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Ko, Kyung Yuk,Jeon, Hye Lyun,Kim, Joohwan,Kim, Tae Sung,Hong, Yoon-hee,Jeong, Mi Kyung,Park, Kyo-Hyun,Kim, Bae-Hwan,Park, Sera,Jang, Won-hee,Cho, Sun-A,An, Susun,Cho, Ah Rang,Yi, Jung-Sun,Kim, Ji-Youn Pergamon 2020 Toxicology in vitro Vol.63 No.-
<P><B>Abstract</B></P> <P>In order to overcome the limitations of single <I>in vitro</I> eye irritation tests, Integrated Approaches to Testing Assessment strategies have been suggested for evaluating eye irritation. This study developed two tiered approaches combining alternative test methods. They were designed in consideration of the solubility property of test chemicals and to use the RhCE tests at final steps. The tiered approach A is composed of the STE, BCOP, HET-CAM or RhCE tests, whereas the tiered approach B is designed to perform simultaneously two <I>in vitro</I> test methods at the first stage and the RhCE test at the final stage. The predictive capacity of the two tiered approaches was estimated using 47 chemicals. The accuracy, sensitivity, and specificity value of the tiered approach A were 95.7% (45/47), 100% (34/34), and 84.6% (11/13), respectively, whereas those of the tiered approach B were 95.7% (45/47), 97.1% (33/34), and 92.3% (12/13), respectively. The approach A and B were considered to be available methods for distinguishing test chemicals of Category 1 (all 73.3%) and No Category (84.6% and 92.3%), respectively. Especially, the approach B was considered as an efficient method as the Bottom-Up approach, because it predicted correctly test chemicals classified as No Category.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The proposed A and B approaches seem to be efficient strategies for evaluating eye irritation potency as they had higher predictive capacity than that of stand-alone <I>in vitro</I> test method. </LI> <LI> The B approach is considered to be an useful method for Bottom-Up approach in eye irritation IATA. </LI> </UL> </P>
이수영(Sooyoung Lee),노주환(Joohwan Roh),이상곤(Sanggon Lee),최진영(Jinyoung Choi),김진학(Jinhak Kim),김세영(Seyoung Kim),고주영(Jooyoung Ko),심재창(Jaechang Shim) 한국멀티미디어학회 2008 한국멀티미디어학회 학술발표논문집 Vol.2008 No.1
인공 지능 로봇의 기본적인 기능에는 시각 기능과 무선 통신 기능이 포함된다. 로봇의 무선통신 기능으로 ZigBee를 적용하였다. ZigBee는 저전력, 근거리, 저속을 위한 무선 표준으로 최근 많이 연구 되고 있다. 로봇이 촬영한 영상 정보를 서버로 ZigBee 통신을 통해 전송하고, 서버에서 패턴인식을 빠르게 적용할 수 있다. 본 연구에서는 근거리 무선 통신망으로 개발된 ZigBee 무선 통신을 영상을 전송할 수 있는 이미지 센서로 제작하고 이 센서를 로봇에 부착하여 이동성을 추가한 시스템의 구현하였다. 연구 결과로 로봇에 시각기능과 ZigBee 무선통신을 부여하고 전송된 영상에서 얼굴 검출을 적용하였다.
Pembrolizumab 투여로 Pseudoprogression 이후 완전 관해에 도달한 호지킨 림프종 1예
홍주현 ( Joohyun Hong ),배주환 ( Joohwan Bae ),이상글 ( Sang Geul Lee ),임민기 ( Mingi Lim ),고영혜 ( Young Hye Ko ),김석진 ( Seok Jin Kim ),김원석 ( Won Seog Kim ) 대한내과학회 2017 대한내과학회지 Vol.92 No.4
Classical Hodgkin lymphoma (cHL) is a highly curable disease, but the prognosis for relapsed/refractory cHL is grave. Pembrolizumab has recently shown impressive effects in patients with relapsed/refractory cHL in a phase Ib study (KEYNOTE-013). This report presents a case of a 17-year-old male with refractory cHL who received multiple chemotherapy regi-mens and radiotherapies, including brentuximab vedotin. Following both the second and fourth cycles of intravenous pem-brolizumab 100 mg (2 mg/kg), positron emission tomography/computed tomography (PET/CT) scan showed progression. However, because performance status and fever improved, treatment was continued, and complete remission was confirmed by PET/CT after eight cycles of pembrolizumab. This case suggests that clinicians need to be aware of the potential for pseudoprog-ression in patients treated with pembrolizumab. (Korean J Med 2017;92:415-418)
Asymmetric Sum and Difference Beam Pattern Synthesis With a Common Weight Vector
Kwak, Semin,Chun, Joohwan,Park, Dongmin,Ko, Young Kwan,Cho, Byung Lae IEEE 2016 IEEE antennas and wireless propagation letters Vol.15 No.-
