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지속적인 직류 자장이 백서의 임의형 피판생존에 미치는 영향에 關한 硏究
백세민,유영준,한흥수,오갑성 大韓成形外科學會 1994 Archives of Plastic Surgery Vol.21 No.3
The present study was undertaken to determine if direct current(DC) electirical fields could improve survival rate of random pattern skin flap in the rat. 20 Sparque- Dawley rats were divided into two groups and caudally based 2cm width and 8cm length random pattern flaps were elevated in all rats. Electrical fields of 9mA were introduced by 1.5V disk button battery. Electrical field was applied for 5days to the stimulation group(B). DC electrical fields shows the enhancement of flap survival by increasing the rate to 33.5%(p<0.01). The enhancement of skin flap survival by application of direct current electrical field has possibility for cover the large skin defect.
한흥수,김우경,김수신,백세민 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.1
Recently, soft tissue expansion technique using tissue expanders has become a popular method for reconstruction of soft tissue defect because it provides high quality tissue with similar color, texture and hair bearing characteristics without significant donor site problems. During the period September, 1983 to December, 1988, we used tissue expanders to treat 36 patients with soft tissue defect, 3 scalp, 10 face, 6 neck, 4 trunk, 10 upper extremity, 3 lower extremity and evaluated the operative techniques, results and complications as follows. 1. We achieved favorable results in 31 cases(86.1%), especially in scalp, face and upper extremity, but poor results in lower extremity, especially below knee in location. 2. We experienced major complications in 2 cases(5.6%) such as implant exposure and minor complications in 7 cases(19.4%) such as hematoma, partial necrosis, infection, underlying bony depression etc. 3. Capsular excision is not desirable, but capsular release may permitted to acquire maximal length of the advancing flap. 4. In case of microtia, expanded tissue which was obtained from expanders is defficient for elevation of framework without skin graft. 5. Accurate and meticulous preoperative evaluation is the most important factor in achieving good and results.
The Inhibitory Effect of New Hydroxamic Acid Derivatives on Melanogenesis
Baek, Heung-Soo,Rho, Ho-Sik,Yoo, Jae-Won,Ahn, Soo-Mi,Lee, Jin-Young,Lee, Jeong-A,Kim, Min-Kee,Kim, Duck-Hee,Chang, Ih-Seop Korean Chemical Society 2008 Bulletin of the Korean Chemical Society Vol.29 No.1
The aim of present study was to examine the inhibitory effects of hydroxamic acid derivatives on the melanogenesis. We found that hydroxamic acid moiety was important for anti-melanogenic activity. Compounds 1a and 1b strongly inhibited melanin synthesis via deactivation of tyrosinase. Hydroxamic acid has metal ion chelating ability which is similar to that kojic acid, however, anti-tyrosinase mechanism of compounds 1a and 1b was different from that of kojic acid. They showed noncompetitive inhibition kinetics
The Inhibitory Effect of New Hydroxamic Acid Derivatives on Melanogenesis
Heung Soo Baek,장이섭,Ho Sik Rho*,Jae Won Yoo,Soo Mi Ahn,Jin Young Lee,Jeonga-Lee,Min-Kee Kim,Duck Hee Kim 대한화학회 2008 Bulletin of the Korean Chemical Society Vol.29 No.1
The aim of present study was to examine the inhibitory effects of hydroxamic acid derivatives on the melanogenesis. We found that hydroxamic acid moiety was important for anti-melanogenic activity. Compounds 1a and 1b strongly inhibited melanin synthesis via deactivation of tyrosinase. Hydroxamic acid has metal ion chelating ability which is similar to that kojic acid, however, anti-tyrosinase mechanism of compounds 1a and 1b was different from that of kojic acid. They showed noncompetitive inhibition kinetics
백흥수 ( Heung Soo Baek ),안수미 ( Soo Mi Ahn ),우병영 ( Byoung Young Woo ),조영석 ( Young Seok Cho ),최수정 ( Soo Jeong Choi ),노호식 ( Ho Sik Rho ),변경희 ( Kyoung Hee Byoun ),신송석 ( Song Seok Shin ),박영호 ( Young Ho Park 대한화장품학회 2013 대한화장품학회지 Vol.39 No.2
Polyhydroxylated benzamide 유도체의 구조변화에 따른 미백효과의 상관관계를 고찰하였다. Adamantyl benzamide 유도체에서 B ring 부분의 치환기가 catechol (3,4-dihydroxyphenyl)인 경우 우수한 멜라닌 생성 저해활성을 보였으나, mono-hydroxyphenyl (3-OH 또는 4-OH)이거나 3,4-dimethoxyphenyl인 경우에 그 활성이 감소하거나 없어졌다. 따라서 catechol unit이 멜라닌 생성 저해에 중요한 인자임을 알 수 있었다. 그리고 A-ring부분의 2-OH의 존재여부는 활성에 큰 영향을 주지는 않았고, A-ring과 B-ring을 연결하는 탄소사슬의 길이 역시 멜라닌 생성저해에 큰 영향을 주는 요소는 아니었다. The structure activity relationship of polyhydroxylated benzamide derivatives for whitening effects was examined. The adamantyl benzamide derivatives with catechol (3,4-dihydroxyphenyl) of B-ring part showed good anti- melanogenesis activity, but the inhibitory activity of mono-hydroxyphenyl (3-OH or 4-OH) or 3,4-dimethoxyphenyl substituted derivatives was decreased or lost. Therefore the catechol unit was appeared to be the crucial factor for the inhibition of melanogenesis. And the existence of 2-OH of A-ring part had minor influence on the activity, the length of carbon chain between A-ring and B-ring was also not the major factor for the anti-melanogenesis activity.
