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Anticancer Activities of Pomegranate Extracts and Genistein in Human Breast Cancer Cells
M.A. Louis Jeune,J. Kumi-Diaka,J. Brown 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.4
Previous studies have demonstrated the anticarcinogenic activity of pomegranate extracts and genistein in aseries of human cancer cells. In the present study, the potential anticancer effects of pomegranate extracts and genistein oninhibition of cell proliferation and induction of apoptosis in human breast cancer cells was investigated. Human breast can-cer cells (MCF-7) were cultured as monolayers in complete RPMI 1640 medium. The cells were cultured for 48 hours to al-low growth and achieve about 80% confluence in 48-well culture plates, and then exposed to the agents for 24 hours in sin-gle and combination treatments. Post-treatment growth rate and apoptosis induction were assessed by the use of a series ofbioassayslactate dehydrogenase and 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetra-zolium (inner salt) for viability and cytotoxicity; acridine orange-ethidium bromide and terminal deoxyribonucleotidyl trans-ferase-mediated dUTP nick-end labeling assays for induction of apoptosis. Both pomegranate extracts and genistein had sig-nificant (dose- and time-dependent) cytotoxic and growth inhibition effects on MCF-7 cancer cells. Both growth inhibitionand cytotoxicity were significantly higher (P. .01) in the combination treatments than in the single treatments with eitheragent. The data revealed that both drugs in single and in combination treatments induced apoptosis in MCF-7 cells. Apop-totic induction in the combination treatments was significantly higher (P. .01) than in single treatments. Both pomegranateextracts and genistein inhibit the growth of MCF-7 breast cancer cells through induction of apoptosis, with combination treat-ment being more efficacious than single treatments.
병원성 원생동물의 변이와 약물내성: Leishmania major의 클로로퀸 내성
전경희(Kyung Hee Jeune),정시련(See Ryun Chung),바바라 밀러(Barbara Miller),캐롤 시블리(Carol Sibley) 大韓藥學會 1991 약학회지 Vol.35 No.2
A comparative study was performed on two different strains of Leishmania majorchloroquine sensitive strains (ChlS) and its mutant chloroquine resistant strains (ChlR). ChlR strains were obtained at 5X10-4M chloroquine. Remarkable differences were observed at the initial chloroquine uptake in ChlR and ChlS, ie., the rate of uptake was very reduced in ChlR (Km values were 70nM and 125nM, respectively). Influx and accumulation of chloroquine were also compared between wild type and mutant. An increasing tendency in both influx and accumulation of chloroquine was shown in ChlS, but ChlR demonstrated a rapid release after a little uptake (influx) at the early stage. This result is thought to be basis of their resistance for ChlR strains.
전경희(Kyung Hee Jeune),박채수(Chae Soo Park),박원학(Won Hark Park),최수정(Soo Jeong Choi),소명숙(Myung Suk So),정시련(See Ryun Chung) 대한약학회 1997 약학회지 Vol.41 No.4
A new lectin was partially purified from starfish,Asterina pectinifera by means of physiological saline extraction, salt fractionation, ion exchange chromatography and hydroxyapatite chromatography, and it was named APL. The biochemical properties of the APL were characterized. In addition, its effects on lymphocyte mitogenicity and cancer cell agglutinability were tested. The APL agglutinated nonspecifically human erythrocytes and rabbit blood cells. Agglutinability was decreased to 30% of control activity below pH 5 and above pH 9 and was relatively unstable at increasing temperatures above 60oC. The activity was reduced by addition of two kinds of metal ions, Ba2+, Mn2+ and chelating agent, EDTA. APL was proved to be glycoproteins containing 9% sugars. For carbohydrate specificity, it was found that the activity of APL was inhibited by D(+)-glucosamine, D(+)-galactosamine, stachyose, N-acetyl-galactosamine and methyl-alpha-D-galactopyranoside among 35 sugars tested. In amino acid composition, the contents of acidic amino acids such as aspartic acid and glutamic acid were relatively high. This result suggest that the isoelectric point would be in a lower range. APL was found that it promotes the division of human lymphocytes. APL was proved to be a potent agglutinin for cancer cells such as HeLa, L929 and L1210 cells. Significant changes on the HeLa cell surfaces affected by APL were observed under the electron microscope.
버섯류의 렉틴 성분 개발연구(II) 야생 버섯류의 생리활성 물질, 렉틴 성분 검색
전경희(Kyung Hee Jeune-Chung),김무경(Moo Kyung Kim),정시련(See Ryun Chung) 대한약학회 1987 약학회지 Vol.31 No.4
Twenty species of higher fungi growing in the wild were collected and studied extensively for their lectin activities by using erythrocytes of human, rabbit and mouse blood. In total, 14 species demonstrated hemagglutination with some kinds of erythrocytes. Of twenty species, eight (Boletus edulis, B. splendidus, Clavaria zollingeri, Lactarius subzonarius, L. volemus, Russula cutefracta, Pholiota squarrosa, and P. aspera) were shown lymphoagglutination with murine splenic lymphocytes. Protein contents were estimated from the crude lectin fraction. Above mentioned eight species contained relatively high amounts of proteins than other mushrooms. Since these species had, coincidently, high hemagglutinating activity as well, we could define them as lectin-containing mushrooms. Some species also contained mitogenic lectins toward murine splenic lymphocytes.
해양 천연물에서 분리한 면역기능 조정제 렉틴 MLA의 림프구 자극분열효과 및 면역화학적 특성
전경희(Kyung Hee Jeune),김장환(Jang Hwan Kim),정시련(See Ryun Chung) 대한약학회 1995 약학회지 Vol.39 No.3
Isolation, purification and characterization of biophysicochemical properties of the three new lectins. MLA-I, MLA-II, MLA-III from the hemolymph of Meretrix lusoria have been reported previously. A series of immunochemical studies were investigated in this work. The three lectins were revealed as having partial identity each other by immunodiffusion and immunoelectrophoresis. These results suggest that MLA lectins are isolectins having similar biophysicochemical properties. Particularly, MLA-I proved to be a potent mitogen for murine splenic as well as human peripheral lymphocytes, and the optimum mitogenic dose were 62.5 and 1.95mcg/ml, respectively.