<P>A radar with a large number of antennas requires efficient design in its feeding network or transmit/receive modules (TRMs). We propose a method for simplifying the antenna system of a monopulse radar by attaching a single common weight to each antenna, both for sum and difference beams. A major novelty of our work lies in that the proposed technique can synthesize arbitrarily asymmetric monopulse beams with a common weight vector, using computationally efficient linear programming, not resorting to slow global optimization techniques. Therefore, common-weight monopulse beams can be produced in real time to reject ground clutter or null jamming signals.</P>
두 가지 단계적 접근법을 이용한 30종 화학물질의 안자극성 평가
전혜련 ( Hye Lyun Jeon ),조아랑 ( Ah Rang Cho ),고경육 ( Kyung Yuk Ko ),김주환 ( Joohwan Kim ),정미경 ( Mi Kyung Jeong ),박교현 ( Kyo-hyun Park ),김배환 ( Bae-hwan Kim ),오원준 ( Won Jun Oh ),이종권 ( Jong Kwon Lee ),박기숙 ( Ki S 한국동물실험대체법학회 2020 동물실험대체법학회지 Vol.14 No.1
Various alternative test methods are being developed to replace in vivo Draize rabbit test that evaluates eye irritation. However, a single alternative method has difficulty to be applied in safety evaluation on substances, because it cannot fully replace the in vivo test by simulating only part of the in vivo system. For this reason, different studies using several alternative test methods and test results of literatures have been under way. Our previous study suggested effective tiered approaches using three tests among Short Time Exposure (STE), Bovine Corneal Opacity and Permeability (BCOP), Hen’s Egg Test-Chorioallantoic Membrane (HET-CAM), re-constructed human cornea epitheliums (RhCE) tests. This study aimed to evaluate eye irritation potential for 30 new test chemicals using two tiered approaches. According to the data generated by direct test performance and literature survey, the accuracy, sensitivity and specificity of the two tiered approaches were 83.3%∼86.7%, 93.3%, 73.3%∼ 80%, respectively. Furthermore, the accuracy, sensitivity, and specificity of the two tiered approaches by applying combined data against 30 test chemicals in our present study and 47 test chemicals in previous study were 90.9%∼92.2%, 95.9%∼98.0%, 78.6%∼85.7%. Consequently, the two tiered approaches may be used to identify between irritants and non-irritants to replace in vivo test.
Yong Sun Lee,Jung-Sun Yi,Hye Rim Lim,Tae Sung Kim,Il Young Ahn,Kyungyuk Ko,JooHwan Kim,Hye-Kyung Park,Soo Jung Sohn,Jong Kwon Lee 한국독성학회 2017 Toxicological Research Vol.33 No.1
With ultraviolet and visible light exposure, some pharmaceutical substances applied systemically or topically may cause phototoxic skin irritation. The major factor in phototoxicity is the generation of reactive oxygen species (ROS) such as singlet oxygen and superoxide anion that cause oxidative damage to DNA, lipids and proteins. Thus, measuring the generation of ROS can predict the phototoxic potential of a given substance indirectly. For this reason, a standard ROS assay (ROS assay) was developed and validated and provides an alternative method for phototoxicity evaluation. However, negative substances are over-predicted by the assay. Except for ultraviolet A (UVA), other UV ranges are not a major factor in causing phototoxicity and may lead to incorrect labeling of some non-phototoxic substances as being phototoxic in the ROS assay when using a solar simulator. A UVA stimulator is also widely used to evaluate phototoxicity in various test substances. Consequently, we identified the applicability of a UVA simulator to the ROS assay for photoreactivity. In this study, we tested 60 pharmaceutical substances including 50 phototoxins and 10 non-phototoxins to predict their phototoxic potential via the ROS assay with a UVA simulator. Following the ROS protocol, all test substances were dissolved in dimethyl sulfoxide or sodium phosphate buffer. The final concentration of the test solutions in the reaction mixture was 20 to 200 μM. The exposure was with 2.0~2.2 mW/㎠ irradiance and optimization for a relevant dose of UVA was performed. The generation of ROS was compared before and after UVA exposure and was measured by a microplate spectrophotometer. Sensitivity and specificity values were 85.7% and 100.0% respectively, and the accuracy was 88.1%. From this analysis, the ROS assay with a UVA simulator is suitable for testing the photoreactivity and estimating the phototoxic potential of various test pharmaceutical substances.