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崔漢祚 대구산업정보대학 1997 논문집 Vol.11 No.1
I-vocal Retrogressive Assimilation occurs frequently in the phonological conditions as follow : ① in the lexical morpheme ② In the case of noun derivative affixes /o/ plus /i/ ③ causative Verb. passive herb affixed /-i/, /-i/ and /-ki/ ④ In the case of verbs of which the stems contain /-ri/ I-Vocal Retrogressive assimilation is caused by the restraint of tone rather than that of phonemes. We found that if the given syllable is a high tone(H) or middle toneme(M) I-Vocal Retrogressive assimilation appears and if low tone(L) or lower middle tone(m, m), umklaut doesn't occurs. In the case of ③, the fact that causative verb'-i'.'-hi'and'-ki'have a particular function of upgrading the tone of given stems while passive verbs have a function of degrading the tone of given syllables caused the I-Vocal Retrogressive assimilation. We can also find in case ④ that I-Vocal Retrogressive assimilation appears in high tone(H) or mid tone(M) with no respect to whether the given consonant is /+coronal/ or not. therefore the I-Vocal Retrogressive assimilation of dialect around this area can be formulated as follows : The changing of I-Vogal Retrogressive assimilation rule ◁그림참조▷(원문을 참조하세요)
Multi-functional porous hydrogels for regenerative medicine
Soon Mo CHOI(최순모),Deepti Singh(팁티 싱),Yong Woo CHO(조용우),Tae Hwan OH(오태환),Sun Mi ZO(조선미),Sung Soo HAN(한성수) 제어로봇시스템학회 2012 제어로봇시스템학회 합동학술대회 논문집 Vol.2012 No.7
The aim of this work is to develop a novel biocompatible drug delivery carrier and tissue engineering scaffold with ability of controlled drug release and also tissue regeneration. We have synthesized HPMADMAEM copolymer based hydrogels loaded with Doxorubicin (DOX) and tested in vitro. In-vitro drug release profile exhibited pH sensitive behavior of the hydrogel. The hydrolytic degradation of gel and in vitro studies of polymer-doxorubicin conjugate and doxorubicin release from hydrogel matrix indicated that hydrogels were stable under acidic conditions (in buffers at pH 4.6. In both drug forms, polymer-doxorubicin conjugate and free doxorubicin could be released from the hydrogel scaffold at a rate depending directly on either the rate of drug diffusion from the hydrogel, or rate of hydrogel degradation or at rate controlled by a combination of the both processes. In-vitro analysis showed homogenous cell attachment and proliferation on synthesized hydrogel matrix.
Hyangkyoung Kim,Han Zo Choi,Yujin Kwon,Nicos Labropoulos 대한외과학회 2023 Annals of Surgical Treatment and Research(ASRT) Vol.105 No.4
Purpose: The purpose of this study was to compare the clinical outcomes of abdominal aortic graft infection (AGI) treated with removal of the graft vs. graft preservation. Methods: The electronic databases PubMed, Embase, and Cochrane Library for studies that reported on AGI were searched. Observational studies and case series of at least 10 cases that reporting on the prevalence, microbiology, and outcomes of AGI were included. Results: Our search identified 23 studies that met our inclusion criteria, reporting on a total of 873 patients who underwent open surgical repair (OSR) or endovascular aneurysm repair (EVAR). Of these patients, 833 received graft removal, and 40 received graft preservation. The prevalence of AGI was reported to be 1.0% (95% confidence interval [CI], 0.5%–1.8%) after OSR and 0.4% (95% CI, 0%–1.1%) after EVAR. The pooled estimates of 1-year, 2-year, and 5-year mortality were 28.7% (95% CI, 19.4%–38.8%), 36.6% (95% CI, 24.6%–49.5%), and 51.8% (95% CI, 38.4%–65.1%) in the graft removal group and 16.1% (95% CI, 4.1%–32.2%), 18.5% (95% CI, 5.7%–35.1%), and 50.0% (95% CI, 31.6%–68.4%) in the graft preservation group. The 30-day mortality rate’s risk ratio (RR) for graft removal vs. preservation was 0.98 (95% CI, 0.40–2.38), while the 1-year mortality rate’s RR was 3.44 (95% CI, 1.60–7.42). Conclusion: The 30-day mortality rate of AGI treatment was found to be high, whether using graft removal or preservation. In selected patients, implementing antibiotics with graft preservation as an initial management may be helpful in reducing the mortality rate.
