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      • SCISCIESCOPUS

        Hierarchical and Multifunctional Three‐Dimensional Network of Carbon Nanotubes for Microfluidic Applications

        Seo, Jeongeun,Lee, Tae Jae,Ko, Seungbin,Yeo, Haegu,Kim, Suhawn,Noh, Taeyong,Song, Simon,Sung, Myung M.,Lee, Haiwon WILEY‐VCH Verlag 2012 Advanced Materials Vol.24 No.15

        <P><B>Three‐Dimensional network of carbon nanotubes:</B> The 3D network of CNTs have hierarchical structures comprised of interconnected SWNTs between Si pillars in microfluidic channels. The Al<SUB>2</SUB>O<SUB>3</SUB> coated 3D networks were used for size different nanoparticles filtration and streptavidin capturing in very diluted solution. The 3D network of SWNTs systems will provide a robust multifuncitonal platform for a variety of biomedical and environmental applications.</P>

      • KCI등재

        폭염사상의 비정상성 빈도해석 및 불확실성 분석

        서지유(Seo, Jiyu),원정은(Won, Jeongeun),최정현(Choi, Jeonghyeon),이옥정(Lee, Okjeong),김상단(Kim, Sangdan) 한국방재학회 2021 한국방재학회논문집 Vol.21 No.1

        지구 온난화로 인하여 지속적이고 극심한 폭염사상에 대한 우려가 점점 증가되고 있다. 일 최고 기온 관측자료는 강한 비정상성을 나타내고 있으며, 폭염사상의 강도 및 지속기간의 증가가 여러 지역에서 현실화하고 있다. 다양한 지속기간에 대한 폭염사상의 강도를 재현기간과 연관시키는 폭염-지속일수-빈도(Heat wave - Persistence day - Frequency, HPF) 곡선은 폭염사상의 빈도해석을 위한 유용한 도구가 될 수 있다. 본 연구에서는 기후변화에 따른 기온 증가의 경향성을 설명하기 위해 비정상성 HPF 곡선이 개발되고, 그에 대한 불확실성이 분석된다. 비정상성 HPF 모형은 공중보건, 공공안전 및 에너지 관리 분야와 같은 기후변화 적응관리 분야에 활용될 수 있을 것이다. Due to global warming, there is an increasing concern regarding persistent and severe heat waves. The maximum daily surface air temperature observations show strong non-stationary features, and the increased intensity and persistence of heat wave events have been observed in many regions. The heat wave persistence day frequency (HPF) curve, which correlates the intensity of a heat wave persistence event for days with return periods, can be a useful tool to analyze the frequency of heat wave events. In this study, non-stationary HPF curves are developed to explain the trend in the increase of the surface air temperature due to climate change, and their uncertainty is analyzed. The non-stationary HPF model can be used in climate change adaptation management such as public health, public safety, and energy management.

      • An exploratory analysis of tuberculosis-related research in North Korean Medical Journal

        ( Haesook Seo ),( Youngsoo Cho ),( Jeongeun Suh ),( Chongkyung Kim ),( Ohwoo Kwon ),( Booyeon Kim ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

        Purpose: Recent rapid changes in relations with North Korea have heightened interest in inter-Korean health and medicine exchanges on humanitarian ground. According to WHO reports, North Korea is one of the highest rates of TB in the the world. In this study, we explored the trend of research on tuberculosis by analyzing the research related to tuberculosis in the North Korean medical journal. Method: The North’s medical journals (Joseon Medical, Medical, Internal Medicine, Preventive Medicine and Basic Medicine) were five kinds, all of which were continuous. The publication year scope of the analysis was based on 2000 or later, and the research items on tuberculosis were divided into five categories. That is, after diagnosis, treatment, treatment, R&D, prevention and policy. Result: Tuberculosis was the most common disease published in the North’s medical journal, and the number of tuberculosis-related studies was on the rise recently. What should be noted in the journal was the DOT strategy, drug-resistant tuberculosis and drug susceptibility test, tuberculosis and immunological associations, and R&D including genetic variation. And we got the name of a health care doctor who did a lot of research. Also, the estimate in the North’s medical journal was a fragmental analysis of the North’s tuberculosis problem, and under the current system in the North, it is not enough to analyze the problem of the whole country’s tuberculosis outbreak. Conclusion: Tuberculosis is a major health problem in North Korea, but it is not enough to analyze its exact conditions. In the end, the accurate understanding of the current state of tuberculosis in North Korea can be confirmed through testimony or experience from North Korean refugees or academic exchanges with North Korean doctors who have done a lot of research.

