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A new recombined porcine reproductive and respiratory syndrome virus virulent strain in China
Jian-guo Dong,Lin-yang Yu,Pei-pei Wang,Le-yi Zhang,Yan-ling Liu,Peng-shuai Liang,Chang-xu Song 대한수의학회 2018 Journal of Veterinary Science Vol.19 No.1
Porcine reproductive and respiratory syndrome (PRRS) is one of the most important swine diseases worldwide. In the present study, a new virulent strain of PRRS virus (PRRSV), GDsg, was isolated in Guangdong province, China, and caused high fever, high morbidity, and high mortality in sows and piglets. The genome of this new strain was 15,413 nucleotides (nt) long, and comparative analysis revealed that GDsg shared 82.4% to 94% identity with type 2 PRRSV strains, but only 61.5% identity with type 1 PRRSV Lelystad virus strain. Phylogenetic analysis indicated that type 2 PRRSV isolates include five subgenotypes (I, II, III, IV, and V), which are represented by NADC30, VR-2332, GM2, CH-1a, and HuN4, respectively. Moreover, GDsg belongs to a newly emerging type 2 PRRSV subgenotype III. More interestingly, the newly isolated GDsg strain has multiple discontinuous nt deletions, 131 (19 + 18 + 94) at position 1404–1540 and a 107 nt insertion in the NSP2 region. Most importantly, the GDsg strain was identified as a virus recombined between low pathogenic field strain QYYZ and vaccine strain JXA1-P80. In conclusion, a new independent subgenotype and recombinant PRRSV strain has emerged in China and could be a new threat to the swine industry of China.
Metastasis associated genomic aberrations in stage II rectal cancer
Hong Zhao,Zhi-Zhou Shi,Rui Jiang,Dong-Bing Zhao,Hai-Tao Zhou,Jian-Wei Liang,Xin-Yu Bi,Jian-Jun Zhao,Zhi-Yu Li,Jian-Guo Zhou,Zhen Huang,Ye-Fan Zhang,Jian Wang,Xin Xu,Yan Cai,Ming-Rong Wang,Yu Zhang 한국유전학회 2016 Genes & Genomics Vol.38 No.11
Genomic aberrations of rectal carcinoma, especially DNA copy number changes associated with metastasis were largely unclear. We aim to identify the metastasis associated biomarkers in stage II rectal cancer. Formalin-fixed, paraffin-embedded primary tumor tissues of stage II rectal carcinoma were analyzed by array-based comparative genomic hybridization, and genomic aberrations were identified by Genomic Workbench and SAM software. Copy number changes and mRNA expressions were validated by Real-time PCR in an independent rectal cancer samples. The results showed that the most frequent gains in stage II rectal cancer were at 1q21.2-q23.1, 3p21.31, 11q12.2-q23.3, 12q24.11-q24.31, 12q13.11-q14.1 and losses in 18q11.2-q23, 17q21.33-q22, 13q31.1-q31.3, 21q21.1-q21.3, 8p23.3-p23.1 and 4q22.1-q23. Twenty-two amplifications and five homozygous deletions were also identified. We further found that S100A1 (1q21.3-q23.1), MCM7 (7q22.1) and JUND (19p13.11) were amplified and overexpressed in stage II rectal cancer. Interestingly, the genomic aberrations affected 14 signaling pathways including VEGF signaling pathway and fatty acid metabolism. Most importantly, loss of 13q31.1-q34 and gain of 1q44 were associated with distant metastasis. Our results indicated that these metastasis associated genomic changes may be useful to reveal the pathogenesis of rectal cancer metastasis and identify candidate biomarkers.
