接觸共形曲率텐서場과 Laplace 演算의 Spectrum

권정환,김운택 대구대학교 부설 과학교육연구소 1991 과학교육 Vol.4 No.-

다형성 교모세포종에서 광범위 전적출술후 단기 재발된 치험 1예

박호권,강중식,조준,문창택,장상근,임정애 건국대학교 의과학연구소 2003 건국의과학학술지 Vol.13 No.-

Glioblasty/ma Multiforme(GBM) is the one of the most common malignant tumors in central nervous system(CNS). The incidence of the tumor is about 12% of all CNS tumors and about 50% of all intracranial tumors. Though the development of the microsurgical technique, radiosurgical technique, and chemotherapy works effectively, complete cure of the GBM has not been achieved. It has been known that the prognosis of GBM depends on the extent of surgical tumor removal, remained tumor volume, radiation dose, and chemotherapy. Not only patient's age but also tumor characteristics such as MRI enhancement, angiogenesis and necrosis are also very important prognostic factors. Authors experienced very aggressive GBM in aged woman, who received gross total tumor removal, but refused other therapeutic motalities postoperatively. Very rapid recurrence of GBM and global cerebral edema in aged woman should be considered fatal. This case demonstrates the effectiveness of aggressive removal and the limited usefulness of neurosurgical tools in GBM recurrence. Authors would suggest that the early diagnostic effort and the verified neurosurgical therapy for malignant tumor are still strongly requested to make better prognosis.

유자과즙을 이용한 식초제조

김용택,서권일,정용진,이용수,심기환 동아시아식생활학회 1997 동아시아식생활학회지 Vol.7 No.3

To enhance the utility value of citron, vinegars were made of citron juice, their properities were investigated, the results are as following. Optimum bacteria was Acetobacter sp. PA 97 for the citron vinegar fermentation, optimum temperature, initial acidity and alcohol concentration were 30℃, 1.5% and 8%, respectively. The lower citron juice was added, the more citric acid was produced, the acidity of sample added sub-nutrition source was higher than that of sample no added. In samples added citron juice of 10, 20 and 30%, and sub-nutrition source, total acidity were 5.42, 5.36 and 5.04%, pure acetic acid yields were 52.69, 45.25 and 35.10%, respectively. Remained alcohol of sample no added sub-nutrition source was more than that of added. In the sensory test, the most suitable concentration of citron juice for vinegar fermentation was 30%.

觀光을 通한 地域活性化에 關한 硏究 : 日本의 內發的 地域活性化의 事例를 中心으로

田元培,權晶澤 大邱大學校 社會科學硏究所 1999 社會科學硏究 Vol.6 No.1

地域의 觀光開發 事業이 活性化되고 관광개발이 地域發展에 미치는 效果를 極大化 하기 위해서는 관광개발에 대한 發想의 轉換이 절실히 요구된다. 換言하여 금후 觀光의 觀光政策은 地方化時代의 定着과 觀光産業의 環境變化 등을 고려할 때 中央政府 차원에 의한 위로부터의 관광개발이 아니라 地域에 基盤을 두고 地域社會와의 連繫 속에서 이루어지는 地域觀光, 즉 地域性을 확보하는 방향으로 槪念轉換이 이루어져야한다. 이를 위해 地域文化 및 主體性의 再發見, 地域特性의 觀光資源化를 적극적으로 추진해야하며 觀光關聯事業에 內發的인 住民의 參與를 誘導하기 위한 方案을 摸索해야 한다. 內發的인 地域活性化는 外部에 대해 地域이미지의 提高와 地域의 自玲心과 愛鄕心을 鼓吹시키고, 나아가 觀光客의 지역에 대한 訪問動機를 자극시켜 방문을 유도하고, 窮極的으로는 地域住民의 삶의 質 向上에 기여한다. 그러나 地方自治制의 역사가 일천하고 觀光의 地域活性化에 대한 效果가 經濟的 效用에 지나치게 중점을 둔 나머지, 관광을 통한 지역의 意識啓發과 文化生活空間을 제공하며 地域住民의 福利增進이라는 面에서는 소홀하게 취급되어왔던 게 사실이다. 지역활성화를 위한 전통적인 전략을 기본적으로 外來型 開發, 즉 外部의 支援에 의한 대규모 개발 사업을 통한 地域開發의 추구였다. 이와 같은 전략 하에서는 國家 政府의 역할이 가장 중시된다. 그러나 최근 世界化, 情報化로 國境, 距離의 개념이 약화되고 경제성장요소의 移動이 보다 다이나믹해 감에 따라 地方化를 더욱 촉진 시키게되고 이러한 환경 하에서 中央政府 主導方式의 地域開發은 그 실효성을 더욱 저하시킬 수밖에 없는 것으로 평가된다. 따라서 전통적 戰略의 代案으로 주목받게 된 이론이 곧 內發的開發이다. 內發的開發은 地域內部의 모든 자원 - 자연적, 인적, 기술적, 문화적, 조직 및 제도적 자 원-을 活用, 이들간의 相互作用을 活性化시키고 統合함으로써 地域力量(regional capacity) 을 極大化시키는 戰略이다. 여기에서 지역의 인적, 조직 및 제도적 자원은 지역개발의 主 體가 되는 資源이고 자연적, 기술적, 문화적 자원은 지역개발의 客體的 資源이 된다.

