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Zhu, Jianhua,Fu, Xinmiao,Koo, Yoon Duck,Zhu, Jian-Kang,Jenney Jr., Francis E.,Adams, Michael W. W.,Zhu, Yanmei,Shi, Huazhong,Yun, Dae-Jin,Hasegawa, Paul M.,Bressan, Ray A. American Society for Microbiology 2007 Molecular and cellular biology Vol.27 No.14
<B>ABSTRACT</B><P>The myristoylated calcium sensor SOS3 and its interacting protein kinase, SOS2, play critical regulatory roles in salt tolerance. Mutations in either of these proteins render <I>Arabidopsis thaliana</I> plants hypersensitive to salt stress. We report here the isolation and characterization of a mutant called <I>enh1-1</I> that enhances the salt sensitivity of <I>sos3-1</I> and also causes increased salt sensitivity by itself. <I>ENH1</I> encodes a chloroplast-localized protein with a PDZ domain at the N-terminal region and a rubredoxin domain in the C-terminal part. Rubredoxins are known to be involved in the reduction of superoxide in some anaerobic bacteria. The <I>enh1-1</I> mutation causes enhanced accumulation of reactive oxygen species (ROS), particularly under salt stress. ROS also accumulate to higher levels in <I>sos2-1</I> but not in <I>sos3-1</I> mutants. The <I>enh1-1</I> mutation does not enhance <I>sos2-1</I> phenotypes. Also, <I>enh1-1</I> and <I>sos2-1</I> mutants, but not <I>sos3-1</I> mutants, show increased sensitivity to oxidative stress. These results indicate that ENH1 functions in the detoxification of reactive oxygen species resulting from salt stress by participating in a new salt tolerance pathway that may involve SOS2 but not SOS3.</P>
Zhu, Jian,Chu, Bing-Feng,Yang, Yi-Peng,Zhang, Sheng-Lai,Zhuang, Ming,Lu, Wen-Jie,Liu, Ying-Bin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Objective: This study aimed to investigate the expression of B7-H4 in human thyroid cancer and determine any association with patient clinicopathological parameters and survival. Methods: B7-H4 expression in 64 clinical thyroid cancer specimens was assessed with immunohistochemistry. Moreover, B7-H4 mRNA expression in 10 fresh resected specimens were evaluated by the reverse transcription-polymerase chain reaction (RT-PCR). Immunohistochemical staining of CD3 was performed to assess the number of tumor infiltrating T lymphocytes (TILs) in thyroid cancers. Results: Positive B7-H4 immunohistochemical staining was observed in 61 out of 64 (95.3%) specimens of thyroid cancer tissues. Significantly more B7-H4 mRNA copies were found in thyroid cancer tissue than that adjacent normal tissue. Moreover, B7-H4 expression in human thyroid cancer tissues was significantly correlated with patient TNM stages and extrathyroidal extension (P<0.05), being inversely correlated with the number of TILs (P<0.05). The overall survival rate of the patients with higher B7-H4 expression was significantly worse than that of the patients with lower B7-H4 expression. Conclusions: This present study suggests that high B7-H4 expression is associated with cancer progression, reduced tumor immunosurveillance and worse patient outcomes in human thyroid cancer.
Involvement of Arabidopsis HOS15 in histone deacetylation and cold tolerance.
