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A cohort study on the association of MDM2 SNP309 with lung cancer risk in Bangladeshi population
Hasan Al Reza,Wardatul Jannat Anamika,Md. Miraj Kobad Chowdhury,Mohammad Golam Mostafa,M. Aftab Uddin 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.3
Background/Aims: Bangladesh is a densely populated country with an increased incidence of lung cancer, mostly due to smoking. Therefore, elucidating the association of mouse double minute 2 homolog (MDM2) single nucleotide polymorphism (SNP) 309 (rs2279744) with lung cancer risk from smoking in Bangladeshi population has become necessary. Methods: DNA was extracted from blood samples of 126 lung cancer patient and 133 healthy controls. The MDM2 SNP309 was genotyped by polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP), using the restriction enzymes MspA1I. Logistic regression was then carried out to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to estimate the risk of lung cancer. A meta-analysis of SNP309 was also carried out on 12,758 control subjects and 11,638 patient subjects. Results: In multivariate logistic regression, significantly increased risk of lung cancer was observed for MDM2 SNP309 in the dominant model (TG + GG vs. TT: OR, 2.13; 95% CI, 1.29 to 3.53). Stratification analysis revealed that age, sex, obesity, and smoking also increases the risk of lung cancer when carrying the MDM2 SNP309. Our meta-analysis revealed that MDM2 SNP309 was considerably associated with lung cancer in Asian populations (TG + GG vs. TT: OR, 1.32; 95% CI , 1.12 to 1.56; p = 0.019 for heterogeneity). Conclusions: The MDM2 SNP309 was associated with high risk of lung cancer in Bangladeshi and Asian population, particularly with increased age, smoking, and body mass index.
Reza Jalali,Mojtaba Parhizkar,Hasan Bidadi,Hamid Naghshara,Seyd Reza Hosseini,Majid Jafari 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.6
TiAlN thin films were deposited by using the reactive magnetron co-sputtering method whitindividual Ti and Al targets, where the Ti and the Al targets were simultaneously powered by usingDC and RF sources, respectively. the electrical resistivity and the structural and microstructuralproperties of the deposited TiAlN thin films and the effects of Al content, substrate temperatureand nitrogen gas flow rate on those properties were investigated. At a low flow rate of nitrogen gas(0.51 sccm), the electrical resistivity of the films was found to increase with increasing AC power,but at a high flow rate of nitrogen gas, it was found to decrease. The structural and microstructuralanalyses performed by using X-ray diffraction and scanning electron microscopy (SEM) showed thatwith increasing substrate temperature from room temperature to 400◦C, the films prepared at 400◦C have a crystalline structure while those prepared at room temperature had an amorphous nature. Also, the SEM analysis revealed that with decreasing AC power and increasing nitrogen flow rate,the size of the grains in the prepared films become larger.
( Hasan Al Reza ),( Wardatul Jannat Anamika ),( Md. Miraj Kobad Chowdhury ),( Mohammad Golam Mostafa ),( M. Aftab Uddin ) 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.3
Background/Aims: Bangladesh is a densely populated country with an increased incidence of lung cancer, mostly due to smoking. Therefore, elucidating the association of mouse double minute 2 homolog (MDM2) single nucleotide polymorphism (SNP) 309 (rs2279744) with lung cancer risk from smoking in Bangladeshi population has become necessary. Methods: DNA was extracted from blood samples of 126 lung cancer patient and 133 healthy controls. The MDM2 SNP309 was genotyped by polymerase chain reaction- restriction fragment length polymorphism (PCR-RFLP), using the restriction enzymes MspA1I. Logistic regression was then carried out to calculate odds ratios (ORs) and 95% confidence intervals (CIs) to estimate the risk of lung cancer. A meta-analysis of SNP309 was also carried out on 12,758 control subjects and 11,638 patient subjects. Results: In multivariate logistic regression, significantly increased risk of lung cancer was observed for MDM2 SNP309 in the dominant model (TG + GG vs. TT: OR, 2.13; 95% CI, 1.29 to 3.53). Stratification analysis revealed that age, sex, obesity, and smoking also increases the risk of lung cancer when carrying the MDM2 SNP309. Our meta-analysis revealed that MDM2 SNP309 was considerably associated with lung cancer in Asian populations (TG + GG vs. TT: OR, 1.32; 95% CI , 1.12 to 1.56; p = 0.019 for heterogeneity). Conclusions: The MDM2 SNP309 was associated with high risk of lung cancer in Bangladeshi and Asian population, particularly with increased age, smoking, and body mass index.
