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오혜근,구자봉,김동출,심재영,박정훈,박영균,임성철 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1
We present a case of angiomyofibroblastoma of the vulva in a 32-year-old woman. The asymptomatic lesion measured 4×3cm and appeared as a gray-white myxoid mass on cut sections Histologically, it appeared as a relatively well-circumscribed spindle cell proliferation with alternating hypercellular and hypocellular areas and proliferation of thin-walled blood vessels. Immunohistochemically, the stromal cells expressed vimentin, CD34 and progesterone receptor, but not desmin, α-smooth muscle actin, S-100 protein and estrogen receptor. These features were similar to those of angiomyofibroblastoma as previously reported in the vulva except negativity for desmin A case of pathologically proven very rare tumor of angiomyofibroblastoma of the vulva is presented with a literature review
Hye Won Chae,Haehum Jung,Eun Jung Kim,Hyun Joo Shim,Joong In Lim,Hye Young Ji,Hye Suk Lee 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.9
(S)-2-ethoxy-3-(4-{3-methyl-5-[4-(3-methyl-isoxazol-5-yl)-phenyl]thiophen-2-ylmethoxy}-phenyl)-propionic acid (PAM-1616) is a novel peroxisome proliferators-activated receptor γ (PPARγ) partial agonist with excellent antihyperglycemic activity. It is a promising new drug candidate for the treatment of type-2 diabetes with reduced possibility of edema in vitro/in vivo. In order to evaluate the pharmacokinetics of PAM-1616, a reliable, selective and sensitive highperformance liquid chromatography/electrospray ionization tandem mass spectrometry was developed for the quantification of PAM-1616 in rat plasma. The analytes were extracted from rat plasma with ethyl acetate, separated on an Atlantis dC18 column with a mobile phase of 75% acetonitrile in 10 mM ammonium formate (pH 4.5), and detected by tandem mass spectrometry in the selective reaction monitoring mode. The calibration curve was linear (r2 = 0.999) over the concentration range of 0.05-20.0 μg/mL and the lower limit of quantification was 0.05 μg/mL. The coefficient of variation and relative error at four QC levels were 1.8% to 14.3% and −10.0% to 6.5%, respectively. The present method was successfully applied to the pharmacokinetic study of PAM-1616 after intravenous administration of PAM-1616 potassium at a dose of 1 mg/kg in rats.
저칼슘혈증으로 인한 발작 뇌파소견을 보인 신생아 경련 1례
류혜경(Hye Kyung Ryu),박상욱(Sang Uk Park),심재원(Jae Won Shim),심정연(Jung Yeon Shim),정혜림(Hye Lim Jung),박문수(Moon Soo Park),김덕수(Deok Soo Kim) 대한소아신경학회 2007 대한소아신경학회지 Vol.15 No.1
저자들은 경련을 주소로 내원한 10일된 신생아에서 응급으로 시행한 뇌파검사상 발작기 뇌파를 관찰하였으며, 혈청학 검사에서 저칼슘혈증이 발견되어 칼슘제재 투여 후 경련이 소실된 증례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Seizures in neonates can occur due to the problems of delivery at birth such as anoxia and cerebral hemorrhage. Other events, such as hypocalcemia, hypoglycemia, hyponatremia, hypernatremia, hypomagnesemia, infection and central nervous system malformations, can cause sezures. Hypocalcemia occurs most commonly in neonates, which is one of the important causes of neonatal seizures over the post few decades. The electroencephalogram (EEG) in neonatal hypocalcemia may show abnormal spikes, specifically focal, rhythmic, high-voltage, and frontocentral discharges that rapidly generalize. We report the ictal EEG findings in a neonate with hypocalcemic seizures.
