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Jonghee Hong,Minji Bang 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.1
Schizophrenia is a debilitating psychiatric disorder with a substantial socioeconomic and humanistic burden. Currently available treatment strategies mostly rely on antipsychotic drugs, which block dopaminergic effects in the mesolimbic pathway of the brain. Although antipsychotic drugs help relieve psychotic symptoms, a definitive cure for schizophrenia has yet to be achieved. Recent advances in neuroinflammation research suggest that proinflammatory processes in the brain could cause alterations in neurobehavioral development and increase vulnerability to schizophrenia. With a growing need for novel strategies in the treatment of schizophrenia, it would be meaningful to review the current evidence supporting the therapeutic potential of anti-inflammatory strategies. This review details the key findings of clinical trials that investigate the efficacy of anti-inflammatory agents as adjuvants to antipsychotic treatment. We further discuss the possibilities of repurposing anti-inflammatory agents and developing novel strategies for the treatment of schizophrenia.
Jonghee Chung,Jin-Hyo Kim,Jae Yoon Lee,Hee Seok Kang,Dong-Wook Lee,Yun-Chul Hong,Mo-Yeol Kang 한국역학회 2022 Epidemiology and Health Vol.45 No.-
OBJECTIVES: Occupational stress management is particularly important for successful business operations, since occupational stress adversely affects workers’ health, eventually lowering their productivity. Therefore, this study aimed to investigate the correlation between occupational stress and health-related productivity loss (HRPL) among Korean workers. METHODS: In 2021, 1,078 workers participated in a web-based questionnaire survey. HRPL was measured using the Work Productivity and Activity Impairment Questionnaire, and occupational stress was measured using the Korean Occupational Stress Scale-Short Form. The occupational stress level was divided into tertiles (low, intermediate, and high), and the low occupational stress group was used as the reference group. Using a generalised linear model, differences in labour productivity loss according to the level of occupational stress were tested after adjusting for demographic characteristics such as age, gender, education level, household income, occupation, and underlying medical conditions. RESULTS: Non-parametric regression analysis of HRPL according to occupational stress showed a direct association between occupational stress and HRPL. A statistically significant difference was observed in HRPL between participants with intermediate and high occupational stress and those with low occupational stress. CONCLUSIONS: Our results support the hypothesis that high occupational stress is associated with decreased labour productivity.
Comparative Evaluation of Voice Activity Detectors in Single Microphone Noise Reduction Algorithms
Jonghee Han,김인영,Dongwook Kim,육순현,남경원,장동표,Sang Min Lee,Sung Hwa Hong 대한의용생체공학회 2012 Biomedical Engineering Letters (BMEL) Vol.2 No.4
Purpose Voice activity detection (VAD) is significantly associated with the performance of single microphone noise reduction algorithms. In this study, the cause and extent of the VAD effect on noise reduction performance were analyzed by comparing conventional VAD algorithms with ideal VAD. Methods A Wiener filter and logMMSE estimator employing various VAD algorithms were implemented using Simulink models and simulated with various 30-second speeches mixed with different noises at -5, 0 and 5 dB SNR. In addition, a noise estimation method not using VAD was also compared to facilitate a more extensive evaluation. The VAD and noise estimation accuracy were analyzed and objective speech quality measures such as fwSNR, PESQ and LLR were calculated. Results Statistical analysis showed that the noise reduction performance using ideal VAD was significantly better than using conventional methods, the performance of which is dependent on noise types and SNR conditions. Conclusions Consequently, there is still much room to improve VAD algorithms to have a high non-speech hit rate and low non-speech false alarm rate for better noise reduction performance in all noisy circumstances.
The Detection of Plant Viruses in Korean Ginseng (Panax ginseng) through RNA Sequencing
Hong-Kyu Lee,So-Yeon Kim,Hee-Ji Yang,Da-Som Lee,Boram Kwon,Dong-Yun Lee,Jonghee Oh,Su-Heon Lee 한국식물병리학회 2020 Plant Pathology Journal Vol.36 No.6
Korean ginseng (Panax ginseng) is a dicotyledonous, medicinal, perennial plant belonging to the genus Panax of the family Araliaceae. We investigated the occurrence and incidence of plant viruses in Panax ginseng in Korea. A total of 656 leaf samples were combined into one and total RNA was extracted from the polled sample, using RNA sequencing (RNA-Seq), a metatranscriptome analysis of the plant virome was conducted. The virus present in Panax ginseng was confirmed by reverse transcription polymerase chain reaction (RT-PCR) assay using virus-specific primers. In RNA-Seq data analysis, the multiplication protein of four viral contigs including Aristotelia chilensis virus 1 (AcV1), Turnip mosaic virus (TuMV), Watermelon mosaic virus (WMV), and Tobamovirus multiplication protein were discovered. From our metatranscriptome analysis and RT-PCR assay, TuMV and WMV were detected, whereas the three viruses reported in China such as tomato yellow leaf curl China virus; panax notoginseng virus A; and panax virus Y were not found in this study. The distribution of domestic ginseng viruses seems different from that recorded in China. Overall, this is the first plant virome analysis of Panax ginseng in Korea.
( Jonghee Han ),( Su Young Yoon ),( Junepill Seok ),( Jin Young Lee ),( Jin Suk Lee ),( Jin Bong Ye ),( Younghoon Sul ),( Seheon Kim ),( Hong Rye Kim ) 대한외상학회 2023 大韓外傷學會誌 Vol.36 No.4
Purpose: In this study, we aimed to compare the characteristics of patients with trauma by age group in a single center in Korea to identify the clinical characteristics and analyze the risk factors affecting mortality. Methods: Patients aged ≥18 years who visited the Chungbuk National University Hospital Regional Trauma Center between January 2016 and December 2022 were included. The accident mechanism, severity of the injury, and outcomes were compared by classifying the patients into group A (18-64 years), group B (65-79 years), and group C (≥80 years). In addition, logistic regression analysis was performed to identify factors affecting death. Results: The most common injury mechanism was traffic accidents in group A (40.9%) and slipping in group B (37.0%) and group C (56.2%). Although group A had the highest intensive care unit admission rate (38.0%), group C had the highest mortality rate (9.5%). In the regression analysis, 3 to 8 points on the Glasgow Coma Scale had the highest odds ratio for mortality, and red blood cell transfusion within 24 hours, intensive care unit admission, age, and Injury Severity Score were the predictors of death. Conclusions: For patients with trauma, the mechanism, injured body region, and severity of injury differed among the age groups. The high mortality rate of elderly patients suggests the need for different treatment approaches for trauma patients according to age. Identifying factors affecting clinical patterns and mortality according to age groups can help improve the prognosis of trauma patients in the future.