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Chemical Constituents from the Leaf and Twig of Acer okamotoanum Nakai and their Cytotoxicity
Wen-Yi Jin,Byung-Sun Min,Ui-Jung Youn,Tran-Manh Hung,Kyung-Sik Song,Yeon-Hee Seong,Ki-Hwan Bae 韓國藥用作物學會 2006 한국약용작물학회지 Vol.14 No.2
As a result of cytotoxic compounds against cancer cell lines from natural sources, senven compounds were isolated from the leaf and twig of Acer okamotoanum Nakai. The compounds (1-7) were identified as ethyl gallate (1), methyl gallate (2), gallic acid (3), trans resveratrol-3-O-β-D-glucopyranoside (4), acertannin (5), nikoenoside (6), and fraxin (7) by physicochemical and spectroscopic data (including mp, UV, IR, MS, 1H-NMR, 13C-NMR, DEPT, and HMBC) in comparison with those of published papers. All the compounds were tested for their cytotoxic activity against L1210, HL-60, K562, and B16F10 cancer cell lines in vitro by MTT assay method. Compounds 1-3 and 5 showed cytotoxic activity against all tested cell lines with IC50 values ranged from 12.5 to 72.2 μM. Of the compounds, methyl gallate (2) exhibited the most potent cytotoxic activity against L1210, HL-60, K562, and B16F10 tumor cells with IC50 values of 12.5, 48.3, 22.8, and 22.8 μM, respectively. Other compounds did not show any cytotoxic activity against four cancer cell lines.
Antioxidant Activity of Cleomiscosins A and C Isolated from Acer okamotoanum
Wen Yi Jin,Phuong Thien Thuong,Nguyen Duy Su,민병선,손건호,장현욱,김현표,강삼식,석대은,배기환 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.3
Phytochemical investigation of Acer okamotoanum leaf and twig led to the isolation of two coumarinolignans, cleomiscosin A (1) and cleomiscosin C (2). Here, we found that 2 dose-dependently inhibits LDL oxidation mediated by either catalytic copper ions (Cu2+) or free radicals generated with the azo compound 2,2'-azobis-(2-amidinopropane)dihydro-chloride (AAPH) with IC50s of 29.5 and 11.9 µM, respectively. By electrophoretic analysis, we also observed that 2 protects apolipoprotein B-100 (apoB-100) against Cu2+-induced fragmentation (65.3% inhibition at 5 µM). Furthermore, fluorescence analyses clearly indicated that both 1 and 2 protect against the oxidative modification of apoB-100 induced by either Cu2+ or HOCl (1, IC50s of 13.4 and 8.1 µM, respectively; 2, IC50s of 23.6 and 3.9 µM, respectively). These findings suggest that 1 and 2 could be beneficial in preventing LDL oxidation in atherosclerotic lesions.
Yi-Xin Zou,Jia Qiao,Hua-Yuan Zhu,Rui-Nan Lu,Yi Xia,Lei Cao,Wei Wu,Hui Jin,Wen-Jie Liu,Jin-Hua Liang,Jia-Zhu Wu,Li Wang,Lei Fan,Wei Xu,Jian-Yong Li 대한암학회 2019 Cancer Research and Treatment Vol.51 No.2
Purpose Chronic lymphocytic leukemia (CLL) is one of the most frequent type of B-cell chronic lymphoproliferative disorders and chronic inflammation takes part in the development of CLL. However, there has been no valid immune biomarker to predict the prognosis of untreated CLL patients. Materials and Methods In this retrospective study, we analyzed the clinical correlations and prognostic value of albumin-to-fibrinogen ratio (AFR) detected at diagnosis in 191 CLL patients. Results The cut-off value of AFR was 9.7 calculated by X-tile. Patients who were more than 65 years old were often accompanied by low level of AFR (p < 0.001). Survival analysis showed that patients with low level of AFR had shorter overall survival (OS) than patients with high level of AFR (p < 0.001). Multivariate analysis illustrated that AFR had a negative impact on OS (p=0.003) and was independent of parameters involved in CLL international prognostic index and other prognostic markers such as CD38 and ZAP-70. Conclusion These data provide a comprehensive view of AFR and shows that AFR at diagnosis is an adverse prognostic factor in untreated CLL patients.
Chemical Constituents from the Leaf and Twig of Acer okamotoanum Nakai and their Cytotoxicity
Jin, Wen-Yi,Min, Byung-Sun,Youn, Ui-Jung,Hung, Tran-Manh,Song, Kyung-Sik,Seong, Yeon-Hee,Bae, Ki-Hwan The Korean Society of Medicinal Crop Science 2006 한국약용작물학회지 Vol.14 No.2
As a result of cytotoxic compounds against cancer cell lines from natural sources, senven compounds were isolated from the leaf and twig of Acer okamotoanum Nakai. The compounds (1-7) were identified as ethyl gallate (1), methyl gallate (2), gallic acid (3), trans $resveratrol-3-O-{\beta}-D-glucopyranoside$ (4), acertannin (5), nikoenoside (6), and fraxin (7) by physicochemical and spectroscopic data (including mp, UV, IR, MS, $^1H-NMR,\;^{13}C-NMR$, DEPT, and HMBC) in comparison with those of published papers. All the compounds were tested for their cytotoxic activity against L1210, HL-60, K562, and B16F10 cancer cell lines in vitro by MTT assay method. Compounds 1-3 and 5 showed cytotoxic activity against all tested cell lines with $IC_{50}$ values ranged from 12.5 to $72.2\;{\mu}M$. Of the compounds, methyl gallate (2) exhibited the most potent cytotoxic activity against L1210, HL-60, K562, and B16F10 tumor cells with $IC_{50}$ values of 12.5, 48.3, 22.8, and $22.8\;{\mu}M$, respectively. Other compounds did not show any cytotoxic activity against four cancer cell lines.