Singh, Dolly,Singh, Deepti,Choi, Soon Mo,Zo, Sun Mi,Painuli, Rakesh Mohan,Kwon, Sung Won,Han, Sung Soo Hindawi Publishing Corporation 2014 Evidence-based Complementary and Alternative Medic Vol.2014 No.-
<P><I>Terminalia chebula</I> is one of the traditional medicines used in the treatment of many diseases. In the present work, different concentrations of various organic and aqueous extracts (solvent-free) of <I>T. chebula</I> were tested on fibroblast (L929) and keratinocytes cells to evaluate its biocompatible concentration by using MTT and live-dead viability/cytotoxic assay. These extracts were found to be effective in decreasing the ammonia accumulation in the media, thereby reducing its toxic effect on cells. DPPH assay further confirmed the free-radical scavenging ability of the extracts which increased with the increase in concentration of each extract. Cell proliferation/apoptosis, cytoskeletal structure, and ECM production were further evaluated by live-dead assay and phalloidin/cytokeratin staining, respectively. The cytoskeletal structure and ECM secretion of the cells treated with extracts showed higher cellular activity in comparison to control. In conclusion, we have demonstrated the effect of these extracts of <I>T. chebula</I> on both types of skin cells and optimized concentration in which it could be used as a bioactive component for wound healing applications by increasing cell proliferation and decreasing free-radical production without affecting the normal cellular matrix. It can also find applications in other therapeutics applications where ammonia toxicity is a limiting factor.</P>
Kim, Jong Soo,Choi, Hyun Woo,Araú,zo-Bravo, Marcos J.,Schö,ler, Hans R.,Do, Jeong Tae The Company of Biologists Ltd. 2015 Journal of cell science Vol.128 No.1
<P>Direct reprogramming of somatic cells to pluripotent stem cells entails the obliteration of somatic cell memory and the reestablishment of epigenetic events. Induced pluripotent stem cells (iPSCs) have been created by reprogramming somatic cells through the transduction of reprogramming factors. During cell reprogramming, female somatic cells must overcome at least one more barrier than male somatic cells in order to enter a pluripotent state, as they must reactivate an inactive X chromosome (Xi). In this study, we investigated whether the sex of somatic cells affects reprogramming efficiency, differentiation potential and the post-transcriptional processing of <I>Xist</I> RNA after reprogramming. There were no differences between male and female iPSCs with respect to reprogramming efficiency or their differentiation potential <I>in vivo</I>. However, reactivating Xi took longer than reactivating pluripotency-related genes. We also found that direct reprogramming leads to gender-appropriate post-transcriptional reprogramming – like male embryonic stem cells (ESCs), male iPSCs expressed only the long <I>Xist</I> isoform, whereas female iPSCs, like female ESCs, expressed both the long and short isoforms.</P>
최기준(Kee Joon Choi),조주희(Joo Hee Zo),한경일(Kyung Il Han),김영권(Young Kwon Kim),조명찬(Myeong Chan Cho),손대원(Dae Won Sohn),이명묵(Myoung Mook Lee),박영배(Young Bae Park),최윤식(Yun Shik Choi),서정돈(Jung Don Seo),이영우(Young 대한내과학회 1990 대한내과학회지 Vol.39 No.5
N/A To observe the clinical features of Takayasu's arteritis and evaluate the incidence and sites of coronary arterial involvement in Takayasu's arteritis, clinical observations were made in 99 patients who were diagnosed as Takayasu's arteritis by clinical features and aortographic findings in Seoul National University Hospital from August 1971 to July 1989 Coronary arteriographies were performed prospectively in 30 patients with Takayasu's arteritis since March 1987. The results were as follows: 1) In 99 cases of Takayasu's arteritis, 15 were male and 84 were female. The male to female ratio was 1:5.7, the mean age was 29.5, and 63% of those studied were under the age of 30. 2) The following were the presenting clinical symptoms and signs in decreasing order of frequency: headache(69%), weak or nonpalpable pulse(68%), carotid or abdominal bruit(55%), Dyspnea on exertion(51%), hypertention(48%), and dizziness(43%). 3) Aorta or arterial involvement in decreasing order of frequency: left subclavian artery(62%), abdominal aorta(58%), right subclavian artery(38%), descending thoracic aorta(37%) and left renal artery(35%). 4) Using Ueno's classification, 29(29%) were Type I, 22(22g) were Type II, and 48(48%) were Type III. Type IV or pulmonary arterial involvements were seen in 11(33%) out of 33 patients. 5) In a prospective study using coronary arteriography, 8(27%) out of 30 patients of Takayasu's ateritis showed coronary involvement. Among the 13 lesions of coronary arterial narrowings in 8 patients with coronary involvements, there were 3 ostial lesions, 5 proximal and 5 middle or distal lesions. 6) Frequently there were no cardiac symptom in patients with Takayasu's arteritis who had coronary arterial lesions, and a myocadial infarction or congestive heart failure may be the first sign of the coronary arterial narrowing.