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- 저자 : Han Eugene (검색결과 71 건)
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Appendicular Skeletal Muscle Mass to Visceral Fat Area Ratio Predicts Hepatic Morbidities
( Eugene Han ),( Yong-ho Lee ),( Sang Hoon Ahn ),( Bong-soo Cha ),( Seung Up Kim ),( Byung-wan Lee ) 대한소화기기능성질환·운동학회 2024 Gut and Liver Vol.18 No.3
Background/Aims: Reports on the association between sarcopenic visceral obesity and nonalcoholic fatty liver disease (NAFLD)-associated morbidities remain scarce. We investigated the association between sarcopenia and visceral obesity, and the influence of this association on hepatic and coronary comorbidities. Methods: The appendicular skeletal muscle mass to visceral fat area ratio (SV ratio) was evaluated using bioelectric impedance analysis. NAFLD and significant liver fibrosis were assessed using transient elastography, and high atherosclerotic cardiovascular disease (ASCVD) risk was defined as a 10-year ASCVD risk score >10%. Sarcopenia was defined as appendicular skeletal muscle mass adjusted by body mass index (<0.789 for men and <0.512 for women). Results: In total, 82.0% (n=1,205) of the entire study population had NAFLD, and 14.6% of these individuals (n=176) exhibited significant liver fibrosis. Individuals with the lowest SV ratio had a significantly increased risk of NAFLD, significant liver fibrosis, and high ASCVD risk (all p<0.05). Individuals with both the lowest SV ratio and sarcopenia had the highest risk of developing NAFLD (odds ratio [OR]=3.11), significant liver fibrosis (OR=2.03), and high ASCVD risk (OR=4.15), compared with those with a higher SV ratio and without sarcopenia (all p<0.05). Conclusions: Low SV ratio combined with sarcopenia was significantly associated with an increased risk of NAFLD, significant liver fibrosis, and high ASCVD risk among individuals with a high risk of NAFLD. (Gut Liver 2024;18:509-519)
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Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal Diseases
Han, Eugene,Lee, Yong-ho Korean Diabetes Association 2017 Diabetes and Metabolism Journal Vol.41 No.6
<P>As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 diabetes mellitus, metabolic syndrome, dyslipidemia, hypertension, cardiovascular or cerebrovascular diseases, and chronic kidney disease. Non-alcoholic steatohepatitis, an advanced type of NAFLD, can aggravate these inter-organ relationships and lead to poorer outcomes. NAFLD induces insulin resistance and exacerbates systemic chronic inflammation and oxidative stress, which leads to organ dysfunction in extra-hepatic tissues. Although more research is needed to identify the pathophysiological mechanisms and causal relationship between NAFLD and cardiometabolic and renal diseases, screening for heart, brain, and kidney diseases, risk assessment for diabetes, and a multidisciplinary approach for managing these patients should be highly encouraged.</P>
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Han, Cheol-Min,Lih, Eugene,Choi, Seul-Ki,Bedair, Tarek M.,Lee, Young-Jae,Park, Wooram,Han, Dong Keun,Son, Jun Sik,Joung, Yoon Ki Elsevier 2018 Journal of industrial and engineering chemistry Vol.67 No.-
<P><B>Abstract</B></P> <P>In this study, a polydioxanone (PDO) and poly(L-lactic acid) (PLLA) sheath-core biphasic monofilament was designed to develop an esophageal stent with improved mechanical properties and controlled biodegradability. The radial force of PDO/PLLA sheath-core stent was 10.24N, while that of PDO stent was 5.64N. Deteriorations of tensile strength, elastic modulus and elongation during degradation test were also delayed on PDO/PLLA group. Hyaluronic acid–dopamine conjugate and BaSO<SUB>4</SUB>/PDO conjugate coating layers provided improved tissue adhesion strength and reasonable X-ray contrast, respectively. Taken all together, the sheath-core filaments with tissue adhesive and radiopaque properties will be useful in designing esophageal stents.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Han Eugene,Kim Mi Kyung,Im Seung-Soon,Kim Hye Soon,Kwon Taeg Kyu,Jang Byoung Kuk 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.3
