Poster Presentation : Dropout Times and Post-Transplant Survival of Patients with Hepatocellular Carcinoma Downstaged by Transarterial Chemotherapy (초)

Myeong Jun Song,Jeong Won Jang,Chan Ran You,Jung Hyun Kwon,Chang Wook Kim,Si Hyun Bae,Jong Young Choi,Seung Kew Yoon,Kyu Won Chung,Young Kyoung You,Dong Goo Kim 대한간학회 2009 Clinical and Molecular Hepatology(대한간학회지) Vol.15 No.4(S)

리튬 이온 배터리 전해질 이성분계 자연발화온도 측정

장유리(You Lee Jang),장유선(You Sun Jang),최재준(Jae Jun Choi),유승돈(Seung Don You),하동명(Dong Myeong Ha) 한국화재소방학회 2022 한국화재소방학회 학술대회 논문집 Vol.2022 No.추계

지구 온난화로 인한 환경문제인 화석연료를 대체할 에너지원의 개발에 관련하여 최근 리튬이온배터리의 소재 및 구성요소에 많은 연구가 활발히 진행 중이다. 그중 현재 리튬이온배터리는 액체 상태의 전해질인 전해액을 사용하고 있으며, 전해액은 양극과 음극 사이 리튬 이온(Li+)의 이동을 가능하게 하는 물질로 양극과 음극의 표면을 안정화 시키며 배터리의 수명과 셀 특성을 향상시킨다. 전자 전도성은 없으며 이온의 전도성만 가지고 있는 특징이다. 전해질은 리튬 염의 해리를 도와주는 용매로, EC(Ethylene carbonate), DMF(N,N-dimethyl methanamide), DEC(Diethyl carbonate)으로 대부분 carbonate 계열이 주로 사용된다. 리튬이온배터리의 폭발은 내외부의 충격이나 발열에 의한 과열로 열축적을 하게 되면서 가스 누출 후 폭발 과정을 거치게 된다. 발열의 원인 중 하나는 용매의 점도가 너무 높거나 낮아 최적의 이온 전도도를 구연하지 못하여 리튬이온배터리의 자연발화 온도에 다다르는 것으로 폭발이나 화재로 이어질 수 있는 위험성이 있다. 자연발화온도란 다른 곳에서 착화원을 부여하지 않고 가연성 물질을 공기 또는 산소 중에서 발화 혹은 폭발을 일으키는 최저 온도를 말한다. 각종 화학물질의 안전 관리를 어렵게 하는 이유는 취급하는 물질의 화재 및 폭발 특성치에 관한 자료가 부족하거나 정확하지 않은 연소특성치를 사용하기 때문이다. 그러므로 전해질의 자연발화온도를 측정하고 정확한 연소 특정 자료를 작성하여 안전 관리 시 화재와 폭발을 예방하고 안전 관리의 신뢰도를 높일 필요성이 있다. 또한 핸드폰 폭발 사건, 전기자동차 폭발사건, ESS 폭발처럼 여러 사례를 해결하기 위하여 안전성 확보에 관한 연구활동을 해야 한다. 본 연구는 리튬 이온 배터리 전해질 이성분계 자연발화온도를 측정하고 현재 문헌들에 개제되어 있는 문헌값들과 비교, 고찰하여 정확한 자연발화온도를 제시함으로써 화재 및 폭발을 예방하기 위해 자료를 제공하며 자연발화 연구에 이용하는 데에 목적을 두고 있다.

Treatment Efficacy and Safety of Tenofovir Disoproxil Fumarate (TDF) in Naive Chronic Hepatitis B: A Real Life Multicenter Cohort Study in Korea