자발성 뇌교출혈 환자의 예후에 관한 임상 분석

조재영,석종식,민병국,권정택,최덕영,황성남,김영백,박승원 중앙대학교 의과대학 의과학연구소 2002 中央醫大誌 Vol.27 No.1

Patients with spontaneous pontine hemorrhage very often develop setvere disturbances of consciousness,pupilary abnormalities, respiratory and motor. They have high mortality rate. Therefore, I analyzed the correlation between the Glasgow outcome scale(GOS)and clincial manifestations or computed tomographic(CT)findings in 48 patients with spontaneous pontine hemorrhage to clarify factors predicting the prognosis. I examined 48 Patients with spontaneous pontine hemorrhage; 33 males and 15 females, age 54.6±8.99(mean±S.D.;range 39 to 68)brought to our hospital between January 1995 and December 1999, retrospectively. Correlations between the clinical manifestations, CT findings and the GOS was assessed with multivariate regression analysis. The results were as follow: 1) Patients with the pontine hemorrhage were of 8.8% in those with intracerebral hemorrhage. The ratio of male and female was 33 to 15. The incidence of age is eqial to 40,50 and 60. Total mortality was 41.6%. 2) The poor prognostic factor were that; Glasgow coma scale(GCS)3∼8, irregular respiration. pupilary abnormality, quadriplegia, Brain CT typeⅠ(massive), hydrocephalus, extrapontine extension, Intraventricular hemorrhage(IVH). These clinical analysis should be useful in determining the level of care and future resuscitative efforts.

후방순환계 뇌동맥류의 임상분석

임동준,이훈갑,정흥섭,김봉룡,권택현,이기찬,서중근 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.11

Microstructure and properties of cross-roll rolled and heat treated metastable TiNbSn alloy.

Jung, Taek-Kyun,Choi, Ho-Joon,Kim, Kyung-Taek,Shin, Young-Chul,Lee, Hyo-Soo,Lim, Sung-Chul,Kwon, Hyouk-Chon,Hanada, Shuji American Scientific Publishers 2014 Journal of Nanoscience and Nanotechnology Vol.14 No.10

<P>A (Ti-35mass%Nb)-4mass%Sn alloy was cross-roll rolled with a reduction ratio of 70% in which the roll axes are tilted by 5 degrees away from the transverse direction of the rolled sample and then aged at 250 degrees C for 2 h. Cross-roll rolling was found to increase yield strength and Young's modulus, simultaneously. Yield strength was higher in cross-roll rolled than in conventionally rolled at same reduction ratio. Yield and tensile strength further increased by a low temperature ageing by ψ precipitation hardening and microstructure refinement. Yield and tensile strength of the aged 70% cross-roll rolled sample were higher than those of the aged 70% conventionally rolled one.</P>

Aluminum Nanoparticles Induce ERK and p38MAPK Activation in Rat Brain

Kwon, Jung-Taek,Seo, Gyun-Baek,Jo, Eunhye,Lee, Mimi,Kim, Hyun-Mi,Shim, Ilseob,Lee, Byung-Woo,Yoon, Byung-Il,Kim, Pilje,Choi, Kyunghee Korean Society of ToxicologyKorea Environmental Mu 2013 Toxicological Research Vol.29 No.3

