중국 경극 표현에 관한 시각화 분석연구

노정정(lu Jing Jing),이창근(lee Chang Keun) 한국콘텐츠학회 2010 한국콘텐츠학회 종합학술대회 논문집 Vol.2010 No.5

Simultaneous treatment with sorafenib and glucose restriction inhibits hepatocellular carcinoma in vitro and in vivo by impairing SIAH1-mediated mitophagy

Zhou Jing,Feng Ji,Wu Yong,Dai Hui-Qi,Zhu Guang-Zhi,Chen Pan-Hong,Wang Li-Ming,Lu Guang,Liao Xi-Wen,Lu Pei-Zhi,Su Wen-Jing,Hooi Shing Chuan,Ye Xin-Pin,Shen Han-Ming,Peng Tao,Lu Guo-Dong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Transarterial chemoembolization (TACE) is the first-line treatment for unresectable intermediate-stage hepatocellular carcinoma (HCC). It is of high clinical significance to explore the synergistic effect of TACE with antiangiogenic inhibitors and the molecular mechanisms involved. This study determined that glucose, but not other analyzed nutrients, offered significant protection against cell death induced by sorafenib, as indicated by glucose deprivation sensitizing cells to sorafenib-induced cell death. Next, this synergistic effect was found to be specific to sorafenib, not to lenvatinib or the chemotherapeutic drugs cisplatin and doxorubicin. Mechanistically, sorafenib-induced mitophagy, as indicated by PINK1 accumulation, increased the phospho-poly-ubiquitination modification, accelerated mitochondrial membrane protein and mitochondrial DNA degradation, and increased the amount of mitochondrion-localized mKeima-Red engulfed by lysosomes. Among several E3 ubiquitin ligases tested, SIAH1 was found to be essential for inducing mitophagy; that is, SIAH1 silencing markedly repressed mitophagy and sensitized cells to sorafenib-induced death. Notably, the combined treatment of glucose restriction and sorafenib abolished ATP generation and mitophagy, which led to a high cell death rate. Oligomycin and antimycin, inhibitors of electron transport chain complexes, mimicked the synergistic effect of sorafenib with glucose restriction to promote cell death mediated via mitophagy inhibition. Finally, inhibition of the glucose transporter by canagliflozin (a clinically available drug used for type-II diabetes) effectively synergized with sorafenib to induce HCC cell death in vitro and to inhibit xenograft tumor growth in vivo. This study demonstrates that simultaneous treatment with sorafenib and glucose restriction is an effective approach to treat HCC, suggesting a promising combination strategy such as transarterial sorafenib-embolization (TASE) for the treatment of unresectable HCC.

레트로(Retro) 패션에 나타난 미디어 간 네트워크 의제설정 (Intermedia Agenda Setting) 연구

육정정(Jing-Jing Lu),권상희(Sang Hee Kweon) 한국방송학회 2021 한국방송학보 Vol.35 No.1

Study on the design for outdoor scene of kindergarten based on the cognitive development of children

Jing Lu,Zhao Chen Xue,Qian Li Zhu 한국공학안전보건예술학회 2010 한국공학예술학회 논문지 Vol.2 No.-

This paper describes an investigation on the spot for designing conducted in the outdoor play yards of kindergarten. Aiming at status quo of the designing for the outdoor environment of kindergarten, the conception of the scene-based design is put forward in this paper: The scene-based design is to construct a desired environment to meet the design principles and, more importantly, the need required for children’s physiological and mental development. The major aim is to supply abundant experiences which let the children be able to feel the space around them in the sense of emotional and visual perception. Basing on the children psychological traits, the question that how to design the scene-based space of being outdoors which can efficiently promote the cognitive development of children ranging from 5 to 6 years old is discussed in this paper. A “scene-based” approach to design and a data collection set including field notes of the children are coverd in the research. Qualitative analysis of these data revealed that high quality of outdoors enviroment for a kindergarten can greatly contribute to the cognitive development of children.

