소아에 많은 외과적 질환(Ⅱ)

황의호 의학교육출판사 1988 Korean Journal of Family Medicine Vol.4 No.10

GIS 기반의 유역물수지 분석모형 개발

황의호,김계현,박진혁,이근상 한국지리정보학회 2004 한국지리정보학회지 Vol.7 No.4

기존 새만금유역의 물수지분석은 유역전체를 단일유역으로 단순화하여 가지야마식으로 산출한 유출량을 기초로 행해졌으나, 새만금유역은 용수공급체계가 복잡 다양하고 향후 임의의 지점에서물수지요소가 변경될 때 탄력적으로 적용하기엔 어려움이 있다 본 연구에서는 새만금유역에 적합한 물수지분석모형 적용을 위하여 수개의 물수지 단위소유역으로 구분하고 각각의 소유역별 수자원의 개발과 이용에 대해 물수지를 상세분석할 수 있는 GIS 기반의 유역물수지모형을 개발하였다. 유역의 물수지 상세 분석을 위하여 UML 다이어그램을 이용한 물수지모형의 추상 및 개년 설계, 용수공급체계 반영을 위한 하천망 구성, GIS 기반의 전처리 및 후처리 모듈 개발, 모형 보정 및 검증 등을 포함하는 연구를 수행하였다. 이러한 물수지분석모형은 수자원의 유출과정 해석을 통해 유역내 효율적인 수자원관리 방안을 수립할 수 있도록 지원이 가능하며, 사웅자로 하여금 유역의체계적인 수자원관리에 있어 수작업을 최소화하고 다원화된 모델 분석체계를 지원함으로써 보다 편리하고, 합리적인 수자원관리방안 수립에 지원이 가능할 것으로 사료된다. Existing Semangeum's water balance analysis simplifies whole basin to single basin and achieved volume of effluence that produce by Kajiyama way to foundation. But Semangeum is complicated and various rice-wine strainer supply system. And there is difficulty to apply as elastic when water balance element is changed at free point. Divided to unit possession station for suitable water balance analysis model application to Semangeum in this study. And developed basin water balance model of GIS base that can do details analysis is bite about development and transfer of an appropriation in the budget of basin water resources. Achieved study including abstraction and concept design that use UML (unified modeling language) diagram for details analysis, stream network composition for rice-wine strainer supply system application, preprocessing of GIS base and postprocessing module development, model revision and verification etc. Support of this water balance analysis model is available to establish efficient water resources administration plan through outward flow process analysis of water resources. And support is considered to be possible in more convenient and, reasonable water resources administration way establishment by minimizing manual processing in systematic water resources government official to user and support diversified analysis system.

소아에 많은 외과적 질환(Ⅰ)

황의호 의학교육출판사 1988 Korean Journal of Family Medicine Vol.4 No.9

소아의 수액 및 전해질 요법

황의호 한국의학사 1984 診斷과治療 Vol.4 No.7

위선암에서 p53, MMP-2 및 TIMP-2의 표출

황호현,김의한,오미혜,조현득,양승하 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

Gastric adenocarcinoma is the most common malignant tumor in Korea. Many oncogens have been found in malignant tumor cells. Among these oncogene, MMP-2 and TIMP-2 show important role in invasivness and metastasis of malignant tumor cells. P53 is regulator of cellular proliferation, and the over expression of p53 relate to malignant transformation and prognosis. To evaluate the expression of MMP-2, TIMP-2, and p53 according to histopathologic features and the relation between these antigens and prognosis in gastric adenocarcinoma, we have performed immune staining, using mouse anti-MMP-2, mouse anti-p53, and mouse anti-TIMP-2 for 91 cases. The results were as follows; 1) The expression rates of MMP-2, TIMP-2, and p53 in gastric adenocacinoma were 58.2%, 57.1%, and 49.5%, respectively. 2) MMP-2 and TIMP-2 in gastric adenocarcinoma showed reverse correlation.(p<0.001) 3) MMP-2 showed more higher expression rates in intesinal type and sell differentiated form of gastric adenocarcinoma, and in cases showing more deeper invasion and metastasis to lymph nodes in advanced carcinoma. 4) TIMP-2 in advanced carcinoma showed more lower expression rates in cases showing more deeper invasion and metastasis to lymph nodes. 5) MMP-2 expression and TIMP-2 non-expression showed more higher frequency in intestinal type of gastric adenocarcinoma and in cases showing more deeper invasion depth in advanced carcinoma. 6) p53 in advanced carcinoma showed more higher expression rates in cases more deeper invasion and metastasis to lymph nodes. Above results indicated that MMP-2 and TIMP-2 in gastric adenocarcinoma shows reverse correlation, and may be show reverse relation according to progression, type, invasion depth, and metastasis to lymph node. The expression of p53 may be related to metastasis to lymph nodes and degree of depth in advanced carcinoma.