Aluminum nanoparticles (Al-NPs) are one of the most widely used nanomaterial in cosmetics and medical materials. For this reason, Al-NP exposure is very likely to occur via inhalation in the environment and the workplace. Nevertheless, little is known about the mechanism of Al-NP neurotoxicity via inhalation exposure. In this study, we investigated the effect AL-NPs on the brain. Rats were exposed to Al-NPs by nasal instillation at 1 mg/kg body weight (low exposure group), 20 mg/kg body weight (moderate exposure group), and 40 mg/kg body weight (high exposure group), for a total of 3 times, with a 24-hr interval after each exposure. Inductively coupled plasma mass spectrometry (ICP-MS) analysis indicated that the presence of aluminum was increased in a dose-dependent manner in the olfactory bulb (OFB) and the brain. In microarray analysis, the regulation of mitogen-activated protein kinases (MAPK) activity (GO: 0043405), including Ptprc, P2rx7, Map2k4, Trib3, Trib1, and Fgd4 was significantly over-expressed in the treated mice than in the controls (p = 0.0027). Moreover, Al-NPs induced the activation of ERK1 and p38 MAPK protein expression in the brain, but did not alter the protein expression of JNK, when compared to the control. These data demonstrate that the nasal exposure of Al-NPs can permeate the brain via the olfactory bulb and modulate the gene and protein expression of MAPK and its activity.

Gene Expression and Pulmonary Toxicity of Chitosan- <i>graft</i> - Polyethylenimine as Aerosol Gene Carrier

Kwon, Jung-Taek,Jiang, Hu-Lin,Minai-Tehrani, Arash,Gyu Woo, Chang,Choi, Mansoo,Cho, Chong-Su,Kim, Yeon-Soo,Cho, Myung-Haing Shaheed Beheshti University of Medical Sciences 2013 Iranian journal of pharmaceutical research Vol.12 No.2

<P>Chitosan-<I>graft</I>-polyethylenimine (CHI-<I>g</I>-PEI) copolymer has been used for the improvement of low transfection efficiency of chitosan. The present study aims to test the pulmonary toxicity and efficiency of CHI-<I>g</I>-PEI as an aerosol gene carrier. Mice were exposed to aerosol containing green-fluorescent protein (GFP)-polyethylenimine (PEI) or GFP-CHI-<I>g</I>-PEI complexes for 30 min during the development of our nose-only exposure chamber (NOEC) system. CHI-<I>g</I>-PEI-mediated aerosol delivery demonstrated 15.65% enhancement of the fluorescence intensity. Compared to PEI, CHI-<I>g</I>-PEI showed no significant pulmonary toxicity. In summary, using CHI-<I>g</I>-PEI is safe and shows high transfection in aerosol gene delivery to animals, and enhanced efficiency was achieved through our aerosol gene delivery system. Therefore, CHI-<I>g</I>-PEI and this system would be applicable to future study for aerosol gene therapy. </P>

Genotyping of apple (Malus × domestica Borkh.) using MdACS1 and MdACO1 functional markers

Jung-Woo Lee,Jeong-Hee Kim,Sun-Il Kwon,Jong-Taek Park,Kyeong-Ho Chung 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07

Apple is a typical climacteric fruit, whose loss of firmness during storage is associated with internal levels of ethylene. MdACS1 (1-aminocyclopropane-1-carboxylate synthase) and MdACO1 (1-aminocyclopropane-1-carboxylate oxidase) genes are characterized well as functional markers for the ethylene production of ripening apple fruit. Presence of two alleles for each gene are commonly reported in cultivated apples. MdACS1-1/1, 1-1/2 and 1-2/2 generally induce high, medium, and low ethylene production, respectively. Homozygosity of MdACO1-1 resulted in low levels of ethylene production than MdACO1-1/2 and 1-2/2. It was reported that cultivars homozygous for MdACS1-2 and MdACO1-1 had superior shelf-life with lowest ethylene production. In this study, genotypes of 42 apple cultivars including Korean-developed ones at MdACS1 and MdACO1 loci were determined. Polymorphisms were detected by PCR and were separated by electrophoresis in a 2.0% agarose gel. Of PCR products of MdACS1, the fragrament of 490 bp was corresponded to the MdACS1-1 allele and 640 bp corresponded to the MdACS1-2 allele. ACO1-1 and ACO1-2 alleles had the fragment size of 525 and 587 bp, respectively. The 42 cultivars could be grouped into three classes to each gene, MdACS1-1/1, MdACS1-1/2 and MdACS1-2/2; MdACO1-1/1, MdACO1-1/2 and MdACO1-2/2.