RESEARCH ARTICLE : Synthesis of 6-dexymollugins and their inhibitory activities on tyrosinase

( Jing Lu Liang ),( Umair Javed ),( Seung Ho Lee ),( Jae Gyu Park ),( Yurngdong Jahng ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0

A series of 6-deoxymollugins were prepared five steps from benzaldehyde and its derivatives via phenylboronic acid-catalyzed chromenylation as a key step. Their inhibitory activities against tyrosinase from mushroom were evaluated to show that the parent, methyl 2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate (9a) showed best and promising inhibitory activity at IC50 = 18.3 μM.

The Economic and Political System of Hong Kong Special Administrative Region

Lu, Jing-Hua(여정화) 경성대학교 인문과학연구소 2016 인문학논총 Vol.42 No.-

홍콩특별행정구(香港特别行政区)는 홍콩섬(香港島, 향항도)과 주룽반도(九竜半島, 구룡반도), 신제(新界, 신계)와 그 밖의 230개의 부속도서로 구성되어 있는 중국의 특별행정구이다. 1840년 아편 전쟁 이후 영국에 의해 점령 된 홍콩은 중국과 영국의 여러 번의 논의 후 1997년 드디어 중국에 반환과 함께 중국홍콩특별행정구가 수립되었다. 홍콩은 중국의 영토이다. 그러나 1941년에 일본이 홍콩을 점령한 뒤 1945년에 다시 해방되었으며 국공내전으로 인해 영국에 다시 점령되었다. “기본법”, “영국-중국 공동 선언”, “일국양제”에 따라 홍콩은 1997년 7월 1일부터 2047년 6월 30일까지 50년간 외교와 국방을 제외한 고도의 자치권이 인정되는 특별행정구의 지위를 유지하도록 되어있다. 지금까지 중국 국내에서 가장 높은 수준의 자율성을 보유하고 있다. 본 논문은 홍콩특별행정구의 중국 반환 20주년에 맞춰 ‘일국양제’의 특징과 시사점을 분석했으며 학계의 많은 관심을 이끌기 위해, 특히 홍콩의 경제와 정치 구조에 대한 분석을 했다. 이러한 독특한 특성은 매우 시의성이 높으며 한국과 다른 체제제도를 유지하는 중국을 이해하는데 도움을 주는 내용으로 구성되어 있다. Hong Kong is China"s territory since ancient times, which have been occupied by Britain after the Opium War of 1840. Since 1979, China and the United Kingdom have began to discuss the issue about Hong Kong several times. In accordance with the Basic Law, the Sino-British Joitnt Declaration and one country and two systems principle, New Territories, New Kowloon and other areas in Hongkong officially handed over to China in July 1, 1997. Comparing with other provinces, Hong Kong Special Administrative Region has a high degree of autonomy. Since the system of Hongkong Special Administrative Region is an innovative system of national political system, this paper just make a preliminary analysis on the political and economic structure of the Hong Kong Special Administrative Region, in order to arouse many academics" attention that continue to explore this rich system constitute, distinctive characteristics of power relations and structure power. The institutional practice of Hong Kong has unique status on the national governance system and governance modernization.

