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Hirotaka Hasegawa,Masahiro Shin,Jun Kawagishi,Hidefumi Jokura,Toshinori Hasegawa,Takenori Kato,Mariko Kawashima,Yuki Shinya,Hiroyuki Kenai,Takuya Kawabe,Manabu Sato,Toru Serizawa,Osamu Nagano,Kyoko Ao 대한뇌졸중학회 2022 Journal of stroke Vol.24 No.2
Background and Purpose To assess the long-term outcomes of intracranial dural arteriovenous fistula (DAVF) treated with stereotactic radiosurgery (SRS) alone or embolization and SRS (Emb- SRS) and to develop a grading system for predicting DAVF obliteration. Methods This multi-institutional retrospective study included 200 patients with DAVF treated with SRS or Emb-SRS. We investigated the long-term obliteration rate and obliteration-associated factors. We developed a new grading system to estimate the obliteration rate. Additionally, we compared the outcomes of SRS and Emb-SRS by using propensity score matching. Results The 3- and 4-year obliteration rates were 66.3% and 78.8%, respectively. The post-SRS hemorrhage rate was 2%. In the matched cohort, the SRS and Emb-SRS groups did not differ in the rates of obliteration (P=0.54) or post-SRS hemorrhage (P=0.50). In multivariable analysis, DAVF location and cortical venous reflux (CVR) were independently associated with obliteration. The new grading system assigned 2, 1, and 0 points to DAVFs in the anterior skull base or middle fossa, DAVFs with CVR or DAVFs in the superior sagittal sinus or tentorium, and DAVFs without these factors, respectively. Using the total points, patients were stratified into the highest (0 points), intermediate (1 point), or lowest (≥2 points) obliteration rate groups that exhibited 4-year obliteration rates of 94.4%, 71.3%, and 60.4%, respectively (P<0.01). Conclusions SRS-based therapy achieved DAVF obliteration in more than three-quarters of the patients at 4 years of age. Our grading system can stratify the obliteration rate and may guide physicians in treatment selection.
Fundamental study on gene transfer utilizing magnetic force and jet injector
Hasegawa, T.,Nakagam, H.,Akiyama, Y.,Nishijima, S. The Korea Institute of Applied Superconductivity a 2017 한국초전도저온공학회논문지 Vol.19 No.1
Recently, DNA vaccination is attracting attentions as a new therapeutic method for lifestyle diseases and autoimmune diseases. However, its clinical applications are limited because a safe and efficient gene transfer method has not been established yet. In this study, a new method of gene transfer was proposed which utilizes the jet injection and the magnetic transfection. The jet injection is a method to inject medical liquid by momentary high pressure without needle. The injected liquid diffuses in the bio tissue and the endocytosis is considered to be improved by the diffusion. The magnetic transfection is a method to deliver the conjugates of plasmid DNA and magnetic particles to the desired site by external magnetic field. It is expected that jet injection of the conjugates causes slight membrane disruptions and the traction of the conjugates by magnetic field induces the efficient gene transfer. In conclusion, the possibility of improvement of the gene expression by the combination of jet injection and magnetic transfection was confirmed.
Hasegawa Yukiko 국제한국어교육문화재단 2015 국제한국어교육 Vol.1 No.1
Korean language education in Japan has rapidly expanded since the beginning of the 2000s, it has undergone a great change qualitatively. I presented at the Korean Society about the actual situation of the Korean language education in Japan 10 years ago. It has also changed greatly since then. This paper shows the actual situation of the institutions of Korean language education in Japan, such as Korean ethnic schools, universities, high schools, civic courses, and so on. Moreover, recent developments in learning needs, teaching materials and qualities of educators will be shown, and research activities for the qualitative improvement of education in Japan will be introduced. An interesting fact related to learning motivation is that according to a questionnaire survey conducted at more than one hundred universities in Japan, Korean language learners started to learn Korean due to preference rather than its importance or usefulness, when compared with other language learners.
Hasegawa, Koichi,Katagiri, Kiyofumi,Matsuda, Astunori,Tatsumisago, Masahiro,Minami, Tsutomu The Korean Ceramic Society 2000 The Korean journal of ceramics Vol.6 No.1
Thick inorganic-organic hybrid films were prepared on ITO-coated glass substrates by the electrophoretic sol-gel deposition of polyphenylsilsesquioxane particles. The morphology of the deposited films changed from the aggregate of the spherical particles to monolith by heat treatment at temperatures higher than $200^{\circ}C$. Transparency of the films was significantly improved accompanied by the morphological change of the particles. The degree of the morphological change was governed by two factors; maximum heat treatment temperature and heating rate. Transparent thick films of ca. 3$\mu\textrm{m}$ in thickness were obtained only by heat treatment at $400^{\circ}C$ for 2h with rapid heating from room temperature to $400^{\circ}C$. These films obtained were strongly adhered to the ITO-coated glass substrates and has a very smooth surface.
UNDERSTANDING AND CONTROL OF INTERFACES FOR COMPOUND SEMICONDUCTOR VLSIs
Hasegawa, Hideki 대한전자공학회 1989 ICVC : International Conference on VLSI and CAD Vol.1 No.1
Interfaces play important role in future III-V compound semiconductor ULSIs. The present status of understanding and control of comound semiconductor interfaces involving semiconductor, insulator and metal are reviewed and key issues for future research and development are identified with a particular emphasis laid on the passivation technology. Presence of a strong correlation among interfaces is pointed out and model's for unified understanding interface's re discussed.
The opposition effect of the asteroid 4 Vesta
Hasegawa, Sunao,Miyasaka, Seidai,Tokimasa, Noritaka,Sogame, Akito,Ibrahimov, Mansur A.,Yoshida, Fumi,Ozaki, Shinobu,Abe, Masanao,Ishiguro, Masateru,Kuroda, Daisuke Oxford University Press 2014 Publications of the Astronomical Society of Japan Vol.66 No.5