Neuroprotective effects of Vitis vinifera extract on prediabetic mice induced by a high-fat diet
( Heung Yong Jin ),( Youn Soo Cha ),( Hong Sun Baek ),( Tae Sun Park ) 대한내과학회 2013 The Korean Journal of Internal Medicine Vol.28 No.5
Background/Aims: Vitis vinifera grape seed extract (VVE) contains oligomeric proanthocyanidins that show antioxidant and free radical-scavenging activities. We evaluated VVE for its neuroprotective effect in prediabetic mice induce by a high-fat diet (HD). Methods: Mice were divided into four groups according to VVE dose: those fed a normal diet (ND; n = 10), HD (n = 10), HD with 100 mg/kg VVE (n = 10), and HD with 250 mg/kg VVE (n = 10). After 12 weeks, immunohistochemical analyses were carried out using a polyclonal antibody against antiprotein gene product 9.5 (protein-gene-product, 9.5), and intraepidermal innervation was subsequently quantified as nerve fiber abundance per unit length of epidermis (intraepidermal nerve fiber, IENF/mm). Results: Daily administration of VVE at doses of 100 or 250 mg/kg for 12 weeks protected HD mice from nerve fiber loss compared to untreated mice, as follows (IENF/mm): controls (40.95 ± 5.40), HD (28.70 ± 6.37), HD with 100 mg/kg (41.14 ± 1.12), and HD with 250 mg/kg (48.98 ± 7.01; p < 0.05, HD with VVE vs. HD). Conclusions: This study provides scientific support for the therapeutic potential of VVE in peripheral neuropathy in an HD mouse model. Our results suggest that VVE could play a role in the management of peripheral neuropathy, similar to other antioxidants known to be beneficial for diabetic peripheral neuropathy.
김수신,김우경,백세민,한흥수 大韓成形外科學會 1989 Archives of Plastic Surgery Vol.16 No.2
Treatment of degloving injury of parts of hand has been one of the difficult problems in hand surgery. Various methods have been applied on the treatment for its unique property. We can classify the methods of treatment into two categories. One is amputation and the other is resurfacing. Due to the fact that most degloving injuries involve mainly the loss of skin and subcutaneous tissue and underlying structures are remained intact, the injured parts can be salvaged when appropriately resurfaced. In Korea, by the Confucian influence, keeping the body intact is an important filial duty. Therefore, there are a great deal of preserve and demands from the traditional perception and from the patient to preserve anything and reattach all that is detached. By so doing, amputation of degloved part is undesirable. The resurfacing is our first goal to obtain maximum functioanl and cosmetic restoration. We use various flaps and microsurgical techniques for the surgical resurfacing. Recently, with the refinement of microsurgical techniques, reattachment surgery using microvascular techniques was performed by many surgeons. Authors report an analysis of 20 cases of completely devascularized degloving injuries of hands which were treated at Guro Hospital, Korea University from September of 1983 to August of 1987. The results are summarized as follows: 1. Fifty percent of the patients were in the age group of 20-30 years and ninty-five percent of the patients were male. 2. Roller accident was the main cause of the injury in 75%. 3. In comparison with other treatment methods, it is represented for the revascularization of the degloved-amputated part using microsurgical technique as the best result aesthetically and functionally. In conclusion, we strongly suggest the reattachment surgery using microsurgical revascularization.
측두 두정 근막 유리 피판술을 이용한 수, 족부 연부 조직 결손의 재건술
김수신,한흥수,정영덕,박성규,백롱민,백세민 大韓成形外科學會 1992 Archives of Plastic Surgery Vol.19 No.1
Soft tissue defect of the hand and foot, which can not be covered with skin graft or local flap, is usually reconstructed with free flap. Recently temporoparietal fascia free flap, which is a thin, pliable, and well vascularized flap, is used as an alternative to the cutaneous flap for the purpose of tendon gliding and cosmetic effects. According to our experience of reconstruction of 5 cases of the hand's and foot's soft tissue defects, the temporoparietal fascial free flap covered with split thickness skin graft is a very useful tool for reconstruction of small soft tissue defects of the hand and foot, functionally and esthetically.