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( Jianhua Liang ),( Hui Qu ),( Xiaowen Wang ),( Aiping Wang ),( Lingling Liu ),( Ping Tu ),( Ruoyu Li ),( Mingyue Wang ) 대한피부과학회 2018 Annals of Dermatology Vol.30 No.1
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a hypersensitivity reaction characterized by maculopapular rash, exfoliative dermatitis, lymphadenopathy, fever, eosinophilia, and involvement of internal organs. Evidence for reactivation of herpes family viruses has been observed in some DRESS patients, and activated CD8+ T lymphocytes are largely directed against Epstein-Barr virus. Here, we report two cases complicated with this infection. Both patients received antibiotics and non-steroidal anti-inflammatory drugs. These patients manifested clinically with high fever, facial edema, diffuse pruritic erythroderma and maculopapules over the entire body, purpuric rashes in both lower limbs and lymphadenopathy of cervical and inguinal nodes. Laboratory tests revealed abnormal liver function, blood eosinophils, and ferritin levels. The patients recovered completely; however, the female patient developed hemophagocytic syndrome on the 15th day of illness. She developed new itchy rash, and laboratory tests rapidly worsened with fibrinogen levels dramatically reduced to 0.61 g/L. Bone marrow aspiration revealed an increased number of macrophages with hemophagocytosis and a reversed CD4/CD8 ratio of 0.45. These cases suggest that human herpes virus and coagulation function evaluations are necessary in DRESS patients. (Ann Dermatol 30(1) 71∼74, 2018)
Jixin Wang,Jianhua Zhang,Yunlong Liang,Yonghai Yang 대한기계학회 2012 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.26 No.5
"The present paper focuses on the simulation of the non-stationary load histories of engineering vehicles for fatigue tests. For the first time, the characteristics of the service loads experienced by engineering vehicles are described. Then rainflow data-reduction contributing to reduce the testing time and extrapolation of each operating section to generate the unavailable extreme loads in a limit test are carried out. Finally, based on the simulated load history of each operating section using Markov chain Monte Carlo method (MCMC) and the corresponding simulation length generated by the Monte Carlo method, a cyclic simulation approach is proposed to generate nonstationary load histories, by which the cyclic characteristic can be reconstructed well. The results of comparison between the observed and simulated load histories show good agreement."
Separation and Characterization of Organic Chlorides in a Chinese Crude Oil
Xiaohui Li,Rui Ma,Liang Ding,Huiying Yuan,Bencheng Wu,Jianhua Zhu 대한화학회 2018 Bulletin of the Korean Chemical Society Vol.39 No.4
A crude oil from Shengli oilfield of China was extracted with N,N‐dimethylformamide (DMF) for separation and enrichment of organic chlorides. The resulting extract with relatively higher chlorine concentration was analyzed with gas chromatography–mass spectrometry (GC/MS). Among the identified heteroatom compounds in the extract sample, nitrogen‐containing compounds were most abundant in the extract sample, followed by chlorine‐, sulfur‐, and oxygen‐containing compounds, respectively. Four organochlorines with an aromatic core structure, i.e., 5‐chloro‐2‐methylaniline, 2‐chloro‐6‐methylaniline, 4‐chloro‐2‐nitrotoluene, and 1‐(5‐chloro‐2‐hydroxyphenyl)ethanone, were identified from crude oil extract. The dominant abundant organic chloride is 5‐chloro‐2‐methylaniline with relative content of 65.1% in the total of identified organic chlorides, followed by 1‐(5‐chloro‐2‐hydroxyphenyl)ethanone of 16.3%, 2‐chloro‐6‐methylaniline of 14.5%, and 4‐chloro‐2‐nitrotoluene of 4.1%, respectively.
Xiaokang Yu,Jinsheng Liang,Jiarui Xu,Xingsong Li,Shan Xing,Huilan Liu,Wan-Li Liu,Dongdong Liu,Jianhua Xu,Lizhen Huang,Hongli Du 한국유방암학회 2018 Journal of breast cancer Vol.21 No.4
Purpose: Breast cancer is the most commonly occurring cancer among women worldwide, and therefore, improved approaches for its early detection are urgently needed. As microRNAs (miRNAs) are increasingly recognized as critical regulators in tumorigenesis and possess excellent stability in plasma, this study focused on using miRNAs to develop a method for identifying noninvasive biomarkers. Methods: To discover critical candidates, differential expression analysis was performed on tissue-originated miRNA profiles of 409 early breast cancer patients and 87 healthy controls from The Cancer Genome Atlas database. We selected candidates from the differentially expressed miRNAs and then evaluated every possible molecular signature formed by the candidates. The best signature was validated in independent serum samples from 113 early breast cancer patients and 47 healthy controls using reverse transcription quantitative real-time polymerase chain reaction. Results: The miRNA candidates in our method were revealed to be associated with breast cancer according to previous studies and showed potential as useful biomarkers. When validated in independent serum samples, the area under curve of the final miRNA signature (miR-21-3p, miR-21-5p, and miR-99a-5p) was 0.895. Diagnostic sensitivity and specificity were 97.9% and 73.5%, respectively. Conclusion: The present study established a novel and effective method to identify biomarkers for early breast cancer. And the method, is also suitable for other cancer types. Furthermore, a combination of three miRNAs was identified as a prospective biomarker for breast cancer early detection.