( Dong Ming Wang ),( Hong Shan Yu ),( Jian Guo Song ),( Yu Feng Xu ),( Chun Ying Liu ),( Feng Xie Jin ) 한국미생물 · 생명공학회 2011 Journal of microbiology and biotechnology Vol.21 No.10
Herein, a novel ginsenosidase, named ginsenosidase type IV, hydrolyzing 6-O-multi-glycosides of protopanaxatrioltype ginsenosides (PPT), such as Re, R1, Rf, and Rg2, was isolated from the Aspergillus sp. 39g strain, purified, and characterized. Ginsenosidase type IV was able to hydrolyze the 6-O-α-L-(1→2)-rhamnoside of Re and the 6-O-β-D- (1→2)-xyloside of R1 into ginsenoside Rg1. Subsequently, it could hydrolyze the 6-O-β-D-glucoside of Rg1 into F1. Similarly, it was able to hydrolyze the 6-O-α-L-(1→2)- rhamnoside of Rg2 and the 6-O-β-D-(1→2)-glucoside of Rf into Rh1, and then further hydrolyze Rh1 into its aglycone. However, ginsenosidase type IV could not hydrolyze the 3-O- or 20-O-glycosides of protopanaxadioltype ginsenosides (PPD), such as Rb1, Rb2, Rb3, Rc, and Rd. These exhibited properties are significantly different from those of glycosidases described in Enzyme Nomenclature by the NC-IUBMB. The optimal temperature and pH for ginsenosidase type IV were 40℃ and 6.0, respectively. The activity of ginsenosidase type IV was slightly improved by the Mg2+ ion, and inhibited by Cu2+ and Fe2+ ions. The molecular mass of the enzyme, based on SDS-PAGE, was noted as being approximately 56 kDa.
DITC of SRM using 4-Level Converter
Jianing Liang,Zhen-Guo Lee(이진국),Dong-Hee Lee(이동희),Jin-Woo Ahn(안진우) 대한전기학회 2006 대한전기학회 학술대회 논문집 Vol.2006 No.4
This paper proposes a DITC(Direct Instantaneous Torque Control) of SRM (Switched Reluctance Motor) using a novel 4-level converter for smooth torque control and high efficiency. DITC of SRM is very useful for smooth torque control, but the driving efficiency is low due to advanced current that does not produce torque. For the high efficiency control of SRM, fast excitation and demagnetization of phase current are required. A novel 4-level converter and a new control scheme are present to improve the driving efficiency. The proposed DITC of SRM using 4-1evel converter is verified by computer simulation.
Improvement of DITC SRM with a Novel 4-level Converter
Jianing Liang,이진국(Zhen-Guo Lee),이동희(Dong-Hee Lee),안진우(Jin-Woo Ahn) 대한전기학회 2006 대한전기학회 학술대회 논문집 Vol.2006 No.7
This paper presents a direct instantaneous torque control (DITC) of Switched Reluctance Motor (SRM) with a novel 4-1evel converter to obtain smooth torque and dynamic performance improvement. The DITC method can reduce the high inherent torque ripple of SRM drive system, but driving efficiency and dynamic performance are somewhat low due to the slow excitation current build-up. Since the 4-level converter can obtain a addition high voltage to get fast excitation current and demagnetization current, so, it can improve dynamic performance easily. As a high performance SRM drive system with low torque ripple and high dynamic performance can be implemented. The validity of proposed method is verified by some computer simulations and comparative experiments.
Jian Dong Cui,Ya Nan Zhang,Gui Xia Zhao,Shi Ru Jia,Guo Qun Zhao,Si Zhang,Jun Lu 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.2
To develop a new method for producing aspartame (APM), a simple and efficient strategy for the isolation of certain microorganisms producing APM from soil samples was designed. A newly strain with secreting certain specific dipeptidase to directly synthesize APM from the substrates of L-aspartic acid (L-Asp) and Lphenylalanine methyl ester (L-PM) without protection for amino acid side chains was screened from soil samples. APM concentration in reaction mixture was quantified by high performance liquid chromatography (HPLC), yield reached 0.015 g/L. Examination of the general morphological characteristics and data from the sequence analysis of the rDNA-ITS gene led to identification of the isolate as a strain of fungal endophyte spp. The newly isolated strain had a high potential for application in industrial processes for APM production. In particular, this new method was low cost for synthesis of APM during the reaction due to avoiding protection for amino acid side chains and optical resolution of the mixtures. As we known it, this is first report that a newly strain with a high potential for selective synthesis of the APM was isolated from soil.
