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Park, Sung Woo,Seo, Mi Kyoung,McIntyre, Roger S.,Mansur, Rodrigo B.,Lee, Yena,Lee, Jae-Hon,Park, Seon-Cheol,Huh, Lyang,Lee, Jung Goo Elsevier 2018 Neuroscience Letters Vol.686 No.-
<P><B>Abstract</B></P> <P>Recent studies have demonstrated that antipsychotic drugs may activate mammalian target of rapamycin complex 1 (mTORC1) signaling in neurons. However, the relationship between mTORC1 signaling activation and currently prescribed antipsychotic drugs remains incompletely understood. The purpose of this study was to determine whether alterations in the level of mTORC1 signaling occur after rat primary hippocampal neurons are treated with olanzapine and haloperidol under toxic conditions. Additionally, we investigated whether these drugs affect dendritic outgrowth and synaptic protein expression through the mTORC1 signaling pathway. We measured changes in mTORC1-mediated and synaptic proteins by Western blotting assay under toxic conditions induced by B27 deprivation. Dendritic outgrowth was determined by a neurite assay. Olanzapine significantly increased the phosphorylated levels of mTORC1, its downstream effectors, and its upstream activators. The increased mTORC1 phosphorylation induced by olanzapine was significantly blocked by specific PI3K, MEK, or mTORC1 inhibitors. Olanzapine also increased dendritic outgrowth and synaptic proteins levels; all of these effects were blocked by rapamycin. However, haloperidol had none of these effects. We demonstrated that olanzapine, but not haloperidol, activated the mTORC1 signaling pathway and increased dendritic outgrowth and synaptic proteins by activating mTORC1 signaling in rat primary hippocampal neurons. These findings suggest that olanzapine affects neuroplasticity by activating mTORC1 signaling.</P> <P><B>Highlights</B></P> <P> <UL> <LI> B27 deprivation in hippocampal cultures decreases mTOR signaling activity. </LI> <LI> Olanzapine can actives the mTOR signaling pathway. </LI> <LI> Olanzapine increases synaptic plasticity through mTOR signaling. </LI> <LI> However, haloperidol has no such effects. </LI> </UL> </P>
( Seung Hon Ham ),( Ji Hoon Park ),( Eun Kyo Chung ),( Dong Uk Park ),( Chung Sik Yoon ) 대한보건협회 2011 대한보건협회 보건종합학술대회 Vol.2011 No.-
[Background] Nanoparticles have been concerned due to their potential toxicity to human health. Although task-based sampling is theoretically considered to be a plausible approach for the assessment of nanoparticle exposure, few data on this type of sampling have yet been published. [Purpose] This study characterized and compared, based on task, the nanoparticle exposure profiles of engineered nanoparticle manufacturing workplaces (ENMW) and workplaces that generated welding fumes containing incidental nanoparticles. [Method] Two ENMW and two welding workplaces were investigated for exposure assessments. Real-time devices that utilized a scanning mobility particle sizer (SMPS), surface area monitor, condensation particle counter (CPC) and dust monitor were utilized to characterize the concentration profiles and size distributions of airborne nanoparticles. Filter-based sampling was performed to measure time-weighted average (TWA) concentrations and for off-line analysis using the electron microscope. [Results] This study demonstrated that the exposure profile, in terms of concentration and size distribution, varies greatly according to the task. For example, certain tasks, such as the pouring of liquid-phase titanium dioxide, grinder cover opening during the manufacturing of aluminum nanopowder, opening of the facility to collect produced nanoparticles, welding, and activities/accidents that included tobacco smoking and spilling of nano solution made the concentration of airborne nanoparticles increase by several fold compared with the background. The size distributions during tasks were different from those during periods with no activity and from the background. The size distributions during tasks were different from those during periods with no activity and from the background. The airborne concentration profiles of the nanoparticles varied according to not only the types of nanoparticles but also the concentration metrics. The airborne concentrations in the workplaces that adapted traditional industrial hygiene control methods, such as an adequate ventilation, containment and good housekeeping, were much lower than those in the workplaces where poor control methods were employed. This study suggests that a task-based exposure assessment could provide much information on the exposure profiles of nanoparticles and could thus be used as an exposure assessment tool.
Adaptive Run-time Overhead Adjustments for Optimizing Multiple Continuous Query Processing
Hyun-Hon Lee,Hong-Kyu Park,Jin-Chul Park,Won-Suk Lee,Kil-Hong Joo 보안공학연구지원센터 2014 International Journal of Software Engineering and Vol.8 No.11
The time-varying characteristics of infinite data streams require continuous queries to be adaptively processed. The order in which multiple join operations are evaluated has serious consequences for the algorithm performance because the selectivity of each join operation can differ significantly from the selectivity of the other operations. The evaluation order may be effectively determined using the k-EGA and A-SEGO schemes, as proposed in previous studies. These methods optimize target continuous queries by monitoring a set of their promising subplans simultaneously. Each scheme also employs a user-defined cost-bound parameter for controlling the number of monitored subplans. A more optimized global plan may be generated by using a more highly configured cost-bound parameter. However, this approach can increase the overhead associated with monitoring the subplans. This paper proposes a new scheme, Adaptive Run-time Overhead Adjustment (AROA), which provides a novel method for adaptively determining the value of a cost-bound parameter based on the system environment. Unlike the previously described A-SEGO scheme, the scheme proposed here automatically selects the cost-bound parameter to reflect the system workloads (e.g., the input tuple rate, and other parameters). This method not only augments the probability of generating an optimized execution plan, it reduces the run-time delay caused by the optimization process. Experimental verification of the proposed scheme AROA demonstrated that AROA outperforms the previous schemes.
