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Kim, Kyu Min,Wijerathne, Tharaka,Hur, Jin-Hoe,Kang, Uk Jung,Kim, Ihn Hyeong,Kweon, Yeong Cheon,Lee, Ah Reum,Jeong, Su Ji,Lee, Sang Kwon,Lee, Yoon Young,Sim, Bo-Woong,Lee, Jong-Hee,Baig, Chunggi,Kim, S National Academy of Sciences 2018 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.115 No.20
<P>Store-operated calcium entry (SOCE), an important mechanism of Ca2+ signaling in a wide range of cell types, is mediated by stromal interaction molecule (STIM), which senses the depletion of endoplasmic reticulum Ca2+ stores and binds and activates Orai channels in the plasma membrane. This inside-out mechanism of Ca2+ signaling raises an interesting question about the evolution of SOCE: How did these two proteins existing in different cellular compartments evolve to interact with each other? We investigated the gating mechanism of Caenorhabditis elegans Orai channels. Our analysis revealed a mechanism of Orai gating by STIM binding to the intracellular 2-3 loop of Orai in C. elegans that is radically different from Orai gating by STIM binding to the N and C termini of Orai in mammals. In addition, we found that the conserved hydrophobic amino acids in the 2-3 loop of Orai1 are important for the oligomerization and gating of channels and are regulated via an intramolecular interaction mechanism mediated by the N and C termini of Orai1. This study identifies a previously unknown SOCE mechanism in C. elegans and suggests that, while the STIM-Orai interaction is conserved between invertebrates and mammals, the gating mechanism for Orai channels differs considerably.</P>
Kim, Hoe-Woong,Joo, Young-Sang,Park, Sang-Jin,Kim, Sung-Kyun Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.4
As the refueling of a sodium-cooled fast reactor is conducted by rotating part of the reactor head without opening it, the monitoring of existing obstacles that can disturb the rotation of the reactor head is one of the most important issues. This paper deals with the ultrasonic ranging technique that directly monitors the existence of possible obstacles located in a lateral gap between the upper internal structure and the reactor core in a prototype generation IV sodium-cooled fast reactor (PGSFR). A 10 m long plate-type ultrasonic waveguide sensor, whose feasibility has been successfully demonstrated through preliminary tests, was employed for the ultrasonic ranging technique. The design of the sensor's wave radiating section was modified to improve the radiation performance, and the radiated field was investigated through beam profile measurements. A test facility simulating the lower part of the upper internal structure and the upper part of the reactor core with the same shapes and sizes as those in the PGSFR was newly constructed. Several under-water performance tests were then carried out at room temperature to investigate the applicability of the developed ranging technique using the plate-type ultrasonic waveguide sensor with the actual geometry of the PGSFR's internal structures.
Complete sequence-based screening of TPMT variants in the Korean population
Kim, Hyun-Young,Lee, Soo Hyun,Lee, Mi-Na,Kim, Jong-Won,Kim, Young-Ho,Kim, Mi Jin,Lee, Yoo Min,Kang, Ben,Choe, Yon Ho,Lee, Na Hee,Kim, Dong Hwan,Yoo, Keon Hee,Sung, Ki Woong,Lee, Soo-Youn,Koo, Hong Hoe Wolters Kluwer Health, Inc. All rights reserved. 2015 PHARMACOGENETICS AND GENOMICS Vol.25 No.3
Thiopurine S-methyltransferase (TPMT) is a cytoplasmic enzyme involved in the metabolism of thiopurine drugs and its activity is largely influenced by polymorphisms of the TPMT gene. To date, more than 35 TPMT variants are known to be associated with reduced enzyme activity, but most studies on the TPMT genotype have included only common nonfunctional variants, such as TPMT*2 and TPMT*3. In this study, we carried out a complete sequencing analysis to screen all TPMT variants in Korean patients. A total of 900 Korean patients were genotyped for TPMT and 30 patients (3.3%) had the known TPMT variant alleles. TPMT*3C was found in 25 patients (2.8%): 24 patients with TPMT*1/*3 and one with TPMT*3/*3. Rare TPMT variants including TPMT*6, TPMT*16, and TPMT*32 were detected in five patients (0.6%) and a novel variant, TPMT*38 (c.514T>C, p.S172P), was identified in two patients. This is the first complete sequence-based screening study evaluating all TPMT variants in Asian populations.
