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- 저자 : Changyang Li (검색결과 3 건)
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Li Cui,Weiquan Bu,Jie Song,Liang Feng,Tingting Xu,Dan Liu,Wenbo Ding,Jianhua Wang,Changyang Li,Binge Ma,Yi Luo,Ziyu Jiang,Chengcheng Wang,Juan Chen,Jian Hou,Hong-mei Yan,Lei Yang,Xiao-bin Jia 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.3
Alantolactone is a sesquiterpene lactone isolatedfrom Inula helenium L. Although alantolactone possessesanti-inflammation and apoptosis-induction activities, theunderlying mechanism of anti-cancer effect on humanbreast cancer cells remains largely unknown. In this study,we explored the possibility of alantolactone as an apoptosis-inducing cytotoxic agent using MDA-MB-231 cells asin vitro model. Alantolactone significantly induced itsapoptosis, demonstrated by cell cycle analysis, annexinV-APC/7-AAD double staining and dUTP nick end labeling. Additionally, alantolactone triggered the mitochondrial-mediated caspase cascade apoptotic pathway, whichwas confirmed by increased Bax/Bcl-2 ratio, loss of MMP,release of cytc from mitochondria to cytoplasm, activationof caspase 9/3, and subsequent cleavage of PARP. Z-VADFMKpartially prevented apoptosis induced by alantolactone. Alantolactone provoked the production of ROS, whileNAC (a scavenger of ROS) reversed alantolactone-mediateddepolarization of MMP and apoptosis. Alantolactonemodulated the activities of MAPKs. As expected, cotreatmentwith SB203580, SP600125 or U0126 could reducedthe apoptotic rate. Furthermore, alantolactone decreasedthe protein expressions of p-NF-kB p65 and p-STAT3,increased p-c-Jun level in a dose-dependent manner. Thesefindings suggested that alantolactone possessed anticanceractivity via ROS-mediated mitochondrial dysfunctioninvolving MAPK pathway, and had an effect on the transcriptionfactors of NF-kB, AP-1 and STAT3.
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Changyang Li,Peng Wang,Dun Zhang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.110 No.-
Co-working by lotus-leaf effect and self-healing shows a great potential against marine corrosion as itcould form a barrier capable of water repelling and microdefect healing on the substrate. We developeda firm and self-healing superhydrophobic coating (SHC) technology, in which carbon steel substrate wasfirst coated with fluoroethylene vinyl ether resin/polycaprolactone (FEVE/PCL) hybrid resin, and thensprayed with SiO2. Results showed that the hybrid resin could strengthen the interface between theSiO2 layer and the substrate and could heal microdefect due to the thermal exudation effect of PCL,and consequently form a corrosion barrier. The SHC exhibited great water resistance, stability, and durability. This dual-layered coating performed excellently in corrosion prevention. With the thermal exudationeffect of PCL, the dual-layered coating could quickly recover its superhydrophobicity and corrosionresistance under thermal stimuli, making it possible to protect metal substrate persistently. Therefore,this approach provides an easy technique against marine corrosion with water repelling and scratchhealingability, and shall be promising for long-term corrosion protection.
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Chang Yang,Decan Yang,Caiping Huang,Zhixiang Huang,Lizhi Ouyang,Landon Onyebueke,Lin Li 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.44 No.5
Earlier works have shown that excessive shear stiffness at the steel-concrete interface causes a non-uniform distribution of shear force in composite structures. When the shear studs are wrapped at the fixed end with flexible materials with a low elastic modulus, the shear stiffness at the interface is reduced. The objective of this study was to investigate the effect of silicone rubber-sleeve mounted on shear studs on the shear stiffness of steel-concrete composite structures. Eighteen push-out tests were conducted to investigate the mechanical behavior of silicone rubber-sleeved shear stud groups (SRS-SSG). The dimension and arrangement of silicon rubber-sleeves (SRS) were taken into consideration. Test results showed that the shear strength of SRS-SSG was higher than that of a shear stud group (SSG), without SRS. For SRS-SSG with SRS heights of 50 mm, 100 mm, 150 mm, the shear strengths were improved by 13%, 20% and 9%, respectively, compared to the SSG alone. The shear strengths of SRS-SSG with the SRS thickness of 2 mm and 4 mm were almost the same. The shear stiffness of the SRS-SSG specimens with SRS heights of 50 mm, 100 mm and 150 mm were 77%, 67% and 66% of the SSG specimens, respectively. Test results of specimens SSG-1 and predicted values based on the three design specifications were compared. The nominal single stud shear strength of SSG-1 specimens was closest to that calculated by the Chinese Code for Design of Steel Structures (GB50017-2017). An equation is proposed to consider the effects of SRS for GB50017-2017, and the predicted values based on the proposed equation agree well with the tested results of SRS-SSG.
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