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Fatigue Design Evaluation of Railway Bogie with Full-Scale Fatigue Test
Seo, Jung-Won,Hur, Hyun-Moo,Jun, Hyun-Kyu,Kwon, Seok-Jin,Lee, Dong-Hyeong Hindawi Limited 2017 Advances in materials science and engineering Vol.2017 No.-
<P>The bogie frame of a railway is an important structural member for the support of vehicle loading. In general, more than 25 years’ durability is necessary. Much study has been carried out in experimental and theoretical domains on the prediction of the structural integrity of the bogie frame. The objective of this paper is to estimate the structural integrity of the bogie frame of an electric railcar. Strength analysis has been performed by finite element analysis. From this analysis, stress concentration areas were investigated. To evaluate the loading conditions, dynamic stress was measured by strain gauge. It has been found that the stress and strain due to the applied loads were multiaxial conditions according to the location of the strain gauge. Fatigue strength evaluations of the bogie frame were performed to investigate the effect of a multiaxial load through the employment of a critical plane approach.</P>
Won Hee Jeong,Il Hyeong Cho,In Seok Seo 위기관리 이론과 실천 2015 Crisisonomy Vol.11 No.11
본 연구는 농업분야 기후변화 영향ㆍ취약성 평가 및 실태조사를 위한 기초연구로써, 농어업·농어촌 및 식품산업 기본법 시행규칙 5조 1항에서 명시하고 있는 5가지 법적 위임 업무에 대한 19개의 세부과제를 도출하고, 이들 간의 우선순위를 분석하였다. 분석결과를 요약하면 다음과 같다. 우선, 중점과제에서 가장 우선적으로 고려되어야 할 것은 기상ㆍ기후의 이상 변화 조사(0.275)인 것으로 나타났다. 다음으로, 중점과제와 세부과제를 종합한복합가중치 우선순위 분석결과에서는 기후변화 영향 및 취약성 조사를 위한 추진기구 설립(0.178)이 가장 높은것으로 나타났으며, 기상이 농작물 생산성에 주는 필지별 변동평가(0.092), 전국 농작물별 이상기상 발생 변동평가(0.076), 전국 고해상도(30m) 기상값 산출 및 평가(0.067), 식량작물, 과수, 채소의 재배적지 변동평가(0.063)도 상대적으로 높은 순위로 확인되었다. This research aims to build fundamental foundation of an assessment and conditional survey on the impact/vulnerability by climate change in the agricultural sector. It derived and prioritized 19 detailed tasks concerning the five legal entrusted businesses stipulated in Paragraph 1, Article 5 of the Agricultural and Fishery Farming and Fishing Village Food Industry Fundamental Law. The results of the analysis are as follows. First, abnormal weather and climate change investigation was found to be regarded as a top priority among the main tasks (0.275). Second, the analysis of the complex weighted values combining the main tasks with the detailed tasks showed that the establishment of the promotion organization investigating climate change impact and vulnerability was given the highest priority (0.178). Lastly, a relatively high priority was given to the assessment of the change in agricultural produce productivity affected due to weather (0.092).
Sphingosylphosphorylcholine induces proinflammatory signaling via activation of mast cells in skin
( Hyeong Rae Kim ),( Dae Kyoung Choi ),( Kyung Cheol Sohn ),( Myung Im ),( Young Lee ),( Chang Deok Kim ),( Jeung Hoon Lee ),( Young Joon Seo ),( Ji Hye Park ),( Chong Won Choi ),( Ga Young Lee ),( So 대한피부과학회 2012 대한피부과학회 학술발표대회집 Vol.64 No.3
Effects of mTORC1 inhibition on proteasome activity and levels
( Seo Hyeong Park ),( Won Hoon Choi ),( Min Jae Lee ) 생화학분자생물학회 2022 BMB Reports Vol.55 No.4
The mechanistic target of rapamycin (mTOR) regulates numerous extracellular and intracellular signals involved in the maintenance of cellular homeostasis and cell growth. mTOR also functions as an endogenous inhibitor of autophagy. Under nutrient-rich conditions, mTOR complex 1 (mTORC1) phosphorylates the ULK1 complex, preventing its activation and subsequent autophago-some formation, while inhibition of mTORC1 using either rapamycin or nutrient deprivation induces autophagy. Autophagy and proteasomal proteolysis provide amino acids necessary for protein translation. Although the connection between mTORC1 and autophagy is well characterized, the association of mTORC1 inhibition with proteasome biogenesis and activity has not been fully elucidated yet. Proteasomes are long-lived cellular organelles. Their spatiotemporal rather than homeostatic regulation could be another adaptive cellular mechanism to respond to starvation. Here, we reviewed several published reports and the latest research from our group to examine the connection between mTORC1 and proteasome. We have also investigated and described the effect of mTORC1 inhibition on proteasome activity using purified proteasomes. Since mTORC1 inhibitors are currently evaluated as treatments for several human diseases, a better understanding of the link between mTORC1 activity and proteasome function is of utmost importance. [BMB Reports 2022; 55(4): 161-165]