Hasan, Md. Mahmudul,Islam, Md. Shihabul,Hoque, Kazi Md. Faisal,Haque, Ariful,Reza, Md Abu Korean Society of ToxicologyKorea Environmental Mu 2019 Toxicological Research Vol.35 No.3
Citrus macroptera (Rutaceae) has long been used in folk medicine in Bangladesh. Considering the folkloric context, this study was aimed to scrutinize anti-proliferative activity of C. macroptera fruit pulp juice (CMFPJ) against Ehrlich's ascites carcinoma (EAC). The anti-proliferative capacity of CMFPJ was investigated and confirmed primarily using MTT assay. In vivo anti-proliferative aptitude of CMFPJ was investigated with 25, 50, and 100 mg/kg/day intraperitoneal (i.p.) treatment. Anti-proliferative efficacy of CMFPJ was assessed based on EAC growth inhibition. CMFPJ inhibited EAC growth in vitro in a dose-dependent manner. And the percentages of in vivo EAC growth inhibition were 19.53, 49.2, and 68.9% at 25, 50, and 100 mg/kg CMFPJ respectively. CMFPJ significantly induced expression of apoptosis regulatory genes caspase-8, caspase-9, cytochrome-c, and caspase-3. This considerable anti-cancer activity was perhaps due to combinatorial effect of lectin, polyphenols, and flavonoids present in CMFPJ.
Reza Nazeran,Ali Hemmati,Hasan Haji Kazemi 국제구조공학회 2024 Structural Engineering and Mechanics, An Int'l Jou Vol.89 No.5
Since the cost of reconstruction is very high and the structure may have been damaged by an earthquake, we must retrofit the structure. Therefore, the importance of studying this issue is very high in order to achieve the desired resistance against the regulations. The present study involved the numerical and experimental analysis of nine concrete frames, consisting of three concrete frames, three concrete frames with bracing, and three concrete frames with a TADAS damper. The purpose of this study is to strengthen the damaged concrete frame using braces and TADAS dampers. Observations were made of the frames as they were subjected to controlled displacement. Also, ABAQUS software was used to compare numerical and experimental results. According to the results, the software was sufficiently capable of modeling the studied frames. Additionally, a parametric study was conducted on the thickness and number of bending plates. Thickness increases from 8 mm to 12 mm, 8 mm to 15 mm, and 8 mm to 20 mm, increasing the base shear by about 6.7%, 11.1%, and 25%, respectively. Furthermore, increasing the number of plates from 4 to 5, 4 to 6, and 4 to 7 increased base shears by about 4.5%, 8.4%, and 14%, respectively.
Reza Afshar Ghotli,Abdul Raman Abdul Aziz,I.M. Atadashi,D.B. Hasan,Pei San Kong,M.K. Aroua 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1
Crude glycerol, the main byproduct of biodiesel production, consists of excess methanol and otherimpurities and can be converted into other useful products through purification or conversion processes. In this work, dynamic viscosities, densities, excess molar volumes and refractive indexes for severalmixtures of biodiesel crude glycerol and methanol with were determined at different temperatures. Thephysiochemical characteristics of crude glycerol in mixture form with methanol could be useful for thedesign of industrial equipment and purification or conversion process. The results demonstratedtemperature dependent behaviors of all binarymixtures. The empirical correlations were obtained basedon the experimental results.
Reza Mohebbati,Maryam Paseban,Farimah Beheshti,Mohammad Soukhtanloo,Mohammad Naser Shafei,Hasan Rakhshandeh,Abolfazl Khajavi Rad 대한약침학회 2018 Journal of pharmacopuncture Vol.21 No.4
Objectives: The hepatotoxicity induced by Acetaminophen (AAP) mostly mediated by effect on oxidative stress parameters. The Zataria multiflora (Z.M) is an herbal medicine with well-known antioxidant effect. The aim of this study is investigation of preventive effects of Z.M and Carvacrol (CAR) on AAP-induced hepatotoxicity in rats. Methods: Rats were randomly divided into four groups including: 1) Control, 2) Acetaminophen (AAP), 3) and 4) CAR. The saline, Z.M (200 mg/kg) and CAR (20 mg/kg) were administrated orally for 6 days, after that AAP (600 mg/kg) was administrated in the 7th day. Blood sampling was performed on the first and last days. Also, the liver tissue was removed for evaluation of Malondyaldehide (MDA), Thiol content, Superoxide dismutase (SOD) and Catalase (CAT). Total Protein (tPro), Glutamic Oxaloacetic Transaminase (GOT), Glutamic Pyruvic Transaminase (GPT) and Alkaline Phosphatase (ALP) in liver tissue were evaluated. The changes (Δ) of enzymes activities were presented. Results: The Δ GOT, Δ GPT and Δ ALP in CAR group significantly decreased compared to AAP group (P < 0.01 to P < 0.001) and Δ GPT in Z.M group was significantly reduced in comparison with AAP group (P < 0.05). Also, MDA, Thiol, SOD and CAT levels in treated groups were attenuated compared to AAP group (P < 0.05 to P < 0.001). Conclusion: Z.M and CAR have a powerful hepatoprotective effect. CAR is more effective than Z.M. Based on the results. Z.M and CAR could be potent supplementary agents against hepatotoxicity of AAP in patients.