Liu Kangjie,Guo Jianhua,Chu Liang,Yu Yuanbin 한국자동차공학회 2021 International journal of automotive technology Vol.22 No.4
Since fuel consumption of parallel Plug-in hybrid electric vehicles (PHEVs) is significantly different in various driving cycles, an adaptive optimal control strategy based on route information is proposed. First, the energy management strategy structure of adaptive Pontryagin’s Minimum Principle (APMP) is established. Second, genetic algorithm is employed to obtain a Map, which is co-state function of driving distances and state of charge (SOC) and makes this strategy used online. Furthermore, co-state value is updated in real time according to route information and reference SOC, which improves the adaptability of APMP control strategy. Finally, MATLAB/Simulink and AVL/Cruise software are employed as simulation tools to verify the proposed APMP control strategy. The performance of APMP control strategy is compared to rule-based (RB) control strategy. Results show that the proposed APMP control strategy could greatly improve the fuel economy of the parallel PHEV for different driving conditions.
Li Cui,Weiquan Bu,Jie Song,Liang Feng,Tingting Xu,Dan Liu,Wenbo Ding,Jianhua Wang,Changyang Li,Binge Ma,Yi Luo,Ziyu Jiang,Chengcheng Wang,Juan Chen,Jian Hou,Hong-mei Yan,Lei Yang,Xiao-bin Jia 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.3
Alantolactone is a sesquiterpene lactone isolatedfrom Inula helenium L. Although alantolactone possessesanti-inflammation and apoptosis-induction activities, theunderlying mechanism of anti-cancer effect on humanbreast cancer cells remains largely unknown. In this study,we explored the possibility of alantolactone as an apoptosis-inducing cytotoxic agent using MDA-MB-231 cells asin vitro model. Alantolactone significantly induced itsapoptosis, demonstrated by cell cycle analysis, annexinV-APC/7-AAD double staining and dUTP nick end labeling. Additionally, alantolactone triggered the mitochondrial-mediated caspase cascade apoptotic pathway, whichwas confirmed by increased Bax/Bcl-2 ratio, loss of MMP,release of cytc from mitochondria to cytoplasm, activationof caspase 9/3, and subsequent cleavage of PARP. Z-VADFMKpartially prevented apoptosis induced by alantolactone. Alantolactone provoked the production of ROS, whileNAC (a scavenger of ROS) reversed alantolactone-mediateddepolarization of MMP and apoptosis. Alantolactonemodulated the activities of MAPKs. As expected, cotreatmentwith SB203580, SP600125 or U0126 could reducedthe apoptotic rate. Furthermore, alantolactone decreasedthe protein expressions of p-NF-kB p65 and p-STAT3,increased p-c-Jun level in a dose-dependent manner. Thesefindings suggested that alantolactone possessed anticanceractivity via ROS-mediated mitochondrial dysfunctioninvolving MAPK pathway, and had an effect on the transcriptionfactors of NF-kB, AP-1 and STAT3.
Douglas-Peucker-Based Accelerated Similarity Measures for Massive AIS Trajectories
Kai WANG,Ryan Wen LIU,Yan LI,Maohan LIANG,Yi LIU,Jianhua WU,Jingxian LIU 국제이네비해양경제학회 2017 International Journal of e-Navigation and Maritime Vol.8 No.1
With the rapid development of the global economy, transport safety and security have become the key issues in maritime transportation all over the world. In practical applications, the Automatic Identification System (AIS)-based measurement of similarities between different vessel trajectories plays an important role in improving maritime transportation, e.g., maritime navigation, maritime supervision and management. However, the received AIS datasets are usually composed of a large amount of redundant information which could significantly increase the computational complexity. To deal with this problem, a Douglas-Peucker (DP)-based calculation method is introduced in this paper to accurately compress the spatio-temporal AIS trajectories while preserving the main geometrical structures. Based on the compressed trajectories, it is able to accelerate the Dynamic Time Warping (DTW) algorithm for the measurement of similarities between different vessel trajectories. In particular, the combination of DP and DTW has the capacity of significantly reducing the computational cost and guaranteeing the accuracy of similarity measures. The experimental results have demonstrated the superior performance of the proposed method in terms of computational cost and accuracy of similarity measures.
Junxia Su,Yu-Hui Wei,Minglong Liu,Tianxi Liu,Jianhua Li,Yuanchun Ji,Jianping Liang 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.10
Rhizoma Dioscoreae septemlobae (RDSE) hasbeen widely used for the treatment of hyperuricemia inChina. However, the therapeutic mechanism has beenunknown. This study investigated the antihyperuricemicmechanisms of the extracts obtained from RDSE and itsmain component dioscin (DIS) in hyperuricemic mice. Hyperuricemic mice were induced by potassium oxonate(250 mg/kg). RDSE or DIS was orally administered tohyperuricemic mice at dosages of 319.22, 638.43,1276.86 mg/kg/day for 10 days, respectively. Uric acid orcreatinine in serum and urine was determined by HPLC orHPLC–MS/MS, respectively. The xanthine oxidase (XO)activities in mice liver were examined in vitro. Proteinlevels of organic anion transporter 1 (mOAT1), uratetransporter 1 (mURAT1) and organic cation transporter 2(mOCT2) in the kidney were analyzed by western blotting. The results indicated that uric acid and creatinine in serumwere significantly increased by potassium oxonate, ascompared to that of control mice. Compared saline-treatedgroup, after RDSE treatment in the high and middle dose,the expression of mOAT1 increased 47.98 and 54.48 %,respectively, which accompanied with the decreasedexpression of mURAT1 (47.63 %) in high dose. After DIS treatment in high, middle and low dose, the expression ofmOAT1 increased 23.93, 32.80 and 25.28 % compared tosaline-treated group, respectively, which accompanied withthe decreased expression of mURAT1 (51.07, 51.42 and51.35 %). However, RDSE and DIS displayed a weak XOinhibition activity compared with allopurinol. Therefore,RDSE and DIS processed uricosuric and nephroprotectiveactions by regulation of mOAT1, mURAT1 and mOCT2.