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다양한 형태의 사물데이터 질의 처리를 위한 단일 색인 및 시각화 방안
한진주(Jinju Han),나철원(Chul-Won Na),이다희(Dahee Lee),이도훈(Do-Hoon Lee),온병원(Byung-Won On),이용(Ryong Lee),박민우(Min-Woo Park),이상환(Sang-Hwan Lee) 한국컴퓨터정보학회 2019 韓國컴퓨터情報學會論文誌 Vol.24 No.9
Recently, a variety of IoT data is collected by attaching geosensors to many vehicles that are on the road. IoT data basically has time and space information and is composed of various data such as temperature, humidity, fine dust, Co2, etc. Although a certain sensor data can be retrieved using time, latitude and longitude, which are keys to the IoT data, advanced search engines for IoT data to handle high-level user queries are still limited. There is also a problem with searching large amounts of IoT data without generating indexes, which wastes a great deal of time through sequential scans. In this paper, we propose a unified spatial index model that handles both grid and trajectory queries using a cell-based space-filling curve method. also it presents a visualization method that helps user grasp intuitively. The Trajectory query is to aggregate the traffic of the trajectory cells passed by taxi on the road searched by the user. The grid query is to find the cells on the road searched by the user and to aggregate the fine dust. Based on the generated spatial index, the user interface quickly summarizes the trajectory and grid queries for specific road and all roads, and proposes a Web-based prototype system that can be analyzed intuitively through road and heat map visualization.
Rasch 분석을 활용한 일터에서의 목표지향성 측정도구 타당화 연구
이진주(Lee, Jinju),문찬영(Moon, Chanyeong),이진주(Lee, Jinju) 한국경영교육학회 2024 경영교육연구 Vol.39 No.3
[연구목적] 본 연구의 목적은 기존 학업 맥락에서 개발되었던 목표지향성 측정도구가 국내 일터 맥락에서 사용될 수 있도록 측정도구의 적용성 및 전반적 유용성을 제고하고, Rasch 분석을 활용하여 측정도구를 타당화 하는 것이다. [연구방법] 국내 일터 맥락을 반영하기 위하여 선행연구 검토와 2차에 걸친 전문가 번역과정을 통해 예비문항을 도출하였다. 이후 국내 성인 근로자 300명을 대상으로 데이터를 수집하였으며, 요인분석, Rasch 분석을 활용하여 목표지향성 측정도구의 개별 문항의 적합도, 곤란도, 응답 범주의 적절성 등을 확인하였다. [연구결과] 첫째, 요인분석을 통해 3개의 하위요인 구조의 타당성을 확인하였다. 둘째, Rasch 분석 결과, 적합도가 기준에 미치지 못하는 3개 문항을 식별하였고, 문항 곤란도와 응답 범주의 적절성을 종합적으로 고려하여 국내 일터에서 활용하기 위한 재검토 방안을 논의하였다. 마지막으로 목표지향성 측정도구는 수용할 수 있는 수준의 신뢰도를 확보하였다. [연구의 시사점] 이상의 과정을 통해 학문적으로는 이론 및 통계적으로 타당한 측정도구를 제안하여 보다 정확한 해석을 통해 연구의 신뢰도를 제고하였으며, 실천적으로는 조직 구성원들의 목표지향성 수준을 측정 및 변별할 수 있는 시사점을 제공하였다. [Purpose] The purpose of this study is to validate goal orientation measurement in the workplace context and improve the applicability and overall usefulness of the measurement using Rasch analysis. [Methodology] In order to reflect the domestic workplace context, a set of preliminary items were derived through a literature review and experts’ validation process. Then, data were collected from 300 workers in Korea. The item suitability, difficulty, and appropriateness of response categories were confirmed using Rasch analysis. [Findings] First, the validity of the three-factor structure was confirmed through factor analysis. Second, Rasch analysis identified three items that did not meet the fit criteria, and a discussion was conducted considering both item difficulties and the category probability curves. Finally, the goal orientation measurement achieved an acceptable level of reliability. [Implications] This study proposes a theoretically valid measurement which enhances the reliability of research based on more accurate interpretations. Practically, it provides implications for measuring the levels of goal orientation among workplace members.
