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Detection of Differentially Expressed Gene Sets in a Partially Paired Microarray Data Set
Lim, Johan,Kim, Jayoun,Kim, Sang-cheol,Yu, Donghyeon,Kim, Kyunga,Kim, Byung Soo Walter de Gruyter GmbH 2012 Statistical applications in genetics and molecular Vol.11 No.3
<P>Partially paired data sets often occur in microarray experiments (Kim et al., 2005; Liu, Liang and Jang, 2006). Discussions of testing with partially paired data are found in the literature (Lin and Stivers 1974; Ekbohm, 1976; Bhoj, 1978). Bhoj (1978) initially proposed a test statistic that uses a convex combination of paired and unpaired t statistics. Kim et al. (2005) later proposed the t3 statistic, which is a linear combination of paired and unpaired t statistics, and then used it to detect differentially expressed (DE) genes in colorectal cancer (CRC) cDNA microarray data. In this paper, we extend Kim et al.'s t3 statistic to the Hotelling's T2 type statistic Tp for detecting DE gene sets of size p. We employ Efron's empirical null principle to incorporate inter-gene correlation in the estimation of the false discovery rate. Then, the proposed Tp statistic is applied to Kim et al's CRC data to detect the DE gene sets of sizes p=2 and p=3. Our results show that for small p, particularly for p=2 and marginally for p=3, the proposed Tp statistic compliments the univariate procedure by detecting additional DE genes that were undetected in the univariate test procedure. We also conduct a simulation study to demonstrate that Efron's empirical null principle is robust to the departure from the normal assumption.</P>
Performance evaluation of the Abbott RealTime HCV Genotype II for hepatitis C virus genotyping
Sohn, Yong-Hak,Ko, Sun-Young,Kim, Myeong Hee,Oh, Heung-Bum Walter de Gruyter GmbH 2010 Clinical chemistry and laboratory medicine Vol.48 No.4
<P>The Abbott RealTime hepatitis C virus (HCV) Genotype II (Abbott Molecular Inc.) for HCV genotyping, which uses real-time PCR technology, has recently been developed.</P>
Association of the CD28/CTLA4/ICOS polymorphisms with susceptibility to rheumatoid arthritis
Kim, Young Ock,Kim, Hak Jae,Kim, Su Kang,Chung, Joo-Ho,Hong, Seung-Jae Walter de Gruyter GmbH 2010 Clinical chemistry and laboratory medicine Vol.48 No.3
<P>Rheumatoid arthritis (RA) is currently thought to be an immune-mediated disease where the host's genes and environmental factors interact. Some of the immuno-regulatory genes that are responsible for an individual's susceptibility to RA have been identified. The co-stimulatory receptor gene cluster on chromosome 2q33 encodes for both the positive T-cell regulators CD28 molecule (CD28) and inducible T-cell co-stimulator (ICOS), and the negative regulator cytotoxic T-lymphocyte-associated protein 4 (CTLA4). The CTLA4 gene has been implicated in several immune-mediated diseases, but it is not known whether RA is associated with any of these genes.</P>
Characterization Of Cladding Hull Wastes From Used Nuclear Fuels
Kang, K.H.,Lee, C.H.,Jeon, M.K.,Han, S.Y.,Park, G.I.,Hwang, S.-M. Walter de Gruyter GmbH 2015 Archives of metallurgy and materials Vol.60 No.2
<B>Abstract</B><P>Used cladding hulls from pressurized water reactor (PWR) are characterized to provide useful information for the treatment and disposal of cladding hull wastes. The radioactivity and the mass of gamma emitting nuclides increases with an increase in the fuel burn-up and their removal ratios are found to be more than 99 wt.% except Co-60 and Cs-137. In the result of measuring the concentrations of U and Pu included in the cladding hull wastes, most of the residues are remained on the surface and the removal ratio of U and Pu are revealed to be over 99.98 wt.% for the fuel burn-up of 35,000 MWd/tU. An electron probe micro-analyzer (EPMA) line scanning shows that radioactive fission products are penetrated into the Zr oxide layer, which is proportional to the fuel burn-up. The oxidative decladding process exhibits more efficient removal ratio of radionuclides.</P>
Secretion of the Antibacterial Recombinant Protein Enbocin
Goo, Tae Won,Yun, Eun Young,Kim, Sung Wan,Choi, Kwang Ho,Kang, Seok Woo,Kwon, Kisang,Choi, Joung-Soon,Kwon, O-Yu Walter de Gruyter GmbH 2008 Zeitschrift fur Naturforschung. Section C Vol.63 No.3
<P>The insect baculovirus expression vector system (BEVS) is useful for the production of biologically active recombinant proteins. However, the overexpression of foreign proteins in this system often results in misfolded proteins and the formation of protein aggregates. To overcome this limitation, we have developed a versatile baculovirus expression and secretion system using the Bombyx mori protein disulfide isomerase (bPDI) as a fusion partner. bPDI gene fusion improved the secretion and antibacterial activity of recombinant enbocin proteins. Thus, bPDI gene fusion is a useful addition to the BEVS for the large-scale production of bioactive recombinant proteins</P>