http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
흰쥐의 뮤시몰투여에 의한 배뇨반사억제효과에 대한 벤조디아제핀 수용체의 영향
허인회(In Hoi Huh),오호정(Ho Jung Oh) 大韓藥學會 1992 약학회지 Vol.36 No.5
The correlation between GABA receptors(GABAA and GABAB receptor) and benzodiazepine receptor on the saline infusion-induced micturition reflex contraction was studied in the female rat. To investigate the effect of gammar-aminobutyric acid(GABA) on the micturition reflex, exogenous GABA(10mg/kg) and GABA transaminase inhibitor(aminooxyacetic acid; AOAA 1mcg) were administered intravenously(i.v.) and intracerebroventriculary(i.c.v.), respectively. In result, both GABA and AOAA inhibited the saline induced micturition reflex contraction. This AOAA induced inhibition of micturition reflex was blocked by both bicuculine, GABAA receptor antagonist, and Ro 15-1788, benzodiazepine receptor antagonist. Muscimol, GABAA receptor antagonist(1mcg i.c.v., 3mcg intrathecal; i.t., 1mg/kg i.v.) and baclofen, GABAB receptor agonist(0.1mcgi.c.v., 3mcg i.t., 1mg/kg i.v.) also inhibited the bladder contraction. Pretreatment of bicuculline(1mcg i.c.v.), but not of 5-aminovaleric acid(AVA, 1mcg i.c.v.), GABAB receptor antagonist blocked the central inhibition of muscimol. These inhibitory effects were reversed by Rol5-1788 but were potentiated by flurazepam, benzodiazepine receptor antagonist. On the other hand, the inhibitory effects of baclofen were not affected by Ro 15-1788. Diazepam and flurazepam also inhibited the micturition reflex contraction when they were administered 3mcg i.c.v., 10mcg i.t., 10mcM, 30mcM transurethrally, respectively. In conclusion, these results suggest that the micturition reflex is mediated by GABAA, GABAB receptor and benzodiazepine receptor. The bezodiazepines increase the receptor binding of GABA to the GABAA receptor, so that the benzodiiazepines show the synergistic effect on the inhibition of the micturition reflex contraction, but not to the GABAB receptor.
Establishment of the National Standard for Prekallikrein Activator with a Collaborative Study
In Soo Shin(신인수),Jae Yeon Cho(조재연),Soon Nam Kim(김순남),Choong Man Hong(홍충만),Ki Hong Lee(이기홍),Ho Jung Oh(오호정),Si Hyung Yoo(유시형),Jae Hyun Lim(임재현),Seung Eun Choi(최승은),Colin Longstaff,Hong Ki Min(민홍기),Sue 한국생물공학회 2004 한국생물공학회 학술대회 Vol.2004 No.4
Polychlorinated Biophenyl類의 毒性에 대한 數種 抽出液의 解毒效果에 關한 硏究
오호정,장판섭 德成女子大學校 藥學硏究所 1990 藥學論文誌 Vol.1 No.1
The effect of the water extracts and ethanol extracts from picrorrhiza kurroa, Gentiana scabra and Lycium chinense on the toxicity of polychlorinated biphenyls (PCBs) were examined and following results were obtained. 1. In the PCBs control group, the body weights were decreased while the weight of liver was increased in comparison with that of normal control group. However, by the administration of these extracts, PCBs intoxicated rats showed the increase in body weight but did not show marked recovery of liver weight. 2. By the administration of these extracts, the hematological parameters of red blood cell and white blood cell, hemoglobin content and hematocrit value which were decreased by the administration of PCBs were shown to be increased. Among these extracts, the extracts of Lycium chinense were especially effective. 3. Cholesterol and total lipids levels in serum were significantly increased in the group fed PCBs. These extracts ameliorated the elevated levels but the recovery was not completed. 4. The activities of s-GOT, s-GPT and alkaline phosphatase were significantly stimulated by PCBs and their stimulation was inhibited by the adminstration of these extracts. Furthermore, the extracts of Picrorrhiza kurroa showed the normalizing tendency in s-GOT, s-GPT and alkaline phosphatase.