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이응룡,강근호,강용진,김우열,최혜연,김봉우,정효순,조쌍구 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10
Many studies revealed the neuroprotective, cardioprotective, and chemopreventive actions of dietary flavonoids. The plausible mechanistic interpretation of the various effects of flavonoids was concentrated on the anti-oxidant or free radical-scavenging properties of these phytochernicals, both in model systems and under in vivo conditions. While there has been a major focus on the anti-oxidant properties. there is an emerging view that flavonoids and their in vivo metabolites. do not act as conventional hydrogen-donating anti-oxidants. but they may exert regulatory functions in cells through actions at protein kinase or lipid kinase signaling pathways. Flavonoids and more recently their metabolites. have been reported to act at phosphoinositide 3-kinase(PI 3-kinase). Akt/protein kinase B(Akt/PKB), protein kinase C (PKC), mitogen activated protein kinase(MAP kinase), and various tyrosine kinases signaling cascades. Inhibitory or stimulatory actions at these pathways are likely to affect cellular function profoundly by altering the phosphorylation state of target molecules and by modulating gene expression. A clear understanding of the mechanisms of action of flavonoids, either as anti-oxidants or modulators of cellular signaling pathways, and the influence of their metabolism on these properties are key to the evaluation of these potent biomolecules as anti-cancer agents, cardio-protectants, and inhibitors of neurodegeneration.
황상일,김혜령,윤순옥 경북대학교 사회과학대학 지리학과 2003 地理學論究 Vol.- No.23
한강하류부에 위치한 김포시 고촌면 김포평야의 충적충과 사면퇴적충에서 퇴적상 분석 및 화분 분석을 실시하여 식생환경, 해면변동, 기후변화와 같은 자연환경인화를 검토하고 이것을 선사시대 인간활동과의 관계에서 살펴보았다. 최종빙기 이래 형성된 연구지역의 퇴적상은 빙기의 선상지성사면퇴적층과 흘로세 충적충으로 구분되며, 화분분석은 흘로세 충적충의 유기질이 다소 포함된 회색실트충, 분해되지 않은 토탄충, 분해된 토탄충에서 이루어졌다. 화분조성은 흘로세 중기 이후 해면미변동을 반영하며, 화분대GP-Ⅰ은 흘로세 해진의 영향으로 수심이 있는 저습지 환경에서 Alnus를 중심으로 한 목본 우점기에 퇴적되었고, 화분대GP-ll시기는 해면의 지속적인 정체와 하강에 따른 지하수위 저하 그리고 활발해진 인간활동의 영향으로 목본이 크게 줄고, 포자와 초본류가 우점하게 되었다. The environmental change such as vegetation environment, sea-level change, climate change and human impact was restored at Gimpo alluvial plain on the upper Han river according to the results of sedimentary facies and pollen analysis. The sedimentary facies which has been constructed since the last glacial stage is composed of the hillslope deposits as the alluvial fan during the glacial stage and Holocene alluvium. Materials for pollen analyses were sampled from gray organic silt layer, peat I layer(abundant fibroid material included the branches of trees and roots of grasses) and peat Ⅱ layer(decomposed peat including organic clay) in the alluvium of the Holocene. The change of the pollen composition reflected sea-level change and vegetation environment during the Holocene. Pollen zone GP-Ⅰ was the period of AP-dominance, including mostly Alnus. Study area was under the lagoon or swamp environment influenced by Flandrian transgression. Pollenzone Ⅱ was the period of Spore & NAP-dominance. It represents that vegetation environment was changed to drier condition by falling the surface of ground-water caused by sea-level regression after long-term stability, and influenced of human activity.