Background/Aims: We explored whether high sodium intake, assessed by urinary excretion, determines the risk of sarcopenia and nonalcoholic fatty liver disease (NAFLD). Methods: We analyzed 10,036 adult participants with normal kidney function from the Korea National Health and Nutrition Examination Survey (2008–2011). NAFLD was identified using the fatty liver index, and the muscle mass was evaluated using dual X-ray absorptiometry. The dietary sodium intake was estimated using Tanaka’s equation. Results: The mean 24-hour urinary sodium excretion was 144.2±36.1 mmol/day (corresponding to 3.3 g/day Na) in the total population. The 24-hour urinary sodium excretion showed moderate accuracy in predicting NAFLD (area under the receiver operating characteristic, 0.702; 95% confidence interval [CI], 0.692 to 0.712). A cutoff value of 99.96 mmol/day (corresponding to 2.30 g/day Na) for urinary sodium excretion in predicting NAFLD showed 76.1% sensitivity and 56.1% specificity. The results of multiple adjusted models indicated that the participants with the highest urinary sodium excretion had a significantly higher risk of NAFLD (odds ratio, 1.46; 95% CI, 1.27 to 1.66; p<0.001) and sarcopenia (odds ratio, 1.49; 95% CI, 1.28 to 1.73; p<0.001) than those with the lowest urinary sodium excretion. The association between a higher 24-hour urinary sodium excretion and NAFLD was independent of sarcopenia. Conclusions: Participants with a high sodium intake, as assessed by sodium excretion, had a substantial risk of NAFLD and sarcopenia.
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Han, Eugene,Park, Hye Sun,Kwon, Obin,Choe, Eun Yeong,Wang, Hye Jin,Lee, Yong-ho,Lee, Sang-Hak,Kim, Chul Hoon,Kim, Lee-Kyung,Kwak, Soo Heon,Park, Kyong Soo,Kim, Chul Sik,Kang, Eun Seok Williams & Wilkins Co 2016 Medicine Vol.95 No.44
<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>Incretin hormone-based therapy in type 2 diabetes has been widely used, and dipepdityl peptidase-4 (DPP-4) inhibitors, which prevent incretin degradation, have become popular oral hypoglycemic agents. The efficacy of DPP-4 inhibitors varies from individuals, and factors determining responses to DPP-4 inhibitors have not been fully established. We aimed to investigate whether genetic variations in glucagon-like peptide (GLP-1) receptor are associated with responses to DPP-4 inhibitors in patients with type 2 diabetes.</P><P>Genetic variations of rs3765467 in GLP-1 receptor were explored in 246 patients with type 2 diabetes who received DPP-4 inhibitors treatment for 24 weeks in addition to previous medication. Patients with glycated hemoglobin (HbA1c) > 7% and who were naive to any DPP-4 inhibitors were enrolled. Responders were defined as those who showed a > 10% reduction in HbA1c after DPP-4 inhibitor treatment.</P><P>DPP-4 inhibitors improved glycemic parameters and lipid profiles. Compared to the major genotype (GG), a larger proportion of patients with the minor allele genotype (GA/AA) were responders (<I>P</I> = 0.018), and also showing greater HbA1c reductions (1.3 ± 1.1 vs 0.9 ± 1.2%; <I>P</I> = 0.022). This genetic effect remained significant even after adjustment for other confounding factors (OR = 2.00, 95% CI = 1.03–3.89).</P><P>Polymorphism in the GLP-1 receptor may influence DPP-4 inhibitor response. Further studies in larger population will help determine the association between genetic variation and interindividual differences in DPP-4 inhibitor therapy.</P></▼2>
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Han Eugene,Lee Yong-ho,Lee Jae Seung,Lee Hye Won,Kim Beom Kyung,Park Jun Yong,Kim Do Young,Ahn Sang Hoon,Lee Byung-Wan,Kang Eun Seok,Cha Bong-Soo,Kim Seung Up 거트앤리버 소화기연관학회협의회 2022 Gut and Liver Vol.16 No.5