Lee, Jinju,Ahn, Hyung Jun Elsevier 2018 Biochemical and biophysical research communication Vol.503 No.3
<P><B>Abstract</B></P> <P>Although siRNA-mediated downregulation technology has been highly successful in suppressing the expression of any disease-related gene, systemic delivery of siRNA for the clinical applications remains challenging, especially in the use of cancer therapy. DC-Chol/DOPE cationic liposomes as one of the most attractive vehicles for gene delivery have been widely exploited for transfection of siRNA into cells, but complexity of systemic delivery has allowed only their direct injection into local targets due to the formation of aggregations with negatively-charged blood components. Herein, we demonstrate the effects of PEGylation on DC-Chol/DOPE cationic liposomes for systemic siRNA delivery in cancer therapy. In contrast to non-PEGylated DC-Chol/DOPE-siRNA lipoplexes, PEGylated DC-Chol/DOPE-siRNA lipoplexes reduce the excretion by kidneys and scavenging in liver, prolonging the circulation time <I>in vivo</I>, and ultimately increase their preferential tumor accumulation. Therefore, systemic injection of PEGylated DC-Chol/DOPE liposomes loaded with siRNA against kinesin spindle protein (KSP) gene exhibited a high level of target gene silencing at tumor sites and substantial suppression of tumor growth. Furthermore, systemically administered PEGylated lipoplexes did not lead to any activation of innate immune responses in the immunocompetent mice. These results suggest the potential of PEGylated DC-Chol/DOPE liposomes as a systemic delivery carrier for siRNA-mediated cancer therapy.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Lee, Dong-Sung,Ko, Wonmin,Yoon, Chi-Su,Kim, Dong-Cheol,Yun, Jinju,Lee, Jun-Kyung,Jun, Ki-Young,Son, Ilhong,Kim, Dong-Woung,Song, Bong-Keun,Choi, Seulah,Jang, Jun-Hyeog,Oh, Hyuncheol,Kim, Sungchul,Kim, Hindawi Publishing Corporation 2014 Evidence-based Complementary and Alternative Medic Vol.2014 No.-
<P>The brain is vulnerable to oxidative stress and inflammation that can occur as a result of aging or neurodegenerative diseases. Our work has sought to identify natural products that regulate heme oxygenase (HO)-1 and to determine their mechanism of action in neurodegenerative diseases. KCHO-1 is a novel herbal therapeutic containing 30% ethanol (EtOH) extracts from nine plants. In this study, we investigated the antineuroinflammatory effects of KCHO-1 in lipopolysaccharide- (LPS-) treated mouse BV2 microglia. KCHO-1 inhibited the protein expression of inducible nitric oxide synthase (iNOS), iNOS-derived nitric oxide (NO), cyclooxygenase- (COX-) 2, and COX-2-derived prostaglandin E2 (PGE<SUB>2</SUB>) in LPS-stimulated BV2 microglia. It also reduced tumor necrosis factor-<I>α</I> (TNF-<I>α</I>), interleukin-1<I>β</I> (IL-1<I>β</I>), and IL-6 production. This effect was correlated with the suppression of inhibitor of nuclear factor kappa B-<I>α</I> (I<I>κ</I>B-<I>α</I>) phosphorylation and degradation and nuclear factor kappa B (NF-<I>κ</I>B) translocation and DNA binding. Additionally, KCHO-1 upregulated HO-1 expression by promoting nuclear translocation of nuclear factor E2-related factor 2 (Nrf2) in mouse BV2 microglia. Tin protoporphyrin (SnPP), an HO activity inhibitor, was used to verify the inhibitory effects of KCHO-1 on proinflammatory mediators and proteins associated with HO-1 expression. Our data suggest that KCHO-1 has therapeutic potential in neurodegenerative diseases caused by neuroinflammation.</P>
Jinju Lee,Youngsin Han,조현희,김미란 대한폐경학회 2019 대한폐경학회지 Vol.25 No.2
Sleep disorders are one of the main symptoms of menopause. Symptoms of sleep disorders that menopausal women complain about include falling asleep, frequent awakening and/or early morning awakening. There are many possible causes of sleep disorders in postmenopausal women, including vasomotor symptoms, ovarian hormone changes, restless legs syndrome, periodic leg movement syndrome, and obstructive sleep apnea. In this review, we discuss the relationship between menopause and sleep disorders.