( Myeong Jun Song ),( Jeong Won Jang ),( Si Hyun Bae ),( Jong Young Choi ),( Seung Kew Yoon ),( Hee Yeon Kim ),( Chang Wook Kim ),( Do Seon Song ),( U Im Chang ),( Jin Mo Yang ),( Chan Ran You ),( San 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: We aimed to evaluate the efficacy and safety of tenofovir disoproxil fumarate (TDF) therapy in naïve chronic hepatitis B (CHB) patients for 144 weeks in Korean real life practice. Methods: 579 naïve CHB patients at 12 medical centers were enrolled from Sep, 2015 to Jan, 2016 by retrospective and prospective design (NCT02533544). We compared the virological responses (HBV DNA< 116 copies) and renal safety of treatment naive patients. Results: In this cohort, 465 (80.3%), 298 (51.4%) and 157 (27.1%) CHB patients completed 48, 96, and 144 weeks, respectively. Overall complete virological response (CVR) showed 59.5%, 78.1%, and 79.6% of patients at week 48, 96, and 144 respectively. In HBeAg positive CHB, CVR at week 48, 96 and 144 showed 49.0%, 71.7% and 78.4%, respectively. HBeAg loss and seroconversion rate at week 46, 96, and 144 showed 17.8%, 22.7%, 36.3%, and 7.8%, 9.2%, 14.7%, respectively. In HBeAg negative CHB, CVR at week 48, 96 and 144 showed 75.0%, 87.5% and 81.3%, respectively. Overall ALT normalization showed 76.2%, 81.1%, and 84.11% of patients at week 48, 96, and 144 respectively. In multivariate analysis, HBeAg positive showed independent factors of CVR at week 46 and 96, although baseline HBV DNA was independent factor of CVR at week 48. However, at week 144, there was no significant factor of CVR including viral factors, BMI, and comorbidities. In renal safety, 2(0.9%) CHB patients showed elevated creatinine ( >0.5mg/dL). In analysis for change of eGFR, older age (≥65) showed significant reduction at week 48 and 96 (P=0.00415 and 0.0412, respectively). Comorbidities (diabetes or hypertension) also significantly showed reduction at week 48 (P=0.0098). Conclusions: TDF therapy demonstrated sustained viral suppression and a favorable safety throughout 3 years. However, close monitoring of eGFR should be mandatory when treating CHB patients receiving TDF, particularly those with older age or comorbidities.

Combination transarterial chemoembolization and radiofrequency ablation therapy for early hepatocellular carcinoma

( Myeong Jun Song ),( Si Hyun Bae ),( June Sung Lee ),( Sung Won Lee ),( Do Seon Song ),( Chan Ran You ),( Jong Young Choi ),( Seung Kew Yoon ) 대한내과학회 2016 The Korean Journal of Internal Medicine Vol.31 No.2

Background/Aims: We compared the recurrence of hepatocellular carcinoma (HCC) and the survival of patients who received radiofrequency ablation (RFA) after transarterial chemoembolization (TACE) with patients treated with TACE or RFA alone. Methods: This study included 201 patients with HCC, who were consecutively enrolled at Seoul St. Mary’s Hospital between December 2004 and February 2010. Inclusion criteria were a single HCC≤5.0 cm or up to three HCCs≤3.0 cm. We used a propensity score model to compare HCC patients (n = 87) who received RFA after TACE (TACE + RFA) with those who received TACE (n = 71) or RFA alone (n = 43). Results: The median follow-up period was 33.3 months (range, 6.8 to 80.9). The TACE + RFA group showed significantly lower local recurrence than the RFA or TACE groups (hazard ratio [HR], 0.309; 95% confidence interval [CI], 0.130 to 0.736; p = 0.008; and HR, 0.352; 95% CI, 0.158 to 0.787; p = 0.011, respectively). The overall survival was significantly better in the TACE + RFA group compared to the RFA group (HR, 0.422; 95% CI, 0.185 to 0.964; p = 0.041). However, the survival benefit was not different between the TACE + RFA and TACE groups (p = 0.124). Subgroup analysis showed that among patients with a tumor size < 3 cm, the TACE + RFA group had significantly better long-term survival than those in the TACE or RFA groups (p = 0.017, p = 0.004, respectively). Conclusions: TACE + RFA combination treatment showed favorable local recurrence and better overall survival rates in early-stage HCC patients. Patients with tumors < 3 cm are likely to benefit more from TACE + RFA combination treatment. Additional studies are needed for the selection of suitable HCC patients for TACE + RFA treatment.