论美元霸权对中国产生的影响与近期相关对策

LU JING HUA,김경환 중국지역학회 2018 중국지역연구 Vol.5 No.3

The U.S. hegemony model is based on the exclusive supply of dollars. In the experience of world history, reckless supply of money leads to a fall in the national economy. But the U.S. maintains its global hegemony despite its huge current and fiscal deficits. This is called the dollar hegemony in the world. The dollar bond remains a monopoly on trade, foreign reserves and resource payments. Countries around the world want to secure dollars for trade payments and resource transactions. In other words, the dollar maintains hegemony through a monopoly in trade and resources. So far, some countries have tried to break away from the dollar, but the United States has blocked it through economic sanctions and war. At that time, countries against the dollar had little impact on the global economy, and they could not escape the dollar's hegemony. The U.S. and China are in an economic conflict in 2018. Conflicts between the U.S. and China, which started from trade conflicts, are expanding due to sanctions against ICT companies. The world is blaming the emergence of U.S. President Trump, but this study analyzed China's challenge to the dollar hegemony. In the early days of the U.S.-China conflict, criticism and criticism of Trump was prevalent, but his chances of re-election after the second half of 2018. Even after the conflict, the U.S.-China trade deficit has not decreased, but President Trump's political standing is on the rise. For this reason, conflict between the U.S. and China is likely to be responsible for China's response as it is largely related to maintaining the dollar's hegemony. According to the study, China is expanding its use of the yuan for crude futures trade dominated by the dollar and expanding its currency-based CIPS to neighboring countries including Southeast Asia in response to the U.S.-led global bank payment network, SWIFT. And international cooperation with major anti-American countries such as Venezuela, Iran, Russia and Turkey is strengthening. As a result, the recent U.S.-China conflict is a showdown over the U.S. Therefore, the conflict will continue for some time. The Korean government and companies need to diversify their export markets and diversify their foreign exchange reserves to prepare for this situation. 미국의 패권모델은 달러의 독점적인 공급에 기초한다. 세계 역사의 경험에서보면 무분별한 화폐의 공급은 국가경제의 몰락을 초래한다. 그러나 미국은 막대한 경상수지적자와 재정적자를 지속하고 있음에도 세계패권을 유지하고 있다. 이를 세계는 달러패권이라 부른다. 달러패권은 무역거래, 외환보유고, 자원결제의 독점으로 유지된다. 세계 각국은 무역결제와 자원거래를 위해 달러를 확보하고자 한다. 다시 말하면 달러는 무역거래와 자원거래의 독점을 통해 패권을유지하는 것이다. 지금까지 일부 국가는 달러패권을 탈피하기 위해 노력하였으나 미국은 경제제재, 전쟁 등을 통해 이를 봉쇄하였다. 당시 달러에 대항한국가들은 세계경제에 미치는 영향이 미미했기 때문에 달러패권을 벗어나지못했다. 미국과 중국은 2018년 경제적 갈등을 벌이고 있다. 무역 갈등에서 시작된 미중 간의 갈등은 ICT기업에 대한 제재 등 확장일로에 있다. 세계는 이를 미국트럼프대통령의 등장에 원인을 두고 있으나 본 연구는 달러패권에 대한 중국의도전이라는 관점에서 분석하였다. 미국사회는 미중 간의 갈등 초기에는 트럼프대통령에 대한 비난과 비판이 주를 이루었으나 2018년 하반기 이후 트럼프대통령의 재선 가능성이 증가하고 있고 11월 거행된 중간선거에서도 공화당이 선전하였다. 갈등 이후에도 미중 간의 무역적자 규모가 감소하지 않은 상황에도 트럼프대통령의 정치적 입지가 오히려 상승하고 있는 것이다. 이런 이유로 미중의 갈등은 달러패권의 유지와 관련이 크기 때문에 중국의 대응에 원인이 있을가능성이 크다. 본 연구결과에 따르면, 중국은 달러가 독점하고 있는 원유선물거래에 위안화사용을 확대하고 있으며 미국이 주도하는 국제은행 결제네트워크인 SWIFT에대응하여 동남아 등 주변국가에 위안화 기반의 CIPS를 확대하고 있다. 그리고베네수엘라, 이란, 러시아, 터키 등 대표적인 반미국가와의 국제적인 공조를 강화하고 있다. 이로 인해 최근 벌어지고 있는 미중갈등은 달러패권에 대한 각축이다. 따라서 이러한 갈등 상황은 당분간 지속될 것이다. 한국정부와 기업은 이러한 상황에 대비하여 수출시장을 다변화하고 외환보유고를 다변화할 필요가있다.

