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Ahn, Ji-Hyun,Lee, Tae-Hyeong,Oh, Jong-Soo,Kim, Su-Yeon,Kim, Hyun-Jung,Park, Il-Kyu,Choi, Baek-Sun,Im, Gun-Ii Mary Ann Liebert 2009 Tissue engineering. Part A Vol.15 No.9
<P>The authors devised a novel biphasic scaffold combining hyaluronic acid and atelocollagen for the chondral phase and combining hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP) for the osseous phase. The biphasic scaffold was fabricated by placing the freeze-dried chondral phase over the HA/beta-TCP scaffold prewetted with hyaluronate/atelocollagen solution. Chondrocytes were isolated in 28 rabbits, expanded, injected inside the chondral phase of the biphasic scaffold, and then cultured in chondrogenic medium. After 2 weeks of in vitro culture, chondrocytes had evenly infiltrated inside the chondral phase and produced extracellular matrix. For in vivo study, a large osteochondral defect was made on the patellar groove of the right distal femur and managed using one of the following methods: filling with cell-biphasic scaffold composite (group I); implanting only biphasic scaffold (group II); placing the removed osteochondral fragments back into the defect (group III, positive control); leaving empty (group IV, negative control). Seven rabbits were allocated to each group. After 12 weeks, the International Cartilage Repair Society Macroscopic Score was highest in group III, followed by group I, group II, and lastly group IV. Depression of the defect was greatest in group IV. There were three rabbits (two in group I and one in group II) that were completely denuded of the chondral phase. The junction to adjacent native cartilage was distinct in rabbits of all groups. The International Cartilage Repair Society Visual Histological Score was highest in group III, followed by groups II and I, and lastly group IV. In conclusion, our results suggest that a biphasic osteochondral composite using a chondral phase consisting of hyaluronate and atelocollagen and an osseous phase consisting of HA and beta-TCP holds the promise for repair of osteochondral defects.</P>
Hwang, Jong-ho,Choi, Cheol Woong,Kim, Hyung-Wook,Kim, Do Hyung,Kwak, Tae Won,Lee, Hye Myeong,Kim, Cy hyun,Chung, Chung Wook,Jeong, Young-II,Kang, Dae Hwan Dove Medical Press 2013 International journal of nanomedicine Vol.8 No.-
<P><B>Purpose</B></P><P>Nanoparticles based on stimuli-sensitive drug delivery have been extensively investigated for tumor targeting. Among them, pH-responsive drug targeting using pH-sensitive polymers has attracted attention because solid tumors have an acidic environment. A dextran-<I>b</I>-poly(<I>L</I>-histidine) (DexPHS) copolymer was synthesized and pH-responsive nanoparticles were fabricated for drug targeting.</P><P><B>Methods and results</B></P><P>A DexPHS block copolymer was synthesized by attaching the reductive end of dextran to the amine groups of poly(L-histidine). pH-responsive nanoparticles incorporating doxorubicin were fabricated and studied in HuCC-T1 cholangiocarcinoma cells. Synthesis of DexPHS was confirmed by 1H nuclear magnetic resonance spectroscopy, with specific peaks of dextran and PHS observed at 2–5 ppm and 7.4–9.0 ppm, respectively. DexPHS nanoparticles showed changes in particle size with pH sensitivity, ie, the size of the nanoparticles increased at an acidic pH and decreased at a basic pH. DexPHS block copolymer nanoparticles incorporating doxorubicin were prepared using the nanoprecipitation dialysis method. The doxorubicin release rate was increased at acidic pH compared with basic pH, indicating that DexPHS nanoparticles have pH-sensitive properties and that drug release can be controlled by variations in pH. The antitumor activity of DexPHS nanoparticles incorporating doxorubicin were studied using HuCC-T1 cholangiocarcinoma cells. Viability was decreased in cells treated with nanoparticles at acidic pH, whereas cell viability in response to treatment with doxorubicin did not vary according to changes of pH.</P><P><B>Conclusion</B></P><P>Our results indicated that DexPHS polymeric micelles are promising candidates for antitumor drug targeting.</P>
권일범 ( Kwon Ii-bum ),김치엽 ( Kim Chi-yeop ),최만용 ( Choi Man-yong ),임종묵 ( Lim Jong-mook ),김인걸 ( Kim In-gul ) 한국구조물진단유지관리공학회 2000 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.4 No.1
PVDF film sensor was applied to measure the stress concentration for monitoring the structur The strain calibration of this film sensor was performed by aluminum beam test. The PVDF se the electrical strain gage were bonded on the beam. When the beam was loaded, the output of strain gage was compared with the output of the PVDF sensor. The waveform of PVDF sensor outpu shown as the same form of the output of electrical strain gage. The gain was determined comparing these two signals to determine the exact value of the strain. The tensile test of specimens was conducted to develop the measurement technique of stress concentration. The outp ratio between the PVDF sensor near the notch and the PVDF sensor far from the notch could g information about the load bearing capacity of steel specimen.
Bone Marrow Mononuclear Cells Have Neurovascular Tropism and Improve Diabetic Neuropathy
Kim, Hyongbum,Park, Jong-seon,Choi, Yong Jin,Kim, Mee-Ohk,Huh, Yang Hoon,Kim, Sung-Whan,Han, Ji Woong,Lee, JiYoon,Kim, Sinae,Houge, Mackenzie A.,Ii, Masaaki,Yoon, Young-sup Wiley (John WileySons) 2009 Stem Cells Vol.27 No.7
<P>Bone marrow-derived mononuclear cells (BMNCs) have been shown to effectively treat ischemic cardiovascular diseases. Because diabetic neuropathy (DN) is causally associated with impaired angiogenesis and deficiency of angiogenic and neurotrophic factors in the nerves, we investigated whether DN can be ameliorated by local injection of BMNCs. Severe peripheral neuropathy, characterized by a significant decrease in the motor and sensory nerve conduction velocities (NCVs), developed 12 weeks after the induction of diabetes with streptozotocin in rats. The injection of BMNCs restored motor and sensory NCVs to normal levels and significantly improved vascular density and blood flow in diabetic nerves over 4 weeks. Fluorescent microscopic observation revealed that DiI-labeled BMNCs preferentially engrafted in sciatic nerves. Whole-mount fluorescent imaging and confocal microscopic evaluation demonstrated that many of the BMNCs localized following the course of the vasa nervorum in close proximity to blood vessels without incorporation into vasa nervorum as endothelial cells at a detectable level. Real-time reverse transcription-polymerase chain reaction analysis showed that the levels of angiogenic and neurotrophic factors were significantly increased in the nerves by BMNC injection. Local transplantation of BMNCs improved experimental DN by augmenting angiogenesis and increasing angiogenic and neurotrophic factors in peripheral nerves. These findings suggest that BMNC transplantation may represent a novel therapeutic option for treating DN.</P>