http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Hyunsu Kim,Kyung‑Wan Baek,고은지,Nguyen Thanh Luan,Yunjin Lim,Heyong Jin Roh,Nameun Kim,Do‑Hyung Kim,Ahran Kim,Yung Hyun Choi,Suhkmann Kim,Heui‑Soo Kim,Mee Sun Ock,차희재 한국유전학회 2020 Genes & Genomics Vol.42 No.7
Background Viral hemorrhagic septicemia (VHS) is a serious viral disease that infects the olive flounder in South Korea. The Korean aquaculture industry experienced an economic loss caused by the high infectivity and mortality. Objective This study aimed to evaluate the infection density of VHSV in various organs of the olive flounder including spleen, liver, kidney, stomach, esophagus, intestine, gill, muscle, heart, and brain. Olive flounders were collected from a local fish farm and injected subcutaneously with 106 PFU/fish. Methods Each 15 fish were sampled at 0, 3, and 7 days post challenge (dpc), respectively, to perform quantitative analysis of VHSV using SYBR-green based real-time PCR in various tissues including spleen, liver, head-kidney, body-kidney, muscle, esophagus, stomach, intestine, gill, and brain. Results Organs infected with VHSV were obtained after 3 and 7 days. Each organs were examined for viral infection using real-time PCR. The data obtained from this experiment revealed copy numbers higher than 10 copies per 100 ng cDNA in the spleen (15.26 ± 3.11 copies/100 ng of cDNA), muscle (11.24 ± 2.25 copies), and gill (14.23 ± 6.26 copies), but lower in liver, head-kidney, body-kidney, esophagus, brain and stomach. Conclusion The present study, together with previous data, demonstrated that the gill, spleen, and muscle are the major target organs of VHSV in olive flounder. Therefore, central monitoring of spleen, gill and muscle should be considered and might be necessary if anti-VHSV treatment is to be successful in infected olive flounder.
Kim, Jong-Hoon,Chung, Hwan-Suck,Kang, Moonkyu,Kim, Yong,Kim, Byung-Su,Kim, Youn-Sub,Bae, Hyunsu Elsevier 2011 Diabetes research and clinical practice Vol.93 No.2
<P><B>Abstract</B></P> <P>PM021, which consists of two herbal components, Mori Folium and Aurantii Fructus, is routinely used to treat diabetes in Korea. In this study, the anti-diabetic effect of PM021 on an animal model of developing type 2 diabetes of Otsuka Long–Evans Tokushima Fatty (OLETF) rats was investigated. Eight weeks of age male OLETF rats were treated daily with PM021 or vehicle for five months. Specifically, changes in body weight, blood glucose, urine volume, food intake and oral glucose tolerance were measured in rats for five months. The rats in this study were divided into four groups: a Long–Evans Tokushima Otsuka (LETO) rat group, which is a genetic control group for OLETF, that received no treatment; a PM021 treatment group of LETO rats; OLETF rats that received no treatment; and OLETF rats that received PM021 treatment. The results showed that PM021 significantly prevented increases in body weight, blood glucose, and urine and food intake that resulted from the induction of obesity and diabetes. PM021 also improved glucose tolerance in OLETO rats. However, PM021 had no effect on LETO rats, a control group of OLETF rats. Taken together, these findings indicate that PM021 has distinct anti-diabetic effects without any adverse effects or toxicities.</P>
EGFR Inhibitors Enhanced the Susceptibility to NK Cell-mediated Lysis of Lung Cancer Cells
Kim, Hyunsu,Kim, Sun-Hee,Kim, Mi-Ju,Kim, So-Jung,Park, Soo-Jung,Chung, Joo-Seop,Bae, Jae-Ho,Kang, Chi-Dug Lippincott Williams Wilkins, Inc. 2011 Journal of immunotherapy Vol.34 No.4
As quercetin, which can inhibit phosphatidylinositol 3-kinase, nuclear factor-kappa B, and protein kinase C (PKC) pathways, induced expression of natural killer group 2, member D (NKG2D) ligands on cancer cells and made the cells sensitive to NK –cell-mediated killing; inhibition of epidermal growth factor receptor (EGFR) pathway might lead to induction of NKG2D ligands. In this study, it was investigated whether EGFR inhibitors, including erlotinib or gefitinib, could regulate expression of NKG2D ligands in various lung cancer cells including A549, NCI-H23, and SW-900. The EGFR inhibitors predominantly increased transcription and surface expression of ULBP1, and subsequently increased susceptibility of the cancer cells to NK-92 cells. When the selective inhibitors of nuclear factor-kappa B, phosphatidylinositol 3-kinase, mitogen-activated protein kinases, and PKC were treated to discriminate downstream signaling of EGFR pathway, expression of ULBP1 in the cancer cells was induced by inhibition of PKC. Treatment with phorbol 12-myristate 13-acetate restored the EGFR inhibitor-induced ULBP1 transcription. Binding activity to ULBP1 promoter region of AP-2α, which suggested as suppressor of expression of ULBP1, was decreased by treatment with EGFR inhibitors, and restored by pretreatment with phorbol 12-myristate 13-acetate in A549 and SW-900. Rottlerin, a PKC&dgr; inhibitor, also decreased the binding activity of AP-2α in dose-dependent manner. This study suggests that EGFR inhibitors enhanced the susceptibility to NK cell-mediated lysis of lung cancer cells by induction of ULBP1 by inhibition of PKC pathway and therapeutic efficacy of EGFR inhibitors in lung cancer may be mediated in part by increased susceptibility to NK cell-mediated cytotoxicity.