Inhibition of Nemo-like Kinase Increases Taxol Sensitivity in Laryngeal Cancer
Dong, Ji-Rui,Guo, Nan,Zhao, Jian-Pu,Liu, Pin-Duo,Feng, Hui-Hong,Li, Yan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Several studies have shown that nemo-like kinase (NLK) plays a vital role in apoptosis of cancer cells. The present research concerned effects and mechanisms of Taxol on NLK knockdown human laryngeal cancerHep-2 cell lines in vitro. Using RNAi, methyl-thiazoltetrazolium (MTT) assays, real-time RT-PCR, Western blotting and flow cytometry analysis, growth and the cell cycle progression of NLK knockdown Hep-2 cells and expression of downstream molecules were observed. Cell growth was obviously suppressed in the Taxol treated group (P<0.001, 48 hours). Cell numbers of combined Taxol-based chemotherapy with lentivirus mediated RNAi treatment group (Lv-shNLK+Taxol goup) were significantly different from NLK-specific siRNA lentivirus infected group (Lv-shNLK group) (p<0.001). Flow cytometry analysis revealed that Lv-shNLK+Taxol caused the G0/G1-phase DNA content to decrease from 44.1 to 3.33% (p<0.001) and the S-phase DNA content to increase from 38.4 to 82.0% (p<0.001), in comparison with the Lv-shNLK+Taxol group. Immunoblot analysis showed that knockdown of NLK led to significant reduction in the levels of cyclin D1, PCNA and PARP, whereas cyclin B1 was elevated in. Cell growth was also obviously suppressed in the Hep-2 cell line, knockdown of NLK making them more sensitive to Taxol treatment. NLK is expected to become a target of new laryngeal cancer gene therapies.
Finite Element Analysis and Optimization of Dither Mechanism in Dithered Ring Laser Gyroscope
Xu-dong Yu,Guo Wei,Xing-wu Long,Jian-xun Tang 한국정밀공학회 2013 International Journal of Precision Engineering and Vol. No.
This paper presents an optimal structural design of dither mechanism in dithered ring laser gyroscope (DRLG) using finite element analysis (FEA). We establish an approximate theoretical model of the dithering mechanism to calculate resonant frequency and adopt the modal analysis and dynamics analysis to search the optimal solution. The validity and efficiency of the FEA are conformed by comparing with the sinusoidal and random vibration experimental results. An optimal dither mechanism is fabricated and measured experimentally. The results demonstrate the good vibration-isolated performance for the optimal design.
Single-Phase SRM Drive With Torque Ripple Reduction and Power Factor Correction
Lee Dong-Hee,Lee Zhen-Guo,Liang Jianing,Ahn Jin-Woo IEEE 2007 IEEE transactions on industry applications Vol.43 No.6
<P>In a single-phase switched reluctance motor (SRM) drive, the dc voltage source is generally supplied by a circuit consisting of a bridge rectifier and a filter capacitor connected to an ac line. The charging time of the capacitor is shorter from the ac source as capacity increases. The bridge rectifier draws pulsating current from the ac source, which results in a degraded power factor (PF) and lower system efficiency. A single-phase SRM drive system is presented in this paper, which includes the realization of a drive circuit for the reduction of torque ripple and PF improvement with a novel switching topology. The proposed drive circuit adds one switch and one diode, which can separate the output of the ac/dc rectifier from the large capacitor and supply power to the SRM alternately. This allows the drive system to realize torque ripple reduction and PF improvement through the switching scheme. The validity of the proposed method is analyzed by mathematical modeling and tested by simulations and experiments.</P>