방사선조사가 당뇨 백서의 치수조직에 미치는 영향

강호덕,황의환,이상래 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.1

Purpose : To observe the histopathological changes in the pulp tissues of mandibular molars in streptozotocininduced diabetic rats after irradiation. Materials and Methods : The male Sprague-Dawley rats weighing approximately 250 gm were divided into four groups: control, diabetes, irradiation, and diabetes-irradiation groups. Diabetes mellitus was induced in the rats by injecting streptozotocin. Rats in control and irradiation groups were injected with citrate buffer only. After 5 days, the head and neck region of the rats in irradiation and diabetes-irradiation groups were irradiated with a single absorbed dose of 10 Gy. All the rats were sacrificed at 3, 7, 14, 21, and 28 days after irradiation. The specimen including the mandibular molars were sectioned and observed using a histopathological method. Results : In the diabetes group, capillary dilatation was observed. However, there was no obvious morphologic alteration of the odontoblasts. In the irradiation group, generalized necrosis of the dental pulp tissues was observed. Vacuolation of the odontoblasts and dilatation of the capillaries were noted in the early experimental phases. In the diabetes-irradiation group, generalized degeneration of the dental pulp tissues was observed. Vacuolation of the dental pulp cells and the odontoblasts was noted in the late experimental phases. Conclusion : This experiment suggests that dilatation of the capillaries in the dental pulp tissues is induced by diabetic state, and generalized degeneration of the dental pulp tissues is induced by irradiation of the diabetic group.

골결손부 치유과정에서 cone beam형 전산화단층영상의 정확도

강호덕,김규태,최용석,황의환 대한구강악안면방사선학회 2007 Imaging Science in Dentistry Vol.37 No.2

Purpose : To evaluate the accuracy of the imaging reformation of cone beam computed tomography for the assessment of bone defect healing in rat model. Materials and Methods : Sprague-Dawley strain rats weighing about 350 gms were selected. Then critical size bone defects were done at parietal bone with implantation of collagen sponge. The rats were divided into seven groups of 3 days, 1 week, 2 weeks, 3 weeks, 4 weeks, 6 weeks, and 8 weeks. The healing of surgical defect was assessed by multiplanar reconstruction (MPR) images and three-dimensional (3-D) images of cone beam computed tomography, compared with soft X-ray radiograph and histopathologic examination. Results : MPR images and 3-D images showed similar reformation of the healing amount at 3 days, 1 week, 2 weeks, and 8 weeks, however, lower reformation at 3 weeks, 4 weeks, and 6 weeks. According to imaging-based methodologies, MPR image revealed similar reformation of the healing amount than 3-D images compare with soft X-ray image. Among the four threshold values for 3-D images, 400-500 HU revealed similar reformation of the healing amount. Histopathologic examination confirmed the newly formed trabeculation correspond with imagingbased methologies. Conclusion : MPR images revealed higher accuracy of the imaging reformation of cone beam computed tomography and cone beam computed tomography is a clinically useful diagnostic tool for the assessment of bone defect healing.

Cone beam형 전산화 단층영상을 이용한 하악전치부 영양관의 연구

강정호,김규태,최용석,황의환 대한구강악안면방사선학회 2006 Imaging Science in Dentistry Vol.36 No.3

Purpose : To evaluate location, distribution, diameter, and length of the nutrient canals on mandibular anterior region using a cone beam computed tomography (CBCT). Materials and Methods : Mandibular CBCT was performed on 33 adults (18 males and 15 females) with no history of systemic disease, and any other dental surgery history. Location, distribution, diameter, and length of the nutrient canals on mandibular anterior region were radiographically evaluated. A statistical comparison was done by SPSS. Results : In the location and distribution of nutrient canals, they were found in 6.8% at labial portion above root apex, in 93.28% at lingual portion above root apex in 46.2% at labial portion below root apex, and in 53.6% at lingual portion below root apex. Nutrient canals at lingual portion above root apex were most frequently observed between central and lateral incisors, and those at labial and lingual portion below root apex were most frequently observed between central incisors. The mean diameters of nutrient canals were 0.54 mm at labial portion above root apex, 0.61 mm at lingual portion above root apex, 0.66 mm at labial portion below root apex, and 0.76 mm at lingual portion below root apex. The mean lengths of nutrient canals were 2.63 mm at labial portion above root apex, 3.74 mm at lingual portion above root apex, 4.51 mm at labial portion below root apex, and 6.77 mm at lingual portion below root apex. Conclusion : CBCT is useful device to evaluate the anatomical structure of nutrient canals on mandibular anterior region.

