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Comparison of MAST-CLA results in chronic urticaria and atopic dermatitis
( Sang Hyeon Hwang ),( Hyun Min Seo ),( Heun Joo Lee ),( Yoon Hwan Kim ),( Joon Hong Min ),( Joon Lee ),( You Jin Yang ),( Seung Jae Lee ),( Ji Hye Park ),( Chong Won Choi ),( Ga Young Lee ),( Soo Hon 대한피부과학회 2012 대한피부과학회 학술발표대회집 Vol.64 No.3
Sung-Hwan Kim,Yong-Seog Oh,Young Choi,Youmi Hwang,Ju Youn Kim,Tae-Seok Kim,Ji-Hoon Kim,Sung-Won Jang,Man Young Lee,정보영,Kee-Joon Choi 대한심장학회 2021 Korean Circulation Journal Vol.51 No.1
Background and Objectives: Cavotricuspid isthmus (CTI) block is easily achieved, and prophylactic ablation can be performed during atrial fibrillation (AF) ablation. However, the previous study was too small and short-term to clarify the efficacy of this block. Methods: Patients who underwent catheter ablation for paroxysmal AF were enrolled, and patients who had previous or induced atrial flutter (AFL) were excluded. We randomly assigned 366 patients to pulmonary vein isolation (PVI) only and prophylactic CTI ablation (PVI vs. PVI+CTI). Results: There was no significant difference in procedure time between the two groups because most CTI blocks were performed during the waiting time after the PVI (176.8±72.6 minutes in PVI vs. 174.2±76.5 minutes in PVI+CTI, p=0.75). All patients were followed up for at least 18 months, and the median follow-up was 3.4 years. The recurrence rate of AF or AFL was not different in the 2 groups (25.7% in PVI vs. 25.7% in PVI+CTI, p=0.92). The recurrence rate of any AFL was not significantly different in the 2 groups (3.3% in PVI vs. 1.6% in PVI+CTI, p=0.31). The recurrence rate of typical AFL also was not different (0.5% in PVI vs. 0.5% in PVI+CTI, p=0.99). Conclusions: In this large and long-term follow-up study, prophylactic CTI ablation had no benefit in patients with paroxysmal AF without typical AFL.
Effects of Steroid Hormones on GVBD and Oocyte Steroidogenesis in Blacktip Grouper
Hwang In-Joon,Kim Seol-Ki,Choi Sang-Jun,Lee Chi-Hoon,Lee Young-Don,Kim Hyung-Bae,Baek Hea-Ja 한국발생생물학회 2012 발생과 생식 Vol.16 No.1
To verify the sex steroids which are involved in oocyte maturation of the blacktip grouper, , we incubated vitellogenic oocytes (0.41 and 0.50 mm in average diameter) in the presence of exogenous steroid precursor (-hydroxyprogesterone). Steroids were extracted, separated and identified by thin layer chromatography. The major metabolites produced were androstenedione, estradiol-, estrone and progestogens. Progestogen metabolites in the oocytes of 0.50 mm were more abundant than those of 0.41 mm. Also, we investigated the effects of human chorionic gonadotropin (HCG; 5, 50 and 500 ), -dihydroxy-4-pregnen-3-one () and -trihydroxy-4-pregnen-3-one (; 5, 50 and 500 , respectively) on oocyte maturation. In the oocytes of 0.41 mm, treatment with 50 IU HCG stimulated GVBD () compared with controls (, <0.05). In the oocytes of 0.50 mm, treatment of (50 and 500 ) stimulated GVBD ( and , respectively) compared with controls (, <0.05). Treatment with 500 IU HCG also stimulated GVBD () compared with controls (<0.05). Taken together, these results suggested that both HCG and were effective on in vitro oocyte maturation and may act as a maturation inducing hormone in blacktip grouper.
The effect of the combination therapy of cryotherapy and TCA in treatment of cutaneous wart
( Joon Hong Min ),( Hyun Min Seo ),( Sang Hyeon Hwang ),( Heun Joo Lee ),( Yoon Hwan Kim ),( Joon Lee ),( You Jin Yang ),( Seung Jae Lee ),( Ji Hye Park ),( Chong Won Choi ),( Ga Young Lee ),( Soo Hon 대한피부과학회 2012 대한피부과학회 학술발표대회집 Vol.64 No.1
( Joon Min Jung ),( Ye Jin Lee ),( Woo Jin Lee ),( Su Yeon Kim ),( Sung Eun Chang ),( Jae Sung Hwang ),( Mi Woo Lee ),( Jee Ho Choi ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Dopamine actions are mediated through five specific cell surface receptors coupled to G proteins and belonging to two main families. Although these receptors have been shown to participate in the regulation of melanogenesis, there has been no report or study concerning the relation of dopamine receptor D4 (DRD4) and melanogenesis. Objectives: Hence, we have proposed a hypothesis that DRD4 antagonist can decrease melanogenesis through its related signaling pathways. Methods: We examined the effects of DRD4 antagonist on melanogenesis and its related signaling pathways using Mel-Ab cells. We also investigated changes in the phosphorylation of ERK and Akt, which is related to melanin regulation Results: Present results showed that melanin content was significantly reduced in the cells after DRD4 antagonist treatment in a dose-dependent manner. Additionally, DRD4 antagonist treatment reduced both microphthalmia-associated transcription factor (MITF) and tyrosinase protein levels. DRD4 antagonist treatment led to the phosphorylation of ERK and Akt. Treatment with specific inhibitor of ERK and Akt, PD98059 and LY294002 respectively, significantlyincreased melanin production with DRD4 antagonist treatment. This result suggests that DRD4 antagonist’s antimelanogenic effect was regulated by ERK and Akt phosphorylation Conclusion: These results suggest that the hypopigmentary action of DRD4 antagonist is due to MITF and tyrosinase downregulation by ERK and Akt activation.
Antioxidant and Anti-inflammatory Activities of Broccoli Florets in LPS-stimulated RAW 264.7 Cells
Joon-Ho Hwang,Sang-Bin Lim 한국식품영양과학회 2014 Preventive Nutrition and Food Science Vol.19 No.2
Broccoli (Brassica oleracea var. italia) florets were extracted with 80% methanol and the extract was sequentially fractionated with n-hexane, ethyl acetate, n-butanol, and distilled water. The extract and the fractions were evaluated for total phenolic content, sulforaphane content, antioxidant activity, and anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. The total phenolic content and sulforaphane content of the ethyl acetate fraction (EF) were 35.5 mg gallic acid equivalents/g and 620.2 ?g/g, respectively. These values were higher than those of the 80% methanol extract and organic solvent fractions. The oxygen radical absorbance capacity of the EF [1,588.7 ?M Trolox equivalents (TE)/mg] was 11-fold higher than that of the distilled water fraction (143.7 ?M TE/mg). The EF inhibited nitric oxide release from LPS-stimulated RAW 264.7 cells in a dose-dependent manner and inhibited I?B-??degradation and nuclear factor-?B activation in LPS-stimulated RAW 264.7 cells. In conclusion, the EF of broccoli florets exerted potent antioxidant and anti-inflammatory effects.