      • KCI등재

        H-지수를 이용한 폭염 정량화 및 미래 폭염 전망

        서지유(Seo, Jiyu),원정은(Won, Jeongeun),최정현(Choi, Jeonghyeon),이옥정(Lee, Okjeong),김상단(Kim, Sangdan) 한국방재학회 2020 한국방재학회논문집 Vol.20 No.6

        전 세계적으로 기온이 상승하면서 일 최고기온 또한 상승하고 있다. 그로 인한 폭염 현상이 증가하고 폭염으로 인한 신체적, 생태계적 피해도 증가하고 있다. 우리나라의 경우 일 최고기온을 통해 폭염을 판단한다. 본 연구에서는 일 최대기온을 이용한H-지수를 산정하여 기상청 ASOS 60개 지점에서의 폭염을 정량화하고자 하였다. 또한 기상청 국가표준 기후변화 시나리오로부터의 미래 기온 정보를 이용하여 미래 H-지수의 변화를 살펴보았다. 연구결과, H-지수를 이용하여 폭염을 정량화하여 폭염거동의 시간적 공간적 변화를 살펴볼 수 있었으며, 미래 H-지수는 현재의 상승추세보다 더 빠르게 증가할 것으로 전망되었다. As global surface air temperature (SAT) rises, the highest daily SAT is also rising. The rise in the highest daily SAT leads to an increase in heat waves, which is turn increases the physical and ecological damage being caused by the heat waves. In Korea, the highest daily SAT is used to determine whether a heat wave has occurred or not. In this study, H-index using the highest daily SAT was calculated to quantify the heat waves at 60 Automated Surface Observing System (ASOS) sites operated by the Korea Meteorological Agency (KMA). The changes in H-index were also investigated using projected future SAT data gathered from KMA s national standard climate change scenarios. As a result, it was possible to investigate the temporal and spatial changes in heat wave behavior by quantifying the heat wave using the H-index. The H-index is expected to increase faster in future than its current upward trend.

      • KCI등재

        낙동강 유역 주요하천 구간에서 가뭄이 수온에 미치는 영향의 확률론적인 평가

        서지유 ( Seo Jiyu ),원정은 ( Won Jeongeun ),이호선 ( Lee Hosun ),김상단 ( Kim Sangdan ) 한국물환경학회 2021 한국물환경학회지 Vol.37 No.5

        In this work, we analyzed the effects of drought on the water temperature (WT) of Nakdong river basin major river sections using Standardized Precipitation Index (SPI) and WT data. The analysis was carried out on a seasonal basis. After calculating the optimal time scale of the SPI through the correlation between the SPI and WT data, we used the copula theory to model the joint probability distribution between the WT and SPI on the optimal time scale. During spring and fall, the possibility of environmental drought caused by high WT increased in most of the river sections. Notably, in summer, the possibility of environmental drought caused by high WT increased in all river sections. On the other hand, in winter, the possibility of environmental drought caused by low WT increased in most river sections. From the risk map, which quantified the sensitivity of WT to the risk of environmental drought, the river sections Nakbon C, Namgang E, and Nakbon K showed increased stress in the water ecosystem due to high WT when drought occurred in summer. When drought occurred in winter, an increased water ecosystem stress caused by falling WT was observed in the river sections Gilan A, Yongjeon A, Nakbon F, Hwanggang B, Nakbon I, Nakbon J, Nakbon K, Nakbon L, and Nakbon M. The methodology developed in this study will be used in the future to quantify the effects of drought on water quality as well as WT.