Fluorogenic reaction-based prodrug conjugates as targeted cancer theranostics
Lee, Min Hee,Sharma, Amit,Chang, Min Jung,Lee, Jinju,Son, Subin,Sessler, Jonathan L.,Kang, Chulhun,Kim, Jong Seung The Royal Society of Chemistry 2018 Chemical Society reviews Vol.47 No.1
<P>Theranostic systems are receiving ever-increasing attention due to their potential therapeutic utility, imaging enhancement capability, and promise for advancing the field of personalized medicine, particularly as it relates to the diagnosis, staging, and treatment of cancer. In this Tutorial Review, we provide an introduction to the concepts of theranostic drug delivery effected <I>via</I> use of conjugates that are able to target cancer cells selectively, provide cytotoxic chemotherapeutics, and produce readily monitored imaging signals <I>in vitro</I> and <I>in vivo</I>. The underlying design concepts, requiring the synthesis of conjugates composed of imaging reporters, masked chemotherapeutic drugs, cleavable linkers, and cancer targeting ligands, are discussed. Particular emphasis is placed on highlighting the potential benefits of fluorogenic reaction-based targeted systems that are activated for both imaging and therapy by cellular entities, <I>e.g.</I>, thiols, reactive oxygen species and enzymes, which are present at relatively elevated levels in tumour environments, physiological characteristics of cancer, <I>e.g.</I>, hypoxia and acidic pH. Also discussed are systems activated by an external stimulus, such as light. The work summarized in this Tutorial Review will help define the role fluorogenic reaction-based, cancer-targeting theranostics may have in advancing drug discovery efforts, as well as improving our understanding of cellular uptake and drug release mechanisms.</P>
( Jinju Oh ),( Hyun Joo Lee ),( Tae Sung Lee ),( Ju Hyun Kim ),( Suk Bong Koh ),( Youn Seok Choi ) 대한산부인과학회 2016 Obstetrics & Gynecology Science Vol.59 No.4
Objective The objective of this study was to evaluate the clinical benefits of routine squamous cell carcinoma antigen (SCC-Ag) monitoring of patients with locally advanced cervical squamous cell carcinoma treated with radiation or chemoradiation. Methods A total of 53 patients with recurrent cervical squamous cell carcinoma treated with radiotherapy or chemoradiation were enrolled in this study. A retrospective review of medical records was conducted. The role of routine monitoring of serum SCC-Ag was evaluated in terms of cost effectiveness and effect on survival after diagnosis of recurrence. Results Serum SCC-Ag abnormality (≥2.5 ng/mL) was observed in 62.3% of patients when recurrent disease was diagnosed. The first indicator of relapse was abnormal serum SCC-Ag level in 21 patients (39.6%), 10 of whom had asymptomatic recurrent disease amenable to salvage therapy. Adding SCC-Ag measurement to the basic follow up protocol improved the sensitivity for detecting recurrence (The sensitivity of the basic protocol vs. addition of SCC-Ag: 49.1% vs. 88.7%, P<0.001). Twenty-three patients who were candidates for salvage therapy with curative intent showed better survival compared with those who were not candidates for therapy (5-year survival: 36.6% vs. 0%, P=0.012). Conclusion Surveillance with routine serum SCC-Ag monitoring can better detect asymptomatic recurrent disease that is potentially amenable to salvage therapy with curative intent. Early diagnosis of recurrent disease that can be treated with salvage therapy may lead to better survival.