are frustrated with clearing the hurdles in clinical trials, and few AD treatments have been approved by regulatory agencies worldwide. In order to develop AD treatments, it is essential to consider the characteristics of AD itself and AD patients, and to devise evaluation methods deriving significant clinical safety and efficacy. Area covered This review focused on pharmacometrics, the latest mechanism-based PK/PD modeling and simulation approaches among strategies for developing AD treatments. Including the basic concept of pharmacometrics, several cases of applying pharmacometrics to AD treatments in the approval or development stage were categorized as PK, PD, and PK-PD models and reviewed. Expert opinion Unlike traditional PK/PD models, the population model-based PK/PD evaluations could apply to sparse data collected from a heterogeneous population. Various covariate factors in patients receiving AD treatments were investigated and quantified through the developed and validated population models. Investigating potential covariates of AD treatments could be employed to optimize the dosage regimen for AD patients. Consequently, a summary of the population PK/PD model will be useful information for clinical pharmacometricians and contribute to the development of AD treatments in the future in decision-making such as dosage optimization.

Stabilization, Carbonization, and Characterization of PAN Precursor Webs Processed by Electrospinning Technique

Cho, Chae-Wook,Cho, Dong-Hwan,Ko, Young-Gwang,Kwon, Oh-Hyeong,Kang, Inn-Kyu Korean Carbon Society 2007 Carbon Letters Vol.8 No.4

In the present study, electrospun PAN precursor webs and the stabilized and carbonized nanofiber webs processed under different heat-treatment conditions were characterized by means of weight loss measurement, elemental analysis, scanning electron microscopy (SEM), attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR), differential scanning calorimetry (DSC), thermogravimentric analysis (TGA), and X-ray diffraction (XRD) analysis. The result indicated that stabilization and carbonization processes with different temperatures and heating rates significantly influenced the chemical and morphological characteristics as well as the thermal properties of the stabilized and then subsequently carbonized nanofiber webs from PAN precursor webs. It was noted that the filament diameter and the carbon content of a carbonized nanofiber web as well as its weight change may be effectively monitored by controlling both stabilization and carbonization processes.