Pregnancy outcomes following the administration of high doses of dexamethasone in early pregnancy
Ahmadabad, Hasan Namdar,Jafari, Sabah Kayvan,Firizi, Maryam Nezafat,Abbaspour, Ali Reza,Gharib, Fahime Ghafoori,Ghobadi, Yusef,Gholizadeh, Samira The Korean Society for Reproductive Medicine 2016 Clinical and Experimental Reproductive Medicine Vol.43 No.1
Objective: In the present study, we aimed to evaluate the effects of high doses of dexamethasone (DEX) in early pregnancy on pregnancy outcomes. Methods: Pregnant BALB/c mice were treated with high-dose DEX in the experimental group or saline in the control group on gestational days (GDs) 0.5 to 4.5. Pregnant mice were sacrificed on GDs 7.5, 13.5, or 18.5 and their peripheral blood, placentas, fetuses, and uterine tissue were collected. Decidual and placenta cell supernatants were examined to evaluate the effect of DEX on the proliferation of mononuclear cells, the quantity of uterine macrophages and uterine natural killer (uNK) cells, and levels of progesterone and $17{\beta}-estradiol$, as determined by an 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide assay, immunohistochemistry, and enzyme-linked immunosorbent assay, respectively. We also were measured fetal and placental growth parameters on GD 18.5. Results: We found that high doses of DEX were associated with an increased abortion rate, enhancement of the immunosuppressive effect of the decidua, alterations in placental growth parameters, decreased progesterone and $17{\beta}-estradiol$ levels, and a reduced frequency of macrophages and uNK cells. Conclusion: Our data suggest that the high-dose administration of DEX during early pregnancy negatively affected pregnancy outcomes.
Mohebbati, Reza,Paseban, Maryam,Beheshti, Farimah,Soukhtanloo, Mohammad,Shafei, Mohammad Naser,Rakhshandeh, Hasan,Rad, Abolfazl Khajavi KOREAN PHARMACOPUNCTURE INSTITUTE 2018 Journal of pharmacopuncture Vol.21 No.4
Objectives: The hepatotoxicity induced by Acetaminophen (AAP) mostly mediated by effect on oxidative stress parameters. The Zataria multiflora (Z.M) is an herbal medicine with well-known antioxidant effect. The aim of this study is investigation of preventive effects of Z.M and Carvacrol (CAR) on AAP-induced hepatotoxicity in rats. Methods: Rats were randomly divided into four groups including: 1) Control, 2) Acetaminophen (AAP), 3) and 4) CAR. The saline, Z.M (200 mg/kg) and CAR (20 mg/kg) were administrated orally for 6 days, after that AAP (600 mg/kg) was administrated in the $7^{th}$ day. Blood sampling was performed on the first and last days. Also, the liver tissue was removed for evaluation of Malondyaldehide (MDA), Thiol content, Superoxide dismutase (SOD) and Catalase (CAT). Total Protein (tPro), Glutamic Oxaloacetic Transaminase (GOT), Glutamic Pyruvic Transaminase (GPT) and Alkaline Phosphatase (ALP) in liver tissue were evaluated. The changes (${\Delta}$) of enzymes activities were presented. Results: The ${\Delta}GOT$, ${\Delta}GPT$ and ${\Delta}ALP$ in CAR group significantly decreased compared to AAP group (P < 0.01 to P < 0.001) and ${\Delta}GPT$ in Z.M group was significantly reduced in comparison with AAP group (P < 0.05). Also, MDA, Thiol, SOD and CAT levels in treated groups were attenuated compared to AAP group (P < 0.05 to P < 0.001). Conclusion: Z.M and CAR have a powerful hepatoprotective effect. CAR is more effective than Z.M. Based on the results. Z.M and CAR could be potent supplementary agents against hepatotoxicity of AAP in patients.