Weight Loss Correlates with Macrophage Inhibitory Cytokine-1 Expression and Might Influence Outcome in Patients with Advanced Esophageal Squamous Cell Carcinoma

Lu, Zhi-Hao,Yang, Li,Yu, Jing-Wei,Lu, Ming,Li, Jian,Zhou, Jun,Wang, Xi-Cheng,Gong, Ji-Fang,Gao, Jing,Zhang, Xiao-Tian,Li, Jie,Li, Yan,Shen, Lin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

Background: Weight loss during chemotherapy has not been exclusively investigated. Macrophage inhibitory cytokine-1 (MIC-1) might play a role in its etiology. Here, we investigated the prognostic value of weight loss before chemotherapy and its relationship with MIC-1 concentration and its occurrence during chemotherapy in patients with advanced esophageal squamous cell carcinoma (ESCC). Materials and Methods: We analyzed 157 inoperable locally advanced or metastatic ESCC patients receiving first-line chemotherapy. Serum MIC-1 concentrations were assessed before chemotherapy. Patients were assigned into two groups according to their weight loss before or during chemotherapy:>5% weight loss group and ${\leq}5%$ weight loss group. Results: Patients with weight loss>5% before chemotherapy had shorter progression-free survival period (5.8 months vs. 8.7 months; p=0.027) and overall survival (10.8 months vs. 20.0 months; p=0.010). Patients with weight loss >5% during chemotherapy tended to have shorter progression-free survival (6.0 months vs. 8.1 months; p=0.062) and overall survival (8.6 months vs. 18.0 months; p=0.022), and if weight loss was reversed during chemotherapy, survival rates improved. Furthermore, serum MIC-1 concentration was closely related to weight loss before chemotherapy (p=0.001) Conclusions: Weight loss both before and during chemotherapy predicted poor outcome in advanced ESCC patients, and MIC-1 might be involved in the development of weight loss in such patients.

Anthocyanins from <i>Vitis coignetiae</i> Pulliat Inhibit Cancer Invasion and Epithelial-Mesenchymal Transition, but These Effects Can Be Attenuated by Tumor Necrosis Factor in Human Uterine Cervical Cancer HeLa Cells

Lu, Jing Nan,Lee, Won Sup,Yun, Jeong Won,Kim, Min Jeong,Kim, Hye Jung,Kim, Dong Chul,Jeong, Jae-Hoon,Choi, Yung Hyun,Kim, Gon-Sup,Ryu, Chung Ho,Shin, Sung Chul Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-

<P>Recently we have demonstrated that anthocyanins from fruits of <I>Vitis coignetiae</I> Pulliat (AIMs) have anticancer effects. Here, we investigate the effects of AIMs on cell proliferation and invasion as well as epithelial-mesenchymal transition (EMT) which have been linked to cancer metastasis in human uterine cervical cancer HeLa cells. AIMs inhibited the invasion of HeLa cells in a dose-dependent manner. AIMs inhibited MMP-9 expression in a dose-dependent manner. AIMs inhibited the motility of HeLa cells in a wound healing test. AIMs still suppressed NF-<I><I>κ</I></I>B activation induced by TNF. AIMs also inhibited EMT in HeLa cells. AIMs suppressed vimentin, N-cadherin, and <I>β</I>-catenin expression and induced E-cadherin. AIMs also suppressed expression of <I>β</I>-catenin and Snail, which was regulated by GSK-3. These effects of AIMs were also limited in the HeLa cells treated with TNF. In conclusion, this study indicates that AIMs have anticancer effects by suppressing NF-<I><I>κ</I></I>B-regulated genes and EMT, which relates to suppression of I<I><I>κ</I></I>B<I><I>α</I></I> phosphorylation and GSK-3 activity, respectively. However, the effects of AIMs were attenuated in the TNF-high condition.</P>

Life Science : Synthesis of benzo-annulated tryptanthrins and theit biological properties

( Jing Lu Liang ),( So Eun Park ),( Young Joo Kwon ),( Yurng Dong Jahng ) 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0

A series of benzo-annulated derivatives of tryptanthrin were prepared and their optical and redoxproperties were studied. Tryptanthrin and its benzo-annulated derivatives showed selective inhibitory activity on topo I with an increase of activity on topo II by benzo-annulation on quinazolin-4(3H)-one moiety. Although the benzo-annulation on quinazolin-4(3H)-one ring did not affect significantly on the inhibitory activities against topo I and II, the benzoannulation on indolin-3-one ring affected the inhibitory activity very much especially by linear annulation. Cytotoxicities were not significantly changed upon benzoannulation, which were not directly related either to the inhibitory activities against topo I and II or to the reduction potentials.