Won Sik Jeong,Seong Su Hong,Changon Seo,Jin Gwan Kwon,Eun Kyung Ahn,Ju Hyeong Park,Hana Cho,Joa Sub Oh 한국약용작물학회 2016 한국약용작물학술대회 발표집 Vol.2016 No.10
Background : The objective of this study was to Amomum tsao-ko Crevost et Lemarié, (Zingiberaceae) is widely distributed among several countries in South Asia and Southeast Asia. It is a well known spice in Asia, produces a nice refreshing effect in the mouth. Additionally, it's dried fruit is used in Traditional Chinese Medicine (TCM) for cardiac diseases, edema, eye trouble, skin, itch and impotence. The objective of this study was evaluated the inhibitory activity on adipogenesis in 3T3-L1 cells from A. tsao-ko. Methods and Results : The fruits of A. tsao-ko were extracted with 80% EtOH two times at room temperature. The EtOH extract was suspended in distilled water and partitioned with solvent to give CH2Cl2, EtOAc and n-BuOH. The CH2Cl2 was suspended in n-hexane and partitioned with solvent to give 50%, 70% and 90% MeOH. The purification of each fraction by column chromatography separation and HPLC analysis. Consequently, several constituents were isolated five known compounds. The identification and structural elucidation of compounds were established by using NMR (1D and 2D) and mass spectrometry. Conclusion : These compounds were identified as fluorenone (1), phenanthrene (2), anthracene (3), methyl linolenate (4), 1,2-benzenediol (5). All isolates were tested for their inhibitory activities on adipogenesis in 3T3-L1 cells.
( Hyeong In Kim ),( Dong Lim Seol ),( Min Young Choi ),( Ji Yeon Seo ),( Young Chul Yoon ),( Soon Ho Cheong ),( Ki Jung Ahn ),( Mi Seon Kang ),( Won Hee Jang ),( Young Il Yang ) 한국조직공학·재생의학회 2009 조직공학과 재생의학 Vol.6 No.1
Ionizing radiation produces both acute and delayed effects on skin and subcutaneous tissues, resulting in profound impairment in wound healing. Adipose tissue-derived stem cells(ASCs) have the potential to differentiate into different cell lineages and could be used to repair numerous injured tissues. We examined whether intradermal injection of ASCs would improve the impaired wound healing in irradiated mice. Mice were locally irradiated to the hindlimb to induce radiation dermatitis. Four weeks after irradiation, syngeneic ASCs were delivered into intradermal area of irradiated skin. To assess the effect of the ASCs injection, phenotypic and morphologic analyses and blood flow rate were assessed. The phenotypic analysis showed a progression from erythema to ulceration in irradiated mice. However, irradiated mice injected with ASCs displayed a complete healing of the epidermis and restoration of dermal components. CD31+ microvessels were significantly increased in irradiated mice injected with ASCs compared to those injected with PBS(p<0.05). Inaddition, blood flow rate was higher in irradiated mice injected with ASCs than those injected with PBS(p<0.01). The injected ASCs mostly located in dermis and formed vimentin-positive stromal cells. A few injected ASCs were incorporated into microvasculatures. In conclusion, ASCs could be used as useful cell therapeutics to accelerate wound healing in radiation-induced tissue damage.
Fatigue Crack Growth and Fracture behavior of Rail Steels
Seo, Jung Won,Kwon, Seok Jin,Lee, Dong Hyeong,Kwon, Sung Tae,Choi, Ha Yong The Korean Society for Railway 2012 International Journal of Railway Vol.5 No.3
Contact fatigue damages on the rail surface, such as head checks and squats are a growing problem. The fatigue cracks forming on the contact surface grow according to load and lubricating conditions and may end up breaking the rail. Rail fracture can be avoided by preventing the cracks from reaching the critical length. Therefore, the crack growth rate needs to be estimated precisely according to the conditions of the track and load to develop a maintenance plan against rail damages. Therefore, it is important to understand the mechanism of cracks initiation and growth on a rail due to repetitive rolling contact. In this study, we have investigated the crack growth behavior on the rail surface by using the twin-disc tests and the finite element analysis.