Ultrasonographic Measurement of Transverse Abdominis in Stroke Patients

김현동,Jun Myeong You,한나미,Mi-Ja Eom,Jong Gil Kim 대한재활의학회 2014 Annals of Rehabilitation Medicine Vol.38 No.3

Objective To compare transverse abdominis (TrA) contractility in stroke patients with hemiparesis and healthy adults using musculoskeletal ultrasonography.Methods Forty-seven stroke patients with hemiparesis and 25 age-matched healthy control subjects participated in this study. Stroke patients were divided into three groups on the basis of their degree of ambulation. Group A consisted of 9 patients with wheelchair ambulation, group B of 23 patients with assisted ambulation, and group C of 15 patients with independent ambulation. Inter-rater reliability regarding ultrasonographic measurement of abdominal muscle thickness in the control group was assessed by two examiners. The TrA contraction ratio (TrA contracted thickness/TrA resting thickness) was measured during abdominal drawing-in maneuver and was compared between the patients and the control group and between the ambulation groups.Results The inter-rater reliability ranged from 0.900 to 0.947. The TrA contraction ratio was higher in the non-paretic side than in the paretic side (1.40±0.62 vs. 1.14±0.35, p<0.01). The TrA contraction ratio of the patient group was lower in the non-paretic side as well as in the paretic side than that of the control group (right 1.85±0.29, left 1.92±0.42; p<0.001). No difference was found between the ambulation regarding the TrA contraction ratio.Conclusion The TrA contractility in hemiparetic stroke patients is significantly decreased in the non-paretic side as well as in the paretic side compared with that of healthy adults. Ultrasonographic measurement can be clinically used in the evaluation of deep abdominal muscles in stroke patients.

GBAS 지상시스템 설치후보지 선정 기준에 관한 연구

정명숙 ( Myeong Sook Jeong ),고유리 ( You Ri Ko ),최철희 ( Chul Hee Choi ),고완진 ( Wan Jin Ko ),배중원 ( Joong Won Bae ),전향식 ( Hyang Sig Jun ),김동민 ( Dong Min Kim ) 한국항공운항학회 2012 한국항공운항학회지 Vol.20 No.3

Since the site chosen for GBAS ground system will have a direct effect on the performance of the GBAS, the GBAS ground system siting is mightily important in the GBAS installation process. Therefore, in this paper, the major equipments of the GBAS ground system are introduced and a formal process is described for the identification and evaluation of candidate GBAS sites. Also, this paper described detail siting requirements for the GBAS ground equipments such as reference receiver, VDB antenna and shelter respectively.

QTL Analysis for Fe and Zn Concentrations in Rice Grains Using a Doubled Haploid Population Derived from a Cross Between Rice (Oryza sativa) Cultivar 93-11 and Milyang 352

( So-myeong Lee ),( Ju-won Kang ),( Ji-yoon Lee ),( Jeonghwan Seo ),( Dongjin Shin ),( Jun-hyeon Cho ),( Sumin Jo ),( You-chun Song ),( Dong-soo Park ),( Jong-min Ko ),( Hee-jong Koh ),( Jong-hee Lee 한국육종학회 2020 Plant Breeding and Biotechnology Vol.8 No.1

Biofortification is a cost-effective method for increasing the availability of micronutrients. Rice breeding for high levels of micronutrients is one of the best approaches to solve the problem of malnutrition. In this study, we developed a doubled haploid (DH) population derived from a cross between the rice cultivars 93-11 and Milyang 352 and evaluated QTLs for grain micronutrients and grain shape. Two co-localized QTLs, qFe3-1 and qZn3-1, were identified in the interval between ah03002520 and cmb0336.5 on chromosome 3, which explained 17.6% and 10.5% of the phenotypic variation, respectively. Correlation analysis between agronomic and micronutrient traits showed positive correlations between grain Fe and Zn contents but a negative correlation between grain Fe content and length-to-width ratio. This indicated the possibility of simultaneously increasing both Fe and Zn content in rice grains for improving the micronutrient profile of rice. We selected some promising lines by recombinant selection using linked markers on chromosome 3. The co-localized QTLs qFe3-1 and qZn3-1 might be useful for the improvement of biofortified rice breeding by marker-assisted selection and gene pyramiding.

