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朴姬淑,金重明 慶北大學校 醫科大學 1972 慶北醫大誌 Vol.13 No.2
In order to study inhibitory effects of DDS, Ciba 1906, INHA and SM in experimentally infected murine leprosy, 102 mice were used: two mice were used for control 50 mice were inoculated subcutaneously at the right side of the lower abdomen and were designated as the group A, another 50 mice were inoculated mycobacteria subcutaneously at the right side of the back and designated as the group B. Each group A and B were divided into 5 subgroups for the control, DDS, Ciba 1906, INAH and SM and were adminstered with respective drug to each subgroup. Group A was observed by spreading method and group B observed by the leprom size. The results were as follows; A. Results of spreading method: 1) The mycobacteria inoculated were observed in the monocytes and polymorphonuclear cells as fine masses on the next day of inoculation. 2) In the control group, the mycobacteria in the monocyte on the 2nd week of inoculation were more elongated and increased in number. There were much increase in number of moncytes and decreas of polymorphonuclear cells. The above feature was more clearly observed on the 4th week of inoculation. The preparation of the spreading method was impossible because of formation of the leprom. 3) Only the INAH was to seem to be effective on the 2nd and 3rd week and the DDS, Ciba 1906 and SM show no inhibitory effect, B.Results of the leprom formation: 1) In the control group, on the 4th week 3 mice began to form leprom and on the 6th week it was formed in all of the mice and on the 8th grow to 18th week, it to maximum size. There was ulcer formation in 5 mice. 2) In the DDS group, on the 4th week the leprom was observed only in one mouse on the 6th week the leprom was found in all of them and reached the maximum size, on the 6th to 16th week. The ulcer was observed only in one mouse. 3) In the Ciba 1906, on the 2nd week the leprom was found only in one mouse, and on the 4th week in 7 mice, and on 6th week it was found in all mice, of the group and reached to maximum size on the 16th week. 4) In the INAH group, on the 4th week the leprom was observed in one mouse but it disappeared on the 6th week and appeared again on the 8th to 10th week and disappeared again on the 12th week and reappeared on the 18th week. In one other mouse, small leprom was found on the 14th week and durated to the 18th week, in other 2 mice the leprom was found on the 18th week. 5) In the SM group, on the 6th week leprom was observed in 2 mice, and on the 10th week it was found in all mice, and they were grown gradually to maximum size in the 18th week. 6) In inhibitory effect of INAH against the experimental murine leprosy was the strongest among the drugs tested.
정상여성에서 월경주기에 따른 갑상선 부피의 변동에 관한 연구
박진우,박형규,유명희 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1
Previous studies demonstrated that the thyroid gland volume was altered during the menstrual cycle in normal women, but the mechanism has not been clarified. To investigate the role of thyroid hormone and ovarian steroid hormones in the cyclic alteration of the thyroid volume in normal women, we performed a compound ultrasonogram and measured thyroid volume with the method based on the electronic planimetry of a sequential transverse ultrasound scans of the thyroid and performed serial measurements of thyroid and ovarian steroid hormones in 8 normal women during the cycles and 8 normal men. Thyroid volume in men was greater than that in women (18.6±1.6 ㎤ vs. 11.7±1.2 ㎤, P<0.05), but the ratio of thyroid volume to body weight showed no significant difference. Serial thyroid volume measurements showed no significant changes in men. However, in women, significant increases on day 22 compared with day 1 and 8. Serum T_(3), T_(4) and TSH levels were not changed significantly during the cycle in women. Serum progesterone levels increased on day 22, compared with on day 1, 8 and serum estradiol levels elevated on day 15 and 22, compared with on day 8 (p<0.05). Positive correlation was found between serum progesterone concentration and thyroid volume (r=0.45, p<0.01), while no significant correlation was found between serum estradiol level and thyroid volume. These data suggest that progesterone might play a role in the cyclic alteration of the thyroid volume during the menstrual cycle in women, probably by changing the vascularity of the thyroid.