Kim, Hye‐,Ryoung,Kim, Hee‐,Seung unknown 2017 NURSING AND HEALTH SCIENCES Vol.19 No.4
<P><B>Abstract</B></P><P>The management of cardiometabolic risk factors, such as abdominal obesity, dyslipidemia, hypertension, and hyperglycemia, is essential for the health of postmenopausal women. In this study, we identified the effects of autonomy‐supportive, Web‐based lifestyle modification for the management cardiometabolic risk of postmenopausal women, and assessed the mediation effect of intrinsic motivation. This study was a randomized trial involving 71 postmenopausal Korean women. For the intervention group, we provided the Web‐based autonomy supports for 12 weeks; however, for the control group, individual consultations on healthy lifestyle was conducted at the first meeting. In the intervention group, cardiometabolic risks ameliorated as follows: waist circumference and waist‐to‐height ratio decreased by 3.9 cm and 0.03 cm, respectively; triglycerides decreased by 8.5 mg/dl; triglycerides‐to‐high‐density‐lipoprotein cholesterol ratio decreased by 0.21; systolic blood pressure decreased by 3.3 mmHg, and the visceral adiposity index decreased. Among the subdomain of intrinsic motivation, perceived competence, effort/importance, and perceived choice showed an association with waist circumference changes. Web‐based autonomy supports can be effective in implementation and maintenance, and the amelioration of cardiometabolic risk in postmenopausal women.</P>
Kim, Hye-Ryoung,Kang, Min-Su,Kim, Mi-Jin,Lee, Hee-Soo,Kwon, Yong-Kuk Poultry Science Association 2013 Poultry science Vol.92 No.8
<P>This study was conducted to characterize infectious laryngotracheitis (ILT) viruses isolated from poultry in South Korea using RFLP analysis of PCR products. Seven wild-type Korean isolates from commercial chicken farms collected between 1986 and 2012 were compared with 3 imported commercial vaccine strains [LT Blen (Hudson strain, United States), Laryngo Vac (Cover strain, United States), and Nobilis ILT (Serva strain, France)] and a Korean chicken embryo origin (CEO) vaccine strain [ILT-VAC (Gyeonggi97 strain, Korea)]. Six of the field isolates were highly virulent viruses, and the Kr12AD37 isolate was considered an attenuated type according to Han’s RFLP method. These virulent Korean ILT viruses were divided into 3 classes (class I, II, and III). The Kr12AD37 isolate was found to have the same RFLP pattern as the Korean CEO vaccine strain, and both of these strains were different from the 3 foreign vaccine strains. The results suggest that the Korean CEO vaccine strain has been responsible for recent outbreaks, and the characterization of ILT viruses by RFLP was useful for diagnosis by providing epidemiological information.</P>
Hye-Ryoung Kim 한국기초간호학회 2023 Journal of korean biological nursing science Vol.25 No.4
Purpose: This study examined the definitions, diagnostic criteria, and measurements of sarcopenic obesity and identified effective exercise interventions that improve cardiometabolic outcomes in middle-aged and older adults, in whom the prevalence of sarcopenic obesity is increasing. Methods: This comprehensive review followed the principles of literature search, data extraction, and review, as described in the PRISMA 2009 guidelines. Results: The 11 articles included in this study presented different concepts of sarcopenic obesity. Exercise interventions for sarcopenic obesity varied in their effects. Resistance exercise improved muscle mass and physical function, while aerobic exercise primarily impacted obesity and cardiometabolic indicators. Combined exercise had mixed results across indicators. Conclusion: This study addressed a pressing public health concern in the context of an aging population, acknowledged the unique challenges of sarcopenic obesity, and attempted to clarify definitions and assessment methods, while identifying effective exercise interventions to reduce cardiometabolic risk. Sarcopenic obesity is a multifaceted condition with varying definitions and diagnostic criteria. Its association with cardiometabolic risk underscores the need for comprehensive assessments considering both muscle and obesity indicators. While exercise interventions hold promise for managing sarcopenic obesity, further research is required to establish effective strategies.
Kim, Hye-Ryoung,Kwon, Yong-Kuk,Il-Jang,,Lee, Youn-Jeong,Kang, Hyun-Mi,Lee, Eun-Kyoung,Song, Byung-Min,Jung, Suk-Chan,Lee, Kyung-Hyun,Lee, Hyun-Kyoung AMERICAN ASSOCIATION OF AVIAN PATHOLOGISTS 2016 Avian diseases Vol.60 No.2
<P>Highly pathogenic avian influenza (HPAI) virus of the H5N8 subtype was isolated from a young ostrich in South Korea in March 2014. Clinical signs characterized by anorexia, depression, and signs of nervousness were observed. The isolated A/ostrich/Korea/H829/2014 (H5N8) virus had a cleavage site motif containing multiple basic amino acids, typical of HPAI virus. The phylogenetic tree of the hemagglutinin gene of the H5 HPAI virus showed that this ostrich H5N8 virus belongs to clade 2.3.4.4 viruses together with H5N8 strains isolated from ducks and wild birds in South Korea in 2014. Pathologically, redness of pancreas, enlargement and hemorrhage of spleen, friability of brain, and hydropericardium were prominently found. Histologic legions were observed in pancreas, spleen, liver, lung, heart, and brain, and influenza A nucleoproteins were detected in the same organs by immunohistochemistry. Other ostriches farmed together in open camps were not infected with HPAI virus based on the serologic and virologic tests. The findings indicate that ostriches are susceptible to H5N8 HPAI virus, but this virus does not spread efficiently among ratites.</P>