커뮤니티 컴퓨팅 솔루션을 활용한 지능적 유비쿼터스 홈 구축
유성훈(Soung-Hon You),박희정(Hui-Jung Park),김현숙(Hyun-Suk Kim),신진아(Jin-A Shin),박정욱(Jung-Uk Park),변유인(U-In Byun),김태수(Tae-Soo Kim),이건우(Gun-U Lee),조위덕(We-Duk Cho) 대한전자공학회 2007 대한전자공학회 학술대회 Vol.2007 No.7
The main goal of Ubiquitous computing is that providing innovated service to user and new computing methodology is required to achieve this goal. The CUS (Center for Ubiquitous System Research Lab) has developed new computing paradigm which is called Community Computing (CC). In this paper, we describe CC briefly and explain how this new paradigm applies to home environment.
화학물질 관리 연구-1. 산업안전보건법상 관리 화학물질의 특성과 노출기준 비교
박지훈 ( Ji Hoon Park ),함승헌 ( Seung Hon Ham ),김선주 ( Sun Ju Kim ),이권섭 ( Kwon Seob Lee ),하권철 ( Kwon Chul Ha ),박동욱 ( Dong Uk Park ),윤충식 ( Chung Sik Yoon ) 한국산업보건학회 2015 한국산업보건학회지 Vol.25 No.1
Objectives: This study aims to compare the physicochemical characteristics, toxicological data with Occupational Exposure Limits (OELs) of chemicals under the Occupational Safety and Health Act(OSHA) regulated by the Ministry of Employment and Labor of Korea. Methods: Information on chemicals which have OELs on physicochemical characteristics and toxicological data was collected using Material Safety Data Sheet(MSDS) from Korea Occupational Safety and Health Agency(KOSHA) and the Korea Information System for Chemical Safety Management(KISChem) in 2014. Statistical analyses including correlation and simple regression were performed to compare the OELs with chemical characteristics including molecular weight, boiling point, odor threshold, vapor pressure, vapor density, solubility and octanol-water partition coefficient(OWPC) and toxicological data such as median lethal dose(LD50) and median lethal concentration(LC50). Results: A total of 656 chemicals have OELs under OSHA in Korea. The numbers of chemicals which have eight-hour time weighted average(TWA) and short term exposure limits(STEL) are 618 and 190, respectively. TWA was significantly correlated with boiling point and STEL was only correlated with vapor pressure among physicochemical characteristics. Solubility and OWPC between “skin” and “no skin” substances which indicate skin penetration were not significantly different. Both LD50 and LC50 were correlated with TWA, while the LC50 was not with STEL. As health indicators, health rating and Emergency Response Planning Guidelines(ERPG) rating as recommended by the National Fire Protection Association(NFPA) and American Industrial Hygiene Association(AIHA) were associated with OELs and reflect the chemical hazards. Conclusions: We found relationships between OEL and chemical information including physicochemical characteristics and toxicological data. The study has an important meaning for understanding present regulatory OELs.
症例(증례) : 고립성 편측 외전신경 마비로 나타난 원발성 알도스테론증
박지현 ( Ji Hyun Park ),노정미 ( Jung Mee Rho ),이가영 ( Ka Yeoung Yi ),오선영 ( Sun Young Oh ),송민주 ( Min Ju Song ),진홍용 ( Heung Yong Jin ),김소영 ( So Young Kim ),강선미 ( Seon Mee Kang ),박태선 ( Tae Sun Park ),백홍선 ( Hon 전북대학교 의과학연구소 2007 全北醫大論文集 Vol.31 No.2
외전신경마비는 급성 복시의 흔한 원인중 하나로써 뇌종양이나 혈관병증, 또는 당뇨병과 같은 전신질환의 한 증상으로도 나타난다. 당뇨병과 같은 전신 질환에서 외전신경마비는 미세혈관장애와 관련된 현상으로 알려져 있으며 60세 이전의 환자에서는 발생이 드물다. 원발성 알도스테론증은 전체 고혈압의 약 10%를 차지하는 이차성 고혈압의 원인 중 가장 흔한 내분비 질환이다. 과혈압과 저칼륨혈증을 특징으로 하며 대부분 수술로 치료가 가능한 질환이다. 임상 증상은 무증상인 경우가 가장 많고 일부에서 높은 혈압이나 저칼륨혈증과 관련된 증상들이 나타날 수 있다. 저자들은 극히 드물게 보고된 외전신경 마비를 동반한 부신의 알도스테론 분비 선종에 의한 원발성 알도스테론증 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Sixth cranial nerve innervates the lateral rectus muscle and its palsy is a common cause of acute diplopia. Isolated sixth nerve palsy may be associated with different pathologic conditions such as brain tumors and vasculopathy, or a symptom of generalized disease such as diabetes. Hypertension had been also frequently reported as being vascular or ischemic etiology of acquired sixth nerve palsy. However, the recent population based-study showed that systemic hypertension dose not seem to be a significant association. Secondary hypertension, there is a known cause, is in about 10% of all hypertension cases. Primary aldosteronism could be the most common identifiable and specifically treatable form of secondary hypertension. The clinical features of primary aldosteronism are not specific. Some patients are completely asymptomatic or have minimal symptoms. There is rare literature about the primary aldosteronism related with sixth nerve palsy. We here report a case of a 41 year old male with secondary hypertension by aldosterone-producing adrenal adenoma presenting with isolated unilateral sixth nerve palsy.