      • KCI등재

        수문학적 추적 기반의 GI 시설 평가 모델 : 생태저류지, 침투도랑, 투수성포장, 식생수로를 대상으로

        원정은(Jeongeun),서지유(Won・,Jiyu Seo),최정현(Jeonghyeon Choi),김상단(Sangdan Kim) 한국습지학회 2021 한국습지학회지 Vol.23 No.1

        도시 개발로 인한 영향을 최소화하여 물 순환 체계를 개선하기 위해서는 적극적인 강우유출수 관리가 필수적이다. 최근에는 도시의강우유출수 관리를 위한 저영향개발(Low Impact Development, LID) 기법이 합리적인 대안으로 주목받고 있다. Storm Water Management Model(SWMM)은 LID 모듈을 통해 다양한 GI(Green Infra) 시설에 대한 모의 기능을 제공하고 있어 도시 물순환개선 사업에 적극 활용되고 있다. 그러나 SWMM을 이용하여 GI 시설을 모의하기 위해서는 복잡한 유역 설정과 GI 시설 배치에많은 어려움이 존재한다. 본 연구에서는 GI 시설의 핵심적인 수문 프로세스를 구현하면서도 상대적으로 간단하게 GI 시설의 성능을평가할 수 있는 모형이 제안된다. 제안된 모형은 수문학적 추적을 기반으로 작동되므로 GI 시설의 침투, 저류, 증발산을 모두 반영할수 있을 뿐만 아니라 GI 시설에 의한 도시 물순환 개선 효과를 정량적으로 평가할 수 있다. 제안된 모형의 결과와 SWMM의 결과를비교함으로써 제안된 모형의 적용성을 검증하였다. 더붙여서 SWMM의 투수성 포장 모의에서 발생되는 오류에 대한 논의가 포함된다. Active stormwater management is essential to minimize the impact of urban development and improve the hydrological cycle system. In recent years, the Low Impact Development (LID) technique for urban stormwater management is attracting attention as a reasonable alternative. The Storm Water Management Model (SWMM) is actively used in urban hydrological cycle improvement projects as it provides simulation functions for various GI (Green Infra) facilities through its LID module. However, in order to simulate GI facilities using SWMM, there are many difficulties in setting up complex watersheds and deploying GI facilities. In this study, a model that can evaluate the performance of GI facilities is proposed while implementing the core hydrological process of GI facilities. Since the proposed model operates based on hydrological routing, it can not only reflect the infiltration, storage, and evapotranspiration of GI facilities, but also quantitatively evaluate the effect of improving urban hydrological cycle by GI facilities. The applicability of the proposed model was verified by comparing the results of the proposed model with the results of SWMM. In addition, a discussion of errors occurring in the SWMM s permeable pavement system simulation is included.

      • MicroRNA Expression Profiling in CCl <sub>4</sub> -Induced Liver Fibrosis of <i>Mus musculus</i>

        Hyun, Jeongeun,Park, Jungwook,Wang, Sihyung,Kim, Jieun,Lee, Hyun-Hee,Seo, Young-Su,Jung, Youngmi MDPI 2016 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.17 No.6

        <P>Liver fibrosis is a major pathological feature of chronic liver diseases, including liver cancer. MicroRNAs (miRNAs), small noncoding RNAs, regulate gene expression posttranscriptionally and play important roles in various kinds of diseases; however, miRNA-associated hepatic fibrogenesis and its acting mechanisms are poorly investigated. Therefore, we performed an miRNA microarray in the fibrotic livers of <I>Mus musculus</I> treated with carbon-tetrachloride (CCl<SUB>4</SUB>) and analyzed the biological functions engaged by the target genes of differentially-expressed miRNAs through gene ontology (GO) and in-depth pathway enrichment analysis. Herein, we found that four miRNAs were upregulated and four miRNAs were downregulated more than two-fold in CCl<SUB>4</SUB>-treated livers compared to a control liver. Eight miRNAs were predicted to target a total of 4079 genes. GO analysis revealed that those target genes were located in various cellular compartments, including cytoplasm, nucleolus and cell surface, and they were involved in protein-protein or protein-DNA bindings, which influence the signal transductions and gene transcription. Furthermore, pathway enrichment analysis demonstrated that the 72 subspecialized signaling pathways were associated with CCl<SUB>4</SUB>-induced liver fibrosis and were mostly classified into metabolic function-related pathways. These results suggest that CCl<SUB>4</SUB> induces liver fibrosis by disrupting the metabolic pathways. In conclusion, we presented several miRNAs and their biological processes that might be important in the progression of liver fibrosis; these findings help increase the understanding of liver fibrogenesis and provide novel ideas for further studies of the role of miRNAs in liver fibrosis.</P>

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