HCC : Expression of Ribosomal Protein S23 in Hepatocellular Carcinoma Tissue as Good Prognostic Marker

( Chan Ran You ),( Myeong Jun Song ),( Chan Kwon Jung ),( Sung Woo Hong ),( Won Hee Hur ),( Sang Wook Choi ),( Si Hyun Bae ),( Jong Young Choi ),( Seung Kew Yoon ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background: Ribosomal proteins (RP) involve in the regulation of apoptosis and carcinogenesis. In recent studies of RP in hepatocellular carcinoma (HCC), the overexpression of ribosomal protein L12, L27, L30 and L36 was found. We aimed to investigate the expression of ribosomal protein S23 (RPS23) and its effect on prognosis in postoperative HCC patients. Methods: Liver tissues were obtained 63 patients who had undergone curative resection for HCC. We enrolled the patients with early tumor stage (≤ UICC stage III) and good liver function (≤ Child Pugh score 6). The expressions of RPS23 in tumor tissue and non-tumor tissue were examined by immunohistochemical staining. Analyses for survival and recurrence were done between tumor RPS23 (t-RPS23) expression group and non-expression group. Results: RPS23 was expressed in 34 patients (54.0%) on tumor tissue and 8 patients (13.1%) in Non-tumor tissues (P=0.016). The patients were grouped according to the expression of RPS26 in tumor tissue. Basal characteristics were not different between t-RPS23 positive and negative group. The three years and five years survival rate was higher in t-RPS23 positive group (90.2% vs. 65.8% of 3 year survival rate, P=0.007, 86.1% vs. 55.7% of 5 year survival rate, P=0.010). On multivariate analysis, t-RPS23 expression (HR 10.95, P=0.004) and tumor number (HR 9.71, P=0.001) were independent prognostic factors for 3 year and 5 year survival. Tumor recurrence during one year after resection was relatively low in t-RPS23 positive group, but not statistically significant (17.8% vs. 36.0%, P=0.084). However, on multivariate analysis, t-RPS23 expression (HR 4.18, P=0.021) and serosa invasion (HR 4.15, P=0.019) were independent factors for 1 year tumor recurrence. Conclusions: The RPS23 expression of HCC patients was higher in tumor tissue than in non- tumor tissues. The RPS23 expression in tumor tissue was good prognostic marker for resected HCC. RPS23 may be associated with good oncogene to have paradoxical function in HCC.

대형 영구자석 기기의 전기자 반작용 자계 해석 및 회로정수 도출

장석명(Seok-Myeong Jang),박현준(Hyun-Jun Park),최지환(Ji-Hwan Choi),구민모(Min-Mo Koo),유대준(Dae-Joon You) 대한전기학회 2013 대한전기학회 학술대회 논문집 Vol.2013 No.7

확장된 계획행동이론을 이용한 대학 교양교육 학습자의 의사결정과정에 대한 연구

성명희(Seong Myeong Hee),이혁진(Lee Hyuk Jin),유근준(You Geun Jun) 학습자중심교과교육학회 2015 학습자중심교과교육연구 Vol.15 No.10

본 연구는 대학교 교양교육 서비스품질을 교육수요자 입장에서 재정의 하고, 교 양교육 서비스품질이 대학 교양교육 학습자의 의사결정과정에 어떠한 영향을 미치 는 지를 알아보기 위해 TPB이론의 변수(태도, 주관적 규범, 지각된 행동통제)에 교 양교육 서비스품질을 확장하여 실증분석 하였다. 연구의 분석결과는 첫째, 교양교육 서비스품질은 태도에 유의한 영향을 미치는 것으로 확인되었다. 둘째, 태도와 주관 적 규범은 학습의도에 유의한 영향을 미치지 못하는 것으로 나타났다. 셋째, 교양교 육 서비스품질이 직접적으로 학습자 학습의도에 유의한 영향을 미치지 않는 것으로 검증되었지만, 교양교육 학습에 필요한 지각된 행동통제감이 학습자 학습의도의 유 의한 긍정적 영향을 미쳐는 것으로 밝혀졌다. This study verified and analyzed the service quality of college general education on top of the other variables (attitudes, subjective norms, and perceived behavioral control) of the Theory of Planned Behavior in order to redefine the service quality of college general education from the side of educational consumers, and to find out what kind of influences the service quality has on the decision-making process of college general education learners. According to the results of this study, first, the service quality of general education proved to have a meaningful influence on attitudes. Second, attitudes and subjective norms proved not to have a meaningful influence on learning intention. Third, the service quality of general education was verified not to have a direct meaningful influence on the learning intention of learners, however, the feeling of perceived behavioral control which is necessary for general education learning was found out to have a meaningful and positive influence on the learning intention of learners.