기상민감질환과 기상요소의 상관관계에 대한 의료진의 기초인식파악을 위한 설문조사기반 연구
김현수 ( Hyunsu Kim ),김유근 ( Yoo-keun Kim ),정주희 ( Ju-hee Jeong ),안혜연 ( Hye Yeon An ),김태희 ( Taehee Kim ),윤진아 ( Jina Yun ),원경미 ( Kyung-mi Won ),이지호 ( Jiho Lee ),오인보 ( Inbo Oh ),이영미 ( Young-mi Lee ),임연주 ( Ye 한국환경과학회 2017 한국환경과학회지 Vol.26 No.5
Provider-oriented weather information has been rapidly changing to become more customer-oriented and personalized. Given the increasing interest in wellness and health topics, the demand for health weather information, and biometeorology, also increased. However, research on changes in the human body according to weather conditions is still insufficient due to various constraints, and interdisciplinary research is also lacking. As part of an effort to change that, this study surveyed medical practitioners at an actual treatment site, using questionnaires, to investigate what kind of weather information they could utilize. Although there was a limit to the empirical awareness that medical staff had about weather information, most respondents noted that there is a correlation between disease and weather, with cardiovascular diseases (coronary artery disease (98.5%) and hypertension (95.9% ), skin diseases (atopic dermatitis (100%), sunburn (93.8%)) being the most common weather-sensitive ailments. Although there are subject-specific differences, most weather-sensitive diseases tend to be affected by temperature and humidity in general. Respiratory and skin diseases are affected by wind and solar radiation, respectively.
연구논문 : 2007년 3월 31일 서해에서 발생한 기상해일에 대한 기상학적 분석
김현수 ( Hyunsu Kim ),김유근 ( Yoo Keun Kim ),우승범 ( Seung Buhm Woo ),김명석 ( Myung Seok Kim ) 한국환경과학회 2014 한국환경과학회지 Vol.23 No.12
A meteo-tsunami occurred along the coastline of South Korea on 31 March 2007, with an estimated maximum amplitude of 240 cm in Yeonggwang (YG). In this study, we investigated the synoptic weather systems around the Yellow sea including the Bohai Bay and Shandong Peninsula using a weather research and forecast model and weather charts of the surface pressure level, upper pressure level and auxiliary analysis. We found that 4-lows passed through the Yellow sea from the Shandung Peninsula to Korea during 5 days. Moreover, the passage of the cold front and the locally heavy rain with a sudden pressure change may make the resonance response in the near-shore and ocean with a regular time-lag. The sea-level pressure disturbance and absolute vorticity in 500 hPa projected over the Yellow sea was propagated with a similar velocity to the coastline of South Korea at the time that meteo-tsunami occurred.
Ko Eun-Ji,Kim Hyunsu,Lee A-Reum,Jeon Kyung‑Yoon,Kim Ahran,Kim Do‑Hyung,Park Chan-Il,Choi Yung Hyun,Kim Suhkmann,Kim Heui-Soo,옥미선,차희재 한국유전학회 2021 Genes & Genomics Vol.43 No.11
Background Rock bream iridovirus (RBIV) is one of the most dangerous pathogens that causes the highest mortality in the aquaculture of rock bream (Oplegnathus fasciatus). Even though RBIV infection leads to huge economic loss, proteome studies on RBIV-infected rock bream have not been conducted to provide information about the diferential protein expression pattern by the host protection system. Objective The purpose of this study was to investigate the protein expression patterns in spleens of rock bream olive after infection by RBIV or mixed infection by RBIV and bacteria. Methods Depending on the infection intensity and sampling time point, fsh were divided into fve groups: uninfected healthy fsh at week 0 as the control (0C), heavily infected fsh at week 0 (0H), heavily mixed RBIV and bacterial infected fsh at week 0 (0MH), uninfected healthy fsh at week 3 (3C), and lightly infected fsh at week 3 (3L). Proteins were extracted from the spleens of infected rock bream. We used 2-DE analysis with LC–MS/MS to investigate proteome changes in infected rock bream. Results The results of the LC–MS/MS analyses showed diferent protein expression profles after infection. Proteins related to oxygen transport and energy generation, such as hemoglobin, beta-globin, and ATP synthase, were mostly expressed in the infected spleen. Whereas proteins involved in structure and cell movement, such as tubulin, myosin, actin binding proteins, and intermediate flament proteins, were down-regulated in the infected spleens. The protein expression profles between infection by RBIV and mixed infection by RBIV and bacteria showed similar patterns. Conclusions Our results indicated that infection by RBIV or mixed infection by RBIV and bacteria triggered energy generation and oxygen-transport, but cell migration and constructional changes in the spleen were extremely decreased.