Simvastatin이 골결손부 회복에 미치는 영향

강정호,김규태,최용석,이현우,황의환 대한구강악안면방사선학회 2008 Imaging Science in Dentistry Vol.38 No.3

Purpose : To observe and evaluate the effects of Simvastatin-induced osteogenesis on the wound healing of defective bone. Materials and Methods : 64 defective bones were created in the parietal bone of 32 New Zealand White rabbits. The defects were grafted with collagen matrix carriers mixed with Simvastatin solution in the experimental group of 16 rabbits and with collagen matrix carriers mixed with water in the controlled group. The rabbits were terminated at an interval of 3, 5, 7, and 9 days, 2, 4, 6, and 8 weeks after the formation of defective bone. The wound healing was evaluated by soft X-ray radiography. The tissues within defective bones were evaluated through the analysis of flow cytometry for the manifestation of Runx2 and Osteocalcin, and observed histopathologically by using H-E stain and Masson’s trichrome stain. Results : 1. In the experimental group, flow cytometry revealed more manifestation of Runx2 at 5, 7, and 9 days and Osteocalcin at 2 weeks than in the controlled groups, but there was few difference in comparison with the controlled group. 2. In the experimental group, flow cytometry revealed considerably more cells and erythrocytes at 5, 7, and 9 days in comparison with the controlled group. 3. In the experimental group, soft x-ray radiography revealed the extended formation of trabeculation at 2, 4, 6, and 8 weeks. 4. Histopathological features of the experimental group showed more fibroblasts and newly formed vessels at 5 and 7 days, and the formation of osteoid tissues at 9 days, and the newly formed trabeculations at 4 and 6 weeks. Conclusion : As the induced osteogenesis by Simvastatin, there was few contrast of the manifestation between Runx2 and Osteocalcin based on the differentiation of osteoblasts. But it was considered that the more formation of cells and erythrocytes depending on newly formed vessels in the experimental group obviously had an effect on the bone regeneration.

악안면부에 대한 수종 온냉요법시의 체열변화에 관한 비교연구

김선호,홍정표,황의환 慶熙大學校 齒科大學 1995 慶熙齒大論文集 Vol.17 No.2

The purpose of this study was t.o assess the efficacy of several thermal therapies using ice pack, moist-hot pack and ultrasound, separately and concomitantly and to obtain the background information on the vascular changes after thermophysical therapies. The author had used 15 healthy subjects were examined and the subjects were divided into 5 groups; ice pack, moist-hot pack, ultrasound, ice pack and moist-hot pack, ice pack and ultrasound. Observation were made immediate before and 0, 5, 10, 20, 30, 45, 60, 90 minutes after treatment. Thermography was performed in an Agema 870 thermovision with 0.1°C difference of gradual temperature shift, The results were as 'follows 1. Using ice pack only, the surface temperature of the masseter region was increased lapse of time, and most remarkably 90 minutes after the treatment. 2. Using moist-hot pack only, the surface temperature of the region was remarkably increased immediately after the treatment, but decreased lapse of time. 3. Using moist-hot pack with ice pack, the surface temperature of the face was remarkably increased immediately after the treatment, and decreased lapse of time. Hyperthermia was maintained for a longer time as compared with the group of moist-hot pack only. 4. Using ultrasound only, the surface temperature of the region was increased gradually, and most remarkably 30 minutes after the treatment, but decreased in the course of time. 5. Using ultrasound combined with ice pack, the surface temperature of the region was gradually decreased until 30 minutes after the treatment, and decrease to some extend at 45 minute And then a gradual increase observed over the remaining period of the experiment. 6. Hyperthermia were maintained for a longer time in the groups using ice pack combined with moist-hot pack and ultrasound as compared with the other groups. Our data suggest that ice pack can promote the efficacy of other thermal therapies.