김종순,김석환,한상웅,김광회,소용선,권기현,이병두,김태형 대한내분비학회 1996 Endocrinology and metabolism Vol.11 No.2
The association of thyroid carcinoma and Hashimoto's thyroiditis in same thyroid gland is controversial. Incidence of carcinoma who has Hashimoto's thyroiditis has been reported from 0.5 to 22.5 per cent by Crile and by Hirabayashi et al. The reason that there are such great differences in the reported incidences of carcinoma in Hashimotos disease is the result of the way the material is reported. The carcinomas of the thyroid which occur in association with Hashirnoto's thyroiditis are predominently papillary tumors of lower grade malignancy. Thyroid carcinoma need not be feared in patients with Hashimoto's thyroiditis, if one examines the gland carefully. When patients with Hashimoto's disease are treated with thyroxine, there is little or no tendency for Hashimoto's disease progress to clinically detectable carcinoma of the thyroid, and the microcarcinoma does not appear. In this case, single thyroid nodule was detected in Hashiimoto's disease patient who was treated with thyroxine. There was no significant volume change of thyroid nodule despite of TSH suppression therapy during six months. Therefore we performed FNABC twice, the results were highly suspicious thyroid malignancy and subtotoal thyroidectomy was performed. The final pathologic result was microscopic papillary carcinoma with background Hashlmoto's thyroiditis. In conclusion, we experienced a case of subsequent microscopic papillary carcinoma of the thyroid in patient with Hashimoto's thyroiditis who was TSH suppression therapy with thyroxine(J Kor Soc Endocrinol 11:214 ~220, 1996).
소듐냉각고속로 원자로용기 가동중검사를 위한 고온 전자기음향 트랜스듀서 개발
김회웅(Hoe-Woong Kim),박상진(Sang-Jin Park),손진관(Jin-Gwan Son),주영상(Young-Sang Joo),김성균(Sung-Kyun Kim),김종범(Jong-Bum Kim) 한국비파괴검사학회 2018 한국비파괴검사학회지 Vol.38 No.4
액체 금속인 소듐을 냉각재로 사용하는 제 4세대 원자로인 소듐냉각고속로의 원자로용기는 가동중 검사 기간에도 소듐의 고화를 방지하기 위해 200°C 정도의 고온 상태로 유지되어야 하고, 소듐-물 반응을 배제하기 위해 검사 시 액체 접촉 매질의 사용이 제한되어 있다. 또한, 원자로용기를 둘러싸고 있는 격납용기와의 간격이 협소하여 직접적인 접근이 어렵기 때문에 원격제어장비를 사용하여 검사를 수행하여야 한다. 이와 같은 가혹한 조건 하에서 원자로용기의 가동중검사를 수행하기 위해 본 연구에서는 원격제어장비에 탑재가 가능한 고온 전자기음향 트랜스듀서를 개발하였다. 먼저, 개발된 고온 전자기음향 트랜스듀서의 방사패턴과 리프트 오프에 따른 신호대잡음비 변화를 측정하여 개발된 트랜스듀서의 특성을 분석하였고, 내부 결함이 모사된 원자로용기 시편에 대한 결함 탐지능 측정시험과 내열성 시험 및 내구성 시험을 수행하여 고온 환경에서의 적용 가능성을 평가하였다. The reactor vessel in a sodium-cooled fast reactor, a generation-IV reactor, is in a high-temperature condition (approximately 200°C) even during the in-service inspection period and the liquid couplant, which is necessary for contact ultrasonic examination, is not permitted to be applied for the inspection to prevent sodiumwater reaction. Moreover, the remotely operated vehicle should be employed for inspection in the narrow gap between the reactor vessel and the containment vessel. For the in-service inspection of the reactor vessel under such harsh conditions, a high-temperature electro-magnetic acoustic transducer installable in the remotely operated vehicle was developed in this study. First, the radiation pattern and the signal-to-noise ratio according to the lift-off variation were investigated to analyze the characteristics of the developed transducer. Furthermore, the detectability, heat resistance, and durability of the developed transducer were then evaluated to demonstrate its applicability.