Background/Aims: Metabolic dysfunction associated fatty liver disease (MAFLD) has recently been introduced to compensate for the conventional concept of nonalcoholic fatty liver disease (NAFLD). We explored whether fibrotic burden determines the risk of atherosclerotic cardiovascular disease (ASCVD) among subjects with MAFLD. Methods: We recruited 9,444 participants from the Korea National Health and Nutrition Examination Survey (2008 to 2011). Liver fibrosis was identified using the fibrosis-4 (FIB-4) index and NAFLD fibrosis score. The 10-year ASCVD risk score (>10%) was used to determine a high probability ASCVD risk. For sensitivity analysis, propensity score matching was assessed to subjects with aged 40 to 75 years free from ASCVD. Results: The prevalence of MAFLD was 38.0% (n=3,592). The ASCVD risk scores stratified in quartile were positively correlated to MAFLD and FIB-4 defined-significant liver fibrosis (p for trend <0.001). Individuals with both MAFLD and FIB-4 defined-significant liver fibrosis had a greater chance of high probability ASCVD risk (odds ratio [OR]=2.40; p<0.001) than those without MAFLD. The impact of MAFLD on high probability ASCVD risk was greater than that of significant liver fibrosis (OR=4.72 for MAFLD vs OR=1.88 for FIB-4 defined-significant liver fibrosis; all p<0.001). Among participants with MAFLD, low muscle mass enhanced the risk of significant liver fibrosis (OR=1.56 to 2.43; p<0.001). When NAFLD fibrosis score was applied to define significant liver fibrosis, similar findings were observed. Conclusions: Individuals with MAFLD had a substantial ASCVD risk compared to those without MAFLD. Accompanying significant liver fibrosis further enhanced the risk of ASCVD among subjects with MAFLD.
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미술놀이치료를 활용한 유아교사의 놀이교수효능감 증진 교사교육 프로그램 개발
한유진 ( Han Eugene ),강민수 ( Kang Minsoo ),안복희 ( An Bogheui ),원용희 ( Won Yonghee ) 열린부모교육학회 2020 열린부모교육연구 Vol.12 No.3
본 연구의 목적은 유아교사의 놀이교수효능감 증진을 위한 교사교육 프로그램을 개발하고, 그 효과를 검증하는데 있다. 우선, 관련 선행연구 및 요구조사를 수행하여 프로그램에 필요한 구성요소들을 추출한 후, 이를 기반으로 미술놀이치료 방법을 접목해 프로그램을 구성하였다. 그리고 개발된 프로그램의 효과를 검증하기 위해 서울 소재 4곳, 민간 어린이집 내 누리과정 담임교사로서, 경력이 2∼3년 이상인 유아교사 20명을 대상으로 총 10회기를 시행하였다. 그 연구대상을 실험집단과 통제집단으로 각각 나눈 후, 실험집단에 대해서는 매 회기 놀이에 대한 교육 및 그에 따른 미술놀이 체험이 이루어지도록 하였고, 반면에 통제집단은 해당 교육이 수행되지 않았다. 그 결과, 미술놀이치료를 활용한 교사교육 프로그램이 유아교사의 놀이교수효능감을 향상하는데 매우 유용한 것으로 나타났으며, 본 연구결과는 새로운 누리과정 교육 개편에 맞는 교사교육의 필요성과 유아교사의 요구를 반영한 프로그램으로써 앞으로 국가차원에서 이루어지는 현직 유아교사 교사교육현장에 적용 가능하다는 점을 보여준다. The purpose of this study is to develop a teacher training program for improving preschool teacher's teaching efficacy on children's play and to verify its effectiveness. First, the preliminary studies and the demand surveys were conducted to extract the necessary components, and then based on that, the program was composed by combining art play therapy methods. And in order to verify the effectiveness of the developed program, a total of ten sessions of the program were carried out at four different private nursery schools in Seoul, for twenty teachers who have two or three years of experience as a teacher and are in the Nuri curriculum. The teachers were divided into the experimental group and the control group, respectively, after that, the experimental group had education on play each session and the art play experience accordingly, and the control group did not perform any education. As a result, it was found that a teacher education program using art play therapy was very useful for improving preschool teacher's teaching efficacy on children's play. The result of this study suggests that the program can reflect the necessity of teacher education and teacher's needs in accordance with the reorganization of new Nuri curriculum, and can be applied to in-service sites for teacher education at the national level.
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