Zhu, Jianhua,Jeong, Jae Cheol,Zhu, Yanmei,Sokolchik, Irina,Miyazaki, Saori,Zhu, Jian-Kang,Hasegawa, Paul M,Bohnert, Hans J,Shi, Huazhong,Yun, Dae-Jin,Bressan, Ray A National Academy of Sciences 2008 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.105 No.12
<P>Histone modification in chromatin is one of the key control points in gene regulation in eukaryotic cells. Protein complexes composed of histone acetyltransferase or deacetylase, WD40 repeat protein, and many other components have been implicated in this process. Here, we report the identification and functional characterization of HOS15, a WD40-repeat protein crucial for repression of genes associated with abiotic stress tolerance through histone deacetylation in Arabidopsis. HOS15 shares high sequence similarity with human transducin-beta like protein (TBL), a component of a repressor protein complex involved in histone deacetylation. Mutation of the HOS15 gene renders mutant plants hypersensitive to freezing temperatures. HOS15 is localized in the nucleus and specifically interacts with histone H4. The level of acetylated histone H4 is higher in the hos15 mutant than in WT plants. Moreover, the stress inducible RD29A promoter is hyperinduced and associated with a substantially higher level of acetylated histone H4 in the hos15 mutant under cold stress conditions. Our results suggest a critical role for gene activation/repression by histone acetylation/deacetylation in plant acclimation and tolerance to cold stress.</P>
Jian Ma,Dingquan Xiao,Bo Wu,Jia-gang Wu,Jian-guo Zhu 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.2
0.95(Na0.96−xKxLi0.04)(Nb0.89Sb0.07Ta0.04)O3-0.05KNbO3 (abbreviated as KxNLNST-KN, x =0.32 − 0.52) lead-free piezoelectric ceramics were prepared by using the conventional solid-statesintering method, and the intentional addition of a pre-calcined KNbO3 powder was used as asintering aid that might inhibit and compensate for the volatilization of alkali metals during thesintering process. The preparation of the ceramics and the effects of K/Na ratio on the structureand the electrical properties of these ceramics were studied in detail. Compared with the relativelyhigher sintering temperature of Li-, Sb-, and Ta-modified KNN ceramics reported in the literature,the dense ceramic samples were obtained at a reduced temperature of 1060 C, and the ceramicswith x = 0.44 possessed optimal properties: d33 = 298 pC/N, kp = 48%, Pr = 21.9 μC/cm2, andEc = 11.5 kV/cm.
A cellulose synthase-like protein is required for osmotic stress tolerance in <i>Arabidopsis</i>
Zhu, Jianhua,Lee, Byeong-Ha,Dellinger, Mike,Cui, Xinping,Zhang, Changqing,Wu, Shang,Nothnagel, Eugene A.,Zhu, Jian-Kang Blackwell Publishing Ltd 2010 The Plant journal Vol.63 No.1
<P>Summary</P><P>Osmotic stress imposed by soil salinity and drought stress significantly affects plant growth and development, but osmotic stress sensing and tolerance mechanisms are not well understood. Forward genetic screens using a root-bending assay have previously identified <I>salt overly sensitive</I> (<I>sos</I>) mutants of Arabidopsis that fall into five loci, <I>SOS1</I> to <I>SOS5.</I> These loci are required for the regulation of ion homeostasis or cell expansion under salt stress, but do not play a major role in plant tolerance to the osmotic stress component of soil salinity or drought. Here we report an additional <I>sos</I> mutant, <I>sos6-1,</I> which defines a locus essential for osmotic stress tolerance<I>. sos6-1</I> plants are hypersensitive to salt stress and osmotic stress imposed by mannitol or polyethylene glycol in culture media or by water deficit in the soil. <I>SOS6</I> encodes a cellulose synthase-like protein, AtCSLD5. Only modest differences in cell wall chemical composition could be detected, but we found that <I>sos6-1</I> mutant plants accumulate high levels of reactive oxygen species (ROS) under osmotic stress and are hypersensitive to the oxidative stress reagent methyl viologen. The results suggest that SOS6/AtCSLD5 is not required for normal plant growth and development but has a critical role in osmotic stress tolerance and this function likely involves its regulation of ROS under stress.</P>
A DoS Detection Method Based on Composition Self-Similarity
( Zhu Jian-qi ),( Fu Feng ),( Chong-kwon Kim ),( Yin Ke-xin ),( Liu Yan-heng ) 한국인터넷정보학회 2012 KSII Transactions on Internet and Information Syst Vol.6 No.5
Based on the theory of local-world network, the composition self-similarity (CSS) of network traffic is presented for the first time in this paper for the study of DoS detection. We propose the concept of composition distribution graph and design the relative operations. The (R/S)d algorithm is designed for calculating the Hurst parameter. Based on composition distribution graph and Kullback Leibler (KL) divergence, we propose the composition self-similarity anomaly detection (CSSD) method for the detection of DoS attacks. We evaluate the effectiveness of the proposed method. Compared to other entropy based anomaly detection methods, our method is more accurate and with higher sensitivity in the detection of DoS attacks.