류혜경(Hye Kyung Ryu),박상욱(Sang Uk Park),심재원(Jae Won Shim),심정연(Jung Yeon Shim),정혜림(Hye Lim Jung),박문수(Moon Soo Park),김덕수(Deok Soo Kim) 대한소아신경학회 2008 대한소아신경학회지 Vol.16 No.2
목 적: 두통은 소아에서 비교적 흔하게 경험하는 증상이며, 일차두통의 빈도도 비교적 높은 편이다. 소아에서는 증상이 경미하고 예후가 좋은 편이나 때로 심한 두통을 호소하기도 하고 쉽게 호전되지 않는 경우도 있으며 일부에서는 성인이 되어서까지 두통이 지속된다. 따라서 소아에서의 일차두통 자연 경과를 파악하는 것이 두통의 치료와 상담에 중요할 것으로 생각되나 이에 대한 국내 보고는 적은 편이다. 본 연구에서는 일차두통으로 진단되었으나 예방적 치료를 하지 않은 환아들에서 2년 후 두통 유무에 대해 살펴 보고자 하였다. 방 법: 2003년 9월부터 2005년 10월까지 본원 소아과에 두통을 주소로 내원하여 편두통과 긴장형 두통으로 진단 받았던 환아 중 두통의 예방적 투약을 하지 않은 51명을 대상으로 하였다. 내원 후 2년이 지난 시점에서 부모와의 전화 인터뷰를 통해 두통의 유무와 호전 정도를 파악하였다. 총 51명의 환아 중에서 연락이 불가능하여 상태를 파악할 수 없었던 경우는 9명으로 탈락률은 17.6%였고, 연락이 가능하였던 42명의 환아를 대상으로 초기 방문시 진단에 따른 2년 후 상태를 확인하였다. 결 과 : 일차 두통 환아의 내원 당시 평균 연령은 11.3세였으며, 남아 23명(54.8%), 여아 19명(45.2%)이었다. 초기 진단 시 편두통 25명(59.5%), 긴장형 두통 17명(40.5%)이었다. 각 두통의 남녀 비는 편두통 1:1.5, 긴장형 두통 3.2:1이었다. 두통의 발생부위는 편두통에서 측두부 52.0%, 긴장형 두통에서 미만성 35.3%로 가장 많았다. 두통의 양상에서는 편두통에서 박동성 60.0%, 긴장형 두통에서 둔통 52.9%로 가장 많았다. 전체 두통 환자의 호전률에서는, 두통이 호전된 군 81.0%, 호전되지 않은 군 19.0%로 나타났다. 편두통 군이 80.0%, 긴장형 두통 군이 82.3%의 호전률을 보여 두 군간의 호전률은 비슷했으며 통계적 유의성은 없었다. 두통의 가족력과 두통 호전과의 관계에서는, 가족력이 있는 군에서 85.7%, 가족력이 없는 군에서 78.6%의 호전률로 유의한 차이를 보이지 않아 두통의 가족력은 호전률에 영향을 주지 않는 것으로 나타났다. 결 론 : 편두통이나 긴장형 두통으로 진단되었으나 예방적 치료를 하지 않은 환아들을 2년 뒤 조사한 결과, 상당수에서 두통이 호전 되었다. 하지만 본 내용은 환아들에게서 직접 정보를 얻은 것이 아니라 부모를 통하여 두통의 증상 여부를 확인하였기 때문에 정확성이 다소 떨어질 수 있으며 진단 전후 두통 일지 등을 통해 두통의 특성을 파악하는 것이 중요하리라 사료된다. 따라서 향후 두통 환아를 전향적으로 추적관찰하여 이들의 임상 경과를 확인하는 것이 필요할 것으로 판단된다. Purpose : Headache is a notable problem in clinical practice and a frequent symptom in children, but a systemic evaluation of the clinical course in affected patients is uncommon. The main aim of the present study is to investigate the natural course of primary headache in children after two years of diagnosis. Methods : Based on the international classification of headache disorder(2nd edition), 51 children were diagnosed as migraine or tension-type headache from September, 2003 to October, 2005. They did not received prophylactic treatment. Their symptoms were reassessed in 42 out of 51 children 2 years after the initial diagnosis. We evaluated the condition of the patients with headache by a telephone interview with their parents. Results : The diagnosed group consisted of 25 patients(59.5%) with migraine and 17 patients(40.5%) with tension-type headache. Regarding the location of the headache, the incidence of temporal area was higher in the migraine(52.0%) group than in the tension-type headache(11.8%) group. In the migraine group, 15 cases(60%) had pulsating headache, which was higher than in the tension-type headache group. At the 2-year follow up, headache-free or improvement was observed in 80.0%(20 cases) of the migraine group and 82.3%(14 cases) of the tension-type headache group. Among 14 children with positive headache family history, 12 patients(85.7%) were headache-free or improved. But there was not significant relationship between headache family history and prognosis. Conclusion : Primary headache had a high tendency to improve without long-term management by a 2-year follow-up in this study. Therefore, it is the way of reducing the unnecessary treatment to decide prophylactic treatment after investigating the severity or frequency of the headache using the headache diary or questionnaire.