Adiponectin과 비만, 제2형 당뇨병 및 관상동맥질환과의 관계
박형규,유명희 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1
Background : Adiponectin is a novel adipose tissue-specific protein that has been shown to modulate insulin sensitivity and energy homeostasis. In addition, adiponectin has been found to inhibit inflammatory process and possibly atherogenesis. In this study, we tried to investigate the relationship of adiponectin to obesity, type 2 diabetes and coronary artery disease (CAD). Material and methods : We measured fasting serum insulin and adiponectin concentrations in 55 diabetic patients and 25 nondiabetic subjects. Subjects who had stenosis at least 1 major coronary artery, or who had developed myocardial infarction, or had previously undergone percutaneous coronary intervention or coronary artery bypass graft were classified as CAD patients. 23 diabetic patients and 8 nondiabetic subjects had CAD. Results : Fasting adiponectin concentrations were significantly lower in men than in women (5.1±0.8 vs. 7.8±1.1 ng/mL, p<0.05). In men, serum adiponectin levels were negatively correlated with body mass index (BMI, r=-0.36, p<0.05) and log-insulin (r=-0.32, p<0.05). With multivariate regression analysis, adiponectin was significantly related to BMI (p<0.05). However, no correlations were found in women. Fasting adiponectin concentrations were significantly lower in CAD patients than in control subjects (2.8±0.4 vs. 7.2±1.5 ng/mL, p<0.05). Serum adiponectin levels between diabetic and nondiabetic control subjects, and between diabetic patients with CAD and those without CAD did not differ. Conclusion : Low adiponectin levels were closely related to obesity and CAD. These findings suggest that hypoadiponectinemia may contribute to accelerated atherogenesis associated with obesity.
음식물쓰레기 관리의 최적화 방안 연구 : 창원, 마산, 진해시를 중심으로 Focused on Changwon, Masan, Jinhae City
이명희,박증석,김종오,백병천 國立 麗水大學校 環境問題硏究所 1998 環境硏究論文集 Vol.1 No.-
Limited landfill area and finance as well as a huge generation of waste, have called for systematic approaches towards potential cost savings. In this study, the management system of food wastes generated from the residential and commercial sources was considered in three citied; Changwon, Masan, and Jinhae city. Total thirteen alternatives were established and compared by applying the WRAP (Waste Resource Allocation Program). The following results were obtained: 1. While relatively small amounts were generated form the commercial sources such as cafeteria, restaurants, and market facilities, almost 80% of food wastes were generated from the residential sources. 2. Unit costs for food waste management in three cities were different according to their present situation, and the highest cost appeared in Jinhae city due to the most expensive construction of coastal landfill site. 3. Considering proper revenue, the whole conversion of food waste into animal feed was selected as the optimal alternative and represented 60% to 74% of management cost of the whole landfill alternative in all cities. Comparing the other alternatives, composting of food waste was more economical than the landfill alternative and the incineration was the most expensive alternative.
Biological Activity of Recombinant Human Erythropoietin (EPO) In Vivo and In Vitro
Park Jong-Ju,Lee Hyen-Gi,Nam In-Suk,Park Hee-Ja,Kim Min-Su,Chung Yun-Hi,Naidansuren Purevjargal,Kang Hye-Young,Lee Poong-Yun,Park Jin-Gi,Seong Hwan-Hoo,Chang Won-Kyong,Kang Myung-Hwa 한국동물번식학회 2005 Reproductive & developmental biology Vol.29 No.2
The hematopoietic growth factor erythropoietin (EPO) is required for the maintenance, proliferation, and differentiation of the stem cells that produce erythrocytes. To analyse the biological activity of the recombinant human EPO (rec-hEPO), we have cloned the EPO cDNA and genomic DNA and produced rec-hEPO in the CHO cell lines. The growth and differentiation of EPO-dependent human leukemic cell line (F36E) were used to measure cytokine dependency and in vitro bioactivity of rec-hEPO. MIT assay values were increased by survival of F36E cells at 24h or 72h. The hematocrit and RBC values were increased by subcutaneous injection of 20 IU (in mice) and 100IU(in rats) rec-hEPO. Hematocrit values remarkably increased at 13.2% (in mice) and 12.2% (in rats). The pharmacokinetic behavior with injection of 6 IU of rec-hEPO remained detectable after 24 h in all mice tested. The highest peat appeared at 2h after injection. The long half-life of rec-hEPO is likely to confer clinical advantages by allowing less frequent dosing in patients treated for anemia. These data demonstratethat ree-hEPO produced in this study has a potent activity in vivo and in vitro. The results also suggest that biological activity of ree-hEPO could be remarkably enhanced by genetic engineering that affects the potential activity, including mutants with added oligosaccharide chain and designed to produce EPO-EPO fusion protein.