Wen Yi Jin,김승형,김호경,장동규,남정범,강영민,황방연,김동선 한국한의학연구원 2013 Integrative Medicine Research Vol.2 No.2
Background: Agents currently used for the treatment and prevention of thrombosis have a number of side effects. We conducted this study to develop antithrombotic agents from herbs that are used in food. Methods: The 80% (v/v) ethanol extracts of Phyllostachys pubescens leaf (PL) and Mume Fructus (MF) and their combinations—2:1 (PM21), 1:1 (PM11), and 1:2 (PM12)—were evaluated on rat platelet aggregation induced by adenosine diphosphate (ADP) in vitro and on arteriovenous shunt thrombosis after 3 days of oral treatment in rats in vivo. Results: At 100 μg/mL, PM21 and PM11 inhibited in vitro ADP-induced aggregation by 44.0 ± 4.3% and 30.0 ± 3.2%, respectively, whereas PL, MF, and PM12 weakly or scarcely inhibited ADP-induced aggregation by 3.9 ± 3.2%, 13.0 ± 2.7%, and 5.2 ± 1.3%, respectively. The IC50 values of PM21 on ADP-, collagen-, and thrombin-induced platelet aggregations were 135.6 ± 7.4 μg/mL, 142.7 ± 5.8 μg/mL, and 186.5 ± 9.7 μg/mL, respectively. In an in vivo rat arteriovenous-shunt thrombosis model, thrombus weight was significantly decreased after the oral administration of 400 mg/kg PL (27.8 ± 3.0%, p < 0.01) or MF (35.2 ± 2.1%, p < 0.01), and with a good accord to the in vitro results, the combination of PL and MF in the ratio of 2:1, PM21 (60.9 ± 1.2%, p < 0.001), showed a superior antithrombotic effect to those of individual extracts. At dosages of 200 mg/kg, 100 mg/kg, and 50 mg/kg, PM21 dose-dependently decreased thrombosis weight (ED50, 314 mg/kg). Conclusion: These results suggest that combination preparations of PL and MF, especially their 2:1 combination, can increase antiplatelet and antithromboticeffects more than PL and MF alone, offering evidence for a potential novel combination antithrombotic therapy.
Triterpenoids and Diarylheptainoids from Alnus hirsuta Inhibit HIF-1 in AGS Cells
Jin, Wen-Yi,Cai, Xing-Fu,Na, Min-Kyun,Lee, Jung-Joon,Bae, Ki-Hwan 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.4
Bioassay-guided fractionation and purification of the EtOAc soluble fraction from the MeOH extract of the stem bark of Alnus hirsuta (Betulaceae), using an in vitro HIF-1 assay, led to the isolation of four triterpenoids (1-4) and six diarylheptanoids (5-10). Their structures were deter-mined by comparison with the physicochemical and spectroscopic data in the literature. These compounds were investigated for their effects on the hypoxia-induced HlF-1 activation using an HIF-1 a mediated reporter gene assay in AGS cells. Among them, two diarylheptanoids, 2-oxatrycyclo[13.2.2.13,7]eicosa-3,5,7(20),15,17,18-hexaen-10-16-diol (6) and 2-oxatrycyclo[13.2.2.13,7]eicosa-3,5,7-(20),15,17,18-hexaen-10-one (7), inhibited HIF-1 activation dose-dependently with IC$_{50}$ values of 11.2 ${\mu}$M and 12.3 ${\mu}$M, respectively. These two compounds had no significant cytotoxicity to the AGS cells at the effective concentration for the inhibition of HIF-1 activation.
Isolation of Constituents and Anti-complement Activity from Acer okamotoanum
Jin, Wen-Yi,Min, Byung-Sun,Lee, Jong-Pill,Thuong, Phuong Thien,Lee, Hyeong-Kyu,Song, Kyung-Sik,Seong, Yeon-Hee,Bae, Ki-Hwan 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.2
A novel acylated sterol glucoside (1) along with four known compounds, ${\beta}$-amyrin acetate (2), 3${\beta}$,24-dihydroxytaraxer-14-ene (3), cleomiscosin A (4), and cleomiscosin C (5), were isolated from the leaf and twig of Acer okamotoanum Nakai (Aceraceae). The structure of the new compound was determined to be ${\beta}$-sitosterol glucoside-3'-O-hexacosanoicate based on chemical and spectroscopic analyses. In addition, the novel compound was found to exhibit a significant inhibitory effect (IC$_{50}$ value of 0.2 ${\mu}$M) on the complement system activated by the classical pathway.
Thermo-mechanical stress analysis of feed-water valves in nuclear power plants
Wen-qing Li,Lei Zhao,Yang Yue,Jia-yi Wu,Zhi-jiang Jin,Jin-yuan Qian 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.3
Feed-water valves (FWVs) are used to regulate the flow rate of water entering steam generators, whichare very important devices in nuclear power plants. Due to the working environment of relatively highpressure and temperature, there is strength failure problem of valve body in some cases. Based on thethermo-fluid-solid coupling model, the valve body stress of the feed-water valve in the opening processis investigated. The flow field characteristics inside the valve and temperature change of the valve bodywith time are studied. The stress analysis of the valve body is carried out considering mechanical stressand thermal stress comprehensively. The results show that the area with relatively high-velocity areamoves gradually from the bottom of the cross section to the top of the cross section with the increase ofthe opening degree. The whole valve body reaches the same temperature of 250C at the time of 1894 s. The maximum stress of the valve body meets the design requirements by stress assessment. This workcan be referred for the design of FWVs and other similar valves.