PET Evidence of the Effect of Donepezil on Cognitive Performance in an Animal Model of Chemobrain
Lim, Ilhan,Joung, Hye-Young,Yu, A Ram,Shim, Insop,Kim, Jin Su Hindawi Publishing Corporation 2016 BioMed research international Vol.2016 No.-
<P>A considerable number of patients with breast cancer complain of cognitive impairment after chemotherapy. In this study, we showed that donepezil enhanced memory function and increased brain glucose metabolism in a rat model of cognitive impairment after chemotherapy using behavioral analysis and positron emission tomography (PET). We found that chemotherapy affected spatial learning ability, reference memory, and working memory and that donepezil improved these cognitive impairments. According to PET analysis, chemotherapy reduced glucose metabolism in the medial prefrontal cortex and hippocampus, and donepezil increased glucose metabolism in the bilateral frontal lobe, parietal lobe, and hippocampus. Reduced glucose metabolism was more prominent after treatment with doxorubicin than cyclophosphamide. Our results demonstrated the neural mechanisms for cognitive impairment after chemotherapy and show that cognition was improved after donepezil intervention using both behavioral and imaging methods. Our results suggested that donepezil can be employed clinically for the treatment of cognitive deficits after chemotherapy.</P>
( Hye Lim Kwak ),( Sun Kyung Han ),( Sung Hoon Park ),( Si Hong Park ),( Jae Yong Shim ),( Mi Hwa Oh ),( Steven C Ricke ),( Hae Yeong Kim ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.9
Previous detection methods for Citrobacter are considered time consuming and laborious. In this study, we have developed a rapid and accurate detection method for Citrobacter species in pork products, using matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry (MS). A total of 35 Citrobacter strains were isolated from 30 pork products and identified by both MALDI-TOF MS and 16S rRNA gene sequencing approaches. All isolates were identified to the species level by the MALDI-TOF MS, while 16S rRNA gene sequencing results could not discriminate them clearly. These results confirmed that MALDITOF MS is a more accurate and rapid detection method for the identification of Citrobacter species.
Shim, Jaewoo,Jang, Sung woon,Lim, Ji-Hye,Kim, Hyeongjun,Kang, Dong-Ho,Kim, Kwan-Ho,Seo, Seunghwan,Heo, Keun,Shin, Changhwan,Yu, Hyun-Yong,Lee, Sungjoo,Ko, Dae-Hong,Park, Jin-Hong The Royal Society of Chemistry 2019 Nanoscale Vol.11 No.27
<P>Recently, there have been various attempts to demonstrate the feasibility of transition metal dichalcogenide (TMD) transistors for digital logic circuits. A complementary inverter circuit, which is a basic building block of a logic circuit, was implemented in earlier works by heterogeneously integrating n- and p-channel transistors fabricated on different TMD materials. Subsequently, to simplify the circuit design and fabrication process, complementary inverters were constructed on single-TMD materials using ambipolar transistors. However, continuous transition from the electron-conduction to the hole-conduction state in the ambipolar devices led to the problem of a high leakage current. Here, we report a polarity-controllable TMD transistor that can operate as both an n- and a p-channel transistor with a low leakage current of a few picoamperes. The device polarity can be switched simply by converting the sign of the drain voltage. This is because a metal-like tungsten ditelluride (WTe2) with a low carrier concentration is used as a drain contact, which subsequently allows selective carrier injection at the palladium/tungsten diselenide (WSe2) junction. In addition, by using the operating principle of the polarity-controllable transistor, we demonstrate a complementary inverter circuit on a single TMD channel material (WSe2), which exhibits a very low static power consumption of a few hundred picowatts. Finally, we confirm the expandability of this polarity-controllable transistor toward more complex logic circuits by presenting the